Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling

Journal of Biological Chemistry

Volumn 288, Issue 2, 2013, Pages 1135-1149

  BasuRay, Soumik ^a   Mukherjee, Sanchita ^a,c   Romero, Elsa G ^a   Seaman, Matthew N J ^b   Wandinger Ness, Angela ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION CYCLES; AUTOSOMAL DOMINANTS; CELL LINES; DOWN-REGULATION; EARLY-TO-LATE; EGFR SIGNALING; ENDOSOMES; EPIDERMAL GROWTH FACTORS; GROWTH FACTOR; GTPASES; INTRACELLULAR SIGNALING; LATE ENDOSOMES; MASTER REGULATORS; MEMBRANE TRANSPORT; NEURONAL FUNCTION; NUCLEAR ACTIVATION; NUCLEAR TRANSCRIPTION; NUCLEAR TRANSLOCATIONS; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSIONS; RECEPTOR TRAFFICKING;

CELL CULTURE; GROWTH KINETICS; TRANSCRIPTION;

PATHOLOGY;

EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; RAB7 PROTEIN; TRANSCRIPTION FACTOR ELK 1;

ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; EGR 1 GENE; ENDOSOME; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; INNERVATION; INTRACELLULAR SIGNALING; INTRACELLULAR TRANSPORT; LYSOSOME; NERVE FIBER GROWTH; NEUROPATHOLOGY; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL NUCLEUS; CHARCOT-MARIE-TOOTH DISEASE; ENDOSOMES; GENES, FOS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MUTAGENESIS; MUTATION, MISSENSE; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84872312700     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.417766     Document Type: Article

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