The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells

Biochemical and Biophysical Research Communications

Volumn 430, Issue 3, 2013, Pages 889-894

  Kume, Kenichi ^a   Haraguchi, Misako ^a   Hijioka, Hiroshi ^a   Ishida, Takayuki ^a   Miyawaki, Akihiko ^b   Nakamura, Norifumi ^a   Ozawa, Masayuki ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Desmoglein 2; E cadherin; Oral squamous cell carcinoma; Snail

Indexed keywords

DESMOGLEIN 2; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; ENDOCYTOSIS; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; MESENCHYME CELL; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION;

CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; DESMOGLEIN 2; ENDOCYTOSIS; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; HYDRAZONES; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; PROTEOLYSIS; TRANSCRIPTION FACTORS; UP-REGULATION;

GASTROPODA;

EID: 84872496581     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.060     Document Type: Article

References (33)

1. Scully C., Felix D.H. Oral medicine-update for the dental practitioner oral cancer. Br. Dent. J. 2006, 200:13-17.
2. Duband J.L., Monier F., Delannet M., Newgreen D. Epithelium-mesenchyme transition during neural crest development. Acta Anat. (Basel) 1995, 154:63-78.
3. Hay E.D. An overview of epithelio-mesenchymal transformation. Acta Anat. (Basel) 1995, 154:8-20.
4. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2:442-454.
5. Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005, 17:548-558.
6. Christiansen J.J., Rajasekaran A.K. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006, 66:8319-8326.
7. Nawshad A., LaGamba D., Polad A., Hay E.D. Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells, Tissues, Organs 2005, 179:11-23.
8. Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 1988, 102:639-655.
9. Schäfer S., Koch P.J., Franke W.W. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp. Cell Res. 1994, 211:391-399.
10. Nieto M.A. The Snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol. 2002, 3:155-166.
11. Barrallo-Gimeno A., Nieto M.A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005, 132:3151-3161.
12. Peinado H., Olmeda D., Cano A. Snail, Zeb, and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat. Rev. Cancer 2007, 7:415-428.
13. Cobaleda C., Pérez-Caro M., Vicente-Dueñas C., Sánchez-García I. Function of the zinc-finger transcription factor SNAI2 in cancer and development. Annu. Rev. Genet. 2007, 41:41-61.
14. Cano A., Pérez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000, 2:76-83.
15. Batlle E., Sancho E., Francí C., Domínguez D., Monfar M., et al. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2000, 2:84-89.
16. Come C., Magnino F., Bibeau F., De Santa Barbara P., et al. Snail and Slug play distinct roles during breast carcinoma progression. Clin. Cancer Res. 2006, 12:5395-5402.
17. Qiao B., Johnson N.W., Gao J. Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions. Int. J. Oncol. 2010, 37:663-668.
18. Joseph M.J., Dangi-Garimella S., Shields M.A., Diamond M.E., et al. Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. J. Cell. Biochem. 2009, 108:726-736.
19. Ohkubo T., Ozawa M. The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J. Cell Sci. 2003, 117:1675-1685.
20. Miyashita Y., Ozawa M. Increased internalization of p120-uncoupled E-cadherin and a requirement for a dileucine motif in the cytoplasmic domain for endocytosis of the protein. J. Biol. Chem. 2007, 282:11540-11548.
21. Ozawa M., Kemler R. Altered cell adhesion activity by pervanadate due to the dissociation of alpha-catenin from the E-cadherin-catenin complex. J. Biol. Chem. 1998, 273:6166-6170.
22. Haraguchi M., Okubo T., miyasita Y., Miyamoto Y., et al. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. J. Biol. Chem. 2008, 283:23514-23523.
23. Bryant D.M., Stow J.L. The ins and outs of E-cadherin trafficking. Trends Cell Biol. 2004, 14:427-434.
24. Delva E., Jennings J.M., Calkins C.C., Kottke M.D., et al. Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. J. Biol. Chem. 2008, 283:18303-18313.
25. Macia E., Ehrlich M., Massol R., Boucrot E., et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 2006, 10:839-850.
26. Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003, 425:577-584.
27. Peinado H., Quintanilla M., Cano A. Transforming growth factor beta-1 induces Snail transcription factor in epithelial cell lines: mechanisms for epithelial-mesenchymal transitions. J. Biol. Chem. 2003, 278:21113-21123.
28. Romano L.A., Runyan R.B. Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev. Biol. 2000, 223:91-102.
29. Moreno-Bueno G., Cubillo E., Sarrió D., et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res. 2006, 66:9543-9556.
30. Wu S.Y., McClay D.R. The Snail repressor is required for PMC ingression in the sea urchin embryo. Development 2007, 134:1061-1070.
31. Chandler H.L., Colitz C.M., Lu P., Saville W.J., Kusewitt D.F. The role of the Slug transcription factor in cell migration during corneal re-epithelialization in the dog. Exp. Eye Res. 2007, 84:400-411.
32. Savagner P., Yamada K.M., Thiery J.P. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 1997, 137:1403-1419.
33. Suzuki K., Takahashi K. Induction of E-cadherin endocytosis by loss of protein phosphatase 2A expression in human breast cancers. Biochem. Biophys. Res. Commun. 2006, 349:255-260.