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Volumn 27, Issue 2, 2013, Pages 834-843

Effects of zinc on epithelial barrier properties and viability in a human and a porcine intestinal cell culture model

Author keywords

Caco 2; Heat shock protein; Intestinal epithelial cell; IPEC J2; Transepithelial electrical resistance; Viability; Zinc

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 70; LACTATE DEHYDROGENASE; MESSENGER RNA; ZINC SULFATE;

EID: 84872710072     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.12.019     Document Type: Article
Times cited : (40)

References (67)
  • 1
    • 0343183909 scopus 로고    scopus 로고
    • Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity
    • Ait-Aissa S., Porcher J., Arrigo A., Lambre C. Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity. Toxicology 2000, 145:147-157.
    • (2000) Toxicology , vol.145 , pp. 147-157
    • Ait-Aissa, S.1    Porcher, J.2    Arrigo, A.3    Lambre, C.4
  • 2
    • 77957185982 scopus 로고
    • Production of metallothionein and heat-shock proteins in response to metals
    • Bauman J.W., Liu J., Klaassen C.D. Production of metallothionein and heat-shock proteins in response to metals. Fundam. Appl. Toxicol. 1993, 21:15-22.
    • (1993) Fundam. Appl. Toxicol. , vol.21 , pp. 15-22
    • Bauman, J.W.1    Liu, J.2    Klaassen, C.D.3
  • 3
    • 0035923720 scopus 로고    scopus 로고
    • Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency
    • Blanchard R.K., Moore J.B., Green C.L., Cousins R.J. Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc. Natl. Acad. Sci. USA 2001, 98:13507-13513.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13507-13513
    • Blanchard, R.K.1    Moore, J.B.2    Green, C.L.3    Cousins, R.J.4
  • 4
    • 43049136553 scopus 로고    scopus 로고
    • Impact of Bacillus thuringiensis toxin Cry1Ab on rumen epithelial cells (REC) - a new in vitro model for safety assessment of recombinant food compounds
    • Bondzio A., Stumpff F., Schon J., Martens H., Einspanier R. Impact of Bacillus thuringiensis toxin Cry1Ab on rumen epithelial cells (REC) - a new in vitro model for safety assessment of recombinant food compounds. Food Chem. Toxicol. 2008, 46:1976-1984.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 1976-1984
    • Bondzio, A.1    Stumpff, F.2    Schon, J.3    Martens, H.4    Einspanier, R.5
  • 6
    • 2442513939 scopus 로고    scopus 로고
    • Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment
    • Boveri M., Pazos P., Gennari A., Casado J., Hartung T., Prieto P. Comparison of the sensitivity of different toxicological endpoints in Caco-2 cells after cadmium chloride treatment. Arch. Toxicol. 2004, 78:201-206.
    • (2004) Arch. Toxicol. , vol.78 , pp. 201-206
    • Boveri, M.1    Pazos, P.2    Gennari, A.3    Casado, J.4    Hartung, T.5    Prieto, P.6
  • 8
    • 69249209813 scopus 로고    scopus 로고
    • Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive oxygen species in cadmium- but not zinc-induced adaptation mechanisms
    • Cardin G.B., Mantha M., Jumarie C. Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive oxygen species in cadmium- but not zinc-induced adaptation mechanisms. Biometals 2009, 22:753-769.
    • (2009) Biometals , vol.22 , pp. 753-769
    • Cardin, G.B.1    Mantha, M.2    Jumarie, C.3
  • 10
    • 15744382143 scopus 로고    scopus 로고
    • Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose, theophylline and 5-HT in piglet small intestinal mucosa
    • Carlson D., Poulsen H.D., Sehested J. Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose, theophylline and 5-HT in piglet small intestinal mucosa. Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 2004, 137:757-765.
    • (2004) Comp. Biochem. Physiol. A: Mol. Integr. Physiol. , vol.137 , pp. 757-765
    • Carlson, D.1    Poulsen, H.D.2    Sehested, J.3
  • 11
    • 33846066766 scopus 로고    scopus 로고
    • Assessment of zinc and copper status in weaned piglets in relation to dietary zinc and copper supply
    • Carlson D., Beattie J.H., Poulsen H.D. Assessment of zinc and copper status in weaned piglets in relation to dietary zinc and copper supply. J. Anim. Physiol. Anim. Nutr. (Berl.) 2007, 91:19-28.
    • (2007) J. Anim. Physiol. Anim. Nutr. (Berl.) , vol.91 , pp. 19-28
    • Carlson, D.1    Beattie, J.H.2    Poulsen, H.D.3
  • 12
    • 36849067408 scopus 로고    scopus 로고
    • Serosal zinc attenuate serotonin and vasoactive intestinal peptide induced secretion in piglet small intestinal epithelium in vitro
    • Carlson D., Sehested J., Feng Z., Poulsen H.D. Serosal zinc attenuate serotonin and vasoactive intestinal peptide induced secretion in piglet small intestinal epithelium in vitro. Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 2008, 149:51-58.
    • (2008) Comp. Biochem. Physiol. A: Mol. Integr. Physiol. , vol.149 , pp. 51-58
    • Carlson, D.1    Sehested, J.2    Feng, Z.3    Poulsen, H.D.4
  • 16
    • 33749866697 scopus 로고    scopus 로고
    • Zinc attenuates forskolin-stimulated electrolyte secretion without involvement of the enteric nervous system in small intestinal epithelium from weaned piglets
    • Feng Z., Carlson D., Poulsen H.D. Zinc attenuates forskolin-stimulated electrolyte secretion without involvement of the enteric nervous system in small intestinal epithelium from weaned piglets. Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 2006, 145:328-333.
    • (2006) Comp. Biochem. Physiol. A: Mol. Integr. Physiol. , vol.145 , pp. 328-333
    • Feng, Z.1    Carlson, D.2    Poulsen, H.D.3
  • 18
    • 0027691872 scopus 로고
    • Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc
    • Hahn J.D., Baker D.H. Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. J. Anim. Sci. 1993, 71:3020-3024.
    • (1993) J. Anim. Sci. , vol.71 , pp. 3020-3024
    • Hahn, J.D.1    Baker, D.H.2
  • 19
    • 0026647638 scopus 로고
    • Characteristic induction of 70,000 da-heat shock protein and metallothionein by zinc in HeLa cells
    • Hatayama T., Tsukimi Y., Wakatsuki T., Kitamura T., Imahara H. Characteristic induction of 70,000 da-heat shock protein and metallothionein by zinc in HeLa cells. Mol. Cell. Biochem. 1992, 112:143-153.
    • (1992) Mol. Cell. Biochem. , vol.112 , pp. 143-153
    • Hatayama, T.1    Tsukimi, Y.2    Wakatsuki, T.3    Kitamura, T.4    Imahara, H.5
  • 20
    • 70449505391 scopus 로고    scopus 로고
    • Therapeutic options to modulate barrier defects in inflammatory bowel disease
    • Hering N.A., Schulzke J.D. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis. 2009, 27:450-454.
    • (2009) Dig. Dis. , vol.27 , pp. 450-454
    • Hering, N.A.1    Schulzke, J.D.2
  • 22
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo I.J., Raub T.J., Borchardt R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96:736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 24
  • 26
    • 0031112021 scopus 로고    scopus 로고
    • Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia
    • Klosterhalfen B., Hauptmann S., Offner F.A., Amo-Takyi B., Tons C., Winkeltau G., Affify M., Kupper W., Kirkpatrick C.J., Mittermayer C. Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia. Shock 1997, 7:254-262.
    • (1997) Shock , vol.7 , pp. 254-262
    • Klosterhalfen, B.1    Hauptmann, S.2    Offner, F.A.3    Amo-Takyi, B.4    Tons, C.5    Winkeltau, G.6    Affify, M.7    Kupper, W.8    Kirkpatrick, C.J.9    Mittermayer, C.10
  • 27
    • 0031132268 scopus 로고    scopus 로고
    • The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia
    • Klosterhalfen B., Hauptmann S., Tietze L., Tons C., Winkeltau G., Kupper W., Kirkpatrick C.J. The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia. Shock 1997, 7:358-363.
    • (1997) Shock , vol.7 , pp. 358-363
    • Klosterhalfen, B.1    Hauptmann, S.2    Tietze, L.3    Tons, C.4    Winkeltau, G.5    Kupper, W.6    Kirkpatrick, C.J.7
  • 28
    • 46549087135 scopus 로고    scopus 로고
    • Porcine intestinal epithelial cell lines as a new in vitro model for studying adherence and pathogenesis of enterotoxigenic Escherichia coli
    • Koh S.Y., George S., Brozel V., Moxley R., Francis D., Kaushik R.S. Porcine intestinal epithelial cell lines as a new in vitro model for studying adherence and pathogenesis of enterotoxigenic Escherichia coli. Vet. Microbiol. 2008, 130:191-197.
    • (2008) Vet. Microbiol. , vol.130 , pp. 191-197
    • Koh, S.Y.1    George, S.2    Brozel, V.3    Moxley, R.4    Francis, D.5    Kaushik, R.S.6
  • 29
    • 19344364551 scopus 로고    scopus 로고
    • Correlation of in vitro cytotoxicity with paracellular permeability in Caco-2 cells
    • Konsoula R., Barile F.A. Correlation of in vitro cytotoxicity with paracellular permeability in Caco-2 cells. Toxicol. In Vitro 2005, 19:675-684.
    • (2005) Toxicol. In Vitro , vol.19 , pp. 675-684
    • Konsoula, R.1    Barile, F.A.2
  • 30
    • 33846928448 scopus 로고    scopus 로고
    • Correlation of in vitro cytotoxicity with paracellular permeability in mortal rat intestinal cells
    • Konsoula R., Barile F.A. Correlation of in vitro cytotoxicity with paracellular permeability in mortal rat intestinal cells. J. Pharmacol. Toxicol. Methods 2007, 55:176-183.
    • (2007) J. Pharmacol. Toxicol. Methods , vol.55 , pp. 176-183
    • Konsoula, R.1    Barile, F.A.2
  • 31
    • 79954615841 scopus 로고    scopus 로고
    • Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model
    • Liedel J.L., Guo Y., Yu Y., Shiou S.R., Chen S., Petrof E.O., Hu S., Musch M.W., Claud E.C. Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model. Pediatr. Res. 2011, 69:395-400.
    • (2011) Pediatr. Res. , vol.69 , pp. 395-400
    • Liedel, J.L.1    Guo, Y.2    Yu, Y.3    Shiou, S.R.4    Chen, S.5    Petrof, E.O.6    Hu, S.7    Musch, M.W.8    Claud, E.C.9
  • 32
    • 0022555843 scopus 로고
    • The heat-shock response
    • Lindquist S. The heat-shock response. Annu. Rev. Biochem. 1986, 55:1151-1191.
    • (1986) Annu. Rev. Biochem. , vol.55 , pp. 1151-1191
    • Lindquist, S.1
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 34
    • 38849179565 scopus 로고    scopus 로고
    • A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea
    • Lukacik M., Thomas R.L., Aranda J.V. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008, 121:326-336.
    • (2008) Pediatrics , vol.121 , pp. 326-336
    • Lukacik, M.1    Thomas, R.L.2    Aranda, J.V.3
  • 38
    • 0032535245 scopus 로고    scopus 로고
    • Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
    • Morimoto R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 1998, 12:3788-3796.
    • (1998) Genes Dev. , vol.12 , pp. 3788-3796
    • Morimoto, R.I.1
  • 39
    • 58249123402 scopus 로고    scopus 로고
    • Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers
    • Mukaizawa F., Taniguchi K., Miyake M., Ogawara K., Odomi M., Higaki K., Kimura T. Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers. Int. J. Pharm. 2009, 367:103-108.
    • (2009) Int. J. Pharm. , vol.367 , pp. 103-108
    • Mukaizawa, F.1    Taniguchi, K.2    Miyake, M.3    Ogawara, K.4    Odomi, M.5    Higaki, K.6    Kimura, T.7
  • 40
    • 0032967906 scopus 로고    scopus 로고
    • Differential metal response and regulation of human heavy metal-inducible genes
    • Murata M., Gong P., Suzuki K., Koizumi S. Differential metal response and regulation of human heavy metal-inducible genes. J. Cell. Physiol. 1999, 180:105-113.
    • (1999) J. Cell. Physiol. , vol.180 , pp. 105-113
    • Murata, M.1    Gong, P.2    Suzuki, K.3    Koizumi, S.4
  • 41
    • 0029937874 scopus 로고    scopus 로고
    • Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury
    • Musch M.W., Ciancio M.J., Sarge K., Chang E.B. Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury. Am. J. Physiol. 1996, 270:C429-C436.
    • (1996) Am. J. Physiol. , vol.270
    • Musch, M.W.1    Ciancio, M.J.2    Sarge, K.3    Chang, E.B.4
  • 42
    • 33750503155 scopus 로고    scopus 로고
    • Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation
    • Odashima M., Otaka M., Jin M., Wada I., Horikawa Y., Matsuhashi T., Ohba R., Hatakeyama N., Oyake J., Watanabe S. Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation. Life Sci. 2006, 79:2245-2250.
    • (2006) Life Sci. , vol.79 , pp. 2245-2250
    • Odashima, M.1    Otaka, M.2    Jin, M.3    Wada, I.4    Horikawa, Y.5    Matsuhashi, T.6    Ohba, R.7    Hatakeyama, N.8    Oyake, J.9    Watanabe, S.10
  • 43
    • 33750634125 scopus 로고    scopus 로고
    • Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins
    • Ohkawara T., Nishihira J., Nagashima R., Takeda H., Asaka M. Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins. World J. Gastroenterol. 2006, 12:6178-6181.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 6178-6181
    • Ohkawara, T.1    Nishihira, J.2    Nagashima, R.3    Takeda, H.4    Asaka, M.5
  • 44
    • 0344662162 scopus 로고    scopus 로고
    • Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody, zinc oxide, fumaric acid, or antibiotic
    • Owusu-Asiedu A., Nyachoti C.M., Marquardt R.R. Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody, zinc oxide, fumaric acid, or antibiotic. J. Anim. Sci. 2003, 81:1790-1798.
    • (2003) J. Anim. Sci. , vol.81 , pp. 1790-1798
    • Owusu-Asiedu, A.1    Nyachoti, C.M.2    Marquardt, R.R.3
  • 46
    • 54049114262 scopus 로고    scopus 로고
    • Transport of surface engineered polyamidoamine (PAMAM) dendrimers across IPEC-J2 cell monolayers
    • Pisal D.S., Yellepeddi V.K., Kumar A., Palakurthi S. Transport of surface engineered polyamidoamine (PAMAM) dendrimers across IPEC-J2 cell monolayers. Drug Deliv. 2008, 15:515-522.
    • (2008) Drug Deliv. , vol.15 , pp. 515-522
    • Pisal, D.S.1    Yellepeddi, V.K.2    Kumar, A.3    Palakurthi, S.4
  • 47
    • 70350126591 scopus 로고    scopus 로고
    • Zinc: role in immunity, oxidative stress and chronic inflammation
    • Prasad A.S. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr. Opin. Clin. Nutr. Metab. Care 2009, 12:646-652.
    • (2009) Curr. Opin. Clin. Nutr. Metab. Care , vol.12 , pp. 646-652
    • Prasad, A.S.1
  • 50
    • 0344306527 scopus 로고    scopus 로고
    • Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli
    • Roselli M., Finamore A., Garaguso I., Britti M.S., Mengheri E. Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli. J. Nutr. 2003, 133:4077-4082.
    • (2003) J. Nutr. , vol.133 , pp. 4077-4082
    • Roselli, M.1    Finamore, A.2    Garaguso, I.3    Britti, M.S.4    Mengheri, E.5
  • 51
    • 33846785395 scopus 로고    scopus 로고
    • Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic Escherichia coli K88 in pig intestinal cells
    • Roselli M., Britti M.S., Le Huerou-Luron I., Marfaing H., Zhu W.Y., Mengheri E. Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic Escherichia coli K88 in pig intestinal cells. Toxicol. In Vitro 2007, 21:224-229.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 224-229
    • Roselli, M.1    Britti, M.S.2    Le Huerou-Luron, I.3    Marfaing, H.4    Zhu, W.Y.5    Mengheri, E.6
  • 52
    • 20044371666 scopus 로고    scopus 로고
    • The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
    • Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 2005, 21:1-26.
    • (2005) Cell Biol. Toxicol. , vol.21 , pp. 1-26
    • Sambuy, Y.1    De Angelis, I.2    Ranaldi, G.3    Scarino, M.L.4    Stammati, A.5    Zucco, F.6
  • 54
    • 55149090684 scopus 로고    scopus 로고
    • Zinc and diarrheal disease: current status and future perspectives
    • Scrimgeour A.G., Lukaski H.C. Zinc and diarrheal disease: current status and future perspectives. Curr. Opin. Clin. Nutr. Metab. Care 2008, 11:711-717.
    • (2008) Curr. Opin. Clin. Nutr. Metab. Care , vol.11 , pp. 711-717
    • Scrimgeour, A.G.1    Lukaski, H.C.2
  • 55
    • 0031182949 scopus 로고    scopus 로고
    • Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs
    • Smith J.W., Tokach M.D., Goodband R.D., Nelssen J.L., Richert B.T. Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs. J. Anim. Sci. 1997, 75:1861-1866.
    • (1997) J. Anim. Sci. , vol.75 , pp. 1861-1866
    • Smith, J.W.1    Tokach, M.D.2    Goodband, R.D.3    Nelssen, J.L.4    Richert, B.T.5
  • 57
    • 67749095999 scopus 로고    scopus 로고
    • Polaprezinc (Zinc l-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection
    • Ueda K., Ueyama T., Oka M., Ito T., Tsuruo Y., Ichinose M. Polaprezinc (Zinc l-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection. J. Pharmacol. Sci. 2009, 110:285-294.
    • (2009) J. Pharmacol. Sci. , vol.110 , pp. 285-294
    • Ueda, K.1    Ueyama, T.2    Oka, M.3    Ito, T.4    Tsuruo, Y.5    Ichinose, M.6
  • 58
    • 0242361633 scopus 로고    scopus 로고
    • Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc
    • Urani C., Calini V., Melchioretto P., Morazzoni F., Canevali C., Camatini M. Different induction of metallothioneins and Hsp70 and presence of the membrane transporter ZnT-1 in HepG2 cells exposed to copper and zinc. Toxicol. In Vitro 2003, 17:553-559.
    • (2003) Toxicol. In Vitro , vol.17 , pp. 553-559
    • Urani, C.1    Calini, V.2    Melchioretto, P.3    Morazzoni, F.4    Canevali, C.5    Camatini, M.6
  • 59
    • 34547619220 scopus 로고    scopus 로고
    • Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
    • Van Molle W., Van Roy M., Van Bogaert T., Dejager L., Van Lint P., Vanlaere I., Sekikawa K., Kollias G., Libert C. Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy. Cancer Res. 2007, 67:7301-7307.
    • (2007) Cancer Res. , vol.67 , pp. 7301-7307
    • Van Molle, W.1    Van Roy, M.2    Van Bogaert, T.3    Dejager, L.4    Van Lint, P.5    Vanlaere, I.6    Sekikawa, K.7    Kollias, G.8    Libert, C.9
  • 60
    • 0022154174 scopus 로고
    • Apical and basolateral endocytosis in Madin-Darby canine kidney (MDCK) cells grown on nitrocellulose filters
    • von Bonsdorff C.H., Fuller S.D., Simons K. Apical and basolateral endocytosis in Madin-Darby canine kidney (MDCK) cells grown on nitrocellulose filters. EMBO J. 1985, 4:2781-2792.
    • (1985) EMBO J. , vol.4 , pp. 2781-2792
    • von Bonsdorff, C.H.1    Fuller, S.D.2    Simons, K.3
  • 62
    • 0025189818 scopus 로고
    • Transport and permeability properties of human Caco-2 cells: an in vitro model of the intestinal epithelial cell barrier
    • Wilson G., Hassan I.F., Dix C.J., Williamson R., Shah R., Mackey M., Artursson P. Transport and permeability properties of human Caco-2 cells: an in vitro model of the intestinal epithelial cell barrier. J. Control Release 1990, 11:25-40.
    • (1990) J. Control Release , vol.11 , pp. 25-40
    • Wilson, G.1    Hassan, I.F.2    Dix, C.J.3    Williamson, R.4    Shah, R.5    Mackey, M.6    Artursson, P.7
  • 63
    • 80053610604 scopus 로고    scopus 로고
    • Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells
    • Zemann N., Zemann A., Klein P., Elmadfa I., Huettinger M. Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells. Eur. J. Nutr. 2010, 50(5):379-386.
    • (2010) Eur. J. Nutr. , vol.50 , Issue.5 , pp. 379-386
    • Zemann, N.1    Zemann, A.2    Klein, P.3    Elmadfa, I.4    Huettinger, M.5
  • 64
    • 70350088307 scopus 로고    scopus 로고
    • Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets
    • Zhang B., Guo Y. Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br. J. Nutr. 2009, 1-7.
    • (2009) Br. J. Nutr. , pp. 1-7
    • Zhang, B.1    Guo, Y.2
  • 65
    • 0031817616 scopus 로고    scopus 로고
    • Cadmium is more toxic to LLC-PK1 cells than to MDCK cells acting on the cadherin-catenin complex
    • Zimmerhackl L.B., Momm F., Wiegele G., Brandis M. Cadmium is more toxic to LLC-PK1 cells than to MDCK cells acting on the cadherin-catenin complex. Am. J. Physiol. 1998, 275:F143-F153.
    • (1998) Am. J. Physiol. , vol.275
    • Zimmerhackl, L.B.1    Momm, F.2    Wiegele, G.3    Brandis, M.4


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