Phorate-induced oxidative stress, DNA damage and transcriptional activation of p53 and caspase genes in male Wistar rats

Toxicology and Applied Pharmacology

Volumn 259, Issue 1, 2012, Pages 54-65

  Saquib, Quaiser ^a   Attia, Sabry M ^c   Siddiqui, Maqsood A ^a   Aboul Soud, Mourad A M ^a,f   Al Khedhairy, Abdulaziz A ^a   Giesy, John P ^a,d,e   Musarrat, Javed ^a,b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b ALIGARH MUSLIM UNIVERSITY   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

^e MICHIGAN STATE UNIVERSITY   (United States)

^f CAIRO UNIVERSITY   (Egypt)

Author keywords

Apoptosis; Histopathology; Organophosphates; Pesticide; Phorate; Toxicity

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; CATALASE; CELL DNA; GLUTATHIONE; LIPID; PHORATE; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL FUNCTION; CELL INFILTRATION; CELL NUCLEUS; CHEMICAL ANALYSIS; COMET ASSAY; COMPARATIVE STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MUSCLE CELL; HISTOPATHOLOGY; INFLAMMATION; KIDNEY NECROSIS; KIDNEY PARENCHYMA; LEUKOCYTE; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PYKNOTIC NUCLEUS; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; UPREGULATION; WISTAR RAT;

ANIMALS; APOPTOSIS; BONE MARROW; CASPASE 3; CASPASE 9; CASPASES; CELL CYCLE; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; INSECTICIDES; KIDNEY; LIVER; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCARDIUM; OXIDATIVE STRESS; PHORATE; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84857109753     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.12.006     Document Type: Article

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