Tetracycline-mediated IgE isotype-specific suppression of ongoing human and murine IgE responses in vivo and murine memory IgE responses induced in vitro

International Immunology

Volumn 22, Issue 4, 2010, Pages 281-288

  Joks, Rauno ^a,b   Smith Norowitz, Tamar ^a,b   Nowakowski, Maja ^a,b   Bluth, Martin H ^a,b,c   Durkin, Helen G ^a,b  

^a Downstate Health Sciences University   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergy; Asthma; Human; IgE; Mice; Tetracycline

Indexed keywords

ALUMINUM POTASSIUM SULFATE; DOXYCYCLINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; KEYHOLE LIMPET HEMOCYANIN; MINOCYCLINE; PENICILLIN G; STEROID;

ADD ON THERAPY; ADULT; AGED; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; CELL COUNT; CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MESENTERY LYMPH NODE; MILD INTERMITTENT ASTHMA; MILD PERSISTENT ASTHMA; MOUSE; NAUSEA; NEPHELOMETRY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SEVERE PERSISTENT ASTHMA; SPLEEN; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; AGED; ANIMALS; ANTI-ALLERGIC AGENTS; ASTHMA; CELLS, CULTURED; DOXYCYCLINE; FEMALE; HEMOCYANIN; HUMANS; IMMUNOGLOBULIN E; IMMUNOLOGIC MEMORY; LYMPH NODES; MALE; MESENTERY; MICE; MICE, INBRED BALB C; MIDDLE AGED; MINOCYCLINE; PENICILLIN G; SPLEEN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954065304     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq004     Document Type: Article

References (37)

1. Saivin, S. and Houin, G. 1988. Clinical pharmacokinetics of doxycycline and minocycline. Clin. Pharmacokinet. 15:355.
2. Joks, R., Daoud, A., Orloff, K. et al. 1998. Minocycline as an antiinflammatory agent in the treatment of asthma (Abstract). J. Allergy Clin. Immunol. 101:12.
3. Daoud, A., Gloria, C. J., Taningco, G. et al. 2008. Minocycline treatment results in reduced oral steroid requirements in adult asthma. Allergy Asthma Proc. 29:286.
4. Lee, K. S., Jin, S. M., Kim, S. S. and Lee, Y. C. 2004. Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthma. J. Allergy Clin. Immunol. 113:902.
5. Kuzin, I. I., Snyder, J. E., Ugine, G. D. et al. 2001. Tetracycline inhibit activated B cell function. Intern. Immunol. 12:921.
6. Smith-Norowitz, T. A., Bluth, M. H., Drew, H. et al. 2002. Effect of minocycline and doxycyline on IgE responses. Ann. Allergy Asthma Immunol. 89:172.
7. Joks, R., Daoud, A., Taningco, G. et al. 2005. Minocycline treatment results in reduced oral steroid requirements and suppresses IgE responses in adult asthma. (Abstract). J. Allergy Clin. Immunol. 115:10.
8. Durkin,H.G.,Bluth,M.,Pincus,M.,Smith-Norowitz,T., Nowakowski, M. and Joks, R. 2005. Minocycline mediated suppression of ongoing IgE responses in vivo and in vitro (Abstract). In NIH Keystone Symposium-Allergy, Allergic Inflammation and Asthma, Beaver Run Resort, Breckenridge, Colorado April 6-April 11, 2006.
9. Durkin, H. G., Smith-Norowitz, T. A., Pincus, M., Nowakowski, M., Bluth, M. H. and Joks, R. 2007. New treatment for suppression of ongoing human and murine IgE responses (Abstract). J. Allergy Clin. Immunol. 119(1 Suppl.):12.
10. Joks, R., Smith-Norowitz, T. A.,Bluth,M.H.,Nowakowski,M. and Durkin, H. G. 2008. Minocycline treatment of allergic asthmatic patients and BPO-KLH sensitized mice at the peak of the hapten specific IgE response suppresses IgE, but not IgM, IgG or IgA responses (Abstract). J. Allergy Clin. Immunol. 121:23.
11. Shapira, L., Soskolne, W. A., Houri, Y., Barak, V., Halabi, A. and Stabholz, A. 1996. Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect. Immun. 64:825.
12. Akamatsu, H., Niwa, Y., Kurokawa, I., Masuda, R., Nishijima, S. and Asada, Y. 1991. Effects of subminimal inhibitory concentrations of minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism. Arch. Dermatol. Res. 283:524.
13. Thong, Y. H. and Ferrante, A. 1979. Inhibition of mitogen induced human lymphocyte proliferative responses by tetracycline analogue. Clin. Exp. Immunol. 35:443.
14. Miyachi, Y., Yoshioka, A., Imamura, S. and Niwa, Y. 1986. Effect of antibiotics on the generation of reactive oxygen species. J. Invest. Dermatol. 86:449.
15. Amin, A. R., Patel, R. N., Thakker, G. D., Lowenstein, C. J., Attur, M. G. and Abramson, S. B. 1997. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett. 410:259.
16. Paemen, L., Martens, E., Norga, K. et al. 1996. The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors. Biochem. Pharmacol. 52:105.
17. Hardman, J. G. and Limbird, L. E. 2001. Tetracyclines. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th edn. p. 124. McGraw-Hill, New York.
18. Durkin, H. G., Bazin, H. and Chice, S. M. 1985. Bacterial regulation of IgE isotype expression by Peyer's patch B lymphocytes. J. Leukoc. Biol. 23:772.
19. Durkin, H. G. and Chice, S. M. 1985. Modulation of IgE isotype expression on B lymphocytes in Peyer's patches of germfree rats. Prog. Clin. Biol. Res. 181:387.
20. Durkin, H. G., Chlce, S. M., Gaetjens, E., Bazin, H., Tarcsay, L. and Dukor, P. 1989. Origin and fate of IgE bearing lymphocytes. II. Modulation of IgE expression by Peyer's patch B cells by feeding with certain bacteria and bacterial cell wall components, or by thymectomy. J. Immunol. 143:1777.
21. Auci, D. L., Chice, S. M., Dukor, P. and Durkin, H. G. 1993. Control of IgE responses. IV. Isotype specific suppression of peak BPOspecific IgE antibody forming cell responses and of BPO specific IgE in serum of BPO-KLH sensitized mice. Int. Arch. Allergy 101:167.
22. Auci, D. L., Kleiner, G. I., Chice, S. M., Athanassiades, T. J., Dukor, P. and Durkin, H. G. 1998. Control of IgE responses. V. Oral administration of a synthetic derivative of the inner bacterial cell wall (SDZ 280.636) to sensitized mice induces isotype specific suppression of peak hapten specific antibody forming cell responses, serum IgE levels and immediate hypersensitivity responses. Immunol. Invest. 27:105.
23. Strachan, D. P. 1989. Hay fever, hygiene and household size. BMJ. 299:1259.
24. Gerhold, K., Avagyan, A., Beier, K., Ahrens, B., Quarcoo, D. and Hamelmann, E. 2005. Prenatal exposure with lipopolysaccharide prevents allergen sensitization and eosinophilic airway inflammation in a murine model. (Abstract). J. Allergy Clin. Immunol. 115:262.
25. National Asthma Education and Prevention Program. Expert Panel Report 2: Guideline for the Diagnosis and Management of Asthma. 1997. National Institutes of Health, Bethesda, MD: Publication No. 97: 4051.
26. Rosenstreich, D. L., Eggleston, P., Kattan, M. et al. 1997. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N. Engl. J. Med. 336:1356.
27. Breedveld, F. C., Dijkmans, B. A. and Mattie, H. 1990. Minocycline treatment for rheumatoid arthritis: an open dose finding study. J. Rheumatol. 17:43.
28. Smith, M. C., Heusser, C., Wagner, K., Blasier, K. and Durkin, H. G. 1990. An in vitro murine model of a penicillin specific IgE, anamnestic response. J. Immunol. Methods 131:55.
29. Seagrott, V. and Anderson, S. G. 1981. The second international reference preparation for human serum immunoglobulin E and the first British standard for human serum immunoglobulins. I. J. Biol. Stand. 9:431.
30. Rose, N. R., Hamilton, R. G. and Detric, B. 2002. Manual of Clinical Laboratory Immunology, 6th edn. p. 179. ASM Press, Washington, DC.
31. Tilley, B. C., Alarcon, G. S., Heyse, S. P. et al. 1995. Minocycline in rheumatoid arthritis. Ann. Intern. Med. 122:81.
32. Braun-Fahrlander, C., Riedler, J., Herz, U. et al. 2002. Environmental exposure to endotoxin and its relation to asthma in schoolage children. N. Engl. J. Med. 347:869.
33. Liu, J., Kuszynski, C. A. and Baxter, B. T. 1999. Doxycycline induces Fas/Fas Ligand-mediated apoptosis in Jurkat T lymphocytes. Biochem. Biophys. Res. Commun. 260:562.
34. Erstein, D. P., Stanek, A., Dapul, G. et al. 2009. Minocycline therapy inhibits development of mast cell mediated cutaneous late phase responses. (Abstract). J. Allergy Clin. Immunol. 123:180.
35. Fay, B. T., Whiddon, A. P., Puumala, S., Black, N. A., O'Dell, J. R. and Mikuls, T. R. 2008. Minocycline-induced hyperpigmentation in rheumatoid arthritis. J. Clin. Rheumatol. 14:17.
36. Sturkenboom, M. C. J. M., Meier, C. R., Jick, H. and Stricker, B. H. C. 1999. Minocycline and lupuslike syndrome in acne patients. Arch. Intern. Med. 159:493.
37. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Available at: www.nhlbi.nih.gov/guidelines/asthma/epr3/index.htm; last accessed August 31, 2007.