Direct numerical simulation of detachment of single captured leukocyte under different flow conditions

Journal of Mechanics in Medicine and Biology

Volumn 11, Issue 2, 2011, Pages 273-284

  Luo, Z Y ^a,b   Xu, F ^b,c   Lu, T J ^b   Bai, B F ^a,b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

detachment; level set method; microfluidics; Single captured leukocyte

Indexed keywords

EID: 79960382069     PISSN: 02195194     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0219519411004034     Document Type: Article

References (33)

1. Kim YG, Moon S, Kuritzkes DR, Demirci U, Quantum dot-based HIV capture and imaging in a microfluidic channel, Biosens Bioelectron 25:253-258, 2009.
2. Moon S, Keles HO, Ozcom A, Khademhosseine A, Haeggstrom D, Kuritykes D, Demirci U, Integrating microfluidics and lensless imaging for point-of-care testing, Biosens Bioelectron 24:3208-3214, 2009.
3. Cheng XH, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M, A microfluidic device for practical label-free CD4+ T-cell counting of HIV-infected subjects, Lab Chip 7:170-178, 2007. (Pubitemid 46238539)
4. Adams AA, Okagbare PI, Feng J, Hupert ML, Patterson D, Gottert J, McCarley RL, Nikitopoulos D, Murphy MC, Soper SA, Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor, J Am Chem Soc 130:8633-8641, 2008. (Pubitemid 351962496)
5. Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Isolation of rare circulating tumour cells in cancer patients by microchip technology, Nature 450:1235-U10, 2007.
6. Phillips JA, Xu Y, Xia Z, Fan ZH, TanWH, Enrichment of cancer cells using aptamers immobilized on a microfluidic channel, Anal Chem 81:1033-1039, 2009.
7. Cheng XH, Gupta A, Chichen C, Tompkins RG, Rodriguez W, Toner M, Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics, Lab Chip 9:1357-1364, 2009.
8. Sin A, Murthy SK, Revzin A, Tompkins RG, Toner M, Enrichment using antibodycoated microfluidic chambers in shear flow: model mixtures of human lymphocytes, Biotechnol Bioeng 91:816-826, 2005. (Pubitemid 41344684)
9. Murthy SK, Sin A, Tompkins RG, Toner M, Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers, Langmuir 20:11649-11655, 2004. (Pubitemid 40049638)
10. Zhang X, Jones P, Haswell SJ, Attachment and detachment of living cells on modified microchannel surfaces in a microfluidic-based lab-on-a-chip system, Chem Eng J 135:S82-S88, 2008. (Pubitemid 350088608)
11. Cheung LSL, Zheng XG, Stopa A, Baygents JC, Guzman R, Schroeder JA, Heimark RL, Zohar Y, Detachment of captured cancer cells under flow acceleration in a biofunctionalized microchannel, Lab Chip 9:1721-1731, 2009.
12. Couzon C, Duperray A, Verdier C, Critical stresses for cancer cell detachment in microchannels, Eur Biophys J Biophys Lett 38:1035-1047, 2009.
13. Verdier C, Couzon C, Duperray A, Singh P, Modeling cell interactions under flow, J Math Biol 58:235-259, 2009.
14. Lim CT, Zhou EH, Quek ST, Mechanical models for living cells-a review, J Biomech 39:195-216, 2006. (Pubitemid 41728994)
15. Sukumaran S, Seifert U, Influence of shear flow on vesicles near a wall: A numerical study, Phys Rev E 64, 2001.
16. Jadhav S, Eggleton CD, Konstantopoulos K, A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling, Biophys J 88: 96-104, 2005. (Pubitemid 40070661)
17. Pappu V, Doddi SK, Bagchi P, A computational study of leukocyte adhesion and its effect on flow pattern in microvessels, J Theor Biol 254:483-498, 2008.
18. Khismatullin DB, Truskey GA, A 3D numerical study of the effect of channel height on leukocyte deformation and adhesion in parallel-plate flow chambers, Microvasc Res 68:188-202, 2004. (Pubitemid 40288115)
19. Liu XH, Wang X, The deformation of an adherent leukocyte under steady shear flow: A numerical study, J Biomech 37:1079-1085, 2004. (Pubitemid 38686332)
20. Khismatullin DB, Truskey GA, Three-dimensional numerical simulation of receptormediated leukocyte adhesion to surfaces: effects of cell deformability and viscoelasticity, Phys Fluids 17:21, 2005.
21. Jin Q, Verdier C, Singh P, Aubry N, Chotard-Ghodsnia R, Duperray A, Migration and deformation of leukocytes in pressure driven flows, Mech Res Comm 34:411-422, 2007. (Pubitemid 47284406)
22. Pappu V, Bagchi P, 3D computational modeling and simulation of leukocyte rolling adhesion and deformation, Comput Biol Med 38:738-753, 2008.
23. N'Dri NA, Shyy W, Tran-Soy-Tay R, Computational modeling of cell adhesion and movement using a continuum-kinetics approach, Biophys J 85:2273-2286, 2003. (Pubitemid 37210778)
24. Dembo M, Torney DC, Saxman K, Hammer D, The reaction-limited kinetics of membrane-to-surface adhesion and detachment, Proc R Soc Lond B Biol Sci 234: 55-83, 1988.
25. Kramers HA, Brownian motion in a field of force and the diffusion model of chemical reactions, Physica 7:284-304, 1940.
26. Ni MJ, Abdou M, Komori S, A variable-density projection method for interfacial flows, Numer Heat Trans B Fund 44:553-574, 2003.
27. Ni MJ, Komori S, Morley N, Projection methods for the calculation of incompressible unsteady flows, Numer Heat Trans B Fund 44:533-551, 2003.
28. Luo ZY, Xu F, Lu TJ, Bai BF, Direct numerical simulation of single leukocyte deformation in microchannel flow for disease diagnosis, J Med Syst, DOI: 10.1007/s10916- 010-9502-3, 2010.
29. Ramanujan S, Pozrikidis C, Deformation of liquid capsules enclosed by elastic membranes in simple shear flow: large deformations and the effect of fluid viscosities, J Fluid Mechan 361:117-143, 1998. (Pubitemid 128488596)
30. Lac E, Barthes-Biesel D, Deformation of a capsule in simple shear flow: effect of membrane prestress, Phys Fluids 17:8, 2005.
31. Bell GI, Models for the specific adhesion of cells to cells, Science 200:618-627, 1978.
32. Vonandrian UH, Hasslen SR, Nelson RD, Erlandsen SL, Butcher EC, A central role for microvillous receptor presentation in leukocyte adhesion under flow, Cell 82:989-999, 1995.
33. Bell GI, DemboM, Bongrand P, Cell adhesion: competition between nonspecific repulsion and specific bonding, Biophys J 45:1051-1064, 1984. (Pubitemid 14099481)