Dichlorvos-induced cell cycle arrest and DNA damage repair activation in primary rat microglial cells

Journal of Neuroscience Research

Volumn 91, Issue 3, 2013, Pages 444-452

  Sunkaria, Aditya ^a   Wani, Willayat Yousuf ^a   Sharma, Deep Raj ^a   Gill, Kiran Dip ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

ATM; Cell cycle; Dichlorvos; Microglia; P21; P53

Indexed keywords

ATM PROTEIN; DICHLORVOS; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; DICHLORVOS; DNA DAMAGE; DNA REPAIR; MICROGLIA; ORGANOPHOSPHATES; PRIMARY CELL CULTURE; RATS; RATS, WISTAR;

EID: 84872613221     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23173     Document Type: Article

References (45)

1. Ahn JY, Li X, Davis HL, Canman CE. 2002. Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. J Biol Chem 277: 19389-19395.
2. Aschner M, Allen JW, Kimelberg HK, LoPachin RM, Streit WJ. 1999. Glial cells in neurotoxicity development. Annu Rev Pharmacol Toxicol 39: 151-173.
3. Atherton KM, Williams FM, Egea Gonzalez FJ, Glass R, Rushton S, Blain PG, Mutch E. 2009. DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure. Biomarkers 14: 443-451.
4. Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506.
5. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW. 1993. Cytotoxicity of microglia. Glia 7: 111-118.
6. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. 1998. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677.
7. Bartek J, Lukas J. 2001. Pathways governing G1/S transition and their response to DNA damage. FEBS Lett 490: 117-122.
8. Boje KM, Arora PK. 1992. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587: 250-256.
9. Bollen M, Beullens M. 2002. Signaling by protein phosphatases in the nucleus. Trends Cell Biol 12: 138-145.
10. Brosnan CF, Battistini L, Raine CS, Dickson DW, Casadevall A, Lee SC. 1994. Reactive nitrogen intermediates in human neuropathology: an overview. Dev Neurosci 16: 152-161.
11. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552-557.
12. Canman CE, Wolff AC, Chen CY, Fornace AJJr, Kastan MB. 1994. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res 54: 5054-5058.
13. Carlson K, Ehrich M. 2008. Distribution of SH-SY5Y human neuroblastoma cells in the cell cycle following exposure to organophosphorus compounds. J Biochem Mol Toxicol 22: 187-201.
14. 1 by stabilizing p53. Genes Dev 14: 278-288.
15. Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. 2005. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J 24: 3411-3422.
16. el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, et al. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174.
17. Eroglu HE. 2009. Toxic nuclear effects of the organophosphorus insecticide dichlorvos (DDVP) in human peripheral blood lymphocytes. Acta Biol Hung 60: 409-416.
18. Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. 2001. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410: 842-847.
19. Gartel AL, Tyner AL. 1999. Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp Cell Res 246: 280-289.
20. Gastaldo J, Viau M, Bencokova Z, Joubert A, Charvet AM, Balosso J, Foray N. 2007. Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways. Toxicol Lett 173: 201-214.
21. Gehrmann J, Banati RB. 1995. Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 54: 680-688.
22. Green MH, Medcalf AS, Arlett CF, Harcourt SA, Lehmann AR. 1974. DNA strand breakage caused by dichlorvos, methyl methanesulphonate and iodoacetamide in Escherichia coli and cultured Chinese hamster cells. Mutat Res 24: 365-378.
23. Ho YS, Wang YJ, Lin JK. 1996. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells. Mol Carcinogen 16: 20-31.
24. Hreljac I, Zajc I, Lah T, Filipic M. 2008. Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells. Environ Mol Mutagen 49: 360-367.
25. Kawanishi S, Hiraku Y, Pinlaor S, Ma N. 2006. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 387: 365-372.
26. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. 1998. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 20: 398-400.
27. Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312-318.
28. Lavin MF, Kozlov S, Gueven N, Peng C, Birrell G, Chen P, Scott S. 2005. Atm and cellular response to DNA damage. Adv Exp Med Biol 570: 457-476.
29. LeBron C, Chen L, Gilkes DM, Chen J. 2006. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J 25: 1196-1206.
30. Li Q, Kobayashi M, Kawada T. 2007. Organophosphorus pesticides induce apoptosis in human NK cells. Toxicology 239: 89-95.
31. Lin SY, Lee TC, Cheng CS, Wang TC. 1988. Cytotoxicity, sister-chromatid exchange, chromosome aberration and transformation induced by 2, 2-dichlorovinyl-O, O-dimethyl phosphate. Mutat Res 206: 439-445.
32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
33. Matsuoka S, Huang M, Elledge SJ. 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897.
34. Mattiuzzo M, Fiore M, Ricordy R, Degrassi F. 2006. Aneuploidy-inducing capacity of two widely used pesticides. Carcinogenesis 27: 2511-2518.
35. McGuire SO, Ling ZD, Lipton JW, Sortwell CE, Collier TJ, Carvey PM. 2001. Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. Exp Neurol 169: 219-230.
36. McKinnon PJ. 2004. ATM and ataxia telangiectasia. EMBO Rep 5: 772-776.
37. Niculescu AB3rd, Chen X, Smeets M, Hengst L, Prives C, Reed SI. 1998. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18: 629-643.
38. Ogryzko VV, Wong P, Howard BH. 1997. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 17: 4877-4882.
39. Oshiro Y, Piper CE, Balwierz PS, Soelter SG. 1991. Chinese hamster ovary cell assays for mutation and chromosome damage: data from non-carcinogens. J Appl Toxicol 11: 167-177.
40. Saquib Q, Attia SM, Siddiqui MA, Aboul-Soud MA, Al-Khedhairy AA, Giesy JP, Musarrat J. 2011. Phorate-induced oxidative stress, DNA damage and transcriptional activation of p53 and caspase genes in male Wistar rats. Toxicol Appl Pharmacol 259: 54-65.
41. Sherr CJ, Roberts JM. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163.
42. Stewart ZA, Mays D, Pietenpol JA. 1999. Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis. Cancer Res 59: 3831-3837.
43. Sunkaria A, Wani WY, Sharma DR, Gill KD. 2012. Dichlorvos exposure results in activation induced apoptotic cell death in primary rat microglia. Chem Res Toxicol 25: 1762-1770.
44. Yamano T. 1996. Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes. Toxicology 108: 49-56.
45. Yang W, Tiffany-Castiglioni E. 2008. Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A 71: 289-299.