Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays

Journal of Biomechanics

Volumn 46, Issue 2, 2013, Pages 276-283

  Bianchi, Elena ^a,c   Molteni, Raffaella ^b   Pardi, Ruggero ^b   Dubini, Gabriele ^a  

^a POLITECNICO DI MILANO   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c EPFL   (Switzerland)

Author keywords

High throughput; Leukocyte adhesion and transmigration; Microfluidics; Parallel plate flow chambers; Shear stress dependent cellular in vitro assay

Indexed keywords

BIOCHEMICAL SIGNAL; BIOMIMETIC ENVIRONMENT; BLOOD FLOW; CELL INTERACTION; CHANNEL DESIGN; CHEMOKINE RECEPTORS; CONTROLLED CONDITIONS; CUSTOM MODELS; HIGH-THROUGHPUT; IN-VITRO; IN-VITRO ASSAYS; IN-VIVO; INFLAMMATORY RESPONSE; INTEGRIN ACTIVATION; LEUKOCYTE ADHESION; MECHANICAL STIMULUS; MULTI-STEP; PARALLEL ASSAYS; PARALLEL-PLATE FLOW; SHEAR FORCE; STATIC ENVIRONMENT; STATISTICAL INTERPRETATION; STRESS-DEPENDENT; SURFACE COATINGS; TECHNOLOGICAL SOLUTION; VESSEL WALLS;

ADHESION; ASSAYS; BIOMIMETIC MATERIALS; BIOMIMETICS; CELL ADHESION; ENDOTHELIAL CELLS; ROAD CONSTRUCTION; SHEAR FLOW; SHEAR STRESS; TISSUE;

MICROFLUIDICS;

CHEMOKINE RECEPTOR; INTEGRIN; SELECTIN;

ARTICLE; BIOMIMETICS; BLOOD FLOW; BOYDEN DEVICE; CELL INTERACTION; DEVICES; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE ADHERENCE; MATERIAL COATING; MICROFLUIDICS; MODEL; NEUTROPHIL CHEMOTAXIS; PARALLEL PLATE FLOW CHAMBER; PRIORITY JOURNAL; SHEAR STRESS; SURFACE PROPERTY;

ANIMALS; CELL ADHESION; CELL COMMUNICATION; ENDOTHELIAL CELLS; HUMANS; LEUKOCYTE ROLLING; LEUKOCYTES; MECHANOTRANSDUCTION, CELLULAR; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; SELECTINS; SHEAR STRENGTH; STRESS, PHYSIOLOGICAL;

EID: 84872613160     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2012.10.024     Document Type: Article

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