The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study

Clinica Chimica Acta

Volumn 412, Issue 23-24, 2011, Pages 2199-2205

  Yoon, Jin Ha ^a   Park, Jong Ku ^a   Oh, Sung Soo ^a   Lee, Ki Hyun ^a   Kim, Sung Kyung ^a   Cho, In Jung ^a   Kim, Jong Koo ^a   Kang, Hee Taik ^a   Ahn, Sung Gyun ^a   Lee, Jun Won ^a   Lee, Seung Hwan ^a   Eom, Aeyong ^b   Kim, Jang Young ^a   Ahn, Song Vogue ^a   Koh, Sang Baek ^a  

^a Yonsei University Wonju College of Medicine   (South Korea)

^b Mokpo National University   (South Korea)

Author keywords

Adiponectin; Insulin resistance; Leptin; Leptin adiponectin ratio; Metabolic syndrome

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPONECTIN; ADULT; AGED; FEMALE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; REPUBLIC OF KOREA;

EID: 80053645518     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2011.08.003     Document Type: Article

References (36)

1. Ahima R.S. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006, 14(Suppl. 5):242S-249S.
2. Fortuno A., Rodriguez A., Gomez-Ambrosi J., Fruhbeck G., Diez J. Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases. J Physiol Biochem 2003, 59:51-60.
3. Yang W., Chuang L. Human genetics of adiponectin in the metabolic syndrome. J Mol Med 2006, 84:112-121.
4. Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000, 102:1296-1301.
5. Shibata R., Sato K., Pimentel D.R., Takemura Y., Kihara S., Ohashi K., et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 2005, 11:1096-1103.
6. Koh S.B., Park J.K., Yoon J.H., Chang S.J., Oh S.S., Kim J.Y., et al. Preliminary report: a serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population. Metabolism 2010, 59:333-337.
7. Nakashima R., Yamane K., Kamei N., Nakanishi S., Kohno N. Low serum levels of total and high molecular weight adiponectin predict the development of metabolic syndrome in Japanese-Americans. J Endocrinol Invest 2010, doi:10.3275/7409.
8. Kajikawa Y., Ikeda M., Takemoto S., Tomoda J., Ohmaru N., Kusachi S. Association of circulating levels of leptin and adiponectin with metabolic syndrome and coronary heart disease in patients with various coronary risk factors. Int Heart J 2011, 52:17-22.
9. Yamagishi S.I., Edelstein D., Du X.L., Kaneda Y., Guzmn M., Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001, 276:25096-25100.
10. Konstantinides S., Schfer K., Koschnick S., Loskutoff D.J. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001, 108:1533-1540.
11. O'Rourke L., Gronning L.M., Yeaman S.J., Shepherd P.R. Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin. J Biol Chem 2002, 277:42557-42562.
12. Yun J.E., Kimm H., Jo J., Jee S.H. Serum leptin is associated with metabolic syndrome in obese and nonobese Korean populations. Metabolism 2010, 59:424-429.
13. Oda N., Imamura S., Fujita T., Uchida Y., Inagaki K., Kakizawa H., et al. The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism 2008, 57:268-273.
14. Samara A., Herbeth B., Aubert R., Berrahmoune H., Fumeron F., Siest G., et al. Sex-dependent associations of leptin with metabolic syndrome-related variables: the Stanislas study. Obesity (Silver Spring) 2010, 18:196-201.
15. Zhuo Q., Wang Z., Fu P., Piao J., Tian Y., Xu J., et al. Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities. Diabetes Res Clin Pract 2009, 84:27-33.
16. Singh B., Saxena A. Surrogate markers of insulin resistance: A review. World J Diabetes 2010, 1:36-47.
17. Inoue M., Yano M., Yamakado M., Maehata E., Suzuki S. Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia. Metabolism 2006, 55:1248-1254.
18. Jin L.H., Chang S.J., Koh S.B., Kim K.S., Lee T.Y., Ryu S.Y., et al. Association between alcohol consumption and bone strength in Korean adults: the Korean Genomic Rural Cohort Study. Metab Clin Exp 2011, 60:351-358.
19. Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
20. Robin X., Turck N., Hainard A., Tiberti N., Lisacek F., Sanchez J.C., et al. pROC: an open-source package for R and S+to analyze and compare ROC curves. BMC Bioinformatics 2011, 12:77.
21. DeLong E.R., DeLong D.M., Clarke-Pearson D.L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988, 44:837-845.
22. Hall J.I., Vora N., Langworthy R., Stock S., Momin A., Sherwood R.A., et al. Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. Ann Clin Biochem 2011, 48:327-331.
23. Inoue M., Maehata E., Yano M., Taniyama M., Suzuki S. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism 2005, 54:281-286.
24. Anderson P.J., Critchley J.A., Chan J.C., Cockram C.S., Lee Z.S., Thomas G.N., et al. Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality. Int J Obes Relat Metab Disord 2001, 25:1782-1788.
25. Hanley A.J., Festa A., D'Agostino R.B., Wagenknecht L.E., Savage P.J., Tracy R.P., et al. Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity. Diabetes 2004, 53:1773-1781.
26. Wang J.J., Qiao Q., Miettinen M.E., Lappalainen J., Hu G., Tuomilehto J. The metabolic syndrome defined by factor analysis and incident type 2 diabetes in a Chinese population with high postprandial glucose. Diabetes Care 2004, 27:2429-2437.
27. Woods S.C., Gotoh K., Clegg D.J. Gender differences in the control of energy homeostasis. Exp Biol Med (Maywood) 2003, 228:1175-1180.
28. Gannage-Yared M.H., Khalife S., Semaan M., Fares F., Jambart S., Halaby G. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. Eur J Endocrinol 2006, 155:167-176.
29. de Aloysio D., Gambacciani M., Meschia M., Pansini F., Bacchi Modena A., Bolis P.F., et al. The effect of menopause on blood lipid and lipoprotein levels. The Icarus Study Group. Atherosclerosis 1999, 147:147-153.
30. Jensen J., Nilas L., Christiansen C. Influence of menopause on serum lipids and lipoproteins. Maturitas 1990, 12:321-331.
31. Akahoshi M., Soda M., Nakashima E., Shimaoka K., Seto S., Yano K. Effects of menopause on trends of serum cholesterol, blood pressure, and body mass index. Circulation 1996, 94:61-66.
32. Torng P.L., Su T.C., Sung F.C., Chien K.L., Huang S.C., Show S.N., et al. Effects of menopause and obesity on lipid profiles in middle-aged Taiwanese women: the Chin-Shan Community Cardiovascular Cohort Study. Atherosclerosis 2000, 153:413-421.
33. Kolovou G.D., Bilianou H.G. Influence of aging and menopause on lipids and lipoproteins in women. Angiology 2008, 59:54S-57S.
34. Matsuda Y., Tanioka T., Yoshioka T., Nagano T., Hiroi T., Yoshikawa K., et al. Gender differences in association of plasma adiponectin with obesity reflect resultant insulin resistance in non-diabetic Japanese patients with schizophrenia. Psychiatry Clin Neurosci 2005, 59:266-273.
35. Janssen I., Powell L.H., Crawford S., Lasley B., Sutton-Tyrrell K. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med 2008, 168:1568-1575.
36. Lobo R.A. Metabolic syndrome after menopause and the role of hormones. Maturitas 2008, 60:10-18.