The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells

Apoptosis

Volumn 16, Issue 12, 2011, Pages 1245-1252

  Morales, Alvaro ^a   Alvarez, Annamil ^a   Arvelo, Francisco ^a,b   Suárez, Alírica I ^c   Compagnone, Reinaldo S ^b   Galindo Castro, Iván ^a  

^a Fundacion Instituto de Estudios Avanzados IDEA   (Venezuela)

^b FACULTAD DE CIENCIAS   (Venezuela)

^c UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

AP 2 Rb; Apoptosis; Bcl 2; E2F1; ent 16 17 Dihydroxykaurane (DHK); Puma

Indexed keywords

APOLIPOPROTEIN B; ENT 16BETA 17ALPHA DIHYDROXYKAURANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAURANE DERIVATIVE; PROTEIN BCL 2; PUMA PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN MCF 7; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; PRIORITY JOURNAL; UPREGULATION;

CELL LINE, TUMOR; DITERPENES, KAURANE; DOWN-REGULATION; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EUPHORBIACEAE;

EID: 82955162610     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0638-5     Document Type: Article

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