Efficacy of Single and Multiple Injections of Human Umbilical Tissue-Derived Cells following Experimental Stroke in Rats

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Shehadah, Amjad ^a   Chen, Jieli ^a   Kramer, Brian ^b   Zacharek, Alex ^a   Cui, Yisheng ^a   Roberts, Cynthia ^a   Lu, Mei ^a   Chopp, Michael ^a,c  

^a HENRY FORD HOSPITAL   (United States)

^b Advanced Technologies and Regenerative Medicine   (United States)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PARAMETERS; CELL TRANSPLANTATION; CELL TYPE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FUNCTIONAL STATUS; HUMAN; HUMAN CELL; HUMAN UMBILICAL TISSUE DERIVED CELL; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL PLASTICITY; NONHUMAN; RAT; TREATMENT OUTCOME; UMBILICUS; VASCULAR DENSITY; VASCULAR PERIMETER;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS; MALE; RATS; RATS, WISTAR; STROKE; TISSUE THERAPY; UMBILICAL CORD;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84872345457     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054083     Document Type: Article

References (47)

1. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, et al. (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359: 1317-1329.
2. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333: 1581-1587.
3. Bliss T, Guzman R, Daadi M, Steinberg GK, (2007) Cell transplantation therapy for stroke. Stroke 38: 817-826.
4. Chopp M, Li Y, Zhang ZG, (2009) Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies. Stroke 40: S143-145.
5. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, et al. (2002) Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 174: 11-20.
6. Omori Y, Honmou O, Harada K, Suzuki J, Houkin K, et al. (2008) Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats. Brain Res 1236: 30-38.
7. Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, et al. (2008) Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells. Brain Res 1234: 172-182.
8. Mochizuki N, Takagi N, Kurokawa K, Onozato C, Moriyama Y, et al. (2008) Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia. Exp Neurol 211: 194-202.
9. Chen J, Sanberg PR, Li Y, Wang L, Lu M, et al. (2001) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32: 2682-2688.
10. Zacharek A, Shehadah A, Chen J, Cui X, Roberts C, et al. (2010) Comparison of bone marrow stromal cells derived from stroke and normal rats for stroke treatment. Stroke 41: 524-530.
11. Alder J, Kramer BC, Hoskin C, Thakker-Varia S, (2012) Brain-derived neurotrophic factor produced by human umbilical tissue-derived cells is required for its effect on hippocampal dendritic differentiation. Dev Neurobiol 72: 755-765.
12. Sun J, Li X, Feng H, Gu H, Blair T, et al. (2011) Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis. PLoS One 6: e24529.
13. Zhang L, Li Y, Zhang C, Chopp M, Gosiewska A, et al. (2011) Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia. Stroke 42: 1437-1444.
14. Chen J, Zacharek A, Li A, Zhang C, Ding J, et al. (2006) Vascular endothelial growth factor mediates atorvastatin-induced mammalian achaete-scute homologue-1 gene expression and neuronal differentiation after stroke in retired breeder rats. Neuroscience 141: 737-744.
15. Chen J, Li Y, Wang L, Zhang Z, Lu D, et al. (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32: 1005-1011.
16. Barth TM, Grant ML, Schallert T, (1990) Effects of MK-801 on recovery from sensorimotor cortex lesions. Stroke 21: III153-157.
17. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST, (2000) CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39: 777-787.
18. Schallert T, Whishaw IQ, (1984) Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats. Behav Neurosci 98: 518-540.
19. Hernandez TD, Schallert T, (1988) Seizures and recovery from experimental brain damage. Exp Neurol 102: 318-324.
20. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, et al. (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10: 290-293.
21. Lu M, Chen J, Lu D, Yi L, Mahmood A, et al. (2003) Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells. J Neurosci Methods 128: 183-190.
22. Ujike H, Takaki M, Kodama M, Kuroda S, (2002) Gene expression related to synaptogenesis, neuritogenesis, and MAP kinase in behavioral sensitization to psychostimulants. Ann N Y Acad Sci 965: 55-67.
23. Yoon YS, Lee N, Scadova H, (2005) Myocardial regeneration with bone-marrow-derived stem cells. Biol Cell 97: 253-263.
24. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, et al. (2004) Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109: 1543-1549.
25. Li Y, Chopp M, (2009) Marrow stromal cell transplantation in stroke and traumatic brain injury. Neurosci Lett 456: 120-123.
26. Li Y, Chen J, Wang L, Lu M, Chopp M, (2001) Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology 56: 1666-1672.
27. Rempe DA, Kent TA, (2002) Using bone marrow stromal cells for treatment of stroke. Neurology 59: 486-487.
28. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, et al. (2011) Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol 20: 204-212.
29. Greenberg DA, Jin K, (2005) From angiogenesis to neuropathology. Nature 438: 954-959.
30. Pratt PF, Medhora M, Harder DR, (2004) Mechanisms regulating cerebral blood flow as therapeutic targets. Curr Opin Investig Drugs 5: 952-956.
31. Zacharek A, Chen J, Cui X, Yang Y, Chopp M, (2009) Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke 40: 254-260.
32. Garcia JH, Cox JV, Hudgins WR, (1971) Ultrastructure of the microvasculature in experimental cerebral infarction. Acta Neuropathol 18: 273-285.
33. Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, et al. (2002) Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab 22: 379-392.
34. Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, et al. (1997) A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 28: 2518-2527.
35. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM, (1994) Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25: 1794-1798.
36. Cramer SC, Chopp M, (2000) Recovery recapitulates ontogeny. Trends Neurosci 23: 265-271.
37. Zhang ZG, Chopp M, (2009) Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 8: 491-500.
38. Kolb B, (1999) Synaptic plasticity and the organization of behaviour after early and late brain injury. Can J Exp Psychol 53: 62-76.
39. Nudo RJ, Plautz EJ, Frost SB, (2001) Role of adaptive plasticity in recovery of function after damage to motor cortex. Muscle Nerve 24: 1000-1019.
40. Bohotin CR, Badescu M, Popescu DN, Bohotin V, (2004) Motor cortex plasticity-from physiology to clinical neurology. Rom J Physiol 41: 99-108.
41. Stroemer RP, Kent TA, Hulsebosch CE (1998) Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats. Stroke 29: 2381-2393; discussion 2393-2385.
42. Masliah E, Fagan AM, Terry RD, DeTeresa R, Mallory M, et al. (1991) Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp Neurol 113: 131-142.
43. Masliah E, Terry RD, DeTeresa RM, Hansen LA, (1989) Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 103: 234-239.
44. Masliah E, Terry RD, Alford M, DeTeresa R, (1990) Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. J Histochem Cytochem 38: 837-844.
45. Cabalka LM, Ritchie TC, Coulter JD, (1990) Immunolocalization and quantitation of a novel nerve terminal protein in spinal cord development. J Comp Neurol 295: 83-91.
46. Cui X, Chopp M, Zacharek A, Roberts C, Buller B, et al. (2010) Niacin treatment of stroke increases synaptic plasticity and axon growth in rats. Stroke 41: 2044-2049.
47. Chen J, Li Y, Wang L, Lu M, Chopp M, (2002) Caspase inhibition by Z-VAD increases the survival of grafted bone marrow cells and improves functional outcome after MCAo in rats. J Neurol Sci 199: 17-24.