Dichlorvos exposure results in activation induced apoptotic cell death in primary rat microglia

Chemical Research in Toxicology

Volumn 25, Issue 8, 2012, Pages 1762-1770

  Sunkaria, Aditya ^a   Wani, Willayat Yousuf ^a   Sharma, Deep Raj ^a   Gill, Kiran Dip ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD11B ANTIGEN; CYTOCHROME C; DICHLORVOS; DNA; INTERLEUKIN 1BETA; NITRIC OXIDE; PROTEIN BAX; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; MICROGLIA; MITOCHONDRION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; UPREGULATION;

ANIMALS; ANTIGENS, CD11B; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELLS, CULTURED; CYTOCHROMES C; DICHLORVOS; DNA FRAGMENTATION; INTERLEUKIN-1BETA; MICROGLIA; MITOCHONDRIA; NITRIC OXIDE; RATS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84865267596     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300234n     Document Type: Article

References (45)

1. Streit, W. J. and Kincaid-Colton, C. A. (1995) The brain's immune system Sci. Am. 273 (54-5) 58-61
2. Streit, W. J., Walter, S. A., and Pennell, N. A. (1999) Reactive microgliosis Prog. Neurobiol. 57, 563-581 (Pubitemid 29148415)
3. Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., and Stella, A. M. (2007) Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity Nat. Rev. Neurosci. 8, 766-775 (Pubitemid 47462116)
4. Takeuchi, H., Wang, J., Kawanokuchi, J., Mitsuma, N., Mizuno, T., and Suzumura, A. (2006) Interferon-gamma induces microglial-activation-induced cell death: a hypothetical mechanism of relapse and remission in multiple sclerosis Neurobiol. Dis. 22, 33-39
5. Mayo, L., Jacob-Hirsch, J., Amariglio, N., Rechavi, G., Moutin, M. J., Lund, F. E., and Stein, R. (2008) Dual role of CD38 in microglial activation and activation-induced cell death J. Immunol. 181, 92-103
6. Costa, L. G. (2006) Current issues in organophosphate toxicology Clin. Chim. Acta 366, 1-13 (Pubitemid 43330962)
7. Perera, P. M., Jayamanna, S. F., Hettiarachchi, R., Abeysinghe, C., Karunatilake, H., Dawson, A. H., and Buckley, N. A. (2009) A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning Trials. 10, 73
8. Sarabia, L., Maurer, I., and Bustos-Obregon, E. (2009) Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA Ecotoxicol. Environ. Saf. 72, 663-668
9. Shenouda, J., Green, P., and Sultatos, L. (2009) An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon Toxicol. Appl. Pharmacol. 241, 135-142
10. Howard, A. S., Bucelli, R., Jett, D. A., Bruun, D., Yang, D., and Lein, P. J. (2005) Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures Toxicol. Appl. Pharmacol. 207, 112-124 (Pubitemid 41135901)
11. Giordano, G., Afsharinejad, Z., Guizzetti, M., Vitalone, A., Kavanagh, T. J., and Costa, L. G. (2007) Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency Toxicol. Appl. Pharmacol. 219, 181-189 (Pubitemid 46282865)
12. Verma, S. K., Kumar, V., and Gill, K. D. (2009) An acetylcholinesterase- independent mechanism for neurobehavioral impairments after chronic low level exposure to Dichlorvos in rats Pharmacol., Biochem. Behav. 92, 173-181
13. Boje, K. M. and Arora, P. K. (1992) Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death Brain Res. 587, 250-256
14. Block, M. L. and Hong, J. S. (2007) Chronic microglial activation and progressive dopaminergic neurotoxicity Biochem. Soc. Trans. 35, 1127-1132 (Pubitemid 350206444)
15. Kim, Y. B., Hur, G. H., Shin, S., Sok, D. E., Kang, J. K., and Lee, Y. S. (1999) Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide Environ. Toxicol. Pharmacol. 7, 147-152 (Pubitemid 29221944)
16. Kawanishi, S., Hiraku, Y., Pinlaor, S., and Ma, N. (2006) Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis Biol. Chem. 387, 365-372
17. Monnet-Tschudi, F., Zurich, M. G., and Honegger, P. (2007) Neurotoxicant-induced inflammatory response in three-dimensional brain cell cultures Hum. Exp. Toxicol. 26, 339-346 (Pubitemid 46733357)
18. Rogers, J., Mastroeni, D., Leonard, B., Joyce, J., and Grover, A. (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int. Rev. Neurobiol. 82, 235-246
19. Lee, J., Hur, J., Lee, P., Kim, J. Y., Cho, N., Kim, S. Y., Kim, H., Lee, M. S., and Suk, K. (2001) Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11 J. Biol. Chem. 276, 32956-32965
20. Mayo, L. and Stein, R. (2007) Characterization of LPS and interferon-gamma triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide Cell Death Differ. 14, 183-186 (Pubitemid 44911905)
21. Giulian, D. and Baker, T. J. (1986) Characterization of ameboid microglia isolated from developing mammalian brain J. Neurosci. 6, 2163-2178 (Pubitemid 16043659)
22. Campanella, M., Sciorati, C., Tarozzo, G., and Beltramo, M. (2002) Flow cytometric analysis of inflammatory cells in ischemic rat brain Stroke 33, 586-592 (Pubitemid 34123411)
23. Tang, D. G., Li, L., Zhu, Z., and Joshi, B. (1998) Apoptosis in the absence of cytochrome c accumulation in the cytosol Biochem. Biophys. Res. Commun. 242, 380-384 (Pubitemid 28412436)
24. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent J. Biol. Chem. 193, 265-275
25. Graeber, M. B. and Streit, W. J. (2010) Microglia: biology and pathology Acta Neuropathol. 119, 89-105
26. Block, M. L. and Hong, J. S. (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism Prog. Neurobiol. 76, 77-98 (Pubitemid 41242883)
27. Buratti, F. M., Leoni, C., and Testai, E. (2007) The Human Metabolism of Organophosphorothionate Pesticides: Consequences for Toxicological Risk Assesment J. Verbr. Lebensm. 2, 37-44
28. Hanisch, U. K. and Kettenmann, H. (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat. Neurosci. 10, 1387-1394 (Pubitemid 350014685)
29. Zhou, L. and Zhu, D. Y. (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications Nitric Oxide 20, 223-230
30. Chang, A. Y., Chan, J. Y., Kao, F. J., Huang, C. M., and Chan, S. H. (2001) Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat J. Biomed. Sci. 8, 475-483 (Pubitemid 33036014)
31. Zimmer, L. A., Ennis, M., and Shipley, M. T. (1997) Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions J. Comp. Neurol. 378, 482-492 (Pubitemid 27061450)
32. Schori, H., Robenshtok, E., Schwartz, M., and Hourvitz, A. (2005) Post-intoxication vaccination for protection of neurons against the toxicity of nerve agents Toxicol. Sci. 87, 163-168 (Pubitemid 41222668)
33. Benford, D. J., Price, S. C., Lawrence, J. N., Grasso, P., and Bremmer, J. N. (1994) Investigations of the genotoxicity and cell proliferative activity of Dichlorvos in mouse forestomach Toxicology 92, 203-215 (Pubitemid 24293226)
34. Messmer, U. K. and Brune, B. (1996) Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways Biochem. J. 319, 299-305 (Pubitemid 26394772)
35. Fehsel, K., Kroncke, K. D., Meyer, K. L., Huber, H., Wahn, V., and Kolb-Bachofen, V. (1995) Nitric oxide induces apoptosis in mouse thymocytes J. Immunol. 155, 2858-2865
36. McDaniel, M. L., Corbett, J. A., Kwon, G., and Hill, J. R. (1997) A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction Adv. Exp. Med. Biol. 426, 313-319
37. Heneka, M. T., Loschmann, P. A., Gleichmann, M., Weller, M., Schulz, J. B., Wullner, U., and Klockgether, T. (1998) Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide J. Neurochem. 71, 88-94 (Pubitemid 28292538)
38. Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease Science 267, 1456-1462
39. Doherty, A. T., Ellard, S., Parry, E. M., and Parry, J. M. (1996) A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines Mutat. Res. 372, 221-231 (Pubitemid 27039401)
40. Eroglu, H. E. (2009) Toxic nuclear effects of the organophosphorus insecticide Dichlorvos (DDVP) in human peripheral blood lymphocytes Acta Biol. Hung. 60, 409-416
41. Kashyap, M. P., Singh, A. K., Kumar, V., Tripathi, V. K., Srivastava, R. K., Agrawal, M., Khanna, V. K., Yadav, S., Jain, S. K., and Pant, A. B. (2011) Monocrotophos induced apoptosis in PC12 cells: role of xenobiotic metabolizing cytochrome P450s PLoS One 6, e17757
42. Saraste, A. (1999) Morphologic criteria and detection of apoptosis Herz 24, 189-195 (Pubitemid 29254659)
43. Ahmadi, F. A., Linseman, D. A., Grammatopoulos, T. N., Jones, S. M., Bouchard, R. J., Freed, C. R., Heidenreich, K. A., and Zawada, W. M. (2003) The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons J. Neurochem. 87, 914-921 (Pubitemid 37444567)
44. Fei, Q., McCormack, A. L., Di Monte, D. A., and Ethell, D. W. (2008) Paraquat neurotoxicity is mediated by a Bak-dependent mechanism J. Biol. Chem. 283, 3357-3364
45. Yang, W. and Tiffany-Castiglioni, E. (2008) Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria J. Toxicol. Environ. Health A 71, 289-299 (Pubitemid 351218582)