Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population

Neuroscience Research

Volumn 64, Issue 2, 2009, Pages 231-234

  Kishi, Taro ^a   Kitajima, Tsuyoshi ^a   Tsunoka, Tomoko ^a   Ikeda, Masashi ^a,b   Yamanouchi, Yoshio ^a   Kinoshita, Yoko ^a   Kawashima, Kunihiro ^a   Okochi, Tomo ^a   Okumura, Takenori ^a   Inada, Toshiya ^c   Ozaki, Norio ^d   Iwata, Nakao ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c SEIWA HOSPITAL   (Japan)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bipolar disorder; Major depressive disorder; Serotonin 2A receptor gene (HTR2A); SNPs

Indexed keywords

SEROTONIN 2A RECEPTOR;

ADULT; ALLELE; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A;

EID: 67349270897     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2009.03.003     Document Type: Article

References (26)

1. Baron M. Genetic models of sex effect in unipolar affective illness. Acta Psychiatr. Scand. 64 1 (1981) 85-91
2. Bowden C.L. Strategies to reduce misdiagnosis of bipolar depression. Psychiatr. Serv. 52 1 (2001) 51-55
3. Currier D., Mann M.J., Oquendo M.A., Galfalvy H., and Mann J.J. Sex differences in the familial transmission of mood disorders. J. Affect. Disord. 95 1-3 (2006) 51-60
4. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 2 (2003) 115-121
5. Faraone S.V., Lyons M.J., and Tsuang M.T. Sex differences in affective disorder: genetic transmission. Genet. Epidemiol. 4 5 (1987) 331-343
6. Kato M., Fukuda T., Wakeno M., Fukuda K., Okugawa G., Ikenaga Y., Yamashita M., Takekita Y., Nobuhara K., Azuma J., and Kinoshita T. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 53 4 (2006) 186-195
7. Kato T. Molecular genetics of bipolar disorder and depression. Psychiatry Clin. Neurosci. 61 1 (2007) 3-19
8. Kishi T., Kitajima T., Ikeda M., Yamanouchi Y., Kinoshita Y., Kawashima K., Okochi T., Ozaki N., and Iwata N. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. Neurosci. Res. 62 4 (2008) 211-215
9. Lekman M., Laje G., Charney D., Rush A.J., Wilson A.F., Sorant A.J., Lipsky R., Wisniewski S.R., Manji H., McMahon F.J., and Paddock S. The FKBP5-gene in depression and treatment response-an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. Biol. Psychiatry 63 12 (2008) 1103-1110
10. Levinson D.F. The genetics of depression: a review. Biol. Psychiatry 60 2 (2006) 84-92
11. McMahon F.J., Buervenich S., Charney D., Lipsky R., Rush A.J., Wilson A.F., Sorant A.J., Papanicolaou G.J., Laje G., Fava M., Trivedi M.H., Wisniewski S.R., and Manji H. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am. J. Hum. Genet. 78 5 (2006) 804-814
12. Murphy D.L., Lerner A., Rudnick G., and Lesch K.P. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol. Interv. 4 2 (2004) 109-123
13. Myers R.L., Airey D.C., Manier D.H., Shelton R.C., and Sanders-Bush E. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biol. Psychiatry 61 2 (2007) 167-173
14. Philip N.S., Carpenter L.L., Tyrka A.R., and Price L.H. Augmentation of antidepressants with atypical antipsychotics: a review of the current literature. J. Psychiatr. Pract. 14 1 (2008) 34-44
15. Purcell S., Cherny S.S., and Sham P.C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 1 (2003) 149-150
16. Sato K., Yoshida K., Takahashi H., Ito K., Kamata M., Higuchi H., Shimizu T., Itoh K., Inoue K., Tezuka T., Suzuki T., Ohkubo T., Sugawara K., and Otani K. Association between -1438G/A promoter polymorphism in the 5-HT (2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder. Neuropsychobiology 46 3 (2002) 136-140
17. Serretti A., and Artioli P. From molecular biology to pharmacogenetics: a review of the literature on antidepressant treatment and suggestions of possible candidate genes. Psychopharmacology (Berl) 174 4 (2004) 490-503
18. Serretti A., and Artioli P. The pharmacogenomics of selective serotonin reuptake inhibitors. Pharmacogenomics J. 4 4 (2004) 233-244
19. Serretti A., Drago A., and De Ronchi D. HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Curr. Med. Chem. 14 19 (2007) 2053-2069
20. Serretti A., and Mandelli L. The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions. Mol. Psychiatry 13 8 (2008) 742-771
21. Spurlock G., Heils A., Holmans P., Williams J., D'Souza U.M., Cardno A., Murphy K.C., Jones L., Buckland P.R., McGuffin P., Lesch K.P., and Owen M.J. A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol. Psychiatry 3 1 (1998) 42-49
22. Stensland M.D., Schultz J.F., and Frytak J.R. Diagnosis of unipolar depression following initial identification of bipolar disorder: a common and costly misdiagnosis. J. Clin. Psychiatry 69 5 (2008) 749-758
23. Sullivan N.R., Burke T., Siafaka-Kapadai A., Javors M., and Hensler J.G. Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells. J. Neurochem. 90 5 (2004) 1269-1275
24. Tsai S.J., Hong C.J., Liou Y.J., Yu Y.W., and Chen T.J. Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. Pharmacogenet. Genomics 18 10 (2008) 869-875
25. Wilkie M.J., Smith G., Day R.K., Matthews K., Smith D., Blackwood D., Reid I.C., and Wolf C.R. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy. Pharmacogenomics J. (2008)
26. Yatham L.N., Liddle P.F., Lam R.W., Adam M.J., Solomons K., Chinnapalli M., and Ruth T.J. A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania. Bipolar Disord. 7 Suppl. 5 (2005) 53-57