Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability

Journal of Neuroscience Research

Volumn 91, Issue 3, 2013, Pages 407-415

  Price, Valerie ^a   Wang, Lulu ^a   D'Mello, Santosh R ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

HDAC4; Histone deacetylase; Knockout mouse; Neuronal cell death; Neuronal survival

Indexed keywords

CRE RECOMBINASE; HISTONE DEACETYLASE 4;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CEREBELLUM DEGENERATION; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA NERVE CELL;

ANIMALS; BRAIN; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; GENE DELETION; HISTONE DEACETYLASES; MICE; MICE, KNOCKOUT; NEURONS;

EID: 84872615923     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23170     Document Type: Article

References (25)

1. Backs J, Olson EN. 2006. Control of cardiac growth by histone cetylation/deacetylation. Circ Res 98: 15-24.
2. Bardai FH, D'Mello SR. 2011. Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. J Neurosci 31: 1746-1751.
3. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao T, Pourc'h C, Matthias P, Khochbin S. 2007. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev 21: 2172-2181.
4. Chen B, Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323: 256-259.
5. Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40: 471-483.
6. D'Mello SR. 2009. Histone deacetylases as targets for the treatment of human neurodegenerative diseases. Drug News Perspect 22: 513-524.
7. Dewachter I, Reverse D, Caluwaerts N, Ris L, Kuiperi C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F. 2002. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci 22: 3445-3453.
8. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR. 2000. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28: 41-51.
9. Graus-Porta D, Blaess S, Senften M, Littlewood-Evans A, Damsky C, Huang Z, Orban P, Klein R, Schittny JC, Muller U. 2001. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31: 367-379.
10. Haberland M, Montgomery RL, Olson EN. 2009. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10: 32-42.
11. Hageman J, Rujano MA, van Waarde MA, Kakkar V, Dirks RP, Govorukhina N, Oosterveld-Hut HM, Lubsen NH, Kampinga HH. 2010. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell 37: 355-369.
12. Iwata A, Riley BE, Johnston JA, Kopito RR. 2005. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem 280: 40282-40292.
13. Kazantsev AG, Thompson LM. 2008. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 7: 854-868.
14. Ma C, D'Mello SR. 2011. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem 286: 4819-4828.
15. Majdzadeh N, Morrison BE, D'Mello SR. 2008a. Class IIA HDACs in the regulation of neurodegeneration. Front Biosci 13: 1072-1082.
16. Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR. 2008b. HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol 68: 1076-1092.
17. Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR. 2006. Neuroprotection by histone deacetylase-related protein. Mol Cell Biol 26: 3550-3564.
18. Morrison BE, Majdzadeh N, D'Mello SR. 2007. Histone deacetylases: focus on the nervous system. Cell Mol Life Sci 64: 2258-2269.
19. Oliva AAJr, Jiang M, Lam T, Smith KL, Swann JW. 2000. Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurons. J Neurosci 20: 3354-3368.
20. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. 2007. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447: 859-863.
21. Pfister JA, Ma C, Morrison BE, D'Mello SR. 2008. Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS ONE 3: e4090.
22. Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. 2009. Putting the "HAT" back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin Invest Drugs 18: 573-584.
23. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.
24. Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN. 2004. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119: 555-566.
25. Yang XJ, Seto E. 2008. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9: 206-218.