Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice

European Journal of Neuroscience

Volumn 37, Issue 2, 2013, Pages 294-302

  Heuer, Andreas ^a   Smith, Gaynor A ^a   Dunnett, Stephen B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Behaviour; Dopamine; Movement time; Operant; Parkinson's disease; Reaction time

Indexed keywords

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN DAMAGE; BRAIN NERVE CELL; BRAIN REGION; CAUSE OF DEATH; CELL LOSS; CONTROLLED STUDY; CONVALESCENCE; FUNCTIONAL STATUS; HEMISPHERIC DOMINANCE; LATENT PERIOD; MALE; MEDIAL FOREBRAIN BUNDLE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RESPONSE TIME; SUBSTANTIA NIGRA; TASK PERFORMANCE;

ANIMALS; CHOICE BEHAVIOR; CONDITIONING, OPERANT; MALE; MEDIAL FOREBRAIN BUNDLE; MICE; MICE, INBRED C57BL; MOVEMENT; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; REACTION TIME; SUBSTANTIA NIGRA;

EID: 84872656242     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12036     Document Type: Article

References (41)

1. Alvarez-Fischer, D., Henze, C., Strenzke, C., Westrich, J., Ferger, B., Hoglinger, G.U., Oertel, W.H. & Hartmann, A. (2008) Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Exp. Neurol., 210, 182-193.
2. Berardelli, A., Rothwell, J.C., Thompson, P.D. & Hallett, M. (2001) Pathophysiology of bradykinesia in Parkinson's disease. Brain, 124, 2131-2146.
3. Blandini, F. & Armentero, M.T. (2012) Animal models of Parkinson's disease. FEBS J., 279, 1156-1166.
4. Blandini, F., Nappi, G., Tassorelli, C. & Martignoni, E. (2000) Functional changes of the basal ganglia circuitry in Parkinson's disease. Prog. Neurobiol., 62, 63-88.
5. Blandini, F., Levandis, G., Bazzini, E., Nappi, G. & Armentero, M.T. (2007) Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model. Eur. J. Neurosci., 25, 397-405.
6. Bloxham, C.A., Mindel, T.A. & Frith, C.D. (1984) Initiation and execution of predictable and unpredictable movements in Parkinson's disease. Brain, 107(Pt 2), 371-384.
7. Bove, J., Prou, D., Perier, C. & Przedborski, S. (2005) Toxin-induced models of Parkinson's disease. NeuroRx, 2, 484-494.
8. Brasted, P.J., Dobrössy, M.D., Robbins, T.W. & Dunnett, S.B. (1998) Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers. Brain Res. Bull., 46, 487-493.
9. Brown, R.G. & Marsden, C.D. (1986) Visuospatial function in Parkinson's disease. Brain, 109(Pt 5), 987-1002.
10. Brown, V.J. & Robbins, T.W. (1989) Deficits in response space following unilateral striatal dopamine depletion in rats. J. Neurosci., 9, 983-989.
11. Carli, M., Evenden, J.L. & Robbins, T.W. (1985) Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention. Nature, 313, 679-682.
12. Carli, M., Jones, G.H. & Robbins, T.W. (1989) Effects of unilateral dorsal and ventral striatal dopamine depletion on visual neglect in the rat: a neural and behavioural analysis. Neuroscience, 29, 309-327.
13. Cenci, M.A. & Lundblad, M. (2007) Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice. Curr. Protoc. Neurosci., 41, 9.25.1-9.25.23.
14. Darbaky, Y., Forni, C., Amalric, M. & Baunez, C. (2003) High frequency stimulation of the subthalamic nucleus has beneficial antiparkinsonian effects on motor functions in rats, but less efficiency in a choice reaction time task. Eur. J. Neurosci., 18, 951-956.
15. Deumens, R., Blokland, A. & Prickaerts, J. (2002) Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp. Neurol., 175, 303-317.
16. Dowd, E. & Dunnett, S.B. (2004) Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants. Eur. J. Neurosci., 20, 1953-1959.
17. Dowd, E. & Dunnett, S.B. (2005a) Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats. Behav. Brain Res., 159, 153-161.
18. Dowd, E. & Dunnett, S.B. (2005b) Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility. Behav. Brain Res., 165, 181-186.
19. Dowd, E., Monville, C., Torres, E.M., Wong, L.F., Azzouz, M., Mazarakis, N.D. & Dunnett, S.B. (2005) Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. Eur. J. Neurosci., 22, 2587-2595.
20. Duty, S. & Jenner, P. (2011) Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease. Br. J. Pharmacol., 164, 1357-1391.
21. Evarts, E.V., Teravainen, H. & Calne, D.B. (1981) Reaction time in Parkinson's disease. Brain, 104, 167-186.
22. Francardo, V., Recchia, A., Popovic, N., Andersson, D., Nissbrandt, H. & Cenci, M.A. (2011) Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease. Neurobiol. Dis., 42, 327-340.
23. Gauntlett-Gilbert, J. & Brown, V.J. (1998) Reaction time deficits and Parkinson's disease. Neurosci. Biobehav. Rev., 22, 865-881.
24. Girotti, F., Carella, F., Grassi, M.P., Soliveri, P., Marano, R. & Caraceni, T. (1986) Motor and cognitive performances of parkinsonian patients in the on and off phases of the disease. J. Neurol. Neurosurg. Psychiatry, 49, 657-660.
25. Grealish, S., Xie, L., Kelly, M. & Dowd, E. (2008) Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat. Brain Res. Bull., 77, 312-319.
26. Grealish, S., Mattsson, B., Draxler, P. & Björklund, A. (2010) Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease. Eur. J. Neurosci., 31, 2266-2278.
27. Heuer, A., Smith, G.A., Lelos, M.J., Lane, E.L. & Dunnett, S.B. (2012) Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites. Behav. Brain Res., 228, 30-43.
28. Iancu, R., Mohapel, P., Brundin, P. & Paul, G. (2005) Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Behav. Brain Res., 162, 1-10.
29. Jordan, N., Sagar, H.J. & Cooper, J.A. (1992) Cognitive components of reaction time in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry, 55, 658-664.
30. Kirik, D., Rosenblad, C. & Björklund, A. (1998) Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp. Neurol., 152, 259-277.
31. Kutukcu, Y., Marks, W.J.Jr., Goodin, D.S. & Aminoff, M.J. (1999) Simple and choice reaction time in Parkinson's disease. Brain Res., 815, 367-372.
32. Lundblad, M., Picconi, B., Lindgren, H. & Cenci, M.A. (2004) A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function. Neurobiol. Dis., 16, 110-123.
33. Lundblad, M., Usiello, A., Carta, M., Hakansson, K., Fisone, G. & Cenci, M.A. (2005) Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia. Exp. Neurol., 194, 66-75.
34. Rafal, R.D., Posner, M.I., Walker, J.A. & Friedrich, F.J. (1984) Cognition and the basal ganglia. Separating mental and motor components of performance in Parkinson's disease. Brain, 107(Pt 4), 1083-1094.
35. Schallert, T., Whishaw, I.Q., Ramirez, V.D. & Teitelbaum, P. (1978) Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats. Science, 199, 1461-1463.
36. Shahed, J. & Jankovic, J. (2007) Motor symptoms in Parkinson's disease. In Aminoff, M.J., Boller, F.O., Swaab, D.F., Koller, W.C. & Melamed, E. (Eds), Handbook of Clinical Neurology. Elsevier, Amsterdam, pp. 329-342.
37. Smith, A.D., Amalric, M., Koob, G.F. & Zigmond, M.J. (2002) Effect of bilateral 6-hydroxydopamine lesions of the medial forebrain bundle on reaction time. Neuropsychopharmacol., 26, 756-764.
38. Smith, G.A., Heuer, A., Dunnett, S.B. & Lane, E.L. (2012) Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia. Behav. Brain Res., 226, 281-292.
39. Torres, E.M. & Dunnett, S.B. (2007) Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease. Eur. Neuropsychopharmacol., 17, 206-214.
40. Ungerstedt, U. (1968) 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur. J. Pharmacol., 5, 107-110.
41. Ungerstedt, U. & Arbuthnott, G.W. (1970) Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res., 24, 485-493.