메뉴 건너뛰기




Volumn 154, Issue 2, 2013, Pages 853-864

Parathyroid hormone-related protein is a mitogenic and a survival factor of mesangial cells from male mice: Role of Intracrine and Paracrine pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MYC PROTEIN; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR E2F1;

EID: 84872731750     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1802     Document Type: Article
Times cited : (27)

References (61)
  • 1
    • 84872509495 scopus 로고    scopus 로고
    • Lupus nephritis: An overview of recent findings
    • de Zubiria Salgado A, Herrera-Diaz C. Lupus nephritis: an overview of recent findings. Autoimmune Dis. 2012;2012:849684.
    • (2012) Autoimmune Dis , vol.2012 , pp. 849684
    • De Zubiria Salgado, A.1    Herrera-Diaz, C.2
  • 3
    • 84860848481 scopus 로고    scopus 로고
    • Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation
    • Liu L, Qiu W, Wang H, et al. Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation. J Biol Chem. 2012;287:16410-16423.
    • (2012) J Biol Chem , vol.287 , pp. 16410-16423
    • Liu, L.1    Qiu, W.2    Wang, H.3
  • 4
    • 0025334609 scopus 로고
    • The mesangium in anti-Thy-1 nephritis. Influx of macrophages, mesangial cell hypercellularity, and macromolecular accumulation
    • Bagchus WM, Jeunink MF, Elema JD. The mesangium in anti-Thy-1 nephritis. Influx of macrophages, mesangial cell hypercellularity, and macromolecular accumulation. Am J Pathol. 1990;137:215-223. (Pubitemid 20229603)
    • (1990) American Journal of Pathology , vol.137 , Issue.1 , pp. 215-223
    • Bagchus, W.M.1    Jeunink, M.F.2    Elema, J.D.3
  • 5
    • 0028116649 scopus 로고
    • Mesangial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis
    • Baker AJ, Mooney A, Hughes J, Lombardi D, Johnson RJ, Savill J. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest. 1994;94:2105-2116. (Pubitemid 24348252)
    • (1994) Journal of Clinical Investigation , vol.94 , Issue.5 , pp. 2105-2116
    • Baker, A.J.1    Mooney, A.2    Hughes, J.3    Lombardi, D.4    Johnson, R.J.5    Savill, J.6
  • 6
    • 0032925127 scopus 로고    scopus 로고
    • Mechanisms for induction of apoptosis and glomerular disease
    • DOI 10.1093/ndt/14.suppl-1.52
    • Kashihara N, Sugiyama H, Makino H. Mechanisms for induction of apoptosis and glomerular disease. Nephrol Dial Transplant. 1999;14 Suppl 1:52-54. (Pubitemid 29041839)
    • (1999) Nephrology Dialysis Transplantation , vol.14 , Issue.SUPPL. 1 , pp. 52-54
    • Kashihara, N.1    Sugiyama, H.2    Makino, H.3
  • 7
    • 0023228836 scopus 로고
    • A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression
    • Suva LJ, Winslow GA, Wettenhall RE, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science. 1987;237:893-896. (Pubitemid 17128278)
    • (1987) Science , vol.237 , Issue.4817 , pp. 893-896
    • Suva, L.J.1    Winslow, G.A.2    Wettenhall, R.E.H.3
  • 10
    • 0001327508 scopus 로고    scopus 로고
    • Synovium as a source of increased amino-terminal parathyroid hormone- related protein expression in rheumatoid arthritis a possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis
    • Funk JL, Cordaro LA, Wei H, Benjamin JB, Yocum DE. Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis. J Clin Invest. 1998;101:1362-1371. (Pubitemid 28166833)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.7 , pp. 1362-1371
    • Funk, J.L.1    Cordaro, L.A.2    Wei, H.3    Benjamin, J.B.4    Yocum, D.E.5
  • 11
    • 84866145957 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein: An update
    • Wysolmerski JJ. Parathyroid hormone-related protein: an update. J Clin Endocrinol Metab. 2012;97:2947-2956.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2947-2956
    • Wysolmerski, J.J.1
  • 12
    • 0031456826 scopus 로고    scopus 로고
    • Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting
    • Massfelder T, Dann P, Wu TL, Vasavada R, Helwig JJ, Stewart AF. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc Natl Acad Sci U S A. 1997;94:13630-13635.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13630-13635
    • Massfelder, T.1    Dann, P.2    Wu, T.L.3    Vasavada, R.4    Helwig, J.J.5    Stewart, A.F.6
  • 13
    • 33750474119 scopus 로고    scopus 로고
    • Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: Definition of an arterial smooth muscle PTHrP/p27kip1 pathway
    • DOI 10.1161/01.RES.0000248184.21644.20, PII 0000301220061027000006
    • Fiaschi-Taesch N, Sicari BM, Ubriani K, et al. Cellular mechanism through which parathyroid hormone-related protein induces proliferation in arterial smooth muscle cells: definition of an arterial smooth muscle PTHrP/p27kip1 pathway. Circ Res. 2006;99:933-942. (Pubitemid 44657796)
    • (2006) Circulation Research , vol.99 , Issue.9 , pp. 933-942
    • Fiaschi-Taesch, N.1    Sicari, B.M.2    Ubriani, K.3    Bigatel, T.4    Takane, K.K.5    Cozar-Castellano, I.6    Bisello, A.7    Law, B.8    Stewart, A.F.9
  • 14
    • 78650073823 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein enhances human ss-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin e expression
    • Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, et al. Parathyroid hormone-related protein enhances human ss-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010;59:3131-3138.
    • (2010) Diabetes , vol.59 , pp. 3131-3138
    • Guthalu Kondegowda, N.1    Joshi-Gokhale, S.2    Harb, G.3
  • 16
    • 0029063164 scopus 로고
    • Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death
    • Henderson JE, Amizuka N, Warshawsky H, et al. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol. 1995;15:4064-4075.
    • (1995) Mol Cell Biol , vol.15 , pp. 4064-4075
    • Henderson, J.E.1    Amizuka, N.2    Warshawsky, H.3
  • 17
    • 34848886113 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K-Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B
    • DOI 10.1093/carcin/bgm106
    • Agouni A, Sourbier C, Danilin S, et al. Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B. Carcinogenesis. 2007;28:1893-1901. (Pubitemid 47500600)
    • (2007) Carcinogenesis , vol.28 , Issue.9 , pp. 1893-1901
    • Agouni, A.1    Sourbier, C.2    Danilin, S.3    Rothhut, S.4    Lindner, V.5    Jacqmin, D.6    Helwig, J.-J.7    Lang, H.8    Massfelder, T.9
  • 18
    • 67651149656 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling
    • Bhatia V, Mula RV, Weigel NL, Falzon M. Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res. 2009;7:1119-1131.
    • (2009) Mol Cancer Res , vol.7 , pp. 1119-1131
    • Bhatia, V.1    Mula, R.V.2    Weigel, N.L.3    Falzon, M.4
  • 19
    • 33646909968 scopus 로고    scopus 로고
    • The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes
    • Izquierdo A, Lopez-Luna P, Ortega A, et al. The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes. Kidney Int. 2006;69:2171-2177.
    • (2006) Kidney Int , vol.69 , pp. 2171-2177
    • Izquierdo, A.1    Lopez-Luna, P.2    Ortega, A.3
  • 23
    • 0032901039 scopus 로고    scopus 로고
    • Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage
    • DOI 10.1046/j.1523-1755.1999.00241.x
    • Largo R, Gomez-Garre D, Santos S, et al. Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage. Kidney Int. 1999;55:82-90. (Pubitemid 29004239)
    • (1999) Kidney International , vol.55 , Issue.1 , pp. 82-90
    • Largo, R.1    Gomez-Garre, D.2    Santos, S.3    Penaranda, C.4    Blanco, J.5    Esbrit, P.6    Egido, J.7
  • 24
    • 0035036346 scopus 로고    scopus 로고
    • A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases
    • DOI 10.1016/S1567-5769(01)00040-6, PII S1567576901000406
    • Funk JL. A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases. Int Immunopharmacol. 2001;1:1101-1121. (Pubitemid 32434427)
    • (2001) International Immunopharmacology , vol.1 , Issue.6 , pp. 1101-1121
    • Funk, J.L.1
  • 26
    • 67449084189 scopus 로고    scopus 로고
    • Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse
    • Wendling O, Bornert JM, Chambon P, Metzger D. Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse. Genesis. 2009;47:14-18.
    • (2009) Genesis , vol.47 , pp. 14-18
    • Wendling, O.1    Bornert, J.M.2    Chambon, P.3    Metzger, D.4
  • 28
    • 0034864296 scopus 로고    scopus 로고
    • The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells
    • DOI 10.1210/en.142.9.4096
    • de Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, et al. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology. 2001;142:4096-4105. (Pubitemid 32802683)
    • (2001) Endocrinology , vol.142 , Issue.9 , pp. 4096-4105
    • De Miguel, F.1    Fiaschi-Taesch, N.2    Lopez-Talavera, J.C.3    Takane, K.K.4    Massfelder, T.5    Helwig, J.-J.6    Stewart, A.F.7
  • 29
    • 79954610144 scopus 로고    scopus 로고
    • LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma
    • Dormoy V, Beraud C, Lindner V, et al. LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma. Oncogene. 2010;30:1753-1763.
    • (2010) Oncogene , vol.30 , pp. 1753-1763
    • Dormoy, V.1    Beraud, C.2    Lindner, V.3
  • 31
    • 84856090603 scopus 로고    scopus 로고
    • c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein
    • Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N. c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein. Endocrinology. 2012;153:861-872.
    • (2012) Endocrinology , vol.153 , pp. 861-872
    • Sicari, B.M.1    Troxell, R.2    Salim, F.3    Tanwir, M.4    Takane, K.K.5    Fiaschi-Taesch, N.6
  • 32
    • 84856188693 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein is a hypertrophy factor for human mesangial cells: Implications for diabetic nephropathy
    • Ortega A, Romero M, Izquierdo A, et al. Parathyroid hormone-related protein is a hypertrophy factor for human mesangial cells: Implications for diabetic nephropathy. J Cell Physiol. 2012;227:1980-1987.
    • (2012) J Cell Physiol , vol.227 , pp. 1980-1987
    • Ortega, A.1    Romero, M.2    Izquierdo, A.3
  • 34
    • 0028848127 scopus 로고
    • Inhibition of MAP kinase by prostaglandin E2 and forskolin in rat renal mesangial cells
    • Li X, Zarinetchi F, Schrier RW, Nemenoff RA. Inhibition of MAP kinase by prostaglandin E2 and forskolin in rat renal mesangial cells. Am J Physiol. 1995;269:C986-991.
    • (1995) Am J Physiol , vol.269
    • Li, X.1    Zarinetchi, F.2    Schrier, R.W.3    Nemenoff, R.A.4
  • 37
    • 0029006719 scopus 로고
    • Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: Evidence for growth-inhibiting and invasion-promoting effects
    • Luparello C, Burtis WJ, Raue F, Birch MA, Gallagher JA. Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: evidence for growth-inhibiting and invasion-promoting effects. Mol Cell Endocrinol. 1995;111:225-232.
    • (1995) Mol Cell Endocrinol , vol.111 , pp. 225-232
    • Luparello, C.1    Burtis, W.J.2    Raue, F.3    Birch, M.A.4    Gallagher, J.A.5
  • 39
    • 0032983681 scopus 로고    scopus 로고
    • Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein
    • DOI 10.1359/jbmr.1999.14.6.915
    • Cornish J, Callon KE, Lin C, Xiao C, Moseley JM, Reid IR. Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein. J Bone Miner Res. 1999;14:915-922. (Pubitemid 29262885)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.6 , pp. 915-922
    • Cornish, J.1    Callon, K.E.2    Lin, C.3    Xiao, C.4    Moseley, J.M.5    Reid, I.R.6
  • 40
    • 77955873729 scopus 로고    scopus 로고
    • Midregion PTHrP and human breast cancer cells
    • Luparello C. Midregion PTHrP and human breast cancer cells. ScientificWorldJournal. 2010;10:1016-1028.
    • (2010) ScientificWorldJournal , vol.10 , pp. 1016-1028
    • Luparello, C.1
  • 41
    • 0033603354 scopus 로고    scopus 로고
    • Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization
    • Lam MH, House CM, Tiganis T, et al. Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization. J Biol Chem. 1999;274:18559- 18566.
    • (1999) J Biol Chem , vol.274 , pp. 18559-18566
    • Lam, M.H.1    House, C.M.2    Tiganis, T.3
  • 42
    • 0037093548 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein enhances PC-3 prostate cancer cell growth via both autocrine/paracrine and intracrine pathways
    • PII S0167011502000071
    • Tovar Sepulveda VA, Falzon M. Parathyroid hormone-related protein enhances PC-3 prostate cancer cell growth via both autocrine/paracrine and intracrine pathways. Regul Pept. 2002;105:109-120. (Pubitemid 34219392)
    • (2002) Regulatory Peptides , vol.105 , Issue.2 , pp. 109-120
    • Tovar, S.V.A.1    Falzon, M.2
  • 43
    • 70349752918 scopus 로고    scopus 로고
    • Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival
    • Bhatia V, Saini MK, Falzon M. Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival. Regul Pept. 2009;158:149-155.
    • (2009) Regul Pept , vol.158 , pp. 149-155
    • Bhatia, V.1    Saini, M.K.2    Falzon, M.3
  • 46
    • 4344624072 scopus 로고    scopus 로고
    • Role of differential and cell type-specific expression of cell cycle regulatory proteins in mediating progressive glomerular injury in human IgA nephropathy
    • DOI 10.1038/labinvest.3700144
    • Qiu LQ, Sinniah R, Hsu SI. Role of differential and cell type-specific expression of cell cycle regulatory proteins in mediating progressive glomerular injury in human IgA nephropathy. Lab Invest. 2004;84:1112-1125. (Pubitemid 39128257)
    • (2004) Laboratory Investigation , vol.84 , Issue.9 , pp. 1112-1125
    • Qiu, L.-Q.1    Sinniah, R.2    Hsu, S.I.-H.3
  • 47
    • 16844362291 scopus 로고    scopus 로고
    • Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism
    • Wang C, Hou X, Mohapatra S, et al. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. J Biol Chem. 2005;280:12339-12343.
    • (2005) J Biol Chem , vol.280 , pp. 12339-12343
    • Wang, C.1    Hou, X.2    Mohapatra, S.3
  • 48
    • 60749098440 scopus 로고    scopus 로고
    • Inhibition of p27Kip1 gene transcription by mitogens
    • Bagui TK, Cui D, Roy S, et al. Inhibition of p27Kip1 gene transcription by mitogens. Cell Cycle. 2009;8:115-124.
    • (2009) Cell Cycle , vol.8 , pp. 115-124
    • Bagui, T.K.1    Cui, D.2    Roy, S.3
  • 49
    • 33645022078 scopus 로고    scopus 로고
    • Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners
    • Iwanaga R, Komori H, Ishida S, et al. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Oncogene. 2006;25:1786-1798.
    • (2006) Oncogene , vol.25 , pp. 1786-1798
    • Iwanaga, R.1    Komori, H.2    Ishida, S.3
  • 50
    • 0032845768 scopus 로고    scopus 로고
    • Regulation of glomerular cell number by apoptosis
    • DOI 10.1046/j.1523-1755.1999.00707.x
    • Savill J. Regulation of glomerular cell number by apoptosis. Kidney Int. 1999;56:1216-1222. (Pubitemid 29451216)
    • (1999) Kidney International , vol.56 , Issue.4 , pp. 1216-1222
    • Savill, J.1
  • 51
    • 54049099247 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2
    • Alonso V, de Gortazar AR, Ardura JA, Andrade-Zapata I, Alvarez-Arroyo MV, Esbrit P. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J Cell Physiol. 2008;217:717-727.
    • (2008) J Cell Physiol , vol.217 , pp. 717-727
    • Alonso, V.1    De Gortazar, A.R.2    Ardura, J.A.3    Andrade-Zapata, I.4    Alvarez-Arroyo, M.V.5    Esbrit, P.6
  • 53
    • 0036789242 scopus 로고    scopus 로고
    • Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro
    • Cebrian A, Garcia-Ocana A, Takane KK, Sipula D, Stewart AF, Vasavada RC. Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro. Diabetes. 2002;51:3003-3013.
    • (2002) Diabetes , vol.51 , pp. 3003-3013
    • Cebrian, A.1    Garcia-Ocana, A.2    Takane, K.K.3    Sipula, D.4    Stewart, A.F.5    Vasavada, R.C.6
  • 55
    • 0024798046 scopus 로고
    • Renal vasodilatation and microvessel adenylate cyclase stimulation by synthetic parathyroid hormone-like protein fragments
    • DOI 10.1016/0014-2999(89)90306-3
    • Musso MJ, Plante M, Judes C, Barthelmebs M, Helwig JJ. Renal vasodilatation and microvessel adenylate cyclase stimulation by synthetic parathyroid hormone-like protein fragments. Eur J Pharmacol. 1989;174:139-151. (Pubitemid 20029393)
    • (1989) European Journal of Pharmacology , vol.174 , Issue.2-3 , pp. 139-151
    • Musso, M.-J.1    Plante, M.2    Judes, C.3    Barthelmebs, M.4    Helwig, J.-J.5
  • 56
    • 0037142080 scopus 로고    scopus 로고
    • + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
    • DOI 10.1038/nature00816
    • Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature. 2002;417:858-861. (Pubitemid 34670333)
    • (2002) Nature , vol.417 , Issue.6891 , pp. 858-861
    • Mahon, M.J.1    Donowitz, M.2    Yun, C.C.3    Segre, G.V.4
  • 57
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/AKT - A major therapeutic target
    • Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim Biophys Acta. 2004;1697:3-16.
    • (2004) Biochim Biophys Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 58
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129:1261-1274. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 60
    • 0038512499 scopus 로고    scopus 로고
    • The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappaB and bad
    • DOI 10.1097/01.ASN.0000066140.99610.32
    • Shimamura H, Terada Y, Okado T, Tanaka H, Inoshita S, Sasaki S. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. J Am Soc Nephrol. 2003;14:1427-1434. (Pubitemid 36687043)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.6 , pp. 1427-1434
    • Shimamura, H.1    Terada, Y.2    Okado, T.3    Tanaka, H.4    Inoshita, S.5    Sasaki, S.6
  • 61
    • 0036223562 scopus 로고    scopus 로고
    • Insulin is a potent survival factor in mesangial cells: Role of the PI3-kinase/Akt pathway
    • DOI 10.1046/j.1523-1755.2002.00257.x
    • Hiromura K, Monkawa T, Petermann AT, Durvasula RV, Shankland SJ. Insulin is a potent survival factor in mesangial cells: role of the PI3-kinase/Akt pathway. Kidney Int. 2002;61:1312-1321. (Pubitemid 34304492)
    • (2002) Kidney International , vol.61 , Issue.4 , pp. 1312-1321
    • Hiromura, K.1    Monkawa, T.2    Petermann, A.T.3    Durvasula, R.V.4    Shankland, S.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.