Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets

British Journal of Nutrition

Volumn 102, Issue 5, 2009, Pages 687-693

  Zhang, Bingkun ^a   Guo, Yuming ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Dietary zinc; Intestinal permeability; Occludin; Piglets; Zonula occludens protein 1 (ZO 1)

Indexed keywords

OCCLUDIN; PROTEIN ZO1; TETRABASIC ZINC CHLORIDE; UNCLASSIFIED DRUG; ZINC CHLORIDE; ZINC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DRUG MECHANISM; FEMALE; FOOD INTAKE; GENE EXPRESSION; ILEUM MUCOSA; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PIGLET; PROTEIN EXPRESSION; WEANING;

ANIMALS; CELL MEMBRANE PERMEABILITY; DIETARY SUPPLEMENTS; INTESTINES; MEMBRANE PROTEINS; PHOSPHOPROTEINS; SWINE; ZINC;

SUIDAE;

EID: 70350088307     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509289033     Document Type: Article

References (42)

1. Pluske JR, Hampson DJ & Williams IH (1997) Factors influencing the structure and function of the small intestine in the weaned pig: A review. Livest Prod Sci 51, 215-236.
2. Hahn JD & Baker DH (1993) Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. J Anim Sci 71, 3020-3024.
3. Poulsen HD (1995) Zinc oxide for weanling piglets. Acta Agr Scand Sect A-Anim Sci 45, 159-167.
4. Zhang BK & Guo YM (2007) Beneficial effects of tetrabasic zinc chloride for weanling piglets and the bioavailability of zinc in tetrabasic form relative to ZnO. Anim Feed Sci Tech 135, 75-85.
5. Zhang BK & Guo YM (2007) The growth-promoting effect of tetrabasic zinc chloride is associated with elevated concentration of growth hormone and ghrelin. Asian Aust J Anim Sci 21, 1473-1478.
6. Boudry G, Péron V, Huërou-Luron IL, et al. (2004) Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine. J Nutr 134, 2256-2262.
7. Ford RPK, Menzies IS, Phillips AD, et al. (1985) Intestinal sugar permeability: Relationship to diarrhoeal disease and small bowel morphology. J Pediatr Gastr Nutr 4, 568-574.
8. Smecuol E, Bai JC, Vazquez H, et al. (1997) Gastrointestinal permeability in celiac disease. Gastroenterology 112, 1129-1136.
9. Sturniolo GC, Fries W, Mazzon E, et al. (2002) Effect of zinc supplementation on intestinal permeability in experimental colitis. J Lab Clin Med 139, 311-315.
10. Roy SK, Behrens RH, Haider R, et al. (1992) Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhea and persistent diarrhea syndrome. J Pediatr Gastr Nutr 15, 289-296.
11. Sazawal S, Black RE, Bhan MK, et al. (1995) Zinc supplementation in young children with acute diarrhea in India. N Engl J Med 333, 839-844.
12. Rodríguez P, Darmon N, Chappuis P, et al. (1996) Intestinal paracellular permeability during malnutrition in guinea pigs: Effect of high dietary zinc. Gut 39, 416-422.
13. Ballard ST, Hunter JH & Taylor AE (1995) Regulation of tightjunction permeability during nutrient absorption across the intestinal epithelium. Annu Rev Nutr 15, 35-55.
14. Blikslager AT, Moeser AJ, Gookin JL, et al. (2007) Restoration of barrier function in injured intestinal mucosa. Physiol Rev 87, 545-564.
15. Sun X, Yang H, Nose K, et al. (2008) Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. Am J Physiol 294, G139-G147.
16. Generoso M, Mario DR, Roberto DR, et al. (2003) Cellobiose and lactulose coupled with mannitol and determined using ion-exchange chromatography with pulsed amperometric detection, are reliable probes for investigation of intestinal permeability. J Chromatogr B 783, 349-357.
17. Bjarnason I, MacPherson A & Hollander D (1995) Intestinal permeability: An overview. Gastroenterology 108, 1566-1581.
18. Kansagra K, Stoll B, Rognerud C, et al. (2003) Total parenteral nutrition adversely affects gut barrier function in neonatal piglets. Am J Physiol 285, G1162-G1170.
19. Mavromichalis I, Webel DM, Parr EN, et al. (2001) Growthpromoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs. Can J Anim Sci 81, 387-391.
20. Lu L & Walker WA (2001) Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium. Am J Clin Nutr 73, 1124S-1130S.
21. Barboza JMS, Silva TMJ, Guerrent RL, et al. (1999) Measurement of intestinal permeability using mannitol and lactulose in children with diarrheal diseases. Braz J Med Biol Res 32, 1499-1504.
22. Elia M, Behrens R, Northrop C, et al. (1987) Evaluation of mannitol, lactulose and 51Cr-labelled ethylenediaminetetra-acetate as markers of intestinal permeability in man. Clin Sci 73, 197-204.
23. Weaver LT, Laker MF, Nelson R, et al. (1987) Milk feeding and changes in intestinal permeability and morphology in the newborn. J Pediatr Gastr Nutr 6, 351-358.
24. Roselli M, Finamore A, Garaguso I, et al. (2003) Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli. J Nutr 133, 4077-4082.
25. Tran CD, Howarth GS, Coyle P, et al. (2003) Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine. Am J Clin Nutr 77, 1296-1303.
26. Gumbiner BM (1993) Breaking through the tight junction barrier. J Cell Biol 123, 1631-1633.
27. Kucharzik T, Walsh SV, Chen J, et al. (2001) Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol 159, 2001-2009.
28. Saitou M, Ando-Akatsuka Y, Itoh M, et al. (1997) Mammalian occludin in epithelial cells: Its expression and subcellular distribution. Eur J Cell Biol 73, 222-231.
29. Wong V & Gumbiner BM (1997) A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol 136, 399-409.
30. Liu Y, Nusrat A, Schnell FJ, et al. (2000) Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 113, 2363-2374.
31. Furuse M, Fujita K, Hiiragi T, et al. (1998) Claudin-1 and claudin-2, novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 141, 1539-1550.
32. Morita K, Furuse K, Fujimoto K, et al. (1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A 96, 511-516.
33. Stevenson BR, Silicano JD, Mooseker M, et al. (1986) Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 103, 755-766.
34. Fanning AS, Jameson BJ, Jesaitis LA, et al. (1998) The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem 273, 29745-29753.
35. Furuse M, Hirase T, Itoh M, et al. (1996) Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol 123, 1777-1788.
36. McCarthy KM, Skare IB, Stankewich MC, et al. (1996) Occludin is a functional component of the tight junction. J Cell Sci 109, 2287-2298.
37. Holmes J, Van Itallie C, Rasmussen J, et al. (2006) Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns 6, 581-588.
38. Osek J (1999) Prevalence of virulence factors of Escherichia coli strains isolated from diarrheic and healthy piglets after weaning. Vet Microbiol 68, 209-217. (Pubitemid 29459026)
39. Bruewer M, Luegering A, Kucharzik T, et al. (2003) Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 171, 6164-6172.
40. Moeser AJ, Ryan KA, Nighot PK, et al. (2007) Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol 293, G413-G421.
41. Farhadi A, Banan A, Fields J, et al. (2003) Intestinal barrier: An interface between health and disease. J Gastroenterol Hepatol 18, 479-497.
42. Balda MS, Whitney JA, Flores C, et al. (1996) Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 134, 1031-1049.