Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 5, 2008, Pages

  Galluccio, Elena ^a   Piatti, PierMarco ^a,b   Citterio, Lorena ^a   Lucotti, Pietro C G ^a   Setola, Emanuela ^a   Cassina, Laura ^a   Oldani, Matteo ^a   Zavaroni, Ivana ^c   Bosi, Emanuele ^a,b   Colombo, Antonio ^a   Alfieri, Ottavio ^a,b   Casari, Giorgio ^a,b   Reaven, Gerald M ^d   Monti, Lucilla D ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Coronary artery disease; NOS3 gene variants; Type 2 diabetes

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ASPARTIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMIC ACID; LEPTIN; DNA; GLYCOSYLATED HEMOGLOBIN; LIPID;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE TOLERANCE; HUMAN; HYPEREMIA; HYPERINSULINEMIA; IN-STENT RESTENOSIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRON; ITALY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NOS3 GENE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNSTABLE ANGINA PECTORIS; VASODILATATION; ANGIOCARDIOGRAPHY; BIOSYNTHESIS; BLOOD; BLOOD FLOW; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FOREARM; GENE FREQUENCY; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GRAFT OCCLUSION; HAPLOTYPE; HYPERINSULINISM; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; VASCULARIZATION;

ADIPONECTIN; AGED; ATHEROSCLEROSIS; BLOOD GLUCOSE; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; DIABETES COMPLICATIONS; DNA; FEMALE; FOREARM; GENE FREQUENCY; GENOTYPE; GLUCOSE TOLERANCE TEST; GRAFT OCCLUSION, VASCULAR; HAPLOTYPES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERINSULINISM; LEPTIN; LIPIDS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; REGIONAL BLOOD FLOW;

EID: 45549102003     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00003.2008     Document Type: Article

References (47)

1. Al Suwaidi J, Hamasaki S, Higano ST, Nishimura RA, Holmes DRJ, Lerman A. Long-term follow-up of subjects with mild coronary artery disease and endothelial dysfunction. Circulation 101: 948-954, 2000.
2. Antoniades C, Tousoulis D, Vasiliadou C, Pitsavos C, Chrysochoou C, Panagiotakos D, Tentolouris C, Marinou K, Koumallos N, Stefanadis C. Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction. J Am Coll Cardiol 46: 1101-1109, 2005.
3. Beckamn JA, Creager MA, Libby P. Diabetes and atherosclerosis. Epidemiology, pathophysiology, and management. JAMA 287: 2570-2581, 2002.
4. Beltowski J. Leptin and atherosclerosis. Atherosclerosis 189: 47-60, 2006.
5. Cam SF, Sekuri C, Tengiz I, Ercan E, Sagcan A, Akin M, Berdeli A. The GLU298ASP polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population. Thromb Res 116: 287-292, 2005.
6. Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: metanalysis of 26 studies involving 23028 subjects. Circulation 109: 1359-1365, 2004.
7. Casas JP, Cavalleri GL, Bautista LE, Smeeeth L, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol 164: 921-935, 2006.
8. 298→Asp polymorphism) to the presence, extent, and severity of coronary disease. Heart 87: 525-528, 2002.
9. Cooke JP, Oka RK. Does leptin cause vascular disease? Circulation 106: 1904-1905, 2002.
10. Correia ML, Haynes WG. Leptin, obesity and cardiovascular disease. Curr Opin Nephrol Hypertens 13: 215-223, 2004.
11. Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 284: R1-R12, 2003.
12. Gomma AH, Elrayess MA, Knight CJ, Hawe E, Fox KM, Humphries SE. The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis. Eur Heart J 23: 1955-1962, 2002.
13. Gorchakova O, Koch W, Von Beckerath N, Mehilli J, Shomig A, Kastrati A. Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement. Eur Heart J 24: 820-827, 2003.
14. Hsueh W, Quinones M. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 92: 10J-17J, 2003.
15. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377: 239-242, 1995.
16. Ishizuka T, Takamizawa-Matsumoto M, Suzuki K, Kurita A. Endothelin-1 enhances vascular cell adhesion molecule-1 expression in tumor necrosis factor alpha-stimulated vascular endothelial cells. Eur J Pharmacol 369: 237-245, 1999.
17. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784-1792, 2006.
18. Kotani K, Sakane N, Saiga K, Kurozawa Y. Leptin:adiponectin ratio as an atherosclerotic index in subjects with type 2 diabetes: relationship of the index to carotid intima-media thickness. Diabetologia 48: 2684-2686, 2005.
19. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863-25866, 2002.
20. Lorenz M, Hewing B, Hui J, Zepp A, Baumann G, Bindereif A, Stangl V, Stangl K. Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity. FASEB J 21: 1556-1564, 2007.
21. Luscher TF, Tanner FC, Tschudi MR, Noll G. Endothelial dysfunction in coronary artery disease. Annu Rev Med 44: 395-418, 1993.
22. Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N, Kumada M, Okamoto Y, Nagaretani H, Nishizawa H, Kishida K, Komuro R, Ouchi N, Kihara S, Nagai R, Funahashi T, Matsuzawa Y. Role of adiponectin in preventing vascular stenosis. The missing link of adipovascular axis. J Biol Chem 277: 37487-37491, 2002.
23. Monti LD, Barlassina C, Citterio L, Galluccio E, Berzuini C, Setola E, Valsecchi G, Lucotti P, Pozza G, Bernardinelli L, Casari G, Piatti PM. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes 52: 1270-1275, 2003.
24. Mozaffarian D, Marfi RM, Levantesi G, Silletta MG, Tavazzi L, Tognoni G, Valagussa F, Marchioli R. Incidence of new-onset diabetes and impaired fasting glucose in subjects with recent myocardial infarction and the effect of clinical and lifestyle risk factors. Lancet 370: 667-675, 2007.
25. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, Motoyama T, Saito Y, Ogawa Y, Miyamoto Y, Nakao K. T786>C mutation in the 5-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99: 2864-2870, 1999.
26. Norata GD, Raselli S, Grigore L, Garlaschelli K, Dozio E, Magni P, Catapano AL. Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 38: 2844-2846, 2007.
27. Numaguchi K, Egashira K, Takemoto M, Kadokami T, Shimokawa H, Sueishi K, Takeshita A. Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension 26: 957-962, 1995.
28. Ohashi Y, Kawashima S, Hirata K, Yamashita T, Ishida T, Inoue N, Sakoda T, Kurihara H, Yazaki Y, Yokoyama M. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest 102: 2061-2071, 1998.
29. Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y, Yamashita S, Funahashi T, Matsuzawa Y. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103: 1057-1063, 2001.
30. Patti G, Pasceri V, Melfi R, Goffredo C, Chello M, D'Ambrosio A, Montesanti R, Di Sciascio G. Impaired flow-mediated dilation and risk of restenosis in subjects undergoing coronary stent implantation. Circulation 111: 70-75, 2005.
31. Piatti PM, Monti LD. Insulin resistance, hyperleptinemia and endothelial dysfunction in coronary restenosis. Curr Opin Pharmacol 5: 160-164, 2005.
32. Piatti PM, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A, Setola E, Lucotti P, Galluccio E, Ronchi C, Origgi A, Zavaroni I, Marginato A, Colombo A. Association of insulin resistance, hyperinsulinemia, and impaired nitric oxide release with in-stent restenosis in subjects undergoing coronary stenting. Circulation 108: 2074-2081, 2003.
33. Radke PW, Voswinkel M, Reith M, Kaiser A, Haager PH K, Hanrath P, Hoffmann R. Relation of fasting insulin plasma levels to restenosis after elective coronary stent implantation in subjects without diabetes mellitus. Am J Cardiol 93: 639-641, 2004.
34. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, Rader DJ, Stephen SE. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 89: 3872-3878, 2004.
35. Ross R. Atherosclerosis-an inflammatory disease. Nature 340: 115-126, 1999.
36. Rossi GP, Seccia TM, Nussdorfer GG. Reciprocal regulation of endothelin-1 and nitric oxide: relevance in the physiology and pathology of the cardiovascular system. Int Rev Cytol 209: 241-272, 2001.
37. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning, A Laboratory Manual. Cold Spring Harbor, NY: CSH, 1989.
38. Rutter MK, Meigs JB, Sullivan LM, D'Agostino RB Sr, Wilson PW. Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study. Diabetes 54: 3252-3257, 2005.
39. Stangl K, Cascorbi I, Laule M, Klein T, Stangl V, Rost S, Wernecke KD, Felix S, Bindereif A, Baumann G, Roots I. High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease. Pharmacogenetics 10: 133-140, 2000.
40. Suzuki T, Okumura K, Sone T, Kosokabe T, Tsuboi H, Kondo J, Mukawa H, Kamiya H, Tomida T, Imai H, Matsui H, Hayakawa T. The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis. Int J Cardiol 86: 71-76, 2002.
41. Takagi T, Akasaka T, Yamamuro A, Honda Y, Hozumi T, Morioka S, Yoshida K. Impact of insulin resistance on neointimal tissue proliferation after coronary stent implantation: intravascular ultrasound studies. J Diabetes Complications 16: 50-55, 2002.
42. Takagi T, Yoshida K, Akasaka T, Kaji S, Kawamoto T, Honda Y, Yamamuro A, Hozumi T, Morioka S. Hyperinsulinemia during oral glucose tolerance test is associated with increased neointimal tissue proliferation after coronary stent implantation in nondiabetic subjects: a serial intravascular ultrasound study. J Am Coll Cardiol 36: 731-738, 2000.
43. The Expert Committee on the Diagnosis, and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183-1197, 1997.
44. Verdon CP, Burto BA, Prior RL. Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP when the Griess reaction is used to assay for nitrite. Anal Biochem 224: 502-508, 1995.
45. Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in subjects with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 27: 567-574, 1996.
46. Wu TC, Chen YH, Chen JW, Chen LC, Lin SJ, Ding PYA, Wang SP, Chang MS. Impaired forearm reactive hyperemia is related to late restenosis after coronary stenting. Am J Cardiol 85: 1071-1076, 2000.
47. Zhang C, Lopez-Ridaura R, Hunter DJ, Rifai N, Hu FB. Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among US diabetic men. Diabetes 55: 2140-2147, 2006.