Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 406-412

  Lee, Wan ^a   Kim, Kwang Youn ^b   Yu, Sun Nyoung ^b   Kim, Sang Hun ^b   Chun, Sung Sik ^c   Ji, Jae Hoon ^d   Yu, Hak Sun ^b   Ahn, Soon Cheol ^a,b  

^a Pusan National University Hospital   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c International University of Korea   (South Korea)

^d Ajou University School of Medicine   (South Korea)

Author keywords

Ca2+ flux; Cell cycle arrest; Mitochondrial membrane potential; Pipernonaline; Prostate cancer; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANDROGEN; ANTINEOPLASTIC AGENT; CALCIUM ION; CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PIPER LONGUM EXTRACT; PIPERNONALINE; PLANT EXTRACT; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL MEMBRANE DEPOLARIZATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PIPER LONGUM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; PIPER; PIPERIDINES; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

PIPER LONGUM;

EID: 84872368422     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.030     Document Type: Article

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