Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway

Journal of Pineal Research

Volumn 54, Issue 1, 2013, Pages 46-57

  Botros, Hany Goubran ^a,b,c   Legrand, Pierre ^d   Pagan, Cecile ^a,b,c   Bondet, Vincent ^b   Weber, Patrick ^e   Ben Abdallah, Mariem ^b   Lemière, Nathalie ^a,b,c   Huguet, Guillaume ^a,b,c   Bellalou, Jacques ^b   Maronde, Erik ^f   Beguin, Pierre ^b   Haouz, Ahmed ^e   Shepard, William ^d,e   Bourgeron, Thomas ^a,b,c  

^a INSTITUT PASTEUR   (France)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d SYNCHROTRON SOLEIL   (France)

^e CNRS   (France)

^f GOETHE UNIVERSITY   (Germany)

Author keywords

ASMT; Crystal structure; Genetic variants; Melatonin; O methyl transferase

Indexed keywords

ACETYLSEROTONIN METHYLTRANSFERASE; COMPLEMENTARY DNA; MELATONIN; N ACETYL SEROTONIN METHYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CHINESE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; WESTERN BLOTTING; X RAY DIFFRACTION;

ASMT; CRYSTAL STRUCTURE; GENETIC VARIANTS; MELATONIN; O-METHYL TRANSFERASE;

ACETYLSEROTONIN O-METHYLTRANSFERASE; AMINO ACID SEQUENCE; ASIAN CONTINENTAL ANCESTRY GROUP; CRYSTALLOGRAPHY, X-RAY; GENE FREQUENCY; HUMANS; MELATONIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; SEQUENCE ALIGNMENT;

EID: 84872684321     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2012.01020.x     Document Type: Article

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