메뉴 건너뛰기




Volumn 273, Issue 2, 2013, Pages 128-137

Anti-angiogenesis and metastasis: A tumour and stromal cell alliance

Author keywords

Anti angiogenic therapy; Hypoxia; Tumour invasion; Tumour metastasis; Tumour stroma; VEGF

Indexed keywords

BEVACIZUMAB; CABOZANTINIB; CRIZOTINIB; PF 04217903; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

EID: 84872517083     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12018     Document Type: Review
Times cited : (56)

References (67)
  • 1
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 2005; 69(Suppl 3): 4-10.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 4-10
    • Carmeliet, P.1
  • 2
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: impact on invasion, disease progression, and metastasis
    • Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Onco 2011; 8: 210-21.
    • (2011) Nat Rev Clin Onco , vol.8 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 3
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 5
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15: 220-31.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 6
    • 84863704553 scopus 로고    scopus 로고
    • Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    • Sennino B, Ishiguro-Oonuma T, Wei Y et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov 2012; 2: 270-87.
    • (2012) Cancer Discov , vol.2 , pp. 270-287
    • Sennino, B.1    Ishiguro-Oonuma, T.2    Wei, Y.3
  • 7
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 38649107709 scopus 로고    scopus 로고
    • Pericytes: gatekeepers in tumour cell metastasis?
    • Gerhardt H, Semb H. Pericytes: gatekeepers in tumour cell metastasis? J Mol Med (Berl) 2008; 86: 135-44.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 135-144
    • Gerhardt, H.1    Semb, H.2
  • 10
    • 33644643376 scopus 로고    scopus 로고
    • Pericytes limit tumor cell metastasis
    • Xian X, Hakansson J, Stahlberg A et al. Pericytes limit tumor cell metastasis. J Clin Invest 2006; 116: 642-51.
    • (2006) J Clin Invest , vol.116 , pp. 642-651
    • Xian, X.1    Hakansson, J.2    Stahlberg, A.3
  • 11
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 12
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820-7.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 13
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008; 8: 579-91.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 14
    • 77951667987 scopus 로고    scopus 로고
    • Mechanisms of resistance to antiangiogenesis therapy
    • Azam F, Mehta S, Harris AL. Mechanisms of resistance to antiangiogenesis therapy. Eur J Cancer 2010; 46: 1323-32.
    • (2010) Eur J Cancer , vol.46 , pp. 1323-1332
    • Azam, F.1    Mehta, S.2    Harris, A.L.3
  • 15
    • 70350244837 scopus 로고    scopus 로고
    • Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe?
    • Michieli P. Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe? Cell Cycle 2009; 8: 3291-6.
    • (2009) Cell Cycle , vol.8 , pp. 3291-3296
    • Michieli, P.1
  • 16
    • 67349129399 scopus 로고    scopus 로고
    • Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
    • Rapisarda A, Melillo G. Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist Updat 2009; 12: 74-80.
    • (2009) Drug Resist Updat , vol.12 , pp. 74-80
    • Rapisarda, A.1    Melillo, G.2
  • 17
    • 41849092178 scopus 로고    scopus 로고
    • Angiogenesis as a strategic target for ovarian cancer therapy
    • Spannuth WA, Sood AK, Coleman RL. Angiogenesis as a strategic target for ovarian cancer therapy. Nat Clin Pract Oncol 2008; 5: 194-204.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 194-204
    • Spannuth, W.A.1    Sood, A.K.2    Coleman, R.L.3
  • 18
    • 69349095364 scopus 로고    scopus 로고
    • Anticancer strategies involving the vasculature
    • Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009; 6: 395-404.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 395-404
    • Heath, V.L.1    Bicknell, R.2
  • 20
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: master regulators of metastasis
    • Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010; 16: 5928-35.
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 21
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
    • De Bock K, Mazzone M, Carmeliet P. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat Rev Clin Oncol 2011; 8: 393-404.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 22
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8: 299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 23
    • 73449132242 scopus 로고    scopus 로고
    • Hypoxia generates a more invasive phenotype of tumour cells: an in vivo experimental setup based on the chorioallantoic membrane
    • Demir R, Naschberger L, Demir I et al. Hypoxia generates a more invasive phenotype of tumour cells: an in vivo experimental setup based on the chorioallantoic membrane. Pathol Oncol Res 2009; 15: 417-22.
    • (2009) Pathol Oncol Res , vol.15 , pp. 417-422
    • Demir, R.1    Naschberger, L.2    Demir, I.3
  • 25
    • 67349189814 scopus 로고    scopus 로고
    • MET receptor tyrosine kinase as a therapeutic anticancer target
    • Stellrecht CM, Gandhi V. MET receptor tyrosine kinase as a therapeutic anticancer target. Cancer Lett 2009; 280: 1-14.
    • (2009) Cancer Lett , vol.280 , pp. 1-14
    • Stellrecht, C.M.1    Gandhi, V.2
  • 26
    • 84863754907 scopus 로고    scopus 로고
    • VEGF inhibits tumor cell invasion and Mesenchymal transition through a MET/VEGFR2 Complex
    • Lu KV, Chang JP, Parachoniak CA et al. VEGF inhibits tumor cell invasion and Mesenchymal transition through a MET/VEGFR2 Complex. Cancer Cell 2012; 22: 21-35.
    • (2012) Cancer Cell , vol.22 , pp. 21-35
    • Lu, K.V.1    Chang, J.P.2    Parachoniak, C.A.3
  • 27
    • 84862776792 scopus 로고    scopus 로고
    • HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis
    • Shojaei F, Simmons BH, Lee JH, Lappin PB, Christensen JG. HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis. Cancer Lett 2012; 320: 48-55.
    • (2012) Cancer Lett , vol.320 , pp. 48-55
    • Shojaei, F.1    Simmons, B.H.2    Lee, J.H.3    Lappin, P.B.4    Christensen, J.G.5
  • 28
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • Ide T, Kitajima Y, Miyoshi A et al. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J Cancer 2006; 119: 2750-9.
    • (2006) Int J Cancer , vol.119 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3
  • 29
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: diversity and escape mechanisms
    • Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 362-74.
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 30
    • 0035152391 scopus 로고    scopus 로고
    • Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
    • Cox EA, Sastry SK, Huttenlocher A. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases. Mol Biol Cell 2001; 12: 265-77.
    • (2001) Mol Biol Cell , vol.12 , pp. 265-277
    • Cox, E.A.1    Sastry, S.K.2    Huttenlocher, A.3
  • 31
    • 70350400725 scopus 로고    scopus 로고
    • Mechanisms of collective cell migration at a glance
    • Ilina O, Friedl P. Mechanisms of collective cell migration at a glance. J Cell Sci 2009; 122: 3203-8.
    • (2009) J Cell Sci , vol.122 , pp. 3203-3208
    • Ilina, O.1    Friedl, P.2
  • 32
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: plasticity and reciprocity
    • Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 2011; 147: 992-1009.
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 33
    • 77954897360 scopus 로고    scopus 로고
    • Cancer dissemination-lessons from leukocytes
    • Madsen CD, Sahai E. Cancer dissemination-lessons from leukocytes. Dev Cell 2010; 19: 13-26.
    • (2010) Dev Cell , vol.19 , pp. 13-26
    • Madsen, C.D.1    Sahai, E.2
  • 34
    • 84857640591 scopus 로고    scopus 로고
    • Cancer associated fibroblasts: the dark side of the coin
    • Cirri P, Chiarugi P. Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res 2011; 1: 482-97.
    • (2011) Am J Cancer Res , vol.1 , pp. 482-497
    • Cirri, P.1    Chiarugi, P.2
  • 35
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009; 9: 239-52.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 37
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11: 83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 38
    • 61349187645 scopus 로고    scopus 로고
    • Endothelial cells form a phalanx to block tumor metastasis
    • Bautch VL. Endothelial cells form a phalanx to block tumor metastasis. Cell 2009; 136: 810-2.
    • (2009) Cell , vol.136 , pp. 810-812
    • Bautch, V.L.1
  • 39
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira R et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136: 839-51.
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    Leite de Oliveira, R.3
  • 40
    • 84860591982 scopus 로고    scopus 로고
    • Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
    • Maione F, Capano S, Regano D et al. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest 2012; 122: 1832-48.
    • (2012) J Clin Invest , vol.122 , pp. 1832-1848
    • Maione, F.1    Capano, S.2    Regano, D.3
  • 41
    • 70449428715 scopus 로고    scopus 로고
    • Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
    • Maione F, Molla F, Meda C et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest 2009; 119: 3356-72.
    • (2009) J Clin Invest , vol.119 , pp. 3356-3372
    • Maione, F.1    Molla, F.2    Meda, C.3
  • 42
    • 42449120630 scopus 로고    scopus 로고
    • Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells
    • Subarsky P, Hill RP. Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells. Clin Exp Metastasis 2008; 25: 253-64.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 253-264
    • Subarsky, P.1    Hill, R.P.2
  • 43
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw B, Song H, Tihan T et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003; 4: 133-46.
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3
  • 44
    • 84858114637 scopus 로고    scopus 로고
    • Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform
    • Casazza A, Kigel B, Maione F et al. Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. EMBO Mol Med 2012; 4: 234-50.
    • (2012) EMBO Mol Med , vol.4 , pp. 234-250
    • Casazza, A.1    Kigel, B.2    Maione, F.3
  • 45
    • 84858140242 scopus 로고    scopus 로고
    • Exploiting pleiotropic activities of semaphorins as multi-target therapies for cancer
    • Moserle L, Casanovas O. Exploiting pleiotropic activities of semaphorins as multi-target therapies for cancer. EMBO Mol Med 2012; 4: 168-70.
    • (2012) EMBO Mol Med , vol.4 , pp. 168-170
    • Moserle, L.1    Casanovas, O.2
  • 46
    • 84863718886 scopus 로고    scopus 로고
    • Differential drug-class specific metastatic effects following treatment with a panel of angiogenesis inhibitors
    • Chung AS, Kowanetz M, Wu X et al. Differential drug-class specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J Pathol 2012; 227: 404-16.
    • (2012) J Pathol , vol.227 , pp. 404-416
    • Chung, A.S.1    Kowanetz, M.2    Wu, X.3
  • 47
    • 84863715967 scopus 로고    scopus 로고
    • Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models
    • Singh M, Couto SS, Forrest WF et al. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models. J Pathol 2012; 227: 417-30.
    • (2012) J Pathol , vol.227 , pp. 417-430
    • Singh, M.1    Couto, S.S.2    Forrest, W.F.3
  • 48
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111: 1287-95.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 49
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005; 23: 939-52.
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 50
    • 0038665460 scopus 로고    scopus 로고
    • Double target for tumor mass destruction
    • Saharinen P, Alitalo K. Double target for tumor mass destruction. J Clin Invest 2003; 111: 1277-80.
    • (2003) J Clin Invest , vol.111 , pp. 1277-1280
    • Saharinen, P.1    Alitalo, K.2
  • 51
    • 76849102403 scopus 로고    scopus 로고
    • Targeted therapies: Sunitinib versus interferon-alpha in metastatic RCC
    • Faris JE, Michaelson MD. Targeted therapies: Sunitinib versus interferon-alpha in metastatic RCC. Nat Rev Clin Oncol 2009; 7: 7-8.
    • (2009) Nat Rev Clin Oncol , vol.7 , pp. 7-8
    • Faris, J.E.1    Michaelson, M.D.2
  • 52
    • 80053523278 scopus 로고    scopus 로고
    • Progression-free survival as a clinical trial endpoint in advanced renal cell carcinoma
    • Hotte SJ, Bjarnason GA, Heng DY et al. Progression-free survival as a clinical trial endpoint in advanced renal cell carcinoma. Curr Oncol 2011; 18(Suppl 2): S11-9.
    • (2011) Curr Oncol , vol.18 , Issue.SUPPL. 2
    • Hotte, S.J.1    Bjarnason, G.A.2    Heng, D.Y.3
  • 53
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6: 734-45.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 54
    • 61649115441 scopus 로고    scopus 로고
    • The clinical implications of the genetics of renal cell carcinoma
    • Rosner I, Bratslavsky G, Pinto PA, Linehan WM. The clinical implications of the genetics of renal cell carcinoma. Urol Oncol 2009; 27: 131-6.
    • (2009) Urol Oncol , vol.27 , pp. 131-136
    • Rosner, I.1    Bratslavsky, G.2    Pinto, P.A.3    Linehan, W.M.4
  • 55
    • 0033035154 scopus 로고    scopus 로고
    • Fas/Fas ligand interaction in human colorectal hepatic metastases: A mechanism of hepatocyte destruction to facilitate local tumor invasion
    • Yoong KF, Afford SC, Randhawa S, Hubscher SG, Adams DH. Fas/Fas ligand interaction in human colorectal hepatic metastases: A mechanism of hepatocyte destruction to facilitate local tumor invasion. Am J Pathol 1999; 154: 693-703.
    • (1999) Am J Pathol , vol.154 , pp. 693-703
    • Yoong, K.F.1    Afford, S.C.2    Randhawa, S.3    Hubscher, S.G.4    Adams, D.H.5
  • 56
    • 0041870830 scopus 로고    scopus 로고
    • Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors
    • Brat DJ, Kaur B, Van Meir EG. Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors. Front Biosci 2003; 8: d100-16.
    • (2003) Front Biosci , vol.8
    • Brat, D.J.1    Kaur, B.2    Van Meir, E.G.3
  • 57
    • 70449517400 scopus 로고    scopus 로고
    • Antiangiogenic therapies for high-grade glioma
    • Norden AD, Drappatz J, Wen PY. Antiangiogenic therapies for high-grade glioma. Nat Rev Neurol 2009; 5: 610-20.
    • (2009) Nat Rev Neurol , vol.5 , pp. 610-620
    • Norden, A.D.1    Drappatz, J.2    Wen, P.Y.3
  • 58
    • 58149456505 scopus 로고    scopus 로고
    • Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan
    • Zuniga RM, Torcuator R, Jain R et al. Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan. J Neurooncol 2009; 91: 329-36.
    • (2009) J Neurooncol , vol.91 , pp. 329-336
    • Zuniga, R.M.1    Torcuator, R.2    Jain, R.3
  • 59
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 60
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 61
    • 33846917709 scopus 로고    scopus 로고
    • Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors
    • Motzer RJ, Nichols CJ, Margolin KA et al. Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors. J Clin Oncol 2007; 25: 247-56.
    • (2007) J Clin Oncol , vol.25 , pp. 247-256
    • Motzer, R.J.1    Nichols, C.J.2    Margolin, K.A.3
  • 62
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008; 26: 5422-8.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 63
    • 65649108112 scopus 로고    scopus 로고
    • Patterns of disease progression in metastatic renal cell carcinoma patients treated with antivascular agents and interferon: impact of therapy on recurrence patterns and outcome measures
    • Plimack ER, Tannir N, Lin E, Bekele BN, Jonasch E. Patterns of disease progression in metastatic renal cell carcinoma patients treated with antivascular agents and interferon: impact of therapy on recurrence patterns and outcome measures. Cancer 2009; 115: 1859-66.
    • (2009) Cancer , vol.115 , pp. 1859-1866
    • Plimack, E.R.1    Tannir, N.2    Lin, E.3    Bekele, B.N.4    Jonasch, E.5
  • 64
    • 79951983770 scopus 로고    scopus 로고
    • Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials
    • Miles D, Harbeck N, Escudier B et al. Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials. J Clin Oncol 2011; 29: 83-8.
    • (2011) J Clin Oncol , vol.29 , pp. 83-88
    • Miles, D.1    Harbeck, N.2    Escudier, B.3
  • 65
    • 79955581584 scopus 로고    scopus 로고
    • Is the postprogression survival time really not shortened in the bevacizumab-containing arms of phase III clinical trials
    • author reply e6.
    • Potemski P. Is the postprogression survival time really not shortened in the bevacizumab-containing arms of phase III clinical trials? J Clin Oncol 2011; 29: e384-5; author reply e6.
    • (2011) J Clin Oncol , vol.29
    • Potemski, P.1
  • 66
    • 77957138161 scopus 로고    scopus 로고
    • Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment
    • Lisanti MP, Martinez-Outschoorn UE, Chiavarina B et al. Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther 2010; 10: 537-42.
    • (2010) Cancer Biol Ther , vol.10 , pp. 537-542
    • Lisanti, M.P.1    Martinez-Outschoorn, U.E.2    Chiavarina, B.3
  • 67
    • 79961101955 scopus 로고    scopus 로고
    • Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors
    • Martinez-Outschoorn UE, Lin Z, Trimmer C et al. Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors. Cell Cycle 2011; 10: 2504-20.
    • (2011) Cell Cycle , vol.10 , pp. 2504-2520
    • Martinez-Outschoorn, U.E.1    Lin, Z.2    Trimmer, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.