Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1833, Issue 3, 2013, Pages 767-779

  Lukášová, Emilie ^a   Kořistek, Zdeněk ^b   Klabusay, Martin ^b   Ondřej, Vladan ^a   Grigoryev, Sergei ^c   Bačíková, Alena ^a   Řezáčová, Martina ^d   Falk, Martin ^a   Vávrová, Jiřina ^e   Kohútová, Viera ^b   Kozubek, Stanislav ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

^e UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

DNA double strand break repair; Higher order chromatin remodeling; HP1 protein; Immature AML neutrophil; In vivo and ex vivo blood stem cells differentiation; Neutrophil extracellular trap (NET)

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; EX VIVO STUDY; GAMMA IRRADIATION; GENE EXPRESSION; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; LEUKOCYTE FUNCTION; MYELOID LEUKEMIA; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; PRIORITY JOURNAL;

BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA DAMAGE; FLUORESCENT ANTIBODY TECHNIQUE; GRANULOCYTES; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; NEUTROPHILS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE;

EID: 84872311219     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.12.012     Document Type: Article

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