Depressive symptoms, bone loss, and fractures in postmenopausal women

Journal of General Internal Medicine

Volumn 23, Issue 5, 2008, Pages 567-574

  Spangler, Leslie ^a   Scholes, Delia ^a   Brunner, Robert L ^b   Robbins, John ^c   Reed, Susan D ^a,d,e,f   Newton, Katherine M ^a,d   Melville, Jennifer L ^a,f   Lacroix, Andrea Z ^a,d,e  

^a CENTER FOR HEALTH STUDIES   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressants; Bone density; Depressive symptoms; Fractures; Prospective

Indexed keywords

ANTIDEPRESSANT AGENT; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ANATOMY; ARTICLE; BONE DENSITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DENSITOMETRY; DEPRESSION; FEMALE; FRACTURE; HAZARD RATIO; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL INFORMATION; OSTEOLYSIS; OUTCOME ASSESSMENT; POSTMENOPAUSE; PROSPECTIVE STUDY; SELF REPORT; SPINE FRACTURE; STATISTICAL SIGNIFICANCE; WRIST FRACTURE; MIDDLE AGED; POSTMENOPAUSE OSTEOPOROSIS; PSYCHOLOGICAL ASPECT;

AGED; ANTIDEPRESSIVE AGENTS; BONE DENSITY; DEPRESSION; FEMALE; FRACTURES, BONE; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; PROSPECTIVE STUDIES;

EID: 42449154971     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-008-0525-0     Document Type: Article

References (53)

1. National Osteoporosis Foundation. NOF Advocacy - The State of Osteoporosis and Low Bone Mass in the US. Available at: http://www.nof.org/ advocacy/prevalence/. Accessed January 18, 2008.
2. Hasin DS, Goodwin RD, Stinson FS, Grant BF. Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry. 2005;62:1097-106.
3. Murphy BE. Steroids and depression. J Steroid Biochem Mol Biol. 1991;38:537-59.
4. Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev. 2005;4:141-94.
5. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuro-psychopharmacol Biol Psychiatry. 2005;29:201-17.
6. Eskandari F, Martinez PE, Torvik S, et al. Low bone mass in premenopausal women with depression. Arch Intern Med. 2007;167(21)2329-36.
7. Hofbauer LC, Khosla S, Dunstan C, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000;15:2-12.
8. Kahl KG, Rudolf S, Stoeckelhuber BM, et al. Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder. Am J Psychiatry. 2005;162:168-74.
9. Warden SJ, Bliziotes MM, Wiren KM, Eshleman AJ, Turner CH. Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine). Mol Cell Endocrinol. 2005;242:1-9.
10. Bliziotes M, Eshleman A, Burt-Pichat B, et al. Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells. Bone. 2006;39:1313-21.
11. Bliziotes MM, Eshleman AJ, Zhang XW, Wiren KM. Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake. Bone. 2001;29:477-86.
12. Battaglino R, Fu J, Spate U, et al. Serotonin regulates osteoclast differentiation through its transporter. J Bone Miner Res. 2004;19:1420-31.
13. Gustafsson BI, Thommesen L, Stunes AK, et al. Serotonin and fluoxetine modulate bone cell function in vitro. J Cell Biochem. 2006;98:139-51.
14. Michelson D, Stratakis C, Hill L, et al. Bone mineral density in women with depression. N Engl J Med. 1996;335:1176-81.
15. Milliken LA, Wilhelmy J, Martin CJ, et al. Depressive symptoms and changes in body weight exert independent and site-specific effects on bone in postmenopausal women exercising for 1 year. J Gerontol A Biol Sci Med Sci. 2006;61:488-94.
16. Diem SJ, Blackwell TL, Stone KL, et al. Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc. 2007;55:824-31.
17. Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS. Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1999;159:484-90.
18. Sogaard AJ, Joakimsen RM, Tverdal A, Fonnebo V, Magnus JH, Berntsen GK. Long-term mental distress, bone mineral density and non-vertebral fractures. The Tromso Study. Osteoporos Int. 2005;16:887-97.
19. Forsen L, Meyer HE, Sogaard AJ, Naess S, Schei B, Edna TH. Mental distress and risk of hip fracture. Do broken hearts lead to broken bones? J Epidemiol Community Health. 1999;53:343-7.
20. Mussolino ME. Depression and hip fracture risk: the NHANES I epidemiologic follow-up study. Public Health Rep. 2005;120:71-5.
21. Langer RD, White E, Lewis CE, Kotchen JM, Hendrix SL, Trevisan M. The Women's Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol. 2003;13:S107-21.
22. LaCroix AZ, Cauley JA, Pettinger M, et al. Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational Study. Ann Intern Med. 2003;139:97-104.
23. WHI Study Group. Design of the Women's Health Initiative clinical trial and observational study. Control Clin Trials. 1998;19:61-109.
24. Hays J, Hunt JR, Hubbell FA, et al. The Women's Health Initiative recruitment methods and results. Ann Epidemiol. 2003;13:S18-77.
25. Curb JD, McTiernan A, Heckbert SR, et al. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann Epidemiol. 2003;13:S122-8.
26. Anderson GL, Manson J, Wallace R, et al. Implementation of the Women's Health Initiative study design. Ann Epidemiol. 2003;13:S5-17.
27. Burnam MA, Wells KB, Leake B, Landsverk J. Development of a brief screening instrument for detecting depressive disorders. Med Care. 1988;26:775-89.
28. Tuunainen A, Langer RD, Klauber MR, Kripke DF. Short version of the CES-D (Burnam screen) for depression in reference to the structured psychiatric interview. Psychiatry Res. 2001;103:261-70.
29. WHI Clinical Coordinating Center. WHI Scientific Resources website: Data Collection Procedures. Available at: http://www.whiscience.org/about/collection. php. Accessed January 18, 2008.
30. DXA Quality Assurance. Available at: www.nhlbi.nih.gov/resources/deca/ whios/studydoc/procedur/bone/1.pdf. Accessed January 18, 2008.
31. Chen Z, Kooperberg C, Pettinger MB, et al. Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials. Menopause. 2004;11:264-74.
32. Bauer DC, Browner WS, Cauley JA, et al. Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann Intern Med. 1993;118:657-65.
33. Greenland S, Rothman KJ. Modern Epidemiology. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1998.
34. Ensrud KE, Blackwell TL, Mangione CM, et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc. 2002;50:1629-37.
35. Yazici KM, Akinci A, Sutcu A, Ozcakar L. Bone mineral density in premenopausal women with major depressive disorder. Psychiatry Res. 2003;117:271-5.
36. Furlan PM, Ten Have T, Cary M, et al. The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density. Biol Psychiatry. 2005;57:911-7.
37. Mussolino ME, Jonas BS, Looker AC. Depression and bone mineral density in young adults: results from NHANES III. Psychosom Med. 2004;66:533-7.
38. Diem SJ, Blackwell TL, Stone KL, et al. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med. 2007;167:1240-5.
39. Ensrud KE, Blackwell T, Mangione CM, et al. Central nervous system active medications and risk for fractures in older women. Arch Intern Med. 2003;163:949-57.
40. Richards JB, Papaioannou A, Adachi JD, et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med. 2007;167:188-94.
41. Vestergaard P, Rejnmark L, Mosekilde L. Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture. Osteoporos Int. 2006;17:807-16.
42. French DD, Campbell R, Spehar A, Cunningham F, Foulis P. Outpatient medications and hip fractures in the US: a national veterans study. Drugs Aging. 2005;22:877-85.
43. Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N. Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet. 1998;351:1303-7.
44. Hubbard R, Farrington P, Smith C, Smeeth L, Tattersfield A. Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol. 2003;158:77-84.
45. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ 3rd. Psychotropic drug use and the risk of hip fracture. N Engl J Med. 1987;316:363-9.
46. Ray WA, Griffin M, Malcolm E. Cyclic antidepressants and the risk of hip fracture. Arch Intern Med. 1991;151:754-6.
47. Schneeweiss S, Wang PS. Association between SSRI use and hip fractures and the effect of residual confounding bias in claims database studies. J Clin Psychopharmacol. 2004;24:632-8.
48. Fink HA, Milavetz DL, Palermo L, et al. What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa? J Bone Miner Res. 2005;20:1216-22.
49. Majumdar SR, Kim N, Colman I, et al. Incidental vertebral fractures discovered with chest radiography in the emergency department: prevalence, recognition, and osteoporosis management in a cohort of elderly patients. Arch Intern Med. 2005;165:905-9.
50. Johnson J, Weissman MM, Klerman GL. Service utilization and social morbidity associated with depressive symptoms in the community. JAMA. 1992;267:1478-83.
51. Simon G, Ormel J, VonKorff M, Barlow W. Health care costs associated with depressive and anxiety disorders in primary care. Am J Psychiatry. 1995;152:352-7.
52. Hansen MS, Fink P, Frydenberg M, Oxhoj ML. Use of health services, mental illness, and self-rated disability and health in medical inpatients. Psychosom Med. 2002;64:668-75.
53. Duddu V, Isaac MK, Chaturvedi SK. Somatization, somatosensory amplification, attribution styles and illness behaviour: a review. Int Rev Psychiatry. 2006;18:25-33.