메뉴 건너뛰기




Volumn 121, Issue 1, 2007, Pages 29-39

Interferon-β therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis

Author keywords

Autoimmunity; CFSE (5 (and 6 ) carboxyfluorescein diacetate succinimidyl ester); Disease progression; Immunotherapy; Myelin antigens; T cell responses

Indexed keywords

BETA1A INTERFERON; CD45RO ANTIGEN; CYTOKINE; INTERFERON BETA SERINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

EID: 34047240587     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02518.x     Document Type: Article
Times cited : (34)

References (70)
  • 2
    • 0036194760 scopus 로고    scopus 로고
    • Degeneracy, as opposed to specificity, in immunotherapy
    • Hafler DA. Degeneracy, as opposed to specificity, in immunotherapy. J Clin Invest 2002; 5:581-4.
    • (2002) J Clin Invest , vol.5 , pp. 581-584
    • Hafler, D.A.1
  • 3
    • 20444457446 scopus 로고    scopus 로고
    • Multiple sclerosis - novel insights and new therapeutic strategies
    • Kieseier BC, Hemmer B, Hartung HP. Multiple sclerosis - novel insights and new therapeutic strategies. Curr Opin Neurol 2005; 18:211-20.
    • (2005) Curr Opin Neurol , vol.18 , pp. 211-220
    • Kieseier, B.C.1    Hemmer, B.2    Hartung, H.P.3
  • 4
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 5
    • 0027418515 scopus 로고
    • Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • IFNB Multiple Sclerosis Study Group
    • IFNB Multiple Sclerosis Study Group. Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43:655-61.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 6
    • 0027521002 scopus 로고    scopus 로고
    • Paty DW, Li DK, UBC MS/MRI Study Group, IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43:662-7.
    • Paty DW, Li DK, UBC MS/MRI Study Group, IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43:662-7.
  • 8
    • 0027432017 scopus 로고
    • In vitro and in vivo inhibition of mitogen-driven T-cell activation by recombinant interferon beta
    • Rudick RA, Carpenter CS, Cookfair DL, Tuohy VK, Ransohoff RM. In vitro and in vivo inhibition of mitogen-driven T-cell activation by recombinant interferon beta. Neurology 1993; 43:2080-7.
    • (1993) Neurology , vol.43 , pp. 2080-2087
    • Rudick, R.A.1    Carpenter, C.S.2    Cookfair, D.L.3    Tuohy, V.K.4    Ransohoff, R.M.5
  • 9
    • 0027366326 scopus 로고
    • Interferon beta decreases T cell activation and interferon gamma production in multiple sclerosis
    • Noronha A, Toscas A, Jensen MA. Interferon beta decreases T cell activation and interferon gamma production in multiple sclerosis. J Neuroimmunol 1993; 46:145-53.
    • (1993) J Neuroimmunol , vol.46 , pp. 145-153
    • Noronha, A.1    Toscas, A.2    Jensen, M.A.3
  • 10
    • 0030864154 scopus 로고    scopus 로고
    • Interferon-β interferes with the proliferation but not with the cytokine secretion of myelin basic protein-specific, T-helper type 1 lymphocytes
    • Pette M, Pette DF, Muraro PA, Farnon E, Martin R, McFarland HF. Interferon-β interferes with the proliferation but not with the cytokine secretion of myelin basic protein-specific, T-helper type 1 lymphocytes. Neurology 1997; 49:385-92.
    • (1997) Neurology , vol.49 , pp. 385-392
    • Pette, M.1    Pette, D.F.2    Muraro, P.A.3    Farnon, E.4    Martin, R.5    McFarland, H.F.6
  • 11
    • 0032753320 scopus 로고    scopus 로고
    • Multiple sclerosis. B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
    • Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R. Multiple sclerosis. B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 1999; 122:2089-99.
    • (1999) Brain , vol.122 , pp. 2089-2099
    • Lindert, R.B.1    Haase, C.G.2    Brehm, U.3    Linington, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 12
    • 0034212893 scopus 로고    scopus 로고
    • Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis
    • van Noort JM, Bajramovic JJ, Plomp AC, van Stipdonk MJ. Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis. J Neuroimmunol 2000; 105:46-57.
    • (2000) J Neuroimmunol , vol.105 , pp. 46-57
    • van Noort, J.M.1    Bajramovic, J.J.2    Plomp, A.C.3    van Stipdonk, M.J.4
  • 15
    • 0035149317 scopus 로고    scopus 로고
    • T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Iglesias A, Bauer J, Litzenburger T, Schubart A, Linington C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 2001; 36:220-34.
    • (2001) Glia , vol.36 , pp. 220-234
    • Iglesias, A.1    Bauer, J.2    Litzenburger, T.3    Schubart, A.4    Linington, C.5
  • 16
    • 0036191549 scopus 로고    scopus 로고
    • + T cells in cerebrospinal fluid from multiple sclerosis patients
    • + T cells in cerebrospinal fluid from multiple sclerosis patients. Brain 2002; 125:538-50.
    • (2002) Brain , vol.125 , pp. 538-550
    • Jacobsen, M.1    Cepok, S.2    Quak, E.3
  • 17
    • 0034254825 scopus 로고    scopus 로고
    • Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
    • Pelfrey CM, Rudick RA, Cotleur AC, Lee JC, Tary-Lehmann M, Lehmann PV. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J Immunol 2000; 165:1641-51.
    • (2000) J Immunol , vol.165 , pp. 1641-1651
    • Pelfrey, C.M.1    Rudick, R.A.2    Cotleur, A.C.3    Lee, J.C.4    Tary-Lehmann, M.5    Lehmann, P.V.6
  • 18
    • 0037376324 scopus 로고    scopus 로고
    • Functional properties of myelin oligodendrocyte glycoproteinreactive T cells in multiple sclerosis patients and controls
    • van der Aa A, Hellings N, Bernard CA, Raus J, Stinissen P. Functional properties of myelin oligodendrocyte glycoproteinreactive T cells in multiple sclerosis patients and controls. J Neuroimmunol 2003; 137:164-76.
    • (2003) J Neuroimmunol , vol.137 , pp. 164-176
    • van der Aa, A.1    Hellings, N.2    Bernard, C.A.3    Raus, J.4    Stinissen, P.5
  • 19
    • 0037376779 scopus 로고    scopus 로고
    • A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis
    • Arbour N, Holz A, Sipe JC, Naniche D, Romine JS, Tyroff J, Oldstone MB. A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis. J Neuroimmunol 2003; 137:197-209.
    • (2003) J Neuroimmunol , vol.137 , pp. 197-209
    • Arbour, N.1    Holz, A.2    Sipe, J.C.3    Naniche, D.4    Romine, J.S.5    Tyroff, J.6    Oldstone, M.B.7
  • 21
    • 2542418993 scopus 로고    scopus 로고
    • + T cells in multiple sclerosis revealed by novel flow cytometric assay
    • + T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 2004; 103:4222-31.
    • (2004) Blood , vol.103 , pp. 4222-4231
    • Crawford, M.P.1    Yan, S.X.2    Ortega, S.B.3
  • 23
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13:227-31.
    • (1983) Ann Neurol , vol.13 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 24
    • 20244369427 scopus 로고    scopus 로고
    • Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice
    • Smith PA, Heijmans N, Ouwerling B, et al. Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice. Eur J Immunol 2005; 35:1311-19.
    • (2005) Eur J Immunol , vol.35 , pp. 1311-1319
    • Smith, P.A.1    Heijmans, N.2    Ouwerling, B.3
  • 25
    • 0027138878 scopus 로고
    • Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
    • Meinl E, Weber F, Drexler K, et al. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. J Clin Invest 1993; 92:2633-43.
    • (1993) J Clin Invest , vol.92 , pp. 2633-2643
    • Meinl, E.1    Weber, F.2    Drexler, K.3
  • 26
    • 0036919939 scopus 로고    scopus 로고
    • Differentiation of human cd T cells towards distinct memory phenotypes
    • Eberl M, Engel R, Beck E, Jomaa H. Differentiation of human cd T cells towards distinct memory phenotypes. Cell Immunol 2002; 218:1-6.
    • (2002) Cell Immunol , vol.218 , pp. 1-6
    • Eberl, M.1    Engel, R.2    Beck, E.3    Jomaa, H.4
  • 27
    • 0032733633 scopus 로고    scopus 로고
    • Carboxyfluorescein succinimidyl esterbased proliferative assay for assessment of T cell function in the diagnostic laboratory
    • Fulcher DA, Wong SW. Carboxyfluorescein succinimidyl esterbased proliferative assay for assessment of T cell function in the diagnostic laboratory. Immunol Cell Biol 1999; 77:559-64.
    • (1999) Immunol Cell Biol , vol.77 , pp. 559-564
    • Fulcher, D.A.1    Wong, S.W.2
  • 28
    • 0036604101 scopus 로고    scopus 로고
    • The human T cell response to myelin oligodendrocyte glycoprotein: A multiple sclerosis family-based study
    • Koehler NK, Genain CP, Giesser B, Hauser SL. The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study. J Immunol 2002; 168:5920-7.
    • (2002) J Immunol , vol.168 , pp. 5920-5927
    • Koehler, N.K.1    Genain, C.P.2    Giesser, B.3    Hauser, S.L.4
  • 29
    • 23444434940 scopus 로고    scopus 로고
    • Autoreactive CD8+ T cells in multiple sclerosis: A new target for therapy?
    • Friese MA, Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 2005; 128:1747-63.
    • (2005) Brain , vol.128 , pp. 1747-1763
    • Friese, M.A.1    Fugger, L.2
  • 30
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • Hemmer B, Archelos JJ, Hartung H. New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 2002; 3:291-301.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.3
  • 33
    • 0034618094 scopus 로고    scopus 로고
    • + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000; 192:393-404.
    • (2000) J Exp Med , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3
  • 36
    • 5644273987 scopus 로고    scopus 로고
    • What do we know about the mechanism of action of disease-modifying treatment in MS?
    • Hartung HP, Bar-Or A, Zoukos Y. What do we know about the mechanism of action of disease-modifying treatment in MS? J Neurol 2004; 251 (Suppl. 5):v12-v29.
    • (2004) J Neurol , vol.251 , Issue.SUPPL. 5
    • Hartung, H.P.1    Bar-Or, A.2    Zoukos, Y.3
  • 37
    • 0027144752 scopus 로고
    • Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    • Kerlero de Rosbo N, Milo R, Lees MB, Burger D, Bernard CC, Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 1993; 92:2602-8.
    • (1993) J Clin Invest , vol.92 , pp. 2602-2608
    • Kerlero de Rosbo, N.1    Milo, R.2    Lees, M.B.3    Burger, D.4    Bernard, C.C.5    Ben-Nun, A.6
  • 39
    • 0032519421 scopus 로고    scopus 로고
    • Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients
    • Lovett-Racke AE, Trotter JL, Lauber J, Perrin PJ, June CH, Racke MK. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. J Clin Invest 1998; 101:725-30.
    • (1998) J Clin Invest , vol.101 , pp. 725-730
    • Lovett-Racke, A.E.1    Trotter, J.L.2    Lauber, J.3    Perrin, P.J.4    June, C.H.5    Racke, M.K.6
  • 43
    • 3242804567 scopus 로고    scopus 로고
    • Cellular mechanisms governing cross-presentation of exogenous antigens
    • Ackerman AL, Cresswell P. Cellular mechanisms governing cross-presentation of exogenous antigens. Nat Immunol 2004; 5:678-84.
    • (2004) Nat Immunol , vol.5 , pp. 678-684
    • Ackerman, A.L.1    Cresswell, P.2
  • 44
    • 2942541735 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    • Heath WR, Belz GT, Behrens GM, et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 2004; 199:9-26.
    • (2004) Immunol Rev , vol.199 , pp. 9-26
    • Heath, W.R.1    Belz, G.T.2    Behrens, G.M.3
  • 45
    • 20444362068 scopus 로고    scopus 로고
    • + T helper-antigen-presenting cells
    • + T helper-antigen-presenting cells. J Immunol 2005; 174:7497-505.
    • (2005) J Immunol , vol.174 , pp. 7497-7505
    • Xiang, J.1    Huang, H.2    Liu, Y.3
  • 47
    • 17844363748 scopus 로고    scopus 로고
    • B lymphocytes participate in cross-presentation of antigen following gene gun vaccination
    • Hon H, Oran A, Brocker T, Jacob J. B lymphocytes participate in cross-presentation of antigen following gene gun vaccination. J Immunol 2005; 174:5233-42.
    • (2005) J Immunol , vol.174 , pp. 5233-5242
    • Hon, H.1    Oran, A.2    Brocker, T.3    Jacob, J.4
  • 48
    • 22044456043 scopus 로고    scopus 로고
    • Professional antigen-presentation function by human γδ T cells
    • Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human γδ T cells. Science 2005; 309:264-8.
    • (2005) Science , vol.309 , pp. 264-268
    • Brandes, M.1    Willimann, K.2    Moser, B.3
  • 49
    • 0032984045 scopus 로고    scopus 로고
    • Flow cytometric analysis of in vitro proinflammatory cytokines secretion in peripheral blood from multiple sclerosis patients
    • Nguyen LT, Ramanathan M, Munschauer F, et al. Flow cytometric analysis of in vitro proinflammatory cytokines secretion in peripheral blood from multiple sclerosis patients. J Clin Immunol 1999; 19:179-85.
    • (1999) J Clin Immunol , vol.19 , pp. 179-185
    • Nguyen, L.T.1    Ramanathan, M.2    Munschauer, F.3
  • 50
    • 0037447796 scopus 로고    scopus 로고
    • Sex differences in in vitro proinflammatory cytokine production from peripheral blood of multiple sclerosis patients
    • Nguyen LT, Ramanathan M, Weinstock-Guttman B, Baier M, Brownscheidle C, Jacobs LD. Sex differences in in vitro proinflammatory cytokine production from peripheral blood of multiple sclerosis patients. J Neurol Sci 2003; 15:93-9.
    • (2003) J Neurol Sci , vol.15 , pp. 93-99
    • Nguyen, L.T.1    Ramanathan, M.2    Weinstock-Guttman, B.3    Baier, M.4    Brownscheidle, C.5    Jacobs, L.D.6
  • 51
    • 0029743819 scopus 로고    scopus 로고
    • Cytokine phenotype of human autoreactive T clones specific for the immunodominant myelin basic protein peptide (83-99)
    • Hemmer B, Vergelli M, Calabresi P, Huang T, McFarland HF, Martin R. Cytokine phenotype of human autoreactive T clones specific for the immunodominant myelin basic protein peptide (83-99). J Neurosci Res 1996; 45:852-62.
    • (1996) J Neurosci Res , vol.45 , pp. 852-862
    • Hemmer, B.1    Vergelli, M.2    Calabresi, P.3    Huang, T.4    McFarland, H.F.5    Martin, R.6
  • 55
    • 12744261338 scopus 로고    scopus 로고
    • Multiple Sclerosis Therapy Consensus Group. Escalating immunotherapy of multiple sclerosis - new aspects and practical application
    • Rieckmann P, Toyka KV, Multiple Sclerosis Therapy Consensus Group. Escalating immunotherapy of multiple sclerosis - new aspects and practical application. J Neurol 2004; 251:1329-39.
    • (2004) J Neurol , vol.251 , pp. 1329-1339
    • Rieckmann, P.1    Toyka, K.V.2
  • 56
    • 0037356044 scopus 로고    scopus 로고
    • Serial analyses of soluble intracellular adhesion molecule-1 level in relapsing-remitting multiple sclerosis patients during IFN-β1b treatment
    • Kilinc M, Saatci-Cekirge I, Karabudak R. Serial analyses of soluble intracellular adhesion molecule-1 level in relapsing-remitting multiple sclerosis patients during IFN-β1b treatment. J Interferon Cytokine Res 2003; 23:127-33.
    • (2003) J Interferon Cytokine Res , vol.23 , pp. 127-133
    • Kilinc, M.1    Saatci-Cekirge, I.2    Karabudak, R.3
  • 57
    • 9744241650 scopus 로고    scopus 로고
    • IFN-β treatment modulates the CD28/CTLA-4 mediated pathway for IL-2 production in patients with relapsing remitting multiple sclerosis
    • Espejo C, Brieva L, Ruggiero G, Río J, Montalban X, Martínez-Cáceres EM. IFN-β treatment modulates the CD28/CTLA-4 mediated pathway for IL-2 production in patients with relapsing remitting multiple sclerosis. Mult Scler 2004; 10:630-5.
    • (2004) Mult Scler , vol.10 , pp. 630-635
    • Espejo, C.1    Brieva, L.2    Ruggiero, G.3    Río, J.4    Montalban, X.5    Martínez-Cáceres, E.M.6
  • 59
    • 12344305533 scopus 로고    scopus 로고
    • Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is unregulated by interferon-β in vitro and in vivo: Rationale for the therapy of multiple sclerosis
    • Mitsdoerffer M, Schreiner B, Kieseier BC, Neuhaus O, Dichgans J, Hartung HP, Weller M, Wiendl H. Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is unregulated by interferon-β in vitro and in vivo: rationale for the therapy of multiple sclerosis. J Neuroimmunol 2005; 159:155-64.
    • (2005) J Neuroimmunol , vol.159 , pp. 155-164
    • Mitsdoerffer, M.1    Schreiner, B.2    Kieseier, B.C.3    Neuhaus, O.4    Dichgans, J.5    Hartung, H.P.6    Weller, M.7    Wiendl, H.8
  • 61
    • 0032798867 scopus 로고    scopus 로고
    • Immunological effects of in vivo interferon-β1b treatment in ten patients with multiple sclerosis: A 1-year follow-up
    • Gelati M, Corsini E, Dufour A, Massa G, La Mantia L, Milanese C, Nespolo A, Salmaggi A. Immunological effects of in vivo interferon-β1b treatment in ten patients with multiple sclerosis: a 1-year follow-up. J Neurol 1999; 1246:569-73.
    • (1999) J Neurol , vol.1246 , pp. 569-573
    • Gelati, M.1    Corsini, E.2    Dufour, A.3    Massa, G.4    La Mantia, L.5    Milanese, C.6    Nespolo, A.7    Salmaggi, A.8
  • 62
    • 3843101531 scopus 로고    scopus 로고
    • Interferon-β stabilizes barrier characteristics of brain endothelial cells in vitro
    • Kraus J, Ling AK, Hamm S, Voigt K, Oschmann P, Engelhardt B. Interferon-β stabilizes barrier characteristics of brain endothelial cells in vitro. Ann Neurol 2004; 56:192-205.
    • (2004) Ann Neurol , vol.56 , pp. 192-205
    • Kraus, J.1    Ling, A.K.2    Hamm, S.3    Voigt, K.4    Oschmann, P.5    Engelhardt, B.6
  • 63
    • 4444355857 scopus 로고    scopus 로고
    • Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis
    • Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung HP, Weller M, Wiendl H. Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol 2004; 155:172-82.
    • (2004) J Neuroimmunol , vol.155 , pp. 172-182
    • Schreiner, B.1    Mitsdoerffer, M.2    Kieseier, B.C.3    Chen, L.4    Hartung, H.P.5    Weller, M.6    Wiendl, H.7
  • 64
    • 20144389230 scopus 로고    scopus 로고
    • Interferon-β1a therapy in human T-lymphotropic virus type I-associated neurologic disease
    • Oh U, Yamano Y, Mora CA, et al. Interferon-β1a therapy in human T-lymphotropic virus type I-associated neurologic disease. Ann Neurol 2005; 57:526-34.
    • (2005) Ann Neurol , vol.57 , pp. 526-534
    • Oh, U.1    Yamano, Y.2    Mora, C.A.3
  • 65
    • 0037377237 scopus 로고    scopus 로고
    • Systemic IFN-β treatment induces apoptosis of peripheral immune cells in MS patients
    • Gniadek P, Aktas O, Wandinger KP, et al. Systemic IFN-β treatment induces apoptosis of peripheral immune cells in MS patients. J Neuroimmunol 2003; 137:187-96.
    • (2003) J Neuroimmunol , vol.137 , pp. 187-196
    • Gniadek, P.1    Aktas, O.2    Wandinger, K.P.3
  • 67
    • 23944497614 scopus 로고    scopus 로고
    • Immunomodulatory effects of IFN-β1a treatment alone or associated with pentoxifylline in patients with relapsing-remitting multiple sclerosis (RRMS)
    • Pede PD, Visintini D, Telera A, Cucurachi L, Campanini C, Immovilli P, Vescovini R, Sansoni P. Immunomodulatory effects of IFN-β1a treatment alone or associated with pentoxifylline in patients with relapsing-remitting multiple sclerosis (RRMS). J Interferon Cytokine Res 2005; 25:485-9.
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 485-489
    • Pede, P.D.1    Visintini, D.2    Telera, A.3    Cucurachi, L.4    Campanini, C.5    Immovilli, P.6    Vescovini, R.7    Sansoni, P.8
  • 68
    • 0030817203 scopus 로고    scopus 로고
    • Interferon gamma producing blood lymphocytes are decreased by interferon beta therapy in patients with multiple sclerosis
    • Petereit HF, Bamborschke S, Esse AD, Heiss WD. Interferon gamma producing blood lymphocytes are decreased by interferon beta therapy in patients with multiple sclerosis. Mult Scler 1997; 3:180-3.
    • (1997) Mult Scler , vol.3 , pp. 180-183
    • Petereit, H.F.1    Bamborschke, S.2    Esse, A.D.3    Heiss, W.D.4
  • 69
    • 0034333099 scopus 로고    scopus 로고
    • Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4
    • Furlan R, Bergami A, Lang R, et al. Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4. J Neuroimmunol 2000; 111:86-92.
    • (2000) J Neuroimmunol , vol.111 , pp. 86-92
    • Furlan, R.1    Bergami, A.2    Lang, R.3
  • 70
    • 0037228948 scopus 로고    scopus 로고
    • Interferon γ and interleukin 4 producing T cells in peripheral blood of multiple sclerosis patients undergoing immunomodulatory treatment
    • Franciotta D, Zardini E, Bergamaschi R, Andreoni L, Cosi V. Interferon γ and interleukin 4 producing T cells in peripheral blood of multiple sclerosis patients undergoing immunomodulatory treatment. J Neurol Neurosurg Psychiatry 2003; 74: 123-6.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 123-126
    • Franciotta, D.1    Zardini, E.2    Bergamaschi, R.3    Andreoni, L.4    Cosi, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.