Alzheimer's disease: Brain desmosterol levels

Journal of Alzheimer's Disease

Volumn 33, Issue 3, 2013, Pages 881-888

  Wisniewski, Thomas ^a   Newman, Kia ^a   Javitt, Norman B ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

8 dehydrocholesterol; Alzheimer's disease; C27 sterol intermediates; desmosterol; DHCR24; Seladin 1

Indexed keywords

CHOLESTANOL; CHOLESTEROL; DESMOSTEROL; LATHOSTEROL; MEMBRANE PROTEIN; PHOSPHOLIPID; SELADIN 1; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; DISEASE COURSE; FRONTAL LOBE; GRAY MATTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; LIPID COMPOSITION; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STRUCTURE ANALYSIS; WHITE MATTER;

EID: 84872467162     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-121453     Document Type: Article

References (39)

1. Martins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ, Martins RN (2009) Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J Neurochem 111, 1275-1308.
2. Bu G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy. Nat Rev Neurosci 10, 333-344.
3. Huang Y (2011) Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: Lessons from ApoE mouse models. Biochem Soc Trans 39, 924-932.
4. Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F (2000) Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol 156, 951-964. (Pubitemid 30626953)
5. Mathew A, Yoshida Y, Maekawa T, Kumar DS (2011) Alzheimer's disease: Cholesterol a menace? Brain Res Bull 86, 1-12.
6. Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM (2000) The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci 20, 7345-7352.
7. Crameri A, Biondi E, Kuehnle K, Lutjohann D, Thelen KM, Perga S, Dotti CG, Nitsch RM, Ledesma MD, Mohajeri MH (2006) The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. EMBO J 25, 432-443. (Pubitemid 43152863)
8. Iivonen S, Hiltunen M, Alafuzoff I,Mannermaa A,Kerokoski P, Puolivali J, Salminen A, Helisalmi S, Soininen H (2002) Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Neuroscience 113, 301-310. (Pubitemid 34786175)
9. Galli G, Galli-Kienle M, Cattabeni F, Fiecchi A, Grossi-Paoletti E, Paoletti R (1970) The sterol precursors of cholesterol in normal and tumor tissues. Adv Enzyme Regul 8, 311-321.
10. Paoletti R, Fumagalli R, Grossi E, Paoletti P (1965) Studies on Brain Sterols in Normal and Pathological Conditions. J Am Oil Chem Soc 42, 400-404.
11. Morell P, Jurevics H (1996) Origin of cholesterol in myelin. Neurochem Res 21, 463-470. (Pubitemid 26159264)
12. Dietschy JM, Turley SD(2004) Thematic reviewseries: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45, 1375-1397. (Pubitemid 39022664)
13. Galli G, Paoletti EG, Weiss JF (1968) Sterol precursors of cholesterol in adult human brain. Science 162, 1495-1496.
14. Lees M, Folch J, Stanley GH, Carr S (1959) A simple procedure for the preparation of brain sulphatides. J Neurochem 4, 9-18.
15. Abel LL, Levy BB, Brodie BB, Kendall FE (1952) A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem 195, 357-366.
16. Sato Y, Suzuki I, Nakamura T, Bernier F, Aoshima K, Oda Y (2012) Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. J Lipid Res 53, 567-576.
17. Ruan B, Gerst N, Emmons GT, Shey J, Schroepfer GJ Jr (1997) Sterol synthesis. A timely look at the capabilities of conventional and silver ion high performance liquid chromatography for the separation of C27 sterols related to cholesterol biosynthesis. J Lipid Res 38, 2615-2626. (Pubitemid 28028145)
18. Griffiths WJ, Alvelius G, Liu S, Sjovall J (2004) High-Energy collision-induced dissociation of oxosteroids derivatised to Girard hydrazones. Eur J Mass Spectrom (Chichester, Eng) 10, 63-88. (Pubitemid 38453221)
19. Griffiths WJ, Sjovall J (2010) Analytical strategies for characterization of bile acid and oxysterol metabolomes. Biochem Biophys Res Commun 396, 80-84.
20. Wassif CA, Yu J, Cui J, Porter FD, Javitt NB (2003) 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: A novel metabolic pathway. Steroids 68, 497-502. (Pubitemid 36945404)
21. Batta AK,Tint GS, Shefer S,Abuelo D, SalenG(1995) Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome. J Lipid Res 36, 705-713.
22. Wilson WK, Sumpter RM, Warren JJ, Rogers PS, Ruan B, Schroepfer GJ Jr (1996) Analysis of unsaturated C27 sterols by nuclear magnetic resonance spectroscopy. J Lipid Res 37, 1529-1555. (Pubitemid 26249984)
23. Heverin M, Bogdanovic N, Lutjohann D, Bayer T, Pikuleva I, Bretillon L, Diczfalusy U, Winblad B, Bjorkhem I (2004) Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res 45, 186-193. (Pubitemid 38180529)
24. O'Brien JS, Sampson EL (1965) Lipid composition of the normal human brain: Gray matter, white matter, and myelin. J Lipid Res 6, 537-544.
25. Vanmierlo T, Bloks VW, van Vark-van der Zee LC, Rutten K, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch HW, Kuipers F, Lutjohann D, Mulder M (2010) Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. J Alzheimers Dis 19, 117-127.
26. Pedretti A, Bocci E, Maggi R, Vistoli G (2008) Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. Steroids 73, 708-719.
27. Andersson HC, Kratz L, Kelley R (2002) Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. Am J Med Genet 113, 315-319. (Pubitemid 35416606)
28. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ (2001) Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet 69, 685-694. (Pubitemid 32868514)
29. Sharpe LJ,Wong J, Garner B, Halliday GM, Brown AJ (2012) Is seladin-1 really a selective Alzheimer's disease indicator? J Alzheimers Dis 30, 35-39.
30. OnoT, ImaiY(1971) Effects of steroid hormones on synthesis of cholesterol in vitro. J Biochem 70, 45-54.
31. Gaylor JL, Chang YJ, Nightingale MS, Recio E, Ying BP (1965) Testicular sterols. IV. End-product steroid inhibition of lanosterol demethylation. Biochemistry 4, 1144-1149.
32. Lindenthal B, Holleran AL, Aldaghlas TA, Ruan B, Schroepfer GJ Jr,Wilson WK, Kelleher JK (2001) Progestins block cholesterol synthesis to produce meiosis-activating sterols. FASEB J 15, 775-784. (Pubitemid 32245996)
33. Baulieu EE (1997) Neurosteroids: Of the nervous system, by the nervous system, for the nervous system. Recent ProgHorm Res 52, 1-32. (Pubitemid 127470204)
34. Reddy DS (2010) Neurosteroids: Endogenous role in the human brain and therapeutic potentials. Prog Brain Res 186, 113-137.
35. Weill-Engerer S, David JP, SazdovitchV, Liere P, Eychenne B, Pianos A, Schumacher M, Delacourte A, Baulieu EE, Akwa Y (2002) Neurosteroid quantification in human brain regions: Comparison between Alzheimer's and nondemented patients. J Clin Endocrinol Metab 87, 5138-5143. (Pubitemid 35316357)
36. Sauer SW, Merle U, Opp S, Haas D, Hoffmann GF, Stremmel W, Okun JG (2011) Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. Biochim Biophys Acta 1812, 1607-1615.
37. Wender M, Adamczewska-Goncerzewicz Z, Szczech J (1994) Free sterols in senile human brain. Folia Neuropathol 32, 75-79.
38. Irons M, Elias ER, Salen G, Tint GS, Batta AK (1993) Defective cholesterol biosynthesis in Smith-Lemli-Opitz syndrome. Lancet 341, 1414. (Pubitemid 23160017)
39. Kelley RI,Wilcox WG, Smith M, Kratz LE, Moser A, Rimoin DS (1999) Abnormal sterol metabolism in patients with Conradi-Hunermann-Happle syndrome and sporadic lethal chondrodysplasia punctata. Am J Med Genet 83, 213-219.