Serotonergic and BDNF genes and risk of depression after stroke

Journal of Affective Disorders

Volumn 136, Issue 3, 2012, Pages 833-840

  Kim, Jae Min ^a,b,c   Stewart, Robert ^a,b,c   Bae, Kyung Yeol ^a,b,c   Kim, Sung Wan ^a,b,c   Kang, Hee Ju ^a,b,c   Shin, Il Seon ^a,b,c   Kim, Joon Tae ^a,b,c   Park, Man Seok ^a,b,c   Kim, Myung Kyu ^a,b,c   Park, Sung Woo ^a,b,c   Kim, Young Hoon ^a,b,c   Kim, Jong Keun ^a,b,c   Cho, Ki Hyun ^a,b,c   Yoon, Jin Sang ^a,b,c  

^a Chonnam National University Medical School   (South Korea)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Inje University College of Medicine   (South Korea)

Author keywords

Brain derived neurotrophic factor; Depression; Genetic association study; Serotonin receptor; Serotonin transporter; Stroke

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; VALINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC RISK; GENOTYPE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; MULTIFACTOR DIMENSIONALITY REDUCTION; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; STROKE;

ADULT; AGED; AGED, 80 AND OVER; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STROKE;

EID: 84857358670     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.09.029     Document Type: Article

References (54)

1. I. Aben, F. Verhey, J. Strik, R. Lousberg, J. Lodder, and A. Honig A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction Journal of Neurology, Neurosurgery, and Psychiatry 74 5 2003 581 585
2. G.S. Alexopoulos, C.F. Murphy, F.M. Gunning-Dixon, C.E. Glatt, V. Latoussakis, R.E. Kelly Jr.; D. Kanellopoulos, S. Klimstra, K.O. Lim, R.C. Young, and M.J. Hoptman Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression Journal of Affective Disorders 119 1-3 2009 132 141
3. G.S. Alexopoulos, C.E. Glatt, M.J. Hoptman, D. Kanellopoulos, C.F. Murphy, R.E. Kelly Jr.; S.S. Morimoto, K.O. Lim, and F.M. Gunning BDNF Val66met polymorphism, white matter abnormalities and remission of geriatric depression Journal of Affective Disorders 125 1-3 2010 262 268
4. M. Anguelova, C. Benkelfat, and G. Turecki A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders Molecular Psychiatry 8 6 2003 574 591
5. S. Battersby, A.D. Ogilvie, C.A. Smith, D.H. Blackwood, W.J. Muir, J.P. Quinn, G. Fink, G.M. Goodwin, and A.J. Harmar Structure of variable number tandem repeat of the serotonin transporter gene and association with affective disorder Psychiatric Genetics 6 4 1996 177 181
6. A. Berg, H. Palomaki, M. Lehtihalmes, J. Lonnqvist, and M. Kaste Poststroke depression in acute phase after stroke Cerebrovascular Diseases 12 1 2001 14 20
7. S.K. Bhogal, R. Teasell, N. Foley, and M. Speechley Lesion location and poststroke depression. Systematic review of the methodological limitations in the literature Stroke 35 3 2004 794 802
8. B. Bonnier, P. Gorwood, M. Hamon, Y. Sarfati, C. Boni, and B. Hardy Association of 5-HT(2A) receptor gene polymorphism with major affective disorder: the case of a subgroup of bipolar disorder with low suicide risk Biological Psychiatry 51 9 2002 762 765
9. A. Caspi, K. Sugden, T.E. Moffitt, A. Talyor, I.W. Craig, H. Harrington, J. McClay, J. Mill, J. Martin, A. Braithwaite, and R. Poulton Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 5631 2003 386 389
10. D.A. Collier, G. Stober, T. Li, A. Heils, M. Catalano, D. Di Bella, M.J. Arranz, R.M. Murray, H.P. Vallada, D. Bengel, C.R. Müller, G.W. Roberts, E. Smeraldi, G. Kirov, P. Sham, and K.P. Lesch A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders Molecular Psychiatry 1 6 1996 453 460
11. L. Du, D. Bakish, Y.D. Lapierre, A.V. Ravindran, and P.D. Hrdina Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder American Journal of Medical Genetics 96 1 2000 56 60
12. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Archives of General Psychiatry 54 7 1997 597 606
13. M.F. Egan, M. Kojima, J.H. Callicott, T.E. Goldberg, B.S. Kolachana, A. Bertolino, E. Zaitsev, B. Gold, D. Goldman, M. Dean, B. Lu, and D.R. Weinberger The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2 2003 257 269
14. A.J. Eisch, C.A. Bolanos, J. de Wit, R.D. Simonak, C.M. Pudiak, M. Barrot, J. Verhaagen, and E.J. Nestler Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression Biological Psychiatry 54 10 2003 994 1005
15. M.A. Enoch, D. Goldman, R. Barnett, L. Sher, C.M. Mazzanti, and N.E. Rosenthal Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, - 1438G/A Molecular Psychiatry 4 1 1999 89 92
16. M.F. Folstein, S.E. Fostein, and P.R. McHugh "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician Journal of Psychiatric Research 12 3 1975 189 198
17. M.L. Hackett, C. Yapa, V. Parag, and C.S. Anderson Frequency of depression after stroke: a systematic review of observational studies Stroke 36 6 2005 1330 1340
18. A. Heils, A. Teufel, S. Petri, M. Seemann, D. Bengel, U. Balling, P. Riederer, and K.P. Lesch Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene Journal of Neural Transmission. General Section 102 3 1995 247 254
19. I.B. Hickie, S.L. Naismith, P.B. Ward, E.M. Scott, P.B. Mitchell, P.R. Schofield, A. Scimone, K. Wilhelm, and G. Parker Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression Journal of Affective Disorders 98 1-2 2007 137 142
20. M. Jansson, M. Gatz, S. Berg, B. Johansson, B. Malmberg, G.E. McClearn, M. Schalling, and N.L. Pedersen Association between depressed mood in the elderly and a 5-HTR2A gene variant American Journal of Medical Genetics 120B 1 2003 79 84
21. M.E. Jarrett, R. Kohen, K.C. Cain, R.L. Burr, A. Poppe, G.P. Navaja, and M.M. Heitkemper Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome Biological Research for Nursing 9 2 2007 161 169
22. S.E. Kasner, J.A. Chalela, J.M. Luciano, B.L. Cucchiara, E.C. Raps, M.L. McGarvey, M.B. Conroy, and R. Localio Reliability and validity of estimating the NIH stroke scale score from medical records Stroke 30 8 1999 1534 1537
23. M. Kato, Y. Ikenaga, M. Wakeno, G. Okugawa, K. Nobuhara, T. Fukuda, K. Fukuda, J. Azuma, and T. Kinoshita Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism International Clinical Psychopharmacology 20 3 2005 151 156
24. J. Kaufman, B.Z. Yang, H. Douglas-Palumberi, D. Grasso, D. Lipschitz, S. Houshyar, J.H. Krystal, and J. Gelernter Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children Biological Psychiatry 59 8 2006 673 680
25. K.S. Kendler, J.W. Kuhn, J. Vittum, C.A. Prescott, and B. Riley The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression Archives of General Psychiatry 62 5 2005 529 535
26. J.M. Kim, R. Stewart, S.W. Kim, S.J. Yang, I.S. Shin, Y.H. Kim, and J.S. Yoon Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders Biological Psychiatry 62 5 2007 423 428
27. J.M. Kim, R. Stewart, S.W. Kim, S.J. Yang, I.S. Shin, Y.H. Kim, and J.S. Yoon BDNF genotype potentially modifying the association between incident stroke and depression Neurobiology of Aging 29 5 2008 789 792
28. J.M. Kim, R. Stewart, S.W. Kim, S.J. Yang, I.S. Shin, and J.S. Yoon Modification by two genes of associations between general somatic health and incident depressive syndrome in older people Psychosomatic Medicine 71 3 2009 286 291
29. R. Kohen, K.C. Cain, P.H. Mitchell, K. Becker, A. Buzaitis, S.P. Millard, G.P. Navaja, L. Teri, D. Tirschwell, and R. Veith Association of serotonin transporter gene polymorphisms with poststroke depression Archives of General Psychiatry 65 11 2008 1296 1302
30. H. Kunugi, M. Hattori, T. Kato, M. Tatsumi, T. Sakai, T. Sasaki, T. Hirose, and S. Nanko Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder Molecular Psychiatry 2 6 1997 457 462
31. H. Kunugi, Y. Iijima, M. Tatsumi, M. Yoshida, R. Hashimoto, T. Kato, K. Sakamoto, T. Fukunaga, T. Inada, T. Suzuki, N. Iwata, N. Ozaki, K. Yamada, and T. Yoshikawa No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study Biological Psychiatry 56 5 2004 376 378
32. E.J. Lenze, M.C. Munin, R.E. Ferrell, B.G. Pollock, E. Skidmore, F. Lotrich, J.C. Rogers, T. Quear, P. Houck, and C.F. Reynolds III Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture The American Journal of Geriatric Psychiatry 13 5 2005 428 432
33. D.F. Levinson The genetics of depression: a review Biological Psychiatry 60 2 2006 84 92
34. X.Y. Lou, G.B. Chen, L. Yan, J.Z. Ma, J. Zhu, R.C. Elston, and M.D. Li A generalized combinational approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence American Journal of Human Genetics 80 6 2007 1125 1137
35. E.A. Lovejoy, A.C. Scott, C.E. Fiskerstrand, V.J. Bubb, and J.P. Quinn The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit The European Journal of Neuroscience 17 2 2003 417 420
36. H.K. Manji, W.C. Drevets, and D.S. Charney The cellular neurobiology of depression Nature Genetics 7 5 2001 541 547
37. C. Minov, T.C. Baghai, C. Schule, P. Zwanzger, M.J. Schwarz, P. Zill, R. Rupprecht, and B. Bondy Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression Neuroscience Letters 303 2 2001 119 122
38. R. Mossner, A. Henneberg, A. Schmitt, Y.V. Syagailo, M. Grassle, T. Hennig, R. Simantov, M. Gerlach, P. Riederer, and K.P. Lesch Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease Molecular Psychiatry 6 3 2001 350 352
39. K. Ohara, M. Nagai, T. Tsukamoto, K. Tani, Y. Suzuki, and K. Ohara 5-HT2A receptor gene promoter polymorphism - 1438G/A and mood disorders Neuroreport 9 6 1998 1139 1141
40. H. Ono, O. Shirakawa, N. Nishiguchi, A. Nishmura, H. Nushida, Y. Ueno, and K. Maeda Serotonin 2A receptor gene polymorphism is not associated with completed suicide Journal of Psychiatric Research 35 3 2001 173 176
41. C. Otte, J. McCaffery, S. Ali, and M.A. Whooley Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study The American Journal of Psychiatry 164 9 2007 1379 1384
42. R. Ramasubbu, R. Tobias, A.M. Buchan, and N.T. Bech-Hansen Serotonin transporter gene promoter region polymorphism associated with poststroke major depression The Journal of Neuropsychiatry and Clinical Neurosciences 18 1 2006 96 99
43. R. Ramasubbu, R. Tobias, and N.T. Bech-Hansen Extended evaluation of serotonin transporter gene functional polymorphisms in subjects with poststroke depression Canadian Journal of Psychiatry 53 3 2008 197 200
44. R.G. Robinson Poststroke depression: prevalence, diagnosis, treatment, and disease progression Biological Psychiatry 54 3 2003 376 387
45. A. Serretti, C. Lorenzi, R. Lilli, and E. Smeraldi Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders Journal of Psychiatric Research 34 2 2000 89 98
46. D.V. Sheehan, Y. Lecrubier, K.H. Sheehan, P. Amorim, J. Janavs, E. Weiller, T. Hergueta, R. Baker, and G.C. Dunbar The mini-international neuropsychiatric interview (M.I.N.I):the development and validation of a structured diagnostic psychiatric interview for DSM-VI and ICD-10 The Journal of Clinical Psychiatry 59 suppl.20 1988 S22 S33
47. G. Spalletta, P. Bossu, A. Ciaramella, P. Bria, C. Caltagirone, and R.G. Robinson The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines Molecular Psychiatry 11 11 2006 984 991
48. B. Vollmayr, S. Keck, F.A. Henn, and P. Schloss Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat Neuroscience Letters 290 2 2000 109 112
49. J.R. Wendland, B.J. Martin, M.R. Kruse, K.P. Lesch, and D.L. Murphy Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 Molecular Psychiatry 11 3 2006 224 226
50. E.M. Whyte, and B.H. Mulsant Post stroke depression: epidemiology, pathophysiology, and biological treatment Biological Psychiatry 52 3 2002 253 264
51. S.W. Yoo, Y.S. Kim, J.S. Noh, K.S. Oh, C.H. Kim, K. Namkoong, J.H. Chae, G.C. Lee, S.I. Jeon, K.J. Min, D.J. Oh, E.J. Joo, H.J. Park, Y.H. Choi, and S.J. Kim Validity of Korean version of the Mini-International Neuropsychiatric Interview Anxiety Mood 2 1 2006 50 55
52. H.Y. Zhang, T. Ishigaki, K. Tani, K. Chen, J.C. Shih, K. Miyasato, K. Ohara, and K. Ohara Serotonin-2A receptor gene polymorphism in mood disorders Biological Psychiatry 41 7 1997 768 773
53. H. Zhang, F. Ozbay, J. Lappalainen, H.R. Kranzler, C.H. van Dyck, D.S. Charney, L.H. Price, S. Southwick, B.Z. Yang, A. Rasmussen, and J. Gelernter Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 141B 4 2006 387 393
54. J.L. Zhang, J.F. Yang, and P. Chan No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese Neuroscience Letters 455 3 2009 155 158