Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and DL-lactide block copolymer as novel drug carriers

Journal of Controlled Release

Volumn 56, Issue 1-3, 1998, Pages 197-208

  Kim, So Yeon ^a   Shin, Il Gyun ^a   Lee, Young Moo ^a  

^a Hanyang University   (South Korea)

Author keywords

Amphiphilic block copolymer; DL lactide; Drug delivery system; Methoxy poly(ethylene glycol); Nanosphere

Indexed keywords

COPOLYMER; DRUG CARRIER; INDOMETACIN; MACROGOL; NANOPARTICLE; POLYLACTIDE;

ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG RELEASE; DRUG SAFETY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; LIGHT SCATTERING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0032484234     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00083-2     Document Type: Article

References (34)

1. R.L. Dunn, R.M. Ottenbrite, Polymeric Drug and Drug Delivery Systems, American Chemical Society, Washington, DC, 1991.
2. M.A. El-Nokaly, D.M. Piatt, B.A. Charpentier, Polymeric Delivery Systems, American Chemical Society, Washington, DC, 1993.
3. F. Puisieux, G. Barratt, G. Couarraze, P. Couvreur, J.P. Devissaguet, C. Dubernet, E. Fattal, H. Fessi, C. Vauthier, Polymeric Biomaterials, Marcel Dekker Inc., 1994, pp. 749-794.
4. Kreuter J. Nanoparticle-based drug delivery systems. J. Contr. Rel. 16:1991;169-176.
5. M.J. Alonso, Drug and the pharmaceutical sciences vol. 77: Microparticulate systems for the delivery of proteins and vaccines, Marcel Dekker Inc., USA, 1996, pp. 203-242.
6. Seijo B., Fattal E., Treupel L.R., Couvreur P. Design of nanoparticles of less than 50 nm diameter: preparation, characterization and loading. Int. J. Pharm. 62:1990;1-7.
7. Peppas L.B. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int. J. Pharm. 116:1995;1-9.
8. Jalil R., Nixon J.R. Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencap. 7:1990;297-325.
9. Uchida T., Yoshida K., Ninomiya A., Goto S. Optimization of preparative conditions for polylactide (PLA) microspheres containing ovalbumin. Chem. Pharm. Bull. 43:1995;1569-1573.
10. Spenlehauer G., Vert M., Benoit J.P., Chabot F., Veillard M. Biodegradable cisplatin microspheres prepared by the solvent evaporation method: molphology and release characteristics. J. Contr. Rel. 7:1988;217-229.
11. Gao Z., Eisenberg A. A model of micellization for block copolymers in solutions. Macromolecules. 26:1993;7353-7360.
12. Quintana J.R., Villacampa M., Munoz M., Andrio A., Katime A. Micellization of a polystyrene-block-poly(ethylene/propylene) copolymer in n-alkanes. 1. Thermodynamic study. Macromolecules. 25:1992;3125-3128.
13. Munk P., Qin A., Tian M., Ramireddy C., Webber S.E., Tuzar Z., Prochazka K. Characterization of block copolymer micelles in aqueous media. J. Appl. Polym. Sci.: Appl. Polym. Symposium. 52:1993;45-54.
14. Hamad E., Qutubuddin S. Theory of micelle formation by amphiphilic side-chain polymers. Macromolecules. 23:1990;4185-4191.
15. Malmsten M., Lindman B. Self-assembly in aqueous block copolymer solutions. Macromolecules. 25:1992;5440-5445.
16. Price C., Stubbersfield R.B., Kafrawy S.E., Kendall K.D. Thermodynamics of micellization of polystyrene-block-poly(ethylene/propylene) copolymers in decane. Br. Polym. J. 21:1989;391-394.
17. Cerrai P., Tricoli M., Andruzzi F., Paci M., Paci M. Polyether-polyester block copolymers by non-catalysed polymerization of ε-caprolactone with poly(ethylene glycol). Polymer. 30:1989;338-343.
18. Tanodekaew S., Pannu R., Heatley F., Attwood D., Booth C. Association and surface properties of diblock copolymers of ethylene oxide and DL-lactide in aqueous solution. Macromol. Chem. Phys. 198:1997;927-944.
19. Shin I.G., Kim S.Y., Lee Y.M., Cho C.S., Sung Y.K. Methoxy poly (ethylene Glycol)/ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin: I. preparation and characterization. J. Contr. Rel. 51:1998;1-11.
20. Kim S.Y., Shin I.G., Lee Y.M., Cho C.S., Sung Y.K. Methoxy poly (ethylene glycol)/ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin: II. Micelle formation and drug release behaviours. J. Contr. Rel. 51:1998;13-22.
21. Huatan H., Collett J.H., Attwood D. The microencapsulation of protein using a novel ternary blend based on poly(ε-caprolactone). J. Microencap. 12(5):1995;557-567.
22. W-J. Lin, R. Donglas, A. Flanagan, R.T. Linhardt, Accelerated degradation of poly(ε-caprolactone) by organic amines, Pharm. Res. 11 (1994) 1030-1035.
23. Marchal-Heussler L., Sirbat D., Hoffman M., Maincent P. Poly(ε-caprolactone) nanocapsules in carteolol ophthalmic delivery. Pharm. Res. 10:1993;386-390.
24. Du Y.J., Lemstra P.J., Nijenhuis A.J., Aert H.A.M., Bastiaansen A. ABA type copolymers of lactide with poly(ethylene glycol), kinetic, mechanistic, and model studies. Macromolecules. 28:1995;2124-2132.
25. Deng X.M., Xiong C.D., Cheng L.M., Huang H.H., Xu R.P. Studies on the block copolymerization of DL-lactide and poly(ethylene glycol) with aluminum complex catalyst. J. Appl. Polym. Sci. 55:1995;1193-1196.
26. Bergsma J.E., Rozema F.R., Bos R.R.M., Boering G., Joziasse C.A.P., Pennings A.J. In vitro predegradation at elevated temperatures of poly(lactide). J. Mater. Sci.: Mater. Med. 6:1995;642-646.
27. Lemoine D., Francois C., Kedzierewicz F., Preat V., Hoffman M., Maincent P. Stability study of nanoparticles of poly(ε-caprolactone), poly(DL-lactide) and poly(DL-lactide-co-glycolide). Biomaterials. 17:1996;2191-2197.
28. R. Gref, Y. Minamitake, M.T. Peracchia, R. Langer, Microparticulate systems for the delivery of protein and vaccines, Marcel Dekker Inc., USA, 1996, pp. 279-306.
29. Cerrai P., Tricoli M., Lelli L., Guerra G.D., Guerra R.S., Cascone M.G., Giusti P. Block copolymers of L-lactide and poly(ethylene glycol) for biomedical applications. J. Mater. Sci.: Mater. Med. 5:1994;308-313.
30. Piskin E., Kaitian X., Denkbas E.B. Novel PDLLA/PEG copolymer micelles as drug carriers. J. Biomater. Sci. Polymer Ed. 7:1995;359.
31. La S.B., Okano T., Kataoka K. Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly (ethylene oxide)-poly(β-benzyl L-asparatate) block copolymer micelles. J. Pharm. Sci. 85:1996;85-90.
32. I. Piirma, Polymeric surfactants, Surfactant science series, 42, pp. 49-86.
33. Provencher S.W., Hendrixs J. Direct determination of molecular weight distributions of polystyrene in cyclohexane with photon correlation. J. Chem. Phys. 69:1978;4273-4276.
34. Cerrai P., Guerra G.D., Lelli L., Tricoli M., Guerra R.S., Cascone M.G., Giusti P. Poly(ester-ether-ester) block copolymers as biomaterials. J. Mater. Sci.: Mater. Med. 5:1994;33-39.