Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X

Biomarkers

Volumn 18, Issue 1, 2013, Pages 44-50

  Liao, Ying Chieh ^a,b,c   Liang, Kae Woei ^a,b,c,d   Lee, Wen Jane ^a,e   Lee, Wen Lieng ^a,b   Lee, I Te ^a,b,c   Wang, Jun Sing ^a,b,c   Ting, Chih Tai ^a,b   Sheu, Wayne H H ^a,b,c,f  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e TUNGHAI UNIVERSITY   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Adiponectin; Cardiac syndrome X (CSX); Leptin; Leptin adiponectin ratio

Indexed keywords

ADIPONECTIN; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEPTIN;

ADULT; ANTHROPOMETRY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART ARRHYTHMIA; HUMAN; INSULIN RESISTANCE INDEX; MAJOR CLINICAL STUDY; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PREDICTION; PROTEIN BLOOD LEVEL; SYNDROME X; VALVULAR HEART DISEASE;

ADIPONECTIN; AGED; FEMALE; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; MICROVASCULAR ANGINA; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 84872534539     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2012.730550     Document Type: Article

References (46)

1. Ahima RS, Flier JS. (2000). Leptin. Annu Rev Physiol 62:413-437.
2. Al Suwaidi J, Higano ST, Holmes DR Jr, Lerman A. (2001). Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography. Mayo Clin Proc 76:813-822.
3. Beltowski J. (2006). Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 24:789-801.
4. Beltrame JF. (2005). Advances in understanding the mechanisms of angina pectoris in cardiac syndrome X. Eur Heart J 26:946-948.
5. Cannon RO 3rd. (2009). Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms. J Am Coll Cardiol 54:877-885.
6. Cannon RO 3rd, Bonow RO, Bacharach SL, Green MV, Rosing DR, Leon MB, Watson RM, Epstein SE. (1985). Left ventricular dysfunction in patients with angina pectoris, normal epicardial coronary arteries, and abnormal vasodilator reserve. Circulation 71:218-226.
7. Cannon RO 3rd, Watson RM, Rosing DR, Epstein SE. (1983). Angina caused by reduced vasodilator reserve of the small coronary arteries. J Am Coll Cardiol 1:1359-1373.
8. Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. (2003). Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278:45021-45026.
9. Eroglu S, Sade LE, Bozbas H, Haberal A, Ozbicer S, Demir O, Muderrisoglu H. (2009). Association of serum adiponectin levels and coronary flow reserve in women with normal coronary angiography. Eur J Cardiovasc Prev Rehabil 16:290-296.
10. Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ, Savage DB; European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group). (2009). Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 52:2345-2349.
11. Friedewald WT, Levy RI, Fredrickson DS. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502.
12. Friedman JM. (1998). Leptin, leptin receptors, and the control of body weight. Nutr Rev 56:s38-s46; discussion s54.
13. Galluccio E, Piatti P, Citterio L, Lucotti PC, Setola E, Cassina L, Oldani M, Zavaroni I, Bosi E, Colombo A, Alfieri O, Casari G, Reaven GM, Monti LD. (2008). Hyperinsulinemia and impaired leptinadiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. Am J Physiol Endocrinol Metab 294:E978-E986.
14. Gensini GG. (1983). A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 51:606.
15. Gualillo O, González-Juanatey JR, Lago F. (2007). The emerging role of adipokines as mediators of cardiovascular function: Physiologic and clinical perspectives. Trends Cardiovasc Med 17:275-283.
16. Hajer GR, van Haeften TW, Visseren FL. (2008). Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959-2971.
17. Han SH, Quon MJ, Kim JA, Koh KK. (2007). Adiponectin and cardiovascular disease: Response to therapeutic interventions. J Am Coll Cardiol 49:531-538.
18. Hong SJ, Seo HS, Rha SW, Oh DJ, Kwon JA, Lee KN, Jang YS, Ro YM, Park CG. (2006). Decrease in plasma adiponectin concentrations in patients with variant angina pectoris. Circ J 70:414-418.
19. Huang SS, Huang PH, Leu HB, Wu TC, Lin SJ, Chen JW. (2010). Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X. Heart 96:1227-1232.
20. Inoue M, Yano M, Yamakado M, Maehata E, Suzuki S. (2006). Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia. Metab Clin Exp 55:1248-1254.
21. Karakas M, Zierer A, Herder C, Baumert J, Meisinger C, Koenig W, Thorand B. (2010). Leptin, adiponectin, their ratio and risk of coronary heart disease: Results from the MONICA/KORA Augsburg Study 1984-2002. Atherosclerosis 209:220-225.
22. Kaski JC, Russo G. (2000). Cardiac syndrome X: An overview. Hosp Pract (Minneap) 35:75-76, 79.
23. Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. (2010). Narrative review: The role of leptin in human physiology: Emerging clinical applications. Ann Intern Med 152:93-100.
24. Kotani K, Sakane N, Saiga K, Kurozawa Y. (2005). Leptin: Adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes: Relationship of the index to carotid intima-media thickness. Diabetologia 48:2684-2686.
25. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y; Osaka CAD Study Group. Coronary artery disease. (2003). Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85-89.
26. Liang KW, Lee WJ, Lee WL, Chen YT, Ting CT, Sheu WH. (2008a). Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels. Clin Chim Acta 388:41-45.
27. Liang KW, Sheu WH, Lee WL, Liu TJ, Ting CT, Hsieh YC, Wang KY, Chen YT, Lee WJ. (2008b). Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. Int J Cardiol 129:76-80.
28. Liang KW, Lee WJ, Lee WL, Ting CT, Sheu WH. (2009). Decreased ratio of high-molecular-weight to total adiponectin is associated with angiographic coronary atherosclerosis severity but not restenosis. Clin Chim Acta 405:114-118.
29. Liang KW, Lee WJ, Lee IT, Lee WL, Lin SY, Hsu SL, Wan CJ, Yu CY, Tsai IC, Fu CP, Ting CT, Sheu WH. (2011). Persistent elevation of paraoxonase-1 specific enzyme activity after weight reduction in obese non-diabetic men with metabolic syndrome. Clin Chim Acta 412:1835-1841.
30. Nakamura Y, Shimada K, Fukuda D, Shimada Y, Ehara S, Hirose M, Kataoka T, Kamimori K, Shimodozono S, Kobayashi Y, Yoshiyama M, Takeuchi K, Yoshikawa J. (2004). Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 90:528-533.
31. Norata GD, Raselli S, Grigore L, Garlaschelli K, Dozio E, Magni P, Catapano AL. (2007). Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 38:2844-2846.
32. Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M. (2008). The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metab Clin Exp 57:268-273.
33. Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H. (2006). Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. J Am Coll Cardiol 48:1155-1162.
34. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y. (1999). Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation 100:2473-2476.
35. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, Kumada M, Ohashi K, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Nagasawa A, Kobayashi H, Hiraoka H, Komai N, Kaibe M, Rakugi H, Ogihara T, Matsuzawa Y. (2003). Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42:231-234.
36. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. (2004). Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291:1730-1737.
37. Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y. (2004). Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27:2488-2490.
38. Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, Ståhle E, Feldman TE, van den Brand M, Bass EJ, Van Dyck N, Leadley K, Dawkins KD, Mohr FW; SYNTAX Investigators. (2009). Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 360:961-972.
39. Shimano M, Shibata R, Tsuji Y, Kamiya H, Uchikawa T, Harata S, Muto M, Ouchi N, Inden Y, Murohara T. (2008). Circulating adiponectin levels in patients with atrial fibrillation. Circ J 72:1120-1124.
40. Singh M, Singh S, Arora R, Khosla S. (2010). Cardiac syndrome X: Current concepts. Int J Cardiol 142:113-119.
41. Singhal A, Farooqi IS, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J. (2002). Influence of leptin on arterial distensibility: A novel link between obesity and cardiovascular disease? Circulation 106:1919-1924.
42. Susam I, Yaylali YT, Dursunoglu D, Göksoy H, Oztürk M, Yaylali O, Semiz E. (2010). Decreased plasma adiponectin concentrations in patients with syndrome X. Acta Cardiol 65:217-220.
43. van den Heuvel M, Sorop O, Koopmans SJ, Dekker R, de Vries R, van Beusekom HM, Eringa EC, Duncker DJ, Danser AH, van der Giessen WJ. (2012). Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes. Am J Physiol Heart Circ Physiol 302:H85-H94.
44. Vermeltfoort IA, Raijmakers PG, Riphagen II, Odekerken DA, Kuijper AF, Zwijnenburg A, Teule GJ. (2010). Definitions and incidence of cardiac syndrome X: Review and analysis of clinical data. Clin Res Cardiol 99:475-481.
45. Yoon JH, Park JK, Oh SS, Lee KH, Kim SK, Cho IJ, Kim JK, Kang HT, Ahn SG, Lee JW, Lee SH, Eom A, Kim JY, Ahn SV, Koh SB. (2011). The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study. Clin Chim Acta 412:2199-2205.
46. Zaletel J, Barlovic DP, Prezelj J. (2010). Adiponectin-leptin ratio: A useful estimate of insulin resistance in patients with Type 2 diabetes. J Endocrinol Invest 33:514-518.