Meta-analysis of association between the -1438a/g (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder

Neurological Research

Volumn 35, Issue 1, 2013, Pages 7-14

  Jin, Chunhui ^a   Xu, Wenwei ^a   Yuan, Jianmin ^a   Wang, Guoqiang ^a   Cheng, Zaohuo ^a  

^a SHANDONG MENTAL HEALTH CENTER   (China)

Author keywords

Major depressive disorder; Meta analysis; Polymorphism; Serotonin 2A receptor

Indexed keywords

SEROTONIN 2A RECEPTOR;

DATA EXTRACTION; DISEASE ASSOCIATION; DNA POLYMORPHISM; HUMAN; MAJOR DEPRESSION; REVIEW; RISK FACTOR; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

DATABASES, FACTUAL; DEPRESSIVE DISORDER, MAJOR; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; SENSITIVITY AND SPECIFICITY;

EID: 84872543671     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000111     Document Type: Review

References (33)

1. Tsuang MT, Taylor L, Faraone SV. An overview of the genetics of psychotic mood disorders. J Psychiatr Res. 2004;38:3-15.
2. Fava M, Kendler KS. Major depressive disorder. Neuron. 2000;28:335-41.
3. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617-27.
4. Lohoff FW. Overview of the genetics of major depressive disorder. Curr Psychiatry Rep. 2010;12:539-46.
5. Owens MJ, Nemeroff CB. The serotonin transporter and depression. Depress Anxiety. 1998;8:5-12.
6. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM, et al. Polymorphism in serotonin transporter gene associated with to major depression. Lancet. 1996; 347:731-3.
7. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES, et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet. 1998;81:58-63.
8. Meltzer HY, Matsubara S, Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther. 1989;251:238-46.
9. Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, et al. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biol Psychiatry. 2007;61:223-30.
10. Jansson M, Gatz M, Berg S, Johansson B, Malmberg B, McClearn GE, et al. Association between depressed mood in the elderly and a 5-HTR2A gene variant. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:79-84.
11. Zhu YZ, Zhang Y, Ma H, Xie SF, Jiang WY, Sun GW, et al, 5-HTR2A gene -1438A/G polymorphism and effect of fluoxetine in major depressive disorder patients. Chin Gen Pract (Chinese). 2010;13:1431-4.
12. Choi MJ, Lee HJ, Lee HJ, Ham BJ, Cha JH, Ryu SH, et al. Association between major depressive disorder and the -1438A/ G polymorphism of the serotonin 2A receptor gene. Neuropsychobiology. 2004;49:38-41.
13. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K. 5-HT2A receptor gene promoter polymorphism-1438G/A and mood disorders. Neuroreport. 1998;9:1139-41.
14. Kishi T, Kitajima T, Tsunoka T, Ikeda M, Yamanouchi Y, Kinoshita Y, et al. Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. Neurosci Res. 2009;64:231-4.
15. Yu Y, Zhao JP, Wu RR, Xun GL, Fang MS. Association study between major depression and the -1438A/G polymorphism of serotonin receptor 2A gene. J Int Psychiatry (Chinese). 2009;2:65-8.
16. Tencomnao T, Thongrakard V, Phuchana W, Sritharathikhun T, Suttirat S. No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population. Genet Mol Res. 2010;9:1171-6.
17. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E, et al. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry. 1999;4:389-92.
18. Bonnier B, Gorwood P, Hamon M, Sarfati Y, Boni C, Hardy-Bayle MC. Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk. Biol Psychiatry. 2002;51:762-5.
19. Illi A, Setala-Soikkeli E, Viikki M, Poutanen O, Huhtala H, Mononen N, et al. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. 2009;20:1125-8.
20. 2A promoter polymorphism, -1438G/A. Mol Psychiatry. 1999;4:89-92.
21. Molnar E, Lazary, J, Benko A, Gonda X, Pap D, Mekli K, et al. Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene. Eur Neuropsychopharmacol. 2010;20:655-62.
22. Lau LS, Blanchard DG, Hye RJ. Diagnosis and management of patients with peripheral macroemboli from thoracic aortic pathology. Ann Vasc Surg. 1997;11:348-53.
23. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-48.
24. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.
25. Zintzaras E. The generalized odds ratio as a measure of risk effect in the analysis and meta-analysis of association studies. Stat Appl Genet Mol. 2010;9:Article 21.
26. Shelton RC, Sanders-Bush E, Manier DH, Lewis DA. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience. 2009;158:1406-15.
27. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K, et al. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry. 1997;41:768-73.
28. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet. 2000;96:56-60.
29. Anguelova M, Benkelfat C, Turecki G.A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry. 2003;8:574-91.
30. Lenze EJ, Shardell M, Ferrell RE, Orwig D, Yu-Yahiro J, Hawkes W, et al. Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fracture. J Affect Disord. 2008;111:61-6.
31. Kim JM, Stewart R, Bae KY, Kim SW, Kang HJ, Shin IS, et al. Serotonergic and BDNF genes and risk of depression after stroke. J Affect Disord. 2012;136:833-40.
32. Judson R, Stephens JC, Windemuth A. The predictive power of haplotypes in clinical response. Pharmacogenomics. 2000;1: 15-26.
33. Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE, et al. Haplotype variation and linkage disequilibrium in 313 human genes. Science. 2001;293:489-93.