Tetracyclines inhibit activated B cell function

International Immunology

Volumn 13, Issue 7, 2001, Pages 921-931

  Kuzin, Igor I ^a   Snyder, Jennifer E ^a   Ugine, Gregory D ^a   Wu, Dongming ^a   Lee, Sang ^a   Bushnell Jr , Timothy ^a   Insel, Richard A ^a   Young, Faith M ^a   Bottaro, Andrea ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

B lymphocyte; Ig; Isotype switching; Metalloproteinase; Tetracycline

Indexed keywords

CELL MARKER; CELL RECEPTOR; DOXYCYCLINE; HYDROXAMIC ACID; IMMUNOGLOBULIN; IMMUNOGLOBULIN J CHAIN; KB 8301; MESSENGER RNA; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; SYNDECAN; TETRACYCLINE; TETRACYCLINE DERIVATIVE;

ALLERGIC DISEASE; ANIMAL CELL; ANTIBIOTIC THERAPY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL FUNCTION; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE REARRANGEMENT; GENETIC RECOMBINATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MEDIATOR; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLUBILITY; TRANSGENE;

EID: 0034919755     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.7.921     Document Type: Article

References (66)

1. A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
2. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines
3. Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline
4. A novel mechanism of action of chemically modified tetracyclines: Inhibition of COX-2-mediated prostaglandin E2 production
5. Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide
6. Tetracyclines inhibit human synovial collagenase in vivo and in vitro
7. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs
8. Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells
9. Effects of tetracyclines on bone metabolism
10. Tetracyclines. inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
11. Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: Correlation with inhibition of cytokine secretion
12. Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes
13. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial
14. Inflammatory and immunological parameters of disease activity in rheumatoid arthritis patients treated with minocycline
15. Effects of oxytetracycline on in vivo proliferation and differentiation of erythroid and lymphoid cells in the rat
16. Effect of doxycycline on immune response in mice
17. Antibiotics modulate vaccine-induced humoral immune response
18. Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues
19. In vitro effects of doxycycline and tetracycline on mitogen stimulated lymphocyte growth
20. Antibiotics and immunity: Effects of antibiotics on mitogen responsiveness of lymphocytes and interleukin-2 production
21. The influence of tetracyclines on T cell activation
22. Effects of tetracycline on human monocyte phagocytosis and lymphocyte proliferation
23. The effects of minocycline and tetracycline on the mitotic response of human peripheral blood-lymphocytes
24. Oxytetracycline-mediated alteration of murine immunocompetence
25. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
26. Transcriptional activation by tetracyclines in mammalian cells
27. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
28. B cell differentiation and isotype switching is related to division cycle number
29. Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4
30. IFN-γ represses ε germline transcription and subsequently down-regulates switch recombination to ε
31. Quantitation of immunoglobulin m-γ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method
32. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
33. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome
34. Immunoglobulin class switching
35. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
36. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
37. Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family
38. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines
39. CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes
40. Metalloproteinase-mediated release of human Fas ligand
41. Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor. Identification with an L-selectin-alkaline phosphatase reporter
42. Metalloproteinase-mediated regulation of L-selectin levels on leucocytes
43. IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (FcεRII)
44. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
45. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
46. CD23 (FcεRII) release from cell membranes is mediated by a membrane-bound metalloprotease
47. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
48. ADAM family proteins in the immune system
49. Notch and the immune system
50. Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes
51. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in reactive and neoplastic lymphoid cells
52. Expression of matrix metalloproteinases by human plasma cells and B lymphocytes
53. Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevents B lymphocyte proliferation and differentiation
54. Regulation of murine B cell growth and differentiation by CD30 ligand
55. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells
56. + B cells
57. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
58. 2-terminal kinase
59. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
60. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
61. Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytes
62. Tumor necrosis factor receptor family members in the immune system
63. Structural biochemistry and activation of matrix metalloproteases
64. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
65. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
66. Concentrations of doxycycline and penicillin G in sera and cerebrospinal fluid of patients treated for neuroborreliosis