Mapping the prescriptiome to fractures in men-a national analysis of prescription history and fracture risk

Osteoporosis International

Volumn 20, Issue 4, 2009, Pages 585-597

  Abrahamsen, B ^a   Brixen, K ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Epidemiology; Fracture risk; Men; Osteoporosis; Pharmacoepidemiology

Indexed keywords

ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; NEUROLEPTIC AGENT; OPIATE; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FRACTURE; GENE MAPPING; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATICS; PRESCRIPTION; PRIORITY JOURNAL; RISK FACTOR; ADVERSE DRUG REACTION; CHEMICALLY INDUCED; COMPLICATION; DENMARK; EPIDEMIOLOGY; FRACTURES, BONE; HIP FRACTURES; MIDDLE AGED; OSTEOPOROSIS; SPINAL FRACTURES; STATISTICS AND NUMERICAL DATA;

AGED; DENMARK; DRUG PRESCRIPTIONS; DRUG THERAPY; EPIDEMIOLOGIC METHODS; FRACTURES, BONE; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; PHARMACEUTICAL PREPARATIONS; SPINAL FRACTURES; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS;

EID: 62149091078     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-008-0711-2     Document Type: Article

References (71)

1. O Johnell J Kanis 2005 Epidemiology of osteoporotic fractures Osteoporos Int 16 Suppl 2 S3 S7
2. LA Fitzpatrick 2002 Secondary causes of osteoporosis Mayo Clin Proc 77 453 468
3. N Binkley D Krueger 2002 Osteoporosis in men WMJ 101 28 32
4. PR Ebeling DM Thomas B Erbas JL Hopper J Szer AP Grigg 1999 Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation J Bone Miner Res 14 342 350
5. T Bardin M Lequesne 1989 The osteoporosis of heparinotherapy and systemic mastocytosis Clin Rheumatol 8 Suppl 2 119 123
6. LA Ahmed H Schirmer GK Berntsen V Fonnebo RM Joakimsen 2006 Self-reported diseases and the risk of non-vertebral fractures: the Tromso study Osteoporos Int 17 46 53
7. P Vestergaard L Mosekilde 2002 Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients Thyroid 12 411 419
8. P Vestergaard L Rejnmark L Mosekilde 2004 Fracture risk associated with use of antiepileptic drugs Epilepsia 45 1330 1337
9. B Takkouche A Montes-Martinez SS Gill M Etminan 2007 Psychotropic medications and the risk of fracture: a meta-analysis Drug Saf 30 171 184
10. JM Meyer D Lehman 2006 Bone mineral density in male schizophrenia patients: a review Ann Clin Psychiatry 18 43 48
11. PE Lonning J Geisler LE Krag B Erikstein Y Bremnes AI Hagen E Schlichting EA Lien ES Ofjord J Paolini A Polli G Massimini 2005 Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer J Clin Oncol 23 5126 5137
12. B Abrahamsen MM Frost S Walther K Brixen 2007 Fracture risk in patients with prostate cancer. A nationwide case-control study Br J Urol 100 4 749 754
13. AV Schwartz DE Sellmeyer E Vittinghoff L Palermo B Lecka-Czernik KR Feingold ES Strotmeyer HE Resnick L Carbone BA Beamer SW Park NE Lane TB Harris SR Cummings 2006 Thiazolidinedione use and bone loss in older diabetic adults J Clin Endocrinol Metab 91 3349 3354
14. NI Paton DC Macallan GE Griffin M Pazianas 1997 Bone mineral density in patients with human immunodeficiency virus infection Calcif Tissue Int 61 30 32
15. H Hakonarson SF Grant JP Bradfield L Marchand CE Kim JT Glessner R Grabs T Casalunovo SP Taback EC Frackelton ML Lawson LJ Robinson R Skraban Y Lu RM Chiavacci CA Stanley SE Kirsch EF Rappaport JS Orange DS Monos M Devoto HQ Qu C Polychronakos 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene Nature 448 7153 591 594
16. D Marshall O Johnell H Wedel 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 312 1254 1259
17. JA Pasco E Seeman MJ Henry EN Merriman GC Nicholson MA Kotowicz 2006 The population burden of fractures originates in women with osteopenia, not osteoporosis Osteoporos Int 17 1404 1409
18. TP van Staa HG Leufkens C Cooper 2002 The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis Osteoporos Int 13 777 787
19. ME Charlson P Pompei KL Ales CR MacKenzie 1987 A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 373 383
20. S Schneeweiss PS Wang J Avorn RJ Glynn 2003 Improved comorbidity adjustment for predicting mortality in Medicare populations Health Serv Res 38 1103 1120
21. Y Hochberg Y Benjamini 1990 More powerful procedures for multiple significance testing Stat Med 9 811 818
22. P Vestergaard L Rejnmark L Mosekilde 2006 Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture Calcif Tissue Int 79 76 783
23. PS Wang RL Bohn RJ Glynn H Mogun J Avorn 2001 Zolpidem use and hip fractures in older people J Am Geriatr Soc 49 1685 1690
24. P Vestergaard L Rejnmark L Mosekilde 2006 Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture Osteoporos Int 17 807 816
25. WA Ray MR Griffin W Schaffner DK Baugh LJ Melton III 1987 Psychotropic drug use and the risk of hip fracture N Engl J Med 316 363 369
26. S Schneeweiss PS Wang 2004 Association between SSRI use and hip fractures and the effect of residual confounding bias in claims database studies J Clin Psychopharmacol 24 632 638
27. B Liu G Anderson N Mittmann T To T Axcell N Shear 1998 Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people Lancet 351 1303 1307
28. RI Shorr MR Griffin JR Daugherty WA Ray 1992 Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene J Gerontol 47 M111 M115
29. P Vestergaard L Rejnmark L Mosekilde 2006 Fracture risk associated with the use of morphine and opiates J Intern Med 260 76 87
30. P Vestergaard L Rejnmark L Mosekilde 2006 Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis Calcif Tissue Int 79 84 94
31. HA Fink MA Kuskowski ES Orwoll JA Cauley KE Ensrud 2005 Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study J Am Geriatr Soc 53 1559 1564
32. JL Schneider HA Fink SK Ewing KE Ensrud SR Cummings 2008 The association of Parkinson's disease with bone mineral density and fracture in older women Osteoporos Int 19 1093 1097
33. L Rejnmark P Vestergaard L Mosekilde 2006 Fracture risk in patients treated with loop diuretics J Intern Med 259 117 124
34. LS Lim HA Fink MA Kuskowski JA Cauley KE Ensrud 2005 Diuretic use and bone mineral density in older USA men: the osteoporotic fractures in men (MrOS) study Age Ageing 34 504 507
35. U Sennerby B Farahmand A Ahlbom S Ljunghall K Michaelsson 2007 Cardiovascular diseases and future risk of hip fracture in women Osteoporos Int 18 10 1355 1362
36. F Richy J Bousquet GE Ehrlich PJ Meunier E Israel H Morii JP Devogelaer N Peel M Haim O Bruyere JY Reginster 2003 Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review Osteoporos Int 14 179 190
37. F de Vries S Pouwels JW Lammers HG Leufkens M Bracke C Cooper TP van Staa 2007 Use of inhaled and oral glucocorticoids, severity of inflammatory disease and risk of hip/femur fracture: a population-based case-control study J Intern Med 261 170 177
38. N Bonnet N Laroche L Vico E Dolleans CL Benhamou D Courteix 2006 Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats J Pharmacol Exp Ther 318 1118 1127
39. N Bonnet C Gadois E McCloskey G Lemineur E Lespessailles D Courteix CL Benhamou 2007 Protective effect of beta blockers in postmenopausal women: influence on fractures, bone density, micro and macroarchitecture Bone 40 1209 1216
40. L Rejnmark P Vestergaard L Mosekilde 2006 Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case-control study J Hypertens 24 581 589
41. C Meisinger M Heier O Lang A Doring 2007 Beta-blocker use and risk of fractures in men and women from the general population: the MONICA/KORA Augsburg cohort study Osteoporos Int 18 1189 1195
42. L Rejnmark P Vestergaard M Kassem BR Christoffersen N Kolthoff K Brixen L Mosekilde 2004 Fracture risk in perimenopausal women treated with beta-blockers Calcif Tissue Int 75 365 372
43. F de Vries PC Souverein C Cooper HGM Leufkens TP van Staa 2007 Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and the Netherlands Calcif Tissue Int 80 69 75
44. V Ferencz S Meszaros E Csupor E Toth K Bors A Falus C Horvath 2006 Increased bone fracture prevalence in postmenopausal women suffering from pollen-allergy Osteoporos Int 17 484 491
45. RW Ross EJ Small 2002 Osteoporosis in men treated with androgen deprivation therapy for prostate cancer J Urol 167 1952 1956
46. VB Shahinian YF Kuo JL Freeman JS Goodwin 2006 Determinants of androgen deprivation therapy use for prostate cancer: role of the urologist J Natl Cancer Inst 98 839 845
47. J Morote JP Morin A Orsola JM Abascal C Salvador E Trilla CX Raventos L Cecchini G Encabo J Reventos 2007 Prevalence of osteoporosis during long-term androgen deprivation therapy in patients with prostate cancer Urology 69 500 504
48. MR Smith SP Boyce E Moyneur MS Duh MK Raut J Brandman 2006 Risk of clinical fractures after gonadotropin-releasing hormone agonist therapy for prostate cancer J Urol 175 136 139
49. AM Lopez MA Pena R Hernandez F Val B Martin JA Riancho 2005 Fracture risk in patients with prostate cancer on androgen deprivation therapy Osteoporos Int 16 707 711
50. P Vestergaard L Rejnmark L Mosekilde 2005 Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk Diabetologia 48 1292 1299
51. MK Clark MF Sowers F Dekordi S Nichols 2003 Bone mineral density and fractures among alcohol-dependent women in treatment and in recovery Osteoporos Int 14 396 403
52. RA Dhonukshe-Rutten SM Pluijm LC de Groot P Lips JH Smit WA van Staveren 2005 Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people J Bone Miner Res 20 921 929
53. Y Sato Y Honda J Iwamoto T Kanoko K Satoh 2005 Effect of folate and mecobalamin on Hip fractures in patients with stroke-a randomized controlled trial JAMA 293 1082 1088
54. ED Weinberg 2006 Iron loading: a risk factor for osteoporosis Biometals 19 633 635
55. The European Agency for the Evaluation of Medicinal Products. Points to consider on multiplicity issues in clinical trials, EMEA CPMP/EWP/908/99, London 2002). 2008; EMEA CPMP/EWP/908/99
56. F de Vries C de Vries C Cooper B Leufkens TP van Staa 2006 Reanalysis of two studies with contrasting results on the association between statin use and fracture risk: the General Practice Research Database Int J of Epid 35 1301 1308
57. L Rejnmark P Vestergaard L Mosekilde 2007 Fracture risk in users of oral anticoagulants: a nationwide case-control study Int J Cardiol 118 338 344
58. M Steinbuch TE Youket S Cohen 2004 Oral glucocorticoid use is associated with an increased risk of fracture Osteoporos Int 15 323 328
59. TP van Staa RF Laan IP Barton S Cohen DM Reid C Cooper 2003 Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy Arthritis Rheum 48 3224 3229
60. P Vestergaard ML Olsen JS Paaske L Rejnmark HT Sorensen L Mosekilde 2003 Corticosteroid use and risk of hip fracture: a population-based case-control study in Denmark J Intern Med 254 486 493
61. TP van Staa P Geusens JW Bijlsma HG Leufkens C Cooper 2006 Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis Arthritis Rheum 54 3104 3112
62. JA Grisso JL Kelsey LA O'Brien CG Miles S Sidney G Maislin K LaPann D Moritz B Peters 1997 Risk factors for hip fracture in men. Hip Fracture Study Group Am J Epidemiol 145 786 793
63. VB Shahinian YF Kuo JL Freeman JS Goodwin 2005 Risk of fracture after androgen deprivation for prostate cancer N Engl J Med 352 154 164
64. PC Souverein DJ Webb JG Weil TP van Staa AC Egberts 2006 Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy Neurology 66 1318 1324
65. P Vestergaard 2005 Epilepsy, osteoporosis and fracture risk-a meta-analysis Acta Neurol Scand 112 277 286
66. P Vestergaard S Tigaran L Rejnmark C Tigaran M Dam L Mosekilde 1999 Fracture risk is increased in epilepsy Acta Neurol Scand 99 269 275
67. JS Teo NK Briffa A Devine SS Dhaliwal RL Prince 2006 Do sleep problems or urinary incontinence predict falls in elderly women? Aust J Physiother 52 19 24
68. AY Avidan BE Fries ML James KL Szafara GT Wright RD Chervin 2005 Insomnia and hypnotic use, recorded in the minimum data set, as predictors of falls and hip fractures in Michigan nursing homes J Am Geriatr Soc 53 955 962
69. WA Ray MR Griffin E Malcolm 1991 Cyclic antidepressants and the risk of hip fracture Arch Intern Med 151 754 756
70. R Hubbard P Farrington C Smith L Smeeth A Tattersfield 2003 Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture Am J Epidemiol 158 77 84
71. MA Whooley KE Kip JA Cauley KE Ensrud MC Nevitt WS Browner 1999 Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group Arch Intern Med 159 484 490