The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-Analysis of association studies

Statistical Applications in Genetics and Molecular Biology

Volumn 9, Issue 1, 2010, Pages

  Zintzaras, Elias ^a  

^a University of Thessaly School of Medicine   (United States)

Author keywords

Association study; Contrast; Disease; Gene; Generalized odds ratio; Genetic; Genetic association; Meta analysis; Model; Multiallelic; Odds ratio; Polymorphism; Progression

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 2; ALCOHOL DEHYDROGENASE 3; ALDEHYDE DEHYDROGENASE ISOENZYME 2; APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN; UNCLASSIFIED DRUG;

ALCOHOLISM; ALLELE; ARTICLE; BREAST CANCER; CORONARY ARTERY DISEASE; DISEASE COURSE; DISEASE SEVERITY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; NEURAL TUBE DEFECT; PHENOTYPE; SCHIZOPHRENIA; SYSTEMATIC REVIEW; VEIN THROMBOSIS; BIOLOGICAL MODEL; GENETIC PREDISPOSITION; META ANALYSIS; METHODOLOGY; RISK; STATISTICS;

ALLELES; DISEASE PROGRESSION; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; META-ANALYSIS AS TOPIC; MODELS, GENETIC; ODDS RATIO;

EID: 77953101407     PISSN: None     EISSN: 15446115     Source Type: Journal    
DOI: 10.2202/1544-6115.1542     Document Type: Article

References (17)

1. Agresti A (1980) Generalized odds ratios for ordinal data. Biometrics 36:59-67.
2. Agresti A (1984) Analysis of Ordinal Categorical Data. New York: Wiley.
3. Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, Keavney B, Collins R, Wiman B, de Faire U, Danesh J (2007) Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298:1300-1311
4. Clayton DG (1974) Some odds ratio statistics for the analysis of ordered categorical data. Biometrika 61:525-531
5. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-818.
6. Edwardes MD, Baltzan M (2000) The generalization of the odds ratio, risk ratio and risk difference to r x k tables. Stat Med 19:1901-1914
7. Goodman LA, Kruskal WH (1963) Measures of association for cross classifications. Part III. Approximate sampling theory. J Am Stat Assoc 58:310-364
8. Goodman LA, Kruskal WH (1972) Measures of association for cross classifications. Part IV. Simplification of asymptotic variances. J Am Stat Assoc 67:415-421
9. Khoury MJ, Beaty TH, Cohen BH (1993) Fundamentals of Genetic Epidemiology. Oxford USA: University Press.
10. Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J (2005) The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol 34:1319-1328
11. Trikalinos TA, Salanti G, Zintzaras E, Ioannidis JP (2008) Meta-analysis methods. Adv Genet 60:311-334
12. Zintzaras E (2008) Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium. Eur J Epidemiol 23:323-326
13. Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28:123-137
14. Zintzaras E, Lau J (2008) Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol 61:634-645
15. Zintzaras E, Papathanasiou AA, Stefanidis I (2009) Endothelial nitric oxide synthase gene polymorphisms and diabetic nephropathy: A HuGE review and meta-analysis. Genet Med 11:695-706.
16. Zintzaras E, Raman G, Kitsios G, Lau J (2008) Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 168:1077-1089
17. Zintzaras E, Stefanidis I, Santos M, Vidal F (2006) Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology 43:352-361