Hypoxia generates a more invasive phenotype of tumour cells: An in vivo experimental setup based on the chorioallantoic membrane

Pathology and Oncology Research

Volumn 15, Issue 3, 2009, Pages 417-422

  Demir, Resit ^a   Naschberger, Lisa ^a   Demir, Ilknur ^a   Melling, Nathaniel ^b   Dimmler, Arno ^c   Papadopoulus, Thomas ^d   Stürzl, Michael ^a   Klein, Peter ^a   Hohenberger, Werner ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b ALBERTINEN KRANKENHAUS   (Germany)

^c Medical Department II   (Germany)

^d VIVANTES HOSPITAL   (Germany)

Author keywords

Chorioallantoic membrane; Hypoxia; Tumor progression; Tumour invasion

Indexed keywords

ANGIOGENESIS; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL HYPOXIA; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; EGG; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MESODERM; METASTASIS; NONHUMAN; PHENOTYPE; TUMOR CELL;

EID: 73449132242     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9140-y     Document Type: Article

References (11)

1. IR Hart A Saini 1992 Biology of tumour metastasis Lancet 339 1453 1457 10.1016/0140-6736(92)92039-I 1:STN:280:DyaK383pt1Oksw%3D%3D 1376386
2. EC Woodhouse RF Chuaqui LA Liotta 1997 General mechanisms of metastasis Cancer 80 1529 1537 10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID- CNCR2>3.0.CO;2-F 1:STN:280:DyaK1c%2Fis1OnsA%3D%3D 9362419
3. G Christofori 2006 New signals from the invasive front Nature 441 444 450 10.1038/nature04872 1:CAS:528:DC%2BD28XkvVyrsro%3D 16724056 (Pubitemid 44050139)
4. T Kirchner T Brabletz 2000 Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation Am J Pathol 157 1113 1121 1:CAS:528:DC%2BD3cXnsVKjtbc%3D 11021815
5. JP Thiery 2002 Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 442 454 10.1038/nrc822 1:CAS:528:DC%2BD38Xksl2ltr8%3D 12189386
6. DM Brizel SP Scully JM Harrelson LJ Layfield RK Dodge HC Charles TV Samulski LR Prosnitz MW Dewhirst 1996 Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas Cancer Res 56 5347 5350 1:CAS:528:DyaK28Xntl2mtrk%3D 8968082
7. R Sullivan CH Graham 2007 Hypoxia-driven selection of the metastatic phenotype Cancer Metastasis Rev 26 319 331 10.1007/s10555-007-9062-2 1:CAS:528:DC%2BD2sXotFWrtb0%3D 17458507
8. A Reizis I Hammel A Ar 2005 Regional and developmental variations of blood vessel morphometry in the chick embryo chorioallantoic membrane J Exp Biol 208 2483 2488 10.1242/jeb.01662 15961734 (Pubitemid 41080421)
9. J Wilting B Christ M Bokeloh HA Weich 1993 In vivo effects of vascular endothelial growth factor on the chicken chorioallantoic membrane Cell Tissue Res 274 163 172 10.1007/BF00327997 1:CAS:528:DyaK2cXhtlel 7694800
10. D Ribatti A Vacca M Iurlaro R Ria L Roncali F Dammacco 1996 Human recombinant interferon alpha-2a inhibits angiogenesis of chick area vasculosa in shell-less culture Int J Microcirc Clin Exp 16 165 169 10.1159/000179169 1:CAS:528:DyaK28XntV2ns7o%3D 8923148
11. R Demir J Hoper 1997 Effect of beta-interferon on vascular density, mitochondrial metabolism and alkaline phosphatase in normoxia and hypoxia Adv Exp Med Biol 428 439 447 1:CAS:528:DyaK1cXivVCksrs%3D 9500083