Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 18, 2010, Pages 8399-8403

  Shimomura, Kazuhiro ^a,b   Lowrey, Phillip L ^a,f   Vitaterna, Martha Hotz ^a,b   Buhr, Ethan D ^a   Kumar, Vivek ^a,c   Hanna, Peter ^a   Omura, Chiaki ^a   Izumo, Mariko ^c   Low, Sharon S ^a   Barrett, R Keith ^a   LaRue, Silvia I ^d   Green, Carla B ^c,d   Takahashi, Joseph S ^a,c,e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f RIDER UNIVERSITY   (United States)

Author keywords

Arylalkylamine N acetyltransferase; Clock gene; N acetylserotonin O methytransferase; Suprachiasmatic nucleus

Indexed keywords

ACETYLSEROTONIN METHYLTRANSFERASE; ARALKYLAMINE ACETYLTRANSFERASE; MELATONIN; RAMELTEON; TRANSCRIPTION FACTOR CLOCK;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CHROMOSOME 11; CIRCADIAN RHYTHM; CONTROLLED STUDY; EXPLANT; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE REPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; X CHROMOSOME;

ACETYLSEROTONIN O-METHYLTRANSFERASE; ANIMALS; ARYLALKYLAMINE N-ACETYLTRANSFERASE; BEHAVIOR, ANIMAL; CHROMOSOMES; CIRCADIAN RHYTHM; CLOCK PROTEINS; DOWN-REGULATION; MELATONIN; MICE; MICE, INBRED C3H; MUTATION; PHENOTYPE;

ANIMALIA; MAMMALIA; MUS;

EID: 77952411362     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004368107     Document Type: Article

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