Non-antibiotic properties of tetracyclines as anti-allergy and asthma drugs

Pharmacological Research

Volumn 64, Issue 6, 2011, Pages 602-609

  Joks, Rauno ^a   Durkin, Helen G ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Allergic rhinitis; Allergic rhinoconjunctivitis; Allergy; Asthma; CD4 T cells; CD8 T cells; IgE; IgG; Late phase response; MAP kinase; Minocycline; Mitogen activated protein kinase; Peripheral blood mononuclear cells (PBMC); Phosphorylated ERK; Phosphorylated JNK; Phosphorylated p38; Rhinoconjunctivitis

Indexed keywords

ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; CICLESONIDE; CORTICOSTEROID; DOXYCYCLINE; ETANERCEPT; GANGLIOSIDE GM1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 4; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; OMALIZUMAB; PLACEBO; ROFLUMILAST; STRESS ACTIVATED PROTEIN KINASE; TETRACYCLINE DERIVATIVE;

ALLERGIC ASTHMA; ALLERGIC DISEASE; ALLERGIC RHINITIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DIZZINESS; DRUG ABSORPTION; DRUG INDUCED HEADACHE; DRUG RECEPTOR BINDING; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; ENZYME PHOSPHORYLATION; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; MAST CELL; NAUSEA; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; SPLEEN CELL; SYMPTOM; UNSPECIFIED SIDE EFFECT;

ALLERGENS; ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ASTHMA; CYTOKINES; HEMOCYANIN; HUMANS; IMMUNOGLOBULIN E; IMMUNOLOGIC MEMORY; MAST CELLS; PENICILLIN G; TETRACYCLINES;

EID: 80054114660     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.04.001     Document Type: Article

References (49)

1. A.B. Kay Allergy and allergic diseases N Engl J Med 344 2001 30 37 (Pubitemid 32064843)
2. D.P. Strachan Hay fever, hygiene and household size BMJ 299 1989 1259
3. J.-F. Bach The effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med 347 2002 911 920
4. R.F. Lemanske, and W.W. Busse Asthma: factors underlying inception, exacerbation, and disease progression J Allergy Clin Immunol 117 2006 S456 461
5. American Lung Assoc. Trends in asthma morbidity and mortality February 2010 Epidemiology and Statistics Unit. Research and Program Services Division
6. E.N. Grant, H. Alp, and K.B. Weiss The relation of socioeconomic factors and racial/ethnic differences in US asthma mortality Am J Public Health 90 12 2000 1923 1925
7. E.N. Grant, H. Alp, and K.B. Weiss The challenge of inner-city asthma Curr Opin Pulm Med 5 1 1999 27 34
8. D.M. Mannino, D.M. Homa, C.A. Pertowski, A. Ashikawa, L.L. Nixon, and C.A. Johnson Surveillance for asthma - United States, 1960-1995 MMWR CDC Surveill Summ 47 1 1998 1 27
9. W.W. Busse, and A. Mitchel Addressing issues of asthma in inner-city children J Allergy Clin Immunol 119 1 2007 43 49 (Pubitemid 46037821)
10. R. Karanicolas, S. Kumar, I. Katayeva, and R. Joks Self reported food allergy prevalence in an immigrant minority adult population in Brooklyn Ann Allergy Asthma Immunol 105 5 2010 A105
11. S. Kumar, P. Shams, P. Nalluri, J. Moallem, and R. Joks Self reported prevalence of food allergy symptoms in an inner city minority general pediatric population J Allergy Clin Immunol 123 2 2010 AB217
12. Expert panel report 3. Guidelines for the diagnosis and management of asthma. Available online at www.nhlbi.nih.gov/guidelines/asthma/epr3/index.htm [last accessed 31.08.07].
13. N.A. Reynolds Ciclesonide Drugs 64 2004 511 519 (Pubitemid 38338728)
14. R.C. Strunk, and G.R. Bloomberg Omalizumab for asthma N Engl J Med 354 2006 2689 2695
15. P.J. Barnes New therapies for asthma Trends Mol Med 12 2006 515 520 (Pubitemid 44633808)
16. J. Bousquet, M. Aubier, J. Sastre, J.L. Izquierdo, L.M. Adler, and P. Hofbauer Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma Allergy 61 2006 72 78 (Pubitemid 43381194)
17. B. Burrows, F.D. Martinez, M. Halonen, R.A. Barbee, and M.G. Cline Association of asthma with serum IgE level and skin-test reactivity to allergens N Engl J Med 320 1989 271 277 (Pubitemid 19045550)
18. M.R. Sears, B. Burrows, E.M. Flannery, G.P. Herbison, C.J. Hewitt, and M.D. Holdaway Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children N Engl J Med 325 1991 1067 1071
19. I.G. Reischl, N. Corvaia, F. Effenberger, B. Wolffwiniski, E. Kromer, and G.C. Mudde Function and regulation of Fc Epsilon R1 expression on monocytes from non-atopic donors Clin Exp Allergy 26 1996 630 641 (Pubitemid 26226577)
20. M. Yamaguchi, C.S. Lantz, H.C. Oettgen, I.M. Katona, T. Fleming, and I. Miyajima IgE enhances mouse mast cell Fc epsilon R1 expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions J Exp Med 185 1997 663 672 (Pubitemid 27098151)
21. D.W. MacGlashan, B.S. Bochner, D.C. Adelman, P.M. Jardieu, A. Togias, and L.M. Lichtenstein Serum IgE level drives basophil and mast cell IgE receptor display Int Arch Allergy Immunol 113 1997 45 47 (Pubitemid 27160716)
22. Blaser K, editor. T cell regulation in allergy, asthma and atopic skin diseases. Chem Immunol Allergy 2008; vol. 94. Basel: Karger. p. 83-92.
23. A. Daoud, C.J. Gloria, G. Taningco, M.R. Hammerschlag, S. Weiss, and M. Gelling Minocycline treatment results in reduced oral steroid requirements in adult asthma Allergy Asthma Proc 29 3 2008 286 294
24. R. Joks, T. Smith-Norowitz, M. Nowakowski, M.H. Bluth, and H.G. Durkin Tetracycline mediated IgE isotype specific suppression of ongoing human and murine IgE responses in vivo and in vitro induction of murine memory IgE responses Int Immunol 22 4 2010 281 288
25. D.P. Erstein, A. Stanek, G. Dapul, R. Shams, H. Solomon, and H.G. Durkin Minocycline therapy inhibits development of mast cell mediated cutaneous late phase responses J Allergy Clin Immunol 123 2 2009 180
26. F.C. Breedveld, B.A.C. Dijkmans, and H. Mattie Minocycline treatment for rheumatoid arthritis: an open dose finding study J Rheumatol 17 1990 43 46 (Pubitemid 20070566)
27. B.C. Tilley, G.S. Alarcon, S.P. Heyse, D.E. Trentham, R. Neuner, and D.A. Kaplan Minocycline in rheumatoid arthritis. A 48 week, double-blind, placebo-controlled trial. The MIRA Trial Group Ann Intern Med 122 1995 81 89
28. D.L. Auci, S.M. Chice, P. Dukor, and H.G. Durkin Control of IgE responses. IV. Isotype specific suppression of peak BPO-specific IgE antibody forming cell responses and of BPO specific IgE in serum of BPO-KLH sensitized mice Int Arch Allergy 101 1993 167 176 (Pubitemid 23197613)
29. D.L. Auci, G.I. Kleiner, S.M. Chice, T.J. Athanassiades, P. Dukor, and H.G. Durkin Control of IgE responses. V. Oral administration of a synthetic derivative of the inner bacterial cell wall (SDZ 280.636) to sensitized mice induces isotype specific suppression of peak hapten specific antibody forming cell responses, serum IgE levels and immediate hypersensitivity responses Immunol Investig 27 1998 105 120 (Pubitemid 28193288)
30. M.C. Smith, C. Heusser, K. Wagner, K. Blasier, and H.G. Durkin An in vitro murine model of a penicillin specific IgE, anamnestic response J lmmunol Methods 131 1990 55
31. K.S. Lee, S.M. Jin, S.S. Kim, and Y.C. Lee Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthma J Allergy Clin Immunol 113 2004 902 909 (Pubitemid 38608600)
32. M. Hoshino, Y. Nakamura, J. Sim, J. Shimojo, and S. Isogai Bronchial subepithelia fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation J Allergy Clin Immunol 102 1998 783 788 (Pubitemid 28543528)
33. I.I. Kuzin, J.E. Snyder, G.D. Ugine, D. Wu, S. Lee, and T. Bushnell Tetracycline inhibits activated B cell function Int Immunol 12 2001 921 931 (Pubitemid 32685204)
34. J. Zhu, and W.E. Paul Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors Immunol Rev 238 1 2010 247 262
35. J. Zhu, and W.E. Paul CD4 T cells: fates, functions, and faults Blood 112 2008 1557 1569
36. T.A. Smith-Norowitz, M.H. Bluth, S.M. Chice, M. Nowakowski, K.B. Norowitz, and K. Liao Two distinct T cell subsets, CD4+ and CD8+CD60+, and their cytokines are required for in vitro induction of human ragweed specific memory IgE responses J Immunol 181 7 2008 4761 4769
37. K. Maneechotesuwan, Y. Xin, K. Ito, E. Jazrawi, K.-Y. Lee, and O.S. Usmani Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3 J Immunol 178 2007 2491 2498 (Pubitemid 46233450)
38. T.A. Smith-Norowitz, R. Joks, J.I. Silverberg, M.H. Bluth, K.B. Norowitz, and S. Chice Effect of minocycline on IgE responses and cytokines in vivo and in vitro Int Immunol 22 Suppl. 1 Pt 1 2010 i138 i141 doi:10.1093/intimm/dxq 108
39. H.H. Jabara, S.M. Fu, R.S. Geha, and D. Vercelli CD40 and IgE: synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells J Exp Med 72 1990 1861 1864
40. T.A. Smith-Norowitz, M.H. Bluth, H. Drew, K.B. Norowitz, S. Chice, and V.N. Shah Effect of minocycline and doxycycline on IgE responses Ann Allergy Asthma Immunol 89 2002 172 179 (Pubitemid 36188050)
41. C.A. Herrick, J.A. Carucci, G.I. Kleiner, and H.G. Durkin Regulation of hapten-specific memory IgE responses induced in vitro. Requirement for both Thy-1+ AsGM1+ and Thy-1+ AsGM1- cells and for IFN-alpha and IL-4 J Immunol 151 7 1993 3440 3449 (Pubitemid 23282656)
42. C. Sandler, E. Ekokoski, K.A. Lindstedt, P.J. Vainio, M. Finel, and T. Sorsa Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C Inflamm Res 54 July (7) 2005 304 312 (Pubitemid 41185492)
43. C. Sandler, K. Nurmi, K.A. Lindstedt, T. Sorsa, L.M. Golub, and P.T. Kovanen Chemically modified tetracyclines induce apoptosis in cultured mast cells Int Immunopharmacol 5 October (11) 2005 1611 1621 (Pubitemid 41019432)
44. Y. Miyachi, A. Yoshioka, S. Imamura, and Y. Niwa Effect of antibiotics on the generation of reactive oxygen species J Invest Dermatol 86 1986 449 453 (Pubitemid 16050027)
45. J. Liu, C.A. Kuszynski, and B.T. Baxter Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes Biochem Biophys Res Commun 260 1999 562 567 (Pubitemid 29352101)
46. Y.H. Thong, and A. Ferrante Inhibition of mitogen induced human lymphocyte proliferative responses by tetracycline analogue Clin Exp Immunol 35 1979 443 446 (Pubitemid 9142375)
47. H. Akamatsu, Y. Niwa, I. Kurokawa, R. Masuda, S. Nishijima, and Y. Asada Effects of subminimal inhibitory concentrations of minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism Arch Dermatol Res 283 1991 524 528
48. S. Milano, F. Arcoleo, P. D'Agostino, and E. Cillari Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood Antimicrob Agents Chemother 41 1997 117 121 (Pubitemid 26428144)
49. Silverberg JI, Durkin HG, Joks R. Phosphorylated p38 MAPK expression by blood lymphocytes of allergic asthmatic humans correlates with their serum IgE levels, and phosphorylated ERK correlates with IgG. Inhibition of phosphorylated p38 MAPK expression by T cells is associated with suppression of IgE responses. FOCIS Late Breaking Abstract (Oral Presentation), Washington, DC, June 2011.