Magnetic resonance imaging of bone marrow Cell-Mediated Interleukin-10 gene therapy of atherosclerosis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Sun, Jihong ^a,b   Li, Xubin ^b   Feng, Hongqing ^b   Gu, Huidong ^b   Blair, Tiffany ^b   Li, Jiakai ^b   Soriano, Stephanie ^b   Meng, Yanfeng ^b   Zhang, Feng ^b   Feng, Qinghua ^b   Yang, Xiaoming ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; LENTIVIRUS VECTOR; SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL LABELING; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; FEASIBILITY STUDY; GENE EXPRESSION PROFILING; GENE THERAPY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SIGNAL TRANSDUCTION; THERAPY EFFECT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; CELL CULTURE; GENETICS; METABOLISM; METHODOLOGY; MOUSE MUTANT; PATHOLOGY;

ANIMALIA; LENTIVIRUS; MUS;

ANIMALS; ATHEROSCLEROSIS; BONE MARROW CELLS; CELLS, CULTURED; GENE THERAPY; INTERLEUKIN-10; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 80052534211     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024529     Document Type: Article

References (29)

1. Xu Y, Arai H, Zhuge X, Sano H, Murayama T, et al. (2004) Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice. Arterioscler Thromb Vasc Biol 24: 477-482.
2. Orlic D, Kajstura J, Chimenti S, Bodine D, Leri A, et al. (2003) Bone marrow stem cells regenerate infarcted myocardium. Pediatr Transplant 7 (Suppl 3): 86-88.
3. Krause D, Theise N, Collector M, Henegariu O, Hwang S, et al. (2001) Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377.
4. Sata M, Saiura A, Kunisato A, Tojo A, Okada S, et al. (2002) Hematopoietic stem cells differentiate into vascular cells that participate in the pathogensis of atherosclerosis. Nature Medicine 8: 403-409.
5. Nabel E, (1995) Gene therapy for cardiovascular disease. Circulation 91: 541-548.
6. Sinnaeve P, Varenne O, Collen D, Janssens S, (1999) Gene therapy in the cardiovascular system: an update. Cardiovasc Res 44: 498-506.
7. Yang X, (2003) Imaging of vascular gene therapy. Radiology 228: 36-49.
8. Namiki M, Kawashima S, Yamashita T, Ozaki M, Sakoda T, et al. (2004) Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice. Atherosclerosis 172: 21-29.
9. Pinderski Oslund LJ, Hedrick CC, Olvera T, Hagenbaugh A, Territo M, et al. (1999) Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler Thromb Vasc Biol 19: 2847-2853.
10. Mallat Z, Besnard S, Duriez M, Deleuze V, Emmanuel F, et al. (1999) Protective role of interleukin-10 in atherosclerosis. Circ Res 85: e17-24.
11. Bulte J, Douglas T, Witwer B, Zhang SC, Strable E, et al. (2001) Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19: 1141-1147.
12. Qiu B, Gao F, Walczak P, Zhang J, Kar S, et al. (2007) In vivo MR imaging of bone marrow cells trafficking to atherosclerotic plaques. J Magn Reson Imaging 26: 339-343.
13. Gao F, Kar S, Zhang J, Qiu B, Walczak P, et al. (2007) MRI of intravenously injected bone marrow cells homing to the site of injured arteries. NMR Biomed 20: 673-681.
14. Qiu B, Yang X, (2008) Molecular MRI of hematopoietic stem-progenitor cells: in vivo monitoring of gene therapy and atherosclerosis. Nat Clin Pract Cardiovasc Med 5: 396-404.
15. National Institues of Health (revised 1985) Guide for the care and use of laboratory animals. NIH Publication No 86-23.
16. Russell J, (2003) Of mice and men, rats and atherosclerosis. Cardiovasc Res 59: 810-811.
17. Tang TY, Howarth SP, Miller SR, Graves MJ, U-King-Im JM, et al. (2008) Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal stenosis. Stroke 39: 2144-2147.
18. Shapiro EM, Sharer K, Skrtic S, Koretsky AP, (2006) In vivo detection of single cells by MRI. Magn Reson Med 55: 242-249.
19. Bos C, Delmas Y, Desmouliere A, Koretsky AP, (2004) In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 233: 781-789.
20. Chae EY, Song EJ, Sohn JY, Kim ST, Woo CW, et al. (2010) Allogeneic renal graft rejection in a rat model: in vivo MR imaging of the homing trait of macrophages. Radiology 256: 847-854.
21. Qiu B, Treuting P, Zhan X, Xie D, Frevert CW, et al. (2010) Dual transfer of GFP gene and MGd into stem-progenitor cells: toward in vivo MRI of stem cell-mediated gene therapy of atherosclerosis. Acad Radiol 17: 547-552.
22. Han X, Kitamoto S, Wang H, Boisvert WA, (2010) Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. FASEB J 24: 2869-2880.
23. Kleemann R, Zadelaar S, Kooistra T, (2008) Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res 79: 360-376.
24. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A, (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765.
25. Blanco E, Monux G, Mas A, Serrano FJ, de la Concha EG, et al. (2008) Role of IL-10 promoter polymorphisms in the development of severe aorto-iliac occlusive disease. Hum Immunol 69: 651-654.
26. Pinderski LJ, Fischbein MP, Subbanagounder G, Fishbein MC, Kubo N, et al. (2002) Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes. Circ Res 90: 1064-1071.
27. Mallat Z, Heymes C, Ohan J, Faggin E, Leseche G, et al. (1999) Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arterioscler Thromb Vasc Biol 19: 611-616.
28. Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM, (1995) IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 96: 2304-2310.
29. Rubic T, Lorenz RL, (2006) Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10. Cardiovasc Res 69: 527-535.