Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers

International Journal of Pharmaceutics

Volumn 367, Issue 1-2, 2009, Pages 103-108

  Mukaizawa, Fuyuki ^a   Taniguchi, Koji ^a   Miyake, Masateru ^b   Ogawara, Ken ichi ^a   Odomi, Masaaki ^b   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Caco 2 cells; Electrophysiological study; Sodium taurocholate; Spermine; Transport pathways

Indexed keywords

BILE SALT; POLYAMINE; REBAMIPIDE; SPERMINE; TAUROCHOLIC ACID; WATER;

ARTICLE; CELL STRAIN CACO 2; CELL VIABILITY; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; DRUG POTENTIATION; DRUG TRANSPORT; DRUG USE; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ABSORPTION; ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, ORAL; ALANINE; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SYNERGISM; ELECTRIC IMPEDANCE; EPITHELIUM; HUMANS; MOUTH MUCOSA; PATCH-CLAMP TECHNIQUES; QUINOLONES; SPERMINE; TAUROCHOLIC ACID;

EID: 58249123402     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.09.027     Document Type: Article

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