-
1
-
-
0037165229
-
The role of the renin-angiotensin system in the development of cardiovascular disease
-
11835903 10.1016/S0002-9149(01)02321-9 1:CAS:528:DC%2BD38XhtVKlur8%3D discussion 10A
-
Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol. 2002;89(2A):3A-9. discussion 10A.
-
(2002)
Am J Cardiol
, vol.89
, Issue.2 A
-
-
Unger, T.1
-
2
-
-
77949536656
-
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
-
20055710 10.1146/annurev.pharmtox.010909.105610 1:CAS:528: DC%2BC3cXisVelu78%3D
-
Bader M. Tissue renin-angiotensin-aldosterone systems: targets for pharmacological therapy. Annu Rev Pharmacol Toxicol. 2010;50:439-65.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 439-465
-
-
Bader, M.1
-
3
-
-
0031777979
-
The importance of the renin-angiotensin system in cardiovascular disease
-
Nicholls MG, Richards AM, Agarwal M. The importance of the renin-angiotensin system in cardiovascular disease. J Hum Hypertens. 1998;12(5):295-9. (Pubitemid 28274359)
-
(1998)
Journal of Human Hypertension
, vol.12
, Issue.5
, pp. 295-299
-
-
Nicholls, M.G.1
Richards, A.M.2
Agarwal, M.3
-
4
-
-
0036773028
-
Vascular and cardiac benefits of angiotensin receptor blockers
-
DOI 10.1016/S0002-9343(02)01241-X, PII S000293430201241X
-
Schiffrin EL. Vascular and cardiac benefits of angiotensin receptor blockers. Am J Med. 2002;113(5):409-18. (Pubitemid 35230007)
-
(2002)
American Journal of Medicine
, vol.113
, Issue.5
, pp. 409-418
-
-
Schiffrin, E.L.1
-
5
-
-
77954056940
-
Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: Current status
-
20590619 10.1111/j.1476-5381.2010.00750.x 1:CAS:528:DC%2BC3cXht1Oit7zM
-
Ma TK, et al. Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status. Br J Pharmacol. 2010;160(6):1273-92.
-
(2010)
Br J Pharmacol
, vol.160
, Issue.6
, pp. 1273-1292
-
-
Ma, T.K.1
-
6
-
-
0030948534
-
Biological functions of angiotensin and its receptors
-
DOI 10.1146/annurev.physiol.59.1.395
-
Matsusaka T, Ichikawa I. Biological functions of angiotensin and its receptors. Annu Rev Physiol. 1997;59:395-412. (Pubitemid 27142448)
-
(1997)
Annual Review of Physiology
, vol.59
, pp. 395-412
-
-
Matsusaka, T.1
Ichikawa, I.2
-
7
-
-
0033960508
-
Localization and function of angiotensin AT1 receptors
-
10678286 10.1016/S0895-7061(99)00249-6 1:CAS:528:DC%2BD3cXhs12htLc%3D
-
Allen AM, Zhuo J, Mendelsohn FA. Localization and function of angiotensin AT1 receptors. Am J Hypertens. 2000;13(1 Pt 2):31S-8.
-
(2000)
Am J Hypertens
, vol.13
, Issue.1 PART 2
-
-
Allen, A.M.1
Zhuo, J.2
Mendelsohn, F.A.3
-
8
-
-
0033824138
-
International union of pharmacology. XXIII. The angiotensin II receptors
-
10977869
-
de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52(3):415-72.
-
(2000)
Pharmacol Rev
, vol.52
, Issue.3
, pp. 415-472
-
-
De Gasparo, M.1
-
9
-
-
18544378161
-
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
-
DOI 10.1074/jbc.M200581200
-
Vickers C, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002;277(17):14838-43. (Pubitemid 34952556)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.17
, pp. 14838-14843
-
-
Vickers, C.1
Hales, P.2
Kaushik, V.3
Dick, L.4
Gavin, J.5
Tang, J.6
Godbout, K.7
Parsons, T.8
Baronas, E.9
Hsieh, F.10
Acton, S.11
Patane, M.12
Nichols, A.13
Tummino, P.14
-
10
-
-
0034721906
-
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
-
10924499 10.1074/jbc.M002615200 1:CAS:528:DC%2BD3cXnvVOqtbw%3D
-
Tipnis SR, et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275(43):33238-43.
-
(2000)
J Biol Chem
, vol.275
, Issue.43
, pp. 33238-33243
-
-
Tipnis, S.R.1
-
11
-
-
0038053724
-
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin i to angiotensin 1-9
-
10969042 10.1161/01.RES.87.5.e1 1:CAS:528:DC%2BD3MXhslOisr8%3D
-
Donoghue M, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87(5):E1-9.
-
(2000)
Circ Res
, vol.87
, Issue.5
, pp. 1-9
-
-
Donoghue, M.1
-
12
-
-
0037478671
-
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
-
DOI 10.1073/pnas.1432869100
-
Santos RA, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A. 2003;100(14):8258-63. (Pubitemid 36842532)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.14
, pp. 8258-8263
-
-
Santos, R.A.S.1
Simoes E Silva, A.C.2
Maric, C.3
Silva, D.M.R.4
Machado, R.P.5
De Buhr, I.6
Heringer-Walther, S.7
Pinheiro, S.V.B.8
Lopes, M.T.9
Bader, M.10
Mendes, E.P.11
Lemos, V.S.12
Campagnole-Santos, M.J.13
Schultheiss, H.-P.14
Speth, R.15
Walther, T.16
-
13
-
-
0141988867
-
Angiotensin-(1-7) formation in the intact human heart: In vivo dependence on angiotensin II as substrate
-
DOI 10.1161/01.CIR.0000094733.61689.D4
-
Zisman LS, et al. Angiotensin-(1-7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate. Circulation. 2003;108(14):1679-81. (Pubitemid 37243653)
-
(2003)
Circulation
, vol.108
, Issue.14
, pp. 1679-1681
-
-
Zisman, L.S.1
Meixell, G.E.2
Bristow, M.R.3
Canver, C.C.4
-
15
-
-
74949087578
-
Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases
-
20038757 10.1161/HYPERTENSIONAHA.109.140145 1:CAS:528: DC%2BC3cXlsleluw%3D%3D
-
Ferreira AJ, et al. Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases. Hypertension. 2010;55(2):207-13.
-
(2010)
Hypertension
, vol.55
, Issue.2
, pp. 207-213
-
-
Ferreira, A.J.1
-
16
-
-
84861511222
-
New cardiovascular and pulmonary therapeutic strategies based on the angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis
-
22319643
-
Ferreira AJ, et al. New cardiovascular and pulmonary therapeutic strategies based on the angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis. Int J Hypertens. 2012;2012:147825.
-
(2012)
Int J Hypertens
, vol.2012
, pp. 147825
-
-
Ferreira, A.J.1
-
17
-
-
62949127898
-
The sweeter side of ACE2: Physiological evidence for a role in diabetes
-
18948167 10.1016/j.mce.2008.09.020 1:CAS:528:DC%2BD1MXjslOgtL8%3D
-
Bindom SM, Lazartigues E. The sweeter side of ACE2: physiological evidence for a role in diabetes. Mol Cell Endocrinol. 2009;302(2):193-202.
-
(2009)
Mol Cell Endocrinol
, vol.302
, Issue.2
, pp. 193-202
-
-
Bindom, S.M.1
Lazartigues, E.2
-
19
-
-
42649115768
-
Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)- Mas axis
-
DOI 10.1113/expphysiol.2008.042002
-
Santos RA, Ferreira AJ, Simoes ESAC. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol. 2008;93(5):519-27. (Pubitemid 351595060)
-
(2008)
Experimental Physiology
, vol.93
, Issue.5
, pp. 519-527
-
-
Santos, R.A.S.1
Ferreira, A.J.2
Simoes E Silva, A.C.3
-
20
-
-
0018556554
-
Purification and properties of angiotensin I-converting enzyme in human lung and its role on the metabolism of vasoactive peptides in pulmonary circulation
-
229710 1:STN:280:DyaL3c%2FosVOksQ%3D%3D
-
Kokubu T, et al. Purification and properties of angiotensin I-converting enzyme in human lung and its role on the metabolism of vasoactive peptides in pulmonary circulation. Adv Exp Med Biol. 1979;120B:467-75.
-
(1979)
Adv Exp Med Biol
, vol.120
, pp. 467-475
-
-
Kokubu, T.1
-
22
-
-
84861074025
-
Angiotensin II type 2 receptor agonists-where should they be applied?
-
22519550 10.1517/13543784.2012.681046 1:CAS:528:DC%2BC38XmvVeht7s%3D
-
Steckelings UM, Unger T. Angiotensin II type 2 receptor agonists-where should they be applied? Expert Opin Investig Drugs. 2012;21(6):763-6.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, Issue.6
, pp. 763-766
-
-
Steckelings, U.M.1
Unger, T.2
-
23
-
-
0036771844
-
AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade
-
12364356 10.1161/01.HYP.0000033224.99806.8A 1:CAS:528: DC%2BD38Xntlams78%3D
-
Widdop RE, et al. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension. 2002;40(4):516-20.
-
(2002)
Hypertension
, vol.40
, Issue.4
, pp. 516-520
-
-
Widdop, R.E.1
-
24
-
-
79952039942
-
Angiotensin type 2 receptor in hypertensive cardiovascular disease
-
21245762 10.1097/MNH.0b013e3283437fcd 1:CAS:528:DC%2BC3MXhslynsrk%3D
-
Savoia C, et al. Angiotensin type 2 receptor in hypertensive cardiovascular disease. Curr Opin Nephrol Hypertens. 2011;20(2):125-32.
-
(2011)
Curr Opin Nephrol Hypertens
, vol.20
, Issue.2
, pp. 125-132
-
-
Savoia, C.1
-
25
-
-
49349107302
-
Renin-angiotensin system revisited
-
18793332 10.1111/j.1365-2796.2008.01981.x 1:STN:280: DC%2BD1cngsFOmtQ%3D%3D
-
Fyhrquist F, Saijonmaa O. Renin-angiotensin system revisited. J Intern Med. 2008;264(3):224-36.
-
(2008)
J Intern Med
, vol.264
, Issue.3
, pp. 224-236
-
-
Fyhrquist, F.1
Saijonmaa, O.2
-
26
-
-
80054084671
-
Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors
-
1:CAS:528:DC%2BC3MXntlSjsbk%3D
-
Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011;121(7):297-303.
-
(2011)
Clin Sci (Lond)
, vol.121
, Issue.7
, pp. 297-303
-
-
Bosnyak, S.1
-
27
-
-
0035966085
-
Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase
-
11707427 10.1074/jbc.C100512200 1:CAS:528:DC%2BD38Xktlarug%3D%3D
-
Albiston AL, et al. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem. 2001;276(52):48623-6.
-
(2001)
J Biol Chem
, vol.276
, Issue.52
, pp. 48623-48626
-
-
Albiston, A.L.1
-
28
-
-
11144314693
-
4 receptor
-
DOI 10.1007/s00018-004-4246-1
-
Chai SY, et al. The angiotensin IV/AT4 receptor. Cell Mol Life Sci. 2004;61(21):2728-37. (Pubitemid 40022434)
-
(2004)
Cellular and Molecular Life Sciences
, vol.61
, Issue.21
, pp. 2728-2737
-
-
Chai, S.Y.1
Fernando, R.2
Peck, G.3
Ye, S.-Y.4
Mendelsohn, F.A.O.5
Jenkins, T.A.6
Albiston, A.L.7
-
29
-
-
0000254274
-
Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide
-
3375255 10.1073/pnas.85.11.4095 1:CAS:528:DyaL1cXks1Oltrg%3D
-
Schiavone MT, et al. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci U S A. 1988;85(11):4095-8.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, Issue.11
, pp. 4095-4098
-
-
Schiavone, M.T.1
-
30
-
-
6344246036
-
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
-
DOI 10.1042/BJ20040634
-
Rice GI, et al. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383(Pt 1):45-51. (Pubitemid 39389449)
-
(2004)
Biochemical Journal
, vol.383
, Issue.1
, pp. 45-51
-
-
Rice, G.I.1
Thomas, D.A.2
Grant, P.J.3
Turner, A.J.4
Hooper, N.M.5
-
31
-
-
0029926375
-
Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide
-
Brosnihan KB, Li P, Ferrario CM. Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension. 1996;27(3 Pt 2):523-8. (Pubitemid 26086221)
-
(1996)
Hypertension
, vol.27
, Issue.3
, pp. 523-528
-
-
Brosnihan, K.B.1
Li, P.2
Ferrario, C.M.3
-
32
-
-
0038024648
-
Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats
-
12573992 1:CAS:528:DC%2BD3sXltVeiu7g%3D
-
Sampaio WO, Nascimento AA, Santos RA. Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats. Am J Physiol Heart Circ Physiol. 2003;284(6):H1985-94.
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.284
, Issue.6
, pp. 1985-1994
-
-
Sampaio, W.O.1
Nascimento, A.A.2
Santos, R.A.3
-
34
-
-
84858332279
-
Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart
-
22285513 10.1016/j.regpep.2012.01.001 1:CAS:528:DC%2BC38XivFynt7w%3D
-
Gava E, et al. Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart. Regul Pept. 2012;175(1-3):30-42.
-
(2012)
Regul Pept
, vol.175
, Issue.1-3
, pp. 30-42
-
-
Gava, E.1
-
35
-
-
38549174602
-
Endothelial dysfunction and elevated blood pressure in Mas gene-deleted mice
-
DOI 10.1161/HYPERTENSIONAHA.107.102764, PII 0000426820080200100025
-
Xu P, et al. Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice. Hypertension. 2008;51(2):574-80. (Pubitemid 351156450)
-
(2008)
Hypertension
, vol.51
, Issue.2 PART 2
, pp. 574-580
-
-
Xu, P.1
Costa-Goncalves, A.C.2
Todiras, M.3
Rabelo, L.A.4
Sampaio, W.O.5
Moura, M.M.6
Santos, S.S.7
Luft, F.C.8
Bader, M.9
Gross, V.10
Alenina, N.11
Santos, R.A.S.12
-
36
-
-
79751504524
-
ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease
-
21124322 10.1038/hr.2010.235 1:CAS:528:DC%2BC3MXhsFynsrY%3D
-
Rabelo LA, Alenina N, Bader M. ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease. Hypertens Res. 2011;34(2):154-60.
-
(2011)
Hypertens Res
, vol.34
, Issue.2
, pp. 154-160
-
-
Rabelo, L.A.1
Alenina, N.2
Bader, M.3
-
37
-
-
40349087454
-
The antithrombotic effect of angiotensin-(1-7) involves Mas-mediated NO release from platelets
-
DOI 10.2119/2007-00073.Fraga-Silva
-
Fraga-Silva RA, et al. The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets. Mol Med. 2008;14(1-2):28-35. (Pubitemid 351356883)
-
(2008)
Molecular Medicine
, vol.14
, Issue.1-2
, pp. 28-35
-
-
Fraga-Silva, R.A.1
Pinheiro, S.V.B.2
Goncalves, A.C.C.3
Alenina, N.4
Bader, M.5
Souza Dos Santos, R.A.6
-
38
-
-
79960879235
-
An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
-
10.1590/S1807-59322011000500021 This work shows that the oral formulations Ang-(1-7)-CyD produces biological activity through increasing Ang-(1-7) plasma level and in a Mas-dependent manner
-
•• Fraga-Silva RA, et al. An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect. Clinics (Sao Paulo). 2011;66(5):837-41. This work shows that the oral formulations Ang-(1-7)-CyD produces biological activity through increasing Ang-(1-7) plasma level and in a Mas-dependent manner.
-
(2011)
Clinics (Sao Paulo)
, vol.66
, Issue.5
, pp. 837-841
-
-
Fraga-Silva, R.A.1
-
39
-
-
84870884733
-
The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases
-
doi: 10.1160/TH12-06-0396
-
Fraga-Silva RA, et al. The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases. Thromb Haemost. 2012;108(6). doi: 10.1160/TH12-06-0396.
-
(2012)
Thromb Haemost.
, vol.108
, Issue.6
-
-
Fraga-Silva, R.A.1
-
40
-
-
0034725602
-
Angiotensin-(1-7): An update
-
10967201 10.1016/S0167-0115(00)00138-5 1:CAS:528:DC%2BD3cXmtVCrsrw%3D
-
Santos RA, Campagnole-Santos MJ, Andrade SP. Angiotensin-(1-7): an update. Regul Pept. 2000;91(1-3):45-62.
-
(2000)
Regul Pept
, vol.91
, Issue.1-3
, pp. 45-62
-
-
Santos, R.A.1
Campagnole-Santos, M.J.2
Andrade, S.P.3
-
41
-
-
33846799192
-
Evidence for a new angiotensin-(1-7) receptor subtype in the aorta of Sprague-Dawley rats
-
DOI 10.1016/j.peptides.2006.10.007, PII S0196978106004633
-
Silva DM, et al. Evidence for a new angiotensin-(1-7) receptor subtype in the aorta of Sprague-Dawley rats. Peptides. 2007;28(3):702-7. (Pubitemid 46204993)
-
(2007)
Peptides
, vol.28
, Issue.3
, pp. 702-707
-
-
Silva, D.M.R.1
Vianna, H.R.2
Cortes, S.F.3
Campagnole-Santos, M.J.4
Santos, R.A.S.5
Lemos, V.S.6
-
42
-
-
84861832045
-
Time-resolved quantitative phosphoproteomics: New insights into angiotensin-(1-7) signaling networks in human endothelial cells
-
This study provides new concepts and new understanding of the Ang-(1-7) signal transduction, shedding light on the mechanisms underlying Mas activation
-
•• Verano-Braga T, et al. Time-resolved quantitative phosphoproteomics: new insights into angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res. 2012;11(6):3370-81. This study provides new concepts and new understanding of the Ang-(1-7) signal transduction, shedding light on the mechanisms underlying Mas activation.
-
(2012)
J Proteome Res.
, vol.11
, Issue.6
, pp. 3370-3381
-
-
Verano-Braga, T.1
-
43
-
-
0035154879
-
Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells
-
Heitsch H, et al. Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells. Hypertension. 2001;37(1):72-6. (Pubitemid 32064242)
-
(2001)
Hypertension
, vol.37
, Issue.1
, pp. 72-76
-
-
Heitsch, H.1
Brovkovych, S.2
Malinski, T.3
Wiemer, G.4
-
44
-
-
33847018997
-
Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
-
DOI 10.1161/01.HYP.0000251865.35728.2f, PII 0000426820070100000034
-
Sampaio WO, et al. Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension. 2007;49(1):185-92. (Pubitemid 46360359)
-
(2007)
Hypertension
, vol.49
, Issue.1
, pp. 185-192
-
-
Sampaio, W.O.1
Dos Santos, R.A.S.2
Faria-Silva, R.3
Da Mata Machado, L.T.4
Schiffrin, E.L.5
Touyz, R.M.6
-
45
-
-
36448975192
-
Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells
-
DOI 10.1161/HYPERTENSIONAHA.106.084848
-
Sampaio WO, et al. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension. 2007;50(6):1093-8. (Pubitemid 350172931)
-
(2007)
Hypertension
, vol.50
, Issue.6
, pp. 1093-1098
-
-
Sampaio, W.O.1
De Castro, C.H.2
Santos, R.A.S.3
Schiffrin, E.L.4
Touyz, R.M.5
-
46
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
DOI 10.1038/sj.onc.1209086, PII 1209086
-
Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 2005;24(50):7410-25. (Pubitemid 41637981)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
47
-
-
80455176679
-
Applications of post-translational modifications of FoxO family proteins in biological functions
-
21669942 10.1093/jmcb/mjr013 1:CAS:528:DC%2BC3MXhsFagsL7O
-
Zhao Y, Wang Y, Zhu WG. Applications of post-translational modifications of FoxO family proteins in biological functions. J Mol Cell Biol. 2011;3(5):276-82.
-
(2011)
J Mol Cell Biol
, vol.3
, Issue.5
, pp. 276-282
-
-
Zhao, Y.1
Wang, Y.2
Zhu, W.G.3
-
48
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell. 1999;96(6):857-68. (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
49
-
-
0036872354
-
Angiotensin-(1-7) inhibits angiotensin II-induced signal transduction
-
DOI 10.1097/00005344-200211000-00007
-
Zhu Z, et al. Angiotensin-(1-7) inhibits angiotensin II-induced signal transduction. J Cardiovasc Pharmacol. 2002;40(5):693-700. (Pubitemid 36109287)
-
(2002)
Journal of Cardiovascular Pharmacology
, vol.40
, Issue.5
, pp. 693-700
-
-
Zhu, Z.1
Zhong, J.2
Zhu, S.3
Liu, D.4
Van Der Giet, M.5
Tepel, M.6
-
50
-
-
42649106140
-
Angiotensin-(1-7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity
-
DOI 10.1113/expphysiol.2007.014269
-
Giani JF, et al. Angiotensin-(1-7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity. Exp Physiol. 2008;93(5):570-8. (Pubitemid 351595049)
-
(2008)
Experimental Physiology
, vol.93
, Issue.5
, pp. 570-578
-
-
Giani, J.F.1
Gironacci, M.M.2
Munoz, M.C.3
Turyn, D.4
Dominici, F.P.5
-
51
-
-
58149352445
-
Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart
-
18845809 10.1161/CIRCRESAHA.108.184911 1:CAS:528:DC%2BD1cXhtlKrt7fO
-
Mercure C, et al. Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circ Res. 2008;103(11):1319-26.
-
(2008)
Circ Res
, vol.103
, Issue.11
, pp. 1319-1326
-
-
Mercure, C.1
-
52
-
-
73849095442
-
Angiotensin-(1-7) prevents cardiomyocyte pathological remodeling through a nitric oxide/guanosine 3',5'-cyclic monophosphate-dependent pathway
-
19996065 10.1161/HYPERTENSIONAHA.109.143255 1:CAS:528:DC%2BD1MXhsFaqtL7K
-
Gomes ER, et al. Angiotensin-(1-7) prevents cardiomyocyte pathological remodeling through a nitric oxide/guanosine 3',5'-cyclic monophosphate-dependent pathway. Hypertension. 2010;55(1):153-60.
-
(2010)
Hypertension
, vol.55
, Issue.1
, pp. 153-160
-
-
Gomes, E.R.1
-
53
-
-
0031601350
-
Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system
-
9453328 10.1161/01.HYP.31.1.356 1:CAS:528:DyaK1cXptF2ntQ%3D%3D
-
Iyer SN, Ferrario CM, Chappell MC. Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system. Hypertension. 1998;31(1 Pt 2):356-61.
-
(1998)
Hypertension
, vol.31
, Issue.1 PART 2
, pp. 356-361
-
-
Iyer, S.N.1
Ferrario, C.M.2
Chappell, M.C.3
-
54
-
-
0031935350
-
Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan
-
Iyer SN, et al. Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan. Hypertension. 1998;31(2):699-705. (Pubitemid 28086958)
-
(1998)
Hypertension
, vol.31
, Issue.2
, pp. 699-705
-
-
Iyer, S.N.1
Chappell, M.C.2
Averill, D.B.3
Diz, D.I.4
Ferrario, C.M.5
-
56
-
-
0036841147
-
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)
-
DOI 10.1161/01.HYP.0000035396.27909.40
-
Kucharewicz I, et al. Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7). Hypertension. 2002;40(5):774-9. (Pubitemid 35278618)
-
(2002)
Hypertension
, vol.40
, Issue.5
, pp. 774-779
-
-
Kucharewicz, I.1
Pawlak, R.2
Matys, T.3
Pawlak, D.4
Buczko, W.5
-
58
-
-
0036900194
-
AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium
-
DOI 10.1161/01.HYP.0000037979.53963.8F
-
Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002;40(6):847-52. (Pubitemid 35434905)
-
(2002)
Hypertension
, vol.40
, Issue.6
, pp. 847-852
-
-
Wiemer, G.1
Dobrucki, L.W.2
Louka, F.R.3
Malinski, T.4
Heitsch, H.5
-
59
-
-
33847780798
-
Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist
-
DOI 10.1111/j.1527-3466.2006.00239.x
-
Santos RA, Ferreira AJ. Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist. Cardiovasc Drug Rev. 2006;24(3-4):239-46. (Pubitemid 46435006)
-
(2006)
Cardiovascular Drug Reviews
, vol.24
, Issue.3-4
, pp. 239-246
-
-
Santos, R.A.S.1
Ferreira, A.J.2
-
60
-
-
84874115837
-
A non-peptide Mas-receptor agonist, facilitates penile erection
-
AVE 0991 doi: 10.1113/expphysiol.2012.068551
-
da Costa-Goncalves AC, et al. AVE 0991, a non-peptide Mas-receptor agonist, facilitates penile erection. Exp Physiol. 2012. doi: 10.1113/expphysiol.2012.068551.
-
(2012)
Exp Physiol.
-
-
Da Costa-Goncalves, A.C.1
-
61
-
-
4644372221
-
Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor mas agonist in the mouse kidney
-
DOI 10.1161/01.HYP.0000141438.64887.42
-
Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004;44(4):490-6. (Pubitemid 39281501)
-
(2004)
Hypertension
, vol.44
, Issue.4
, pp. 490-496
-
-
Pinheiro, S.V.B.1
Simoes E Silva, A.C.2
Sampaio, W.O.3
De Paula, R.D.4
Mendes, E.P.5
Bontempo, E.D.6
Pesquero, J.B.7
Walther, T.8
Alenina, N.9
Bader, M.10
Bleich, M.11
Santos, R.A.S.12
-
62
-
-
24344509196
-
The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of Mas-knockout mice
-
DOI 10.1097/01.fjc.0000175237.41573.63
-
Lemos VS, et al. The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice. J Cardiovasc Pharmacol. 2005;46(3):274-9. (Pubitemid 41262828)
-
(2005)
Journal of Cardiovascular Pharmacology
, vol.46
, Issue.3
, pp. 274-279
-
-
Lemos, V.S.1
Silva, D.M.R.2
Walther, T.3
Alenina, N.4
Bader, M.5
Santos, R.A.S.6
-
63
-
-
33846956137
-
The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction
-
17056670 10.1152/ajpheart.00828.2006 1:CAS:528:DC%2BD2sXjt1GntLw%3D
-
Ferreira AJ, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007;292(2):H1113-9.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
, Issue.2
, pp. 1113-1119
-
-
Ferreira, A.J.1
-
64
-
-
34548507186
-
Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991
-
DOI 10.1016/j.lfs.2007.07.022, PII S0024320507005358
-
Ferreira AJ, et al. Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991. Life Sci. 2007;81(11):916-23. (Pubitemid 47374211)
-
(2007)
Life Sciences
, vol.81
, Issue.11
, pp. 916-923
-
-
Ferreira, A.J.1
Oliveira, T.L.2
Castro, M.C.M.3
Almeida, A.P.4
Castro, C.H.5
Caliari, M.V.6
Gava, E.7
Kitten, G.T.8
Santos, R.A.S.9
-
65
-
-
33644860787
-
Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME
-
16403946 10.1152/ajpheart.00632.2005 1:CAS:528:DC%2BD28XhsFKju7Y%3D
-
Benter IF, et al. Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. Am J Physiol Heart Circ Physiol. 2006;290(2):H684-91.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
, Issue.2
, pp. 684-691
-
-
Benter, I.F.1
-
66
-
-
33644637224
-
Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats
-
16087780 10.1161/01.HYP.0000174594.17052.33 1:CAS:528:DC%2BD2MXhtVeksbfO
-
Faria-Silva R, Duarte FV, Santos RA. Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension. 2005;46(4):948-52.
-
(2005)
Hypertension
, vol.46
, Issue.4
, pp. 948-952
-
-
Faria-Silva, R.1
Duarte, F.V.2
Santos, R.A.3
-
67
-
-
34548840277
-
Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats
-
DOI 10.1161/HYPERTENSIONAHA.107.094987, PII 0000426820071000000031
-
Carvalho MB, et al. Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats. Hypertension. 2007;50(4):762-7. (Pubitemid 47442743)
-
(2007)
Hypertension
, vol.50
, Issue.4
, pp. 762-767
-
-
Carvalho, M.B.L.1
Duarte, F.V.2
Faria-Silva, R.3
Fauler, B.4
Da Mata Machado, L.T.5
De Paula, R.D.6
Campagnole-Santos, M.J.7
Santos, R.A.S.8
-
68
-
-
84871766448
-
Effect of combination of renin inhibitor and Mas-receptor agonist in DOCA-salt-induced hypertension in rats
-
doi: 10.1007/s11010-012-1489-2
-
Singh Y, Singh K, Sharma PL. Effect of combination of renin inhibitor and Mas-receptor agonist in DOCA-salt-induced hypertension in rats. Mol Cell Biochem. 2012. doi: 10.1007/s11010-012-1489-2.
-
(2012)
Mol Cell Biochem.
-
-
Singh, Y.1
Singh, K.2
Sharma, P.L.3
-
69
-
-
58049193594
-
Discovery and validation of novel peptide agonists for G-protein-coupled receptors
-
18854305 10.1074/jbc.M805181200 1:CAS:528:DC%2BD1cXhsVGqtrnP
-
Shemesh R, et al. Discovery and validation of novel peptide agonists for G-protein-coupled receptors. J Biol Chem. 2008;283(50):34643-9.
-
(2008)
J Biol Chem
, vol.283
, Issue.50
, pp. 34643-34649
-
-
Shemesh, R.1
-
70
-
-
77953811506
-
Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor
-
20479330 10.1161/HYPERTENSIONAHA.110.152942 1:CAS:528: DC%2BC3cXnsFGkur8%3D This recent study was the first indicating that the novel Mas agonist, CGEN-856S, might have a therapeutic value, since it induces vasorelaxation, antihypertensive, and cardioprotective effects
-
• Savergnini SQ, et al. Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor. Hypertension. 2010;56(1):112-20. This recent study was the first indicating that the novel Mas agonist, CGEN-856S, might have a therapeutic value, since it induces vasorelaxation, antihypertensive, and cardioprotective effects.
-
(2010)
Hypertension
, vol.56
, Issue.1
, pp. 112-120
-
-
Savergnini, S.Q.1
-
71
-
-
35349001774
-
Study of angiotensin-(1-7) vasoactive peptide and its β-cyclodextrin inclusion complexes: Complete sequence-specific NMR assignments and structural studies
-
DOI 10.1016/j.peptides.2007.08.011, PII S019697810700280X
-
Lula I, et al. Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies. Peptides. 2007;28(11):2199-210. (Pubitemid 47610792)
-
(2007)
Peptides
, vol.28
, Issue.11
, pp. 2199-2210
-
-
Lula, I.1
Denadai, A.L.2
Resende, J.M.3
De Sousa, F.B.4
De Lima, G.F.5
Pilo-Veloso, D.6
Heine, T.7
Duarte, H.A.8
Santos, R.A.S.9
Sinisterra, R.D.10
-
72
-
-
16344364096
-
Design and evaluation of cyclodextrin-based drug formulation
-
DOI 10.1248/cpb.52.900
-
Uekama K. Design and evaluation of cyclodextrin-based drug formulation. Chem Pharm Bull (Tokyo). 2004;52(8):900-15. (Pubitemid 41701863)
-
(2004)
Chemical and Pharmaceutical Bulletin
, vol.52
, Issue.8
, pp. 900-915
-
-
Uekama, K.1
-
73
-
-
79953243160
-
An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted and isoproterenol-treated rats
-
21282558 10.1161/HYPERTENSIONAHA.110.167346 1:CAS:528: DC%2BC3MXitVOis70%3D This work is the first showing the cardioprotective effects of Ang-(1-7) formulation, Ang-(1-7)-CyD
-
•• Marques FD, et al. An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted and isoproterenol-treated rats. Hypertension. 2011;57(3):477-83. This work is the first showing the cardioprotective effects of Ang-(1-7) formulation, Ang-(1-7)-CyD.
-
(2011)
Hypertension
, vol.57
, Issue.3
, pp. 477-483
-
-
Marques, F.D.1
-
74
-
-
62449281004
-
Angiotensin-(1-7) with thioether bridge: An angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog
-
19038778 10.1124/jpet.108.146431 1:CAS:528:DC%2BD1MXislalsL8%3D In this work it was developed the cyclized Ang-(1-7) compound which was proposed as an excellent method to render more resistance against proteolytic breakdown but preserving its activity
-
• Kluskens LD, et al. Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J Pharmacol Exp Ther. 2009;328(3):849-54. In this work it was developed the cyclized Ang-(1-7) compound which was proposed as an excellent method to render more resistance against proteolytic breakdown but preserving its activity.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, Issue.3
, pp. 849-854
-
-
Kluskens, L.D.1
-
75
-
-
84861507620
-
The effect of the thioether-bridged, stabilized Angiotensin-(1-7) analogue cyclic ang-(1-7) on cardiac remodeling and endothelial function in rats with myocardial infarction
-
22121478
-
Durik M, et al. The effect of the thioether-bridged, stabilized Angiotensin-(1-7) analogue cyclic ang-(1-7) on cardiac remodeling and endothelial function in rats with myocardial infarction. Int J Hypertens. 2012;2012:536426.
-
(2012)
Int J Hypertens
, vol.2012
, pp. 536426
-
-
Durik, M.1
-
76
-
-
42349105833
-
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
-
DOI 10.1161/HYPERTENSIONAHA.107.108944, PII 0000426820080500000013
-
Hernandez Prada JA, et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008;51(5):1312-7. (Pubitemid 351555943)
-
(2008)
Hypertension
, vol.51
, Issue.5
, pp. 1312-1317
-
-
Hernandez Prada, J.A.1
Ferreira, A.J.2
Katovich, M.J.3
Shenoy, V.4
Qi, Y.5
Santos, R.A.S.6
Castellano, R.K.7
Lampkins, A.J.8
Gubala, V.9
Ostrov, D.A.10
Raizada, M.K.11
-
77
-
-
79951509062
-
Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases
-
21148624 10.1113/expphysiol.2010.055277 1:CAS:528:DC%2BC3MXlsF2rtLk%3D
-
Ferreira AJ, et al. Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. Exp Physiol. 2011;96(3):287-94.
-
(2011)
Exp Physiol
, vol.96
, Issue.3
, pp. 287-294
-
-
Ferreira, A.J.1
-
78
-
-
66249133083
-
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension
-
19246717 10.1164/rccm.200811-1678OC 1:CAS:528:DC%2BD1MXnt1artb0%3D
-
Ferreira AJ, et al. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med. 2009;179(11):1048-54.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, Issue.11
, pp. 1048-1054
-
-
Ferreira, A.J.1
-
79
-
-
77951955278
-
ACE2 activation promotes antithrombotic activity
-
20111697 1:CAS:528:DC%2BC3cXmtlSqtr0%3D
-
Fraga-Silva RA, et al. ACE2 activation promotes antithrombotic activity. Mol Med. 2010;16(5-6):210-5.
-
(2010)
Mol Med
, vol.16
, Issue.5-6
, pp. 210-215
-
-
Fraga-Silva, R.A.1
-
80
-
-
84862770709
-
Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction
-
22595130 10.1016/j.regpep.2012.05.093 1:CAS:528:DC%2BC38XotVeltbg%3D
-
Murca TM, et al. Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul Pept. 2012;177(1-3):107-15.
-
(2012)
Regul Pept
, vol.177
, Issue.1-3
, pp. 107-115
-
-
Murca, T.M.1
-
81
-
-
84862630741
-
Chronic activation of endogenous angiotensin-converting enzyme 2 protects diabetic rats from cardiovascular autonomic dysfunction
-
22286369 1:CAS:528:DC%2BC38XhtFaktLzK
-
Murca TM, et al. Chronic activation of endogenous angiotensin-converting enzyme 2 protects diabetic rats from cardiovascular autonomic dysfunction. Exp Physiol. 2012;97(6):699-709.
-
(2012)
Exp Physiol
, vol.97
, Issue.6
, pp. 699-709
-
-
Murca, T.M.1
-
82
-
-
0035569025
-
Effects of angiotensin-(1-7) on forearm circulation in normotensive subjects and patients with essential hypertension
-
Sasaki S, et al. Effects of angiotensin-(1-7) on forearm circulation in normotensive subjects and patients with essential hypertension. Hypertension. 2001;38(1):90-4. (Pubitemid 34224777)
-
(2001)
Hypertension
, vol.38
, Issue.1
, pp. 90-94
-
-
Sasaki, S.1
Higashi, Y.2
Nakagawa, K.3
Matsuura, H.4
Kajiyama, G.5
Oshima, T.6
-
83
-
-
0032888404
-
Effect of angiotensin-(1-7) and bradykinin in patients with heart failure treated with an ACE inhibitor
-
Davie AP, McMurray JJ. Effect of angiotensin-(1-7) and bradykinin in patients with heart failure treated with an ACE inhibitor. Hypertension. 1999;34(3):457-60. (Pubitemid 29426763)
-
(1999)
Hypertension
, vol.34
, Issue.3
, pp. 457-460
-
-
Davie, A.P.1
McMurray, J.J.V.2
|