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Volumn 149, Issue 1-2, 2013, Pages 9-18

In vitro assessment of mesenchymal stem cells immunosuppressive potential in multiple sclerosis patients

Author keywords

Immunosuppression; Mesenchymal stem cells; Multiple sclerosis

Indexed keywords

GAMMA INTERFERON RECEPTOR 1; MITOGENIC AGENT; MYELIN;

EID: 84872406089     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.10.010     Document Type: Article
Times cited : (19)

References (73)
  • 1
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan A.I. Mesenchymal stem cells. J Orthop Res 1991, 9(5):641-650.
    • (1991) J Orthop Res , vol.9 , Issue.5 , pp. 641-650
    • Caplan, A.I.1
  • 4
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008, 8(9):726-736.
    • (2008) Nat Rev Immunol , vol.8 , Issue.9 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 5
    • 0035480052 scopus 로고    scopus 로고
    • Immunotherapy of multiple sclerosis: the end of the beginning
    • Steinman L. Immunotherapy of multiple sclerosis: the end of the beginning. Curr Opin Immunol 2001, 13(5):597-600.
    • (2001) Curr Opin Immunol , vol.13 , Issue.5 , pp. 597-600
    • Steinman, L.1
  • 6
    • 79751504754 scopus 로고    scopus 로고
    • Mesenchymal stem cells: mechanisms of inflammation
    • Singer N.G., Caplan A.I. Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol Mech Dis 2011, 6:457-478.
    • (2011) Annu Rev Pathol Mech Dis , vol.6 , pp. 457-478
    • Singer, N.G.1    Caplan, A.I.2
  • 7
    • 38649103172 scopus 로고    scopus 로고
    • How do mesenchymal stromal cells suppress T cells?
    • Keating A. How do mesenchymal stromal cells suppress T cells?. Cell Stem Cell 2008, 2(2):106-108.
    • (2008) Cell Stem Cell , vol.2 , Issue.2 , pp. 106-108
    • Keating, A.1
  • 8
    • 67549119363 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells for autoimmune disease: teaching new dogs old tricks
    • Tyndall A., Uccelli A. Multipotent mesenchymal stromal cells for autoimmune disease: teaching new dogs old tricks. Bone Marrow Transplant 2009, 43(11):821-828.
    • (2009) Bone Marrow Transplant , vol.43 , Issue.11 , pp. 821-828
    • Tyndall, A.1    Uccelli, A.2
  • 9
    • 84863171061 scopus 로고    scopus 로고
    • Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation
    • Sajic M., Hunt D.P., Lee W., Compston D.A., Schweimer J.V., Gregson N.A., et al. Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation. PLoS One 2012, 7(2):e30708.
    • (2012) PLoS One , vol.7 , Issue.2
    • Sajic, M.1    Hunt, D.P.2    Lee, W.3    Compston, D.A.4    Schweimer, J.V.5    Gregson, N.A.6
  • 10
    • 47549110548 scopus 로고    scopus 로고
    • Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment
    • Mazzanti B., Aldinucci A., Biagioli T., Barilaro A., Urbani S., Dal Pozzo S., et al. Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment. J Neuroimmunol 2008, 199(1-2):142-150.
    • (2008) J Neuroimmunol , vol.199 , Issue.1-2 , pp. 142-150
    • Mazzanti, B.1    Aldinucci, A.2    Biagioli, T.3    Barilaro, A.4    Urbani, S.5    Dal Pozzo, S.6
  • 12
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M., Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 13
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R., Linington C., Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129(8):1953-1971.
    • (2006) Brain , vol.129 , Issue.8 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 14
    • 2542418993 scopus 로고    scopus 로고
    • High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
    • Crawford M.P., Yan S.X., Ortega S.B., Mehta R.S., Hewitt R.E., Price D.A., et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 2004, 103(11):4222-4231.
    • (2004) Blood , vol.103 , Issue.11 , pp. 4222-4231
    • Crawford, M.P.1    Yan, S.X.2    Ortega, S.B.3    Mehta, R.S.4    Hewitt, R.E.5    Price, D.A.6
  • 15
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009, 9(6):393-407.
    • (2009) Nat Rev Immunol , vol.9 , Issue.6 , pp. 393-407
    • Goverman, J.1
  • 16
    • 22844440946 scopus 로고    scopus 로고
    • The activation of memory CD4+ T cells and CD8+ T cells in patients with multiple sclerosis
    • Okuda Y., Okuda M., Apatoff B.R., Posnett D.N. The activation of memory CD4+ T cells and CD8+ T cells in patients with multiple sclerosis. J Neurol Sci 2005, 235:11-17.
    • (2005) J Neurol Sci , vol.235 , pp. 11-17
    • Okuda, Y.1    Okuda, M.2    Apatoff, B.R.3    Posnett, D.N.4
  • 18
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • Sallusto F., Geginat J., Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004, 22:745-763.
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 19
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basic for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
    • Hohlfeld R., Wekerle H. Autoimmune concepts of multiple sclerosis as a basic for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci U S A 2004, 101(2):14599-14606.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.2 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 20
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E., Casazza S., Pedemonte E., Benvenuto F., Bonanni I., Gerdoni E., et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005, 106(5):1755-1761.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3    Benvenuto, F.4    Bonanni, I.5    Gerdoni, E.6
  • 21
    • 70349745515 scopus 로고    scopus 로고
    • Predicting responders to therapies for multiple sclerosis
    • Río J., Comabella M., Montalban X. Predicting responders to therapies for multiple sclerosis. Nat Rev Neurol 2009, 5(10):553-560.
    • (2009) Nat Rev Neurol , vol.5 , Issue.10 , pp. 553-560
    • Río, J.1    Comabella, M.2    Montalban, X.3
  • 22
    • 51649096202 scopus 로고    scopus 로고
    • Monoclonal antibody therapies and neurologic disorders
    • Novak J.C., Lovett-Racke A.E., Racke M.K. Monoclonal antibody therapies and neurologic disorders. Arch Neurol 2008, 65(9):1162-1165.
    • (2008) Arch Neurol , vol.65 , Issue.9 , pp. 1162-1165
    • Novak, J.C.1    Lovett-Racke, A.E.2    Racke, M.K.3
  • 23
    • 79951818195 scopus 로고    scopus 로고
    • Glatiramer acetate treatment of multiple sclerosis: an immunological perspective
    • Racke M.K., Lovett-Racke A.E. Glatiramer acetate treatment of multiple sclerosis: an immunological perspective. J Immunol 2011, 186(4):1887-1890.
    • (2011) J Immunol , vol.186 , Issue.4 , pp. 1887-1890
    • Racke, M.K.1    Lovett-Racke, A.E.2
  • 25
    • 38049086826 scopus 로고    scopus 로고
    • Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases
    • Karussis D., Kassis I., Kurkalli B.G., Slavin S. Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases. J Neurol Sci 2008, 265(1-2):131-135.
    • (2008) J Neurol Sci , vol.265 , Issue.1-2 , pp. 131-135
    • Karussis, D.1    Kassis, I.2    Kurkalli, B.G.3    Slavin, S.4
  • 26
    • 45149103232 scopus 로고    scopus 로고
    • Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis
    • Kassis I., Grigoriadis N., Gowda-Kurkalli B., Mizrachi-Kol R., Ben-Hur T., Slavin S., Abramsky O., et al. Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis. Arch Neurol 2008, 65(6):753-761.
    • (2008) Arch Neurol , vol.65 , Issue.6 , pp. 753-761
    • Kassis, I.1    Grigoriadis, N.2    Gowda-Kurkalli, B.3    Mizrachi-Kol, R.4    Ben-Hur, T.5    Slavin, S.6    Abramsky, O.7
  • 28
    • 0347600715 scopus 로고    scopus 로고
    • Immunomodulatory effects of fetal and adult mesenchymal stem cells
    • Le Blanc K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003, 5(6):485-489.
    • (2003) Cytotherapy , vol.5 , Issue.6 , pp. 485-489
    • Le Blanc, K.1
  • 29
    • 79958829029 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases
    • Uccelli A., Laroni A., Freedman M.S. Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol 2011, 10(7):649-656.
    • (2011) Lancet Neurol , vol.10 , Issue.7 , pp. 649-656
    • Uccelli, A.1    Laroni, A.2    Freedman, M.S.3
  • 30
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S., Pittenger M. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105(4):1815-1822.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.2
  • 31
    • 34548833007 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression
    • Gieseke F., Schütt B., Viebahn S., Koscielniak E., Friedrich W., Handgretinger R., et al. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression. Blood 2007, 110(6):2197-2200.
    • (2007) Blood , vol.110 , Issue.6 , pp. 2197-2200
    • Gieseke, F.1    Schütt, B.2    Viebahn, S.3    Koscielniak, E.4    Friedrich, W.5    Handgretinger, R.6
  • 32
    • 15944376184 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    • Glennie S., Soeiro I., Dyson P.J., Lam E.W., Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005, 105(7):2821-2827.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2821-2827
    • Glennie, S.1    Soeiro, I.2    Dyson, P.J.3    Lam, E.W.4    Dazzi, F.5
  • 33
    • 69249119079 scopus 로고    scopus 로고
    • Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    • Ren G., Su J., Zhang L., Zhao X., Ling W., L'huillie A., et al. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 2009, 27(8):1954-1962.
    • (2009) Stem Cells , vol.27 , Issue.8 , pp. 1954-1962
    • Ren, G.1    Su, J.2    Zhang, L.3    Zhao, X.4    Ling, W.5    L'huillie, A.6
  • 34
    • 49149102464 scopus 로고    scopus 로고
    • Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms
    • Nasef A., Ashammakhi N., Fouillard L. Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms. Regen Med 2008, 3(4):531-546.
    • (2008) Regen Med , vol.3 , Issue.4 , pp. 531-546
    • Nasef, A.1    Ashammakhi, N.2    Fouillard, L.3
  • 35
    • 68049122875 scopus 로고    scopus 로고
    • Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration
    • Kode J.A., Mukherjee S., Joglekar M.V., Hardikar A.A. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 2009, 11(4):377-391.
    • (2009) Cytotherapy , vol.11 , Issue.4 , pp. 377-391
    • Kode, J.A.1    Mukherjee, S.2    Joglekar, M.V.3    Hardikar, A.A.4
  • 36
    • 79952084861 scopus 로고    scopus 로고
    • The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    • Connick P., Kolappan M., Patani R., Scott M.A., Crawley C., He X.L., et al. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials 2011, 12:62.
    • (2011) Trials , vol.12 , pp. 62
    • Connick, P.1    Kolappan, M.2    Patani, R.3    Scott, M.A.4    Crawley, C.5    He, X.L.6
  • 37
    • 77957964299 scopus 로고    scopus 로고
    • Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    • Karussis D., Karageorgiou C., Vaknin-Dembinsky A., Gowda-Kurkalli B., Gomori J.M., Kassis I., et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010, 67(10):1187-1194.
    • (2010) Arch Neurol , vol.67 , Issue.10 , pp. 1187-1194
    • Karussis, D.1    Karageorgiou, C.2    Vaknin-Dembinsky, A.3    Gowda-Kurkalli, B.4    Gomori, J.M.5    Kassis, I.6
  • 38
    • 0021035886 scopus 로고
    • Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS)
    • Kurtzke J.F. Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, 33(11):1444-1452.
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 39
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011, 69(2):292-302.
    • (2011) Ann Neurol , vol.69 , Issue.2 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3    Clanet, M.4    Cohen, J.A.5    Filippi, M.6
  • 41
    • 0037494418 scopus 로고    scopus 로고
    • Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation
    • John Wiley & Sons, Inc., New York
    • Parish Ch., Warren H.S. Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation. Current protocols in immunology 2001, John Wiley & Sons, Inc., New York, Supplement 42.
    • (2001) Current protocols in immunology , Issue.SUPPLEMENT. 42
    • Parish, C.1    Warren, H.S.2
  • 43
    • 66449113393 scopus 로고    scopus 로고
    • Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?
    • Longbrake E.E., Racke M.K. Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?. Expert Rev Neurother 2009, 9(3):319-321.
    • (2009) Expert Rev Neurother , vol.9 , Issue.3 , pp. 319-321
    • Longbrake, E.E.1    Racke, M.K.2
  • 44
    • 0036400960 scopus 로고    scopus 로고
    • Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects
    • Pender M.P., Wolfe N.P. Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects. Intern Med J 2002, 32(11):554-563.
    • (2002) Intern Med J , vol.32 , Issue.11 , pp. 554-563
    • Pender, M.P.1    Wolfe, N.P.2
  • 45
    • 77958467862 scopus 로고    scopus 로고
    • Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications
    • Ghannam S., Bouffi C., Djouad F., Jorgensen C., Noël D. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther 2010, 1(1):2.
    • (2010) Stem Cell Res Ther , vol.1 , Issue.1 , pp. 2
    • Ghannam, S.1    Bouffi, C.2    Djouad, F.3    Jorgensen, C.4    Noël, D.5
  • 46
    • 80054892015 scopus 로고    scopus 로고
    • Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function
    • Abdelrazik H., Spaggiari G.M., Chiossone L., Moretta L. Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function. Eur J Immunol 2011, 41(11):3281-3290.
    • (2011) Eur J Immunol , vol.41 , Issue.11 , pp. 3281-3290
    • Abdelrazik, H.1    Spaggiari, G.M.2    Chiossone, L.3    Moretta, L.4
  • 47
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P.D., Matteucci P., et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99(10):3838-3843.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6
  • 48
    • 34147126415 scopus 로고    scopus 로고
    • Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
    • Gerdoni E., Gallo B., Casazza S., Musio S., Bonanni I., Pedemonte E., et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 2007, 61(3):219-227.
    • (2007) Ann Neurol , vol.61 , Issue.3 , pp. 219-227
    • Gerdoni, E.1    Gallo, B.2    Casazza, S.3    Musio, S.4    Bonanni, I.5    Pedemonte, E.6
  • 49
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003, 101(9):3722-3729.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3    Scott, D.4    Laylor, R.5    Simpson, E.6
  • 50
    • 15044348816 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    • Rasmusson I., Ringden O., Sundberg B., Le Blank K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res 2005, 305(1):33-41.
    • (2005) Exp Cell Res , vol.305 , Issue.1 , pp. 33-41
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blank, K.4
  • 51
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A., Sturgeon C., Siatskas M., Ferrer K., McIntosh K., Patil S., et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002, 30(1):42-48.
    • (2002) Exp Hematol , vol.30 , Issue.1 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3    Ferrer, K.4    McIntosh, K.5    Patil, S.6
  • 52
    • 65649113921 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    • Bai L., Lennon D.P., Eaton V., Maier K., Caplan A.I., Miller S.D., et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 2009, 57(11):1192-1203.
    • (2009) Glia , vol.57 , Issue.11 , pp. 1192-1203
    • Bai, L.1    Lennon, D.P.2    Eaton, V.3    Maier, K.4    Caplan, A.I.5    Miller, S.D.6
  • 53
    • 70349883762 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis
    • Rafei M., Birman E., Forner K., Galipeau J. Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis. Mol Ther 2009, 17(10):1799-1803.
    • (2009) Mol Ther , vol.17 , Issue.10 , pp. 1799-1803
    • Rafei, M.1    Birman, E.2    Forner, K.3    Galipeau, J.4
  • 54
    • 84856305316 scopus 로고    scopus 로고
    • The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms
    • Morando S., Vigo T., Esposito M., Casazza S., Novi G., Principato M.C., et al. The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms. Stem Cell Res Ther 2012, 3(1):3.
    • (2012) Stem Cell Res Ther , vol.3 , Issue.1 , pp. 3
    • Morando, S.1    Vigo, T.2    Esposito, M.3    Casazza, S.4    Novi, G.5    Principato, M.C.6
  • 55
    • 84856023693 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
    • Connick P., Kolappan M. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012, 11(2):150-156.
    • (2012) Lancet Neurol , vol.11 , Issue.2 , pp. 150-156
    • Connick, P.1    Kolappan, M.2
  • 57
    • 77952583096 scopus 로고    scopus 로고
    • Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis
    • Rice C.M., Mallam E.A., Whone A.L., Wals P., Brooks D.J., Kane N., et al. Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis. Clin Pharmacol Ther 2010, 87(6):679-685.
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.6 , pp. 679-685
    • Rice, C.M.1    Mallam, E.A.2    Whone, A.L.3    Wals, P.4    Brooks, D.J.5    Kane, N.6
  • 58
    • 0032753320 scopus 로고    scopus 로고
    • Multiple sclerosis. B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
    • Lindert R.B., Haase C.G., Brehm U., Linington C., Wekerle H., Hohlfeld R. Multiple sclerosis. B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 1999, 122:2089-2099.
    • (1999) Brain , vol.122 , pp. 2089-2099
    • Lindert, R.B.1    Haase, C.G.2    Brehm, U.3    Linington, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 59
    • 0036773624 scopus 로고    scopus 로고
    • Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus
    • Bruno R., Sabater L., Sospedra M., Ferrer-Francesch X., Escudero D., Martínez-Cáceres E., et al. Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur J Immunol 2002, 32(10):2737-2747.
    • (2002) Eur J Immunol , vol.32 , Issue.10 , pp. 2737-2747
    • Bruno, R.1    Sabater, L.2    Sospedra, M.3    Ferrer-Francesch, X.4    Escudero, D.5    Martínez-Cáceres, E.6
  • 60
    • 0035254476 scopus 로고    scopus 로고
    • T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls
    • Hellings N., Barée M., Verhoeven C., D'hooghe M.B., Medaer R., Bernard C.C., et al. T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J Neurosci Res 2001, 63(3):290-302.
    • (2001) J Neurosci Res , vol.63 , Issue.3 , pp. 290-302
    • Hellings, N.1    Barée, M.2    Verhoeven, C.3    D'hooghe, M.B.4    Medaer, R.5    Bernard, C.C.6
  • 61
    • 0036604101 scopus 로고    scopus 로고
    • The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study
    • Koehler N.K., Genain C.P., Giesser B., Hauser S.L. The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study. J Immunol 2002, 168(11):5920-5927.
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5920-5927
    • Koehler, N.K.1    Genain, C.P.2    Giesser, B.3    Hauser, S.L.4
  • 62
    • 1542723658 scopus 로고    scopus 로고
    • Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis
    • Bielekova B., Sung M.H., Kadom N., Simon R., McFarland H., Martin R. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J Immunol 2004, 72:3893-3904.
    • (2004) J Immunol , vol.72 , pp. 3893-3904
    • Bielekova, B.1    Sung, M.H.2    Kadom, N.3    Simon, R.4    McFarland, H.5    Martin, R.6
  • 63
    • 77955159550 scopus 로고    scopus 로고
    • Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis
    • Mallam E., Kemp K., Wilkins A., Rice C., Scolding N. Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis. Mult Scler 2010, 16(8):909-918.
    • (2010) Mult Scler , vol.16 , Issue.8 , pp. 909-918
    • Mallam, E.1    Kemp, K.2    Wilkins, A.3    Rice, C.4    Scolding, N.5
  • 64
    • 80052220161 scopus 로고    scopus 로고
    • Harnessing the therapeutic potential of mesenchymal stem cells in multiple sclerosis
    • Darlington P.J., Boivin M.N., Bar-Or A. Harnessing the therapeutic potential of mesenchymal stem cells in multiple sclerosis. Expert Rev Neurother 2011, 11(9):1295-1303.
    • (2011) Expert Rev Neurother , vol.11 , Issue.9 , pp. 1295-1303
    • Darlington, P.J.1    Boivin, M.N.2    Bar-Or, A.3
  • 65
    • 34447520313 scopus 로고    scopus 로고
    • Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis
    • Cipriani P., Guiducci S., Miniati I., Cinelli M., Urbani S., Marrelli A., et al. Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum 2007, 56:1994-2004.
    • (2007) Arthritis Rheum , vol.56 , pp. 1994-2004
    • Cipriani, P.1    Guiducci, S.2    Miniati, I.3    Cinelli, M.4    Urbani, S.5    Marrelli, A.6
  • 66
    • 33847374613 scopus 로고    scopus 로고
    • Abnormality of bone morrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • Sun L.Y., Zhang H.Y., Feng X.B., Hou Y.Y., Lu L.W., Fan L.M. Abnormality of bone morrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007, 16:121-128.
    • (2007) Lupus , vol.16 , pp. 121-128
    • Sun, L.Y.1    Zhang, H.Y.2    Feng, X.B.3    Hou, Y.Y.4    Lu, L.W.5    Fan, L.M.6
  • 68
    • 34447298069 scopus 로고    scopus 로고
    • Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • Ryan J.M., Barry F., Murphy J.M., Mahon B.P. Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 2007, 149(2):353-363.
    • (2007) Clin Exp Immunol , vol.149 , Issue.2 , pp. 353-363
    • Ryan, J.M.1    Barry, F.2    Murphy, J.M.3    Mahon, B.P.4
  • 69
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta A.J., Fibbe W.E. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007, 110(10):3499-3506.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2
  • 70
    • 77952895427 scopus 로고    scopus 로고
    • Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1)
    • Lanz T.V., Opitz C.A., Ho P.P., Agrawal A., Lutz C., Weller M., et al. Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1). Stem Cells Dev 2010, 19(5):657-668.
    • (2010) Stem Cells Dev , vol.19 , Issue.5 , pp. 657-668
    • Lanz, T.V.1    Opitz, C.A.2    Ho, P.P.3    Agrawal, A.4    Lutz, C.5    Weller, M.6
  • 71
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M., Cosmi L., Angeli R., Pasini A., Liotta F., Andreini A., et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006, 24(2):386-398.
    • (2006) Stem Cells , vol.24 , Issue.2 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3    Pasini, A.4    Liotta, F.5    Andreini, A.6
  • 72
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation
    • Francois M., Romie-Mourez R., Li M., Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 2012, 20(1):187-195.
    • (2012) Mol Ther , vol.20 , Issue.1 , pp. 187-195
    • Francois, M.1    Romie-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 73
    • 0030240383 scopus 로고    scopus 로고
    • Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor
    • Novelli F., Bernabei P., Ozmen L., Rigamonti L., Allione A., Pestka S., et al. Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor. J Immunol 1996, 157(5):1935-1943.
    • (1996) J Immunol , vol.157 , Issue.5 , pp. 1935-1943
    • Novelli, F.1    Bernabei, P.2    Ozmen, L.3    Rigamonti, L.4    Allione, A.5    Pestka, S.6


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