Na+,K+-ATPase as a docking station: Protein-protein complexes of the Na+,K+-ATPase

Cellular and Molecular Life Sciences

Volumn 70, Issue 2, 2013, Pages 205-222

  Reinhard, Linda ^a   Tidow, Henning ^a   Clausen, Michael J ^a   Nissen, Poul ^a  

^a DANISH NATIONAL RESEARCH FOUNDATION   (Denmark)

Author keywords

Cardiotonic steroids; Na+,K+ ATPase; Protein protein complexes; Signaling; Src kinase

Indexed keywords

ADDUCIN; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA3; AMPA RECEPTOR; AQUAPORIN 4; COFILIN; DOPAMINE RECEPTOR; FOLLISTATIN; FOLLISTATIN LIKE 1; GLUTAMATE TRANSPORTER; ISOENZYME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEIN PHOSPHATASE 2A; POLYCYSTIN 1; PROTEIN TYROSINE KINASE; SALT INDUCIBLE KINASE 1; SODIUM CHANNEL; TRANSLATIONALLY CONTROLLED TUMOR PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; CAVEOLA; CELL LEVEL; CELLULAR DISTRIBUTION; CHANNEL GATING; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; INTRACELLULAR SIGNALING; MEMBRANE STRUCTURE; MOLECULAR DOCKING; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SODIUM TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL MEMBRANE; HUMANS; ION TRANSPORT; MULTIPROTEIN COMPLEXES; POTASSIUM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SODIUM; SODIUM-POTASSIUM-EXCHANGING ATPASE;

ANIMALIA;

EID: 84872278697     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1039-9     Document Type: Review

References (162)

1. Skou JC (1957) The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim Biophys Acta 23:394-401
2. Pedersen PL, Carafoli E (1987) Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem Sci 12:146-150. doi: 10.1016/0968-0004(87)90071-5
3. Erecinska M, Silver IA (1994) Ions and energy in mammalian brain. Prog Neurobiol 43:37-71
4. Craig WS, Kyte J (1980) Stoichiometry and molecular weight of the minimum asymmetric unit of canine renal sodium and potassium ion-Activated adenosine triphosphatase. J Biol Chem 255:6262-6269
5. +-ATPase alpha-subunit from rat brain. Biochemistry 25:8125-8132
6. Pressley TA, Allen JC, Clarke CH, Odebunmi T, Higham SC (1996) Amino-terminal processing of the catalytic subunit from Na(+)-K(+)-ATPase. Am J Physiol 271:C825-C832
7. Poulsen H, Khandelia H, Morth JP, Bublitz M, Mouritsen OG, Egebjerg J, Nissen P (2010) Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase. Nature 467:99-102. doi: 10.1038/nature09309
8. Ackermann U, Geering K (1990) Mutual dependence of Na, K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport. FEBS Lett 269:105-108
9. Geering K (2001) The functional role of beta subunits in oligomeric P-type ATPases. J Bioenerg Biomembr 33:425-438
10. +-ATPase. J Cell Sci 125:1605-1616. doi: 10.1242/jcs.100149
11. Geering K (2005) Function of FXYD proteins, regulators of Na, K-ATPase. J Bioenerg Biomembr 37:387-392. doi: 10.1007/s10863-005-9476-x
12. Sweadner KJ, Rael E (2000) The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68:41-56. doi: 10.1006/geno.2000.6274
13. Geering K (2006) FXYD proteins: new regulators of Na-K-ATPase. Am J Physiol Ren Physiol 290:F241-F250. doi: 10.1152/ajprenal.00126.2005
14. Morth JP, Pedersen BP, Toustrup-Jensen MS, Sorensen TL, Petersen J, Andersen JP, Vilsen B, Nissen P (2007) Crystal structure of the sodium-potassium pump. Nature 450:1043-1049. doi: 10.1038/nature06419
15. +-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci USA 106:13742-13747. doi: 10.1073/pnas.0907054106
16. Shinoda T, Ogawa H, Cornelius F, Toyoshima C (2009) Crystal structure of the sodium-potassium pump at 2.4 A resolution. Nature 459:446-450. doi: 10.1038/nature07939
17. +-ATPase. J Struct Biol 174:296-306. doi: 10.1016/j.jsb.2010.12.004
18. Lingrel JB (2010) The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na, K-ATPase. Annu Rev Physiol 72:395-412. doi: 10.1146/annurev-physiol-021909-135725
19. Crambert G, Hasler U, Beggah AT, Yu C, Modyanov NN, Horisberger JD, Lelievre L, Geering K (2000) Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem 275:1976-1986
20. Wang J, Velotta JB, McDonough AA, Farley RA (2001) All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am J Physiol Cell Physiol 281:C1336-C1343
21. Sanchez G, Nguyen AN, Timmerberg B, Tash JS, Blanco G (2006) The Na, K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility. Mol Hum Reprod 12:565-576. doi: 10.1093/molehr/gal062
22. Sonntag Y, Musgaard M, Olesen C, Schiott B, Moller JV, Nissen P, Thogersen L (2011) Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes. Nat Commun 2:304. doi: 10.1038/ncomms1307
23. Hasler U, Wang X, Crambert G, Beguin P, Jaisser F, Horisberger JD, Geering K (1998) Role of beta-subunit domains in the assembly, stable expression, intracellular routing, and functional properties of Na, K-ATPase. J Biol Chem 273:30826-30835
24. Beggah A, Mathews P, Beguin P, Geering K (1996) Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na, K-ATPase correlate with interaction of BiP. J Biol Chem 271:20895-20902
25. Geering K, Kraehenbuhl JP, Rossier BC (1987) Maturation of the catalytic alpha-subunit of Na, K-ATPase during intracellular transport. J Cell Biol 105:2613-2619
26. Beguin P, Hasler U, Beggah A, Horisberger JD, Geering K (1998) Membrane integration of Na, K-ATPase alpha-subunits and beta-subunit assembly. J Biol Chem 273:24921-24931
27. Morton MJ, Farr GA, Hull M, Capendeguy O, Horisberger JD, Caplan MJ (2010) Association with beta-COP regulates the trafficking of the newly synthesized Na, K-ATPase. J Biol Chem 285:33737-33746. doi: 10.1074/jbc.M110. 141119
28. Farr GA, Hull M, Mellman I, Caplan MJ (2009) Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol 186:269-282. doi: 10.1083/jcb.200901021
29. Razani B, Woodman SE, Lisanti MP (2002) Caveolae: from cell biology to animal physiology. Pharmacol Rev 54:431-467
30. Liu P, Rudick M, Anderson RG (2002) Multiple functions of caveolin-1. J Biol Chem 277:41295-41298. doi: 10.1074/jbc.R200020200
31. Williams TM, Lisanti MP (2004) The caveolin proteins. Genome Biol 5:214. doi: 10.1186/gb-2004-5-3-214
32. +-ATPase. J Biol Chem 279:17250-17259. doi: 10.1074/jbc.M313239200
33. +-ATPase and Ca2-ATPase, the gatekeeper and the pivot. J Bioenerg Biomembr 39:357-366. doi: 10.1007/s10863-007-9106-x
34. + formed by elongation of A-domain/M1′-linker and beryllium fluoride binding. J Biol Chem 285:24538-24547. doi: 10.1074/jbc.M110.144535
35. Cai T, Wang H, Chen Y, Liu L, Gunning WT, Quintas LE, Xie ZJ (2008) Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. J Cell Biol 182:1153-1169. doi: 10.1083/jcb.200712022
36. +-ATPase. Am J Physiol Cell Physiol 284:C1550-C1560. doi: 10.1152/ajpcell.00555.2002
37. Liang M, Tian J, Liu L, Pierre S, Liu J, Shapiro J, Xie ZJ (2007) Identification of a pool of non-pumping Na/K-ATPase. J Biol Chem 282:10585-10593. doi: 10.1074/jbc.M609181200
38. Liu L, Ivanov AV, Gable ME, Jolivel F, Morrill GA, Askari A (2011) Comparative properties of caveolar and noncaveolar preparations of kidney Na(+)/K(+)-ATPase. Biochemistry 50:8664-8673. doi: 10.1021/bi2009008
39. Barlet-Bas C, Khadouri C, Marsy S, Doucet A (1990) Enhanced intracellular sodium concentration in kidney cells recruits a latent pool of Na-K-ATPase whose size is modulated by corticosteroids. J Biol Chem 265:7799-7803
40. +-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression. Mol Biol Cell 21:4400-4408. doi: 10.1091/mbc.E10-06-0507
41. McGrail K, Phillips J, Sweadner K (1991) Immunofluorescent localization of three Na, K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na, K-ATPase. J Neurosci Off J Soc Neurosci 11:381-472
42. Bottger P, Tracz Z, Heuck A, Nissen P, Romero-Ramos M, Lykke-Hartmann K (2011) Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain. J Comp Neurol 519:376-780. doi: 10.1002/cne.22524
43. + pump current dynamics. Nat Neurosci 13:53-62. doi: 10.1038/nn.2444
44. + buffers control the strength of a fast post-tetanic hyperpolarization mediated by the alpha3 Na(+)/K(+)-ATPase. Nat Neurosci 10:196-401. doi: 10.1038/nn1839
45. +-ATPase in dendritic spines dissected by nanoscale superresolution STED microscopy. BMC Neurosci 12:16
46. + channels by interaction with a family of membrane-Associated guanylate kinases. Nature 378:85-93. doi: 10.1038/378085a0
47. Kornau H, Schenker L, Kennedy M, Seeburg P (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (New York, NY) 269:1737-1777
48. Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl T, Südhof T (1997) Binding of neuroligins to PSD-95. Science (New York, NY) 277:1511-1516
49. +-ATPase alpha subunit in the synaptic plasma membrane of rat brain. Neurosci Lett 413:42-47. doi: 10.1016/j.neulet.2006.11.061
50. Schoner W, Scheiner-Bobis G (2007) Endogenous and exogenous cardiac glycosides and their mechanisms of action. Am J Cardiovasc Drugs 7:173-189
51. Hamlyn JM, Blaustein MP, Bova S, DuCharme DW, Harris DW, Mandel F, Mathews WR, Ludens JH (1991) Identification and characterization of a ouabain-like compound from human plasma. Proc Natl Acad Sci USA 88:6259-6263
52. Bagrov AY, Shapiro JI (2008) Endogenous digitalis: pathophysiologic roles and therapeutic applications. Nat Clin Pract Nephrol 4:378-392. doi: 10.1038/ncpneph0848
53. Aydemir-Koksoy A, Abramowitz J, Allen JC (2001) Ouabain-induced signaling and vascular smooth muscle cell proliferation. J Biol Chem 276:46605-46611. doi: 10.1074/jbc.M106178200
54. +-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-Activated protein kinases. J Biol Chem 277:18694-18702. doi: 10.1074/jbc.M111357200
55. Kulikov A, Eva A, Kirch U, Boldyrev A, Scheiner-Bobis G (2007) Ouabain activates signaling pathways associated with cell death in human neuroblastoma. Biochim Biophys Acta 1768:1691-1702. doi: 10.1016/j.bbamem.2007.04.012
56. Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP et al (2009) Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Res 69:6556-6564. doi: 10.1158/0008-5472.CAN-09-0891
57. Thomas SM, Brugge JS (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13:513-609. doi: 10.1146/annurev.cellbio.13.1. 513
58. Aleshin A, Finn RS (2010) SRC: a century of science brought to the clinic. Neoplasia 12:599-607
59. Moran MF, Koch CA, Anderson D, Ellis C, England L, Martin GS, Pawson T (1990) Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci USA 87:8622-8626
60. Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL (1992) Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science 258:1665-1668
61. Machida K, Mayer BJ (2005) The SH2 domain: versatile signaling module and pharmaceutical target. Biochim Biophys Acta 1747:1-25. doi: 10.1016/j.bbapap.2004.10.005
62. Kaneko T, Li L, Li SS (2008) The SH3 domain-A family of versatile peptide- and protein-recognition module. Front Biosci 13:4938-4952
63. MacAuley A, Cooper JA (1989) Structural differences between repressed and derepressed forms of p60c-src. Mol Cell Biol 9:2648-2656
64. Xu W, Harrison SC, Eck MJ (1997) Three-dimensional structure of the tyrosine kinase c-Src. Nature 385:595-602. doi: 10.1038/385595a0
65. Cowan-Jacob SW, Fendrich G, Manley PW, Jahnke W, Fabbro D, Liebetanz J, Meyer T (2005) The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation. Structure 13:861-871. doi: 10.1016/j.str.2005.03.012
66. +-ATPase forms a functional signaling complex. Mol Biol Cell 17:317-326. doi: 10.1091/mbc.E05-08-0735
67. Li Z, Cai T, Tian J, Xie JX, Zhao X, Liu L, Shapiro JI, Xie Z (2009) NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-Activated signal transduction in cultured cells. J Biol Chem 284:21066-21076. doi: 10.1074/jbc.M109.013821
68. Ye Q, Li Z, Tian J, Xie JX, Liu L, Xie Z (2011) Identification of a potential receptor that couples ion transport to protein kinase activity. J Biol Chem 286:6225-6232. doi: 10.1074/jbc.M110.202051
69. Li Z, Zhang Z, Xie JX, Li X, Tian J, Cai T, Cui H, Ding H, Shapiro JI, Xie Z (2011) Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells. J Biol Chem 286:32394-32403. doi: 10.1074/jbc.M110.207597
70. Olesen C, Picard M, Winther AM, Gyrup C, Morth JP, Oxvig C, Moller JV, Nissen P (2007) The structural basis of calcium transport by the calcium pump. Nature 450:1036-1042. doi: 10.1038/nature06418
71. Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON (1992) A limited set of SH2 domains binds BCR through a high-Affinity phosphotyrosine-independent interaction. Mol Cell Biol 12:5087-5093
72. Raffel GD, Parmar K, Rosenberg N (1996) In vivo association of v-Abl with Shc mediated by a non-phosphotyrosine-dependent SH2 interaction. J Biol Chem 271:4640-4645
73. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ (1999) Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell 4:555-561
74. Huang Q, Szebenyi DM (2010) Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4. J Biol Chem 285:42130-42139. doi: 10.1074/jbc.M110.143412
75. Karpova LV, Bulygina ER, Boldyrev AA (2010) Different neuronal Na(+)/K(+)-ATPase isoforms are involved in diverse signaling pathways. Cell Biochem Funct 28:135-141. doi: 10.1002/cbf.1632
76. Konrad L, Dietze R, Kirch U, Kirch H, Eva A, Scheiner-Bobis G (2011) Cardiotonic steroids trigger non-classical testosterone signaling in Sertoli cells via the alpha4 isoform of the sodium pump. Biochim Biophys Acta 1813:2118-2124. doi: 10.1016/j.bbamcr.2011.07.012
77. Weigand KM, Swarts HG, Fedosova NU, Russel FG, Koenderink JB (2012) Na, K-ATPase activity modulates Src activation: a role for ATP/ADP ratio. Biochim Biophys Acta 1818:1269-1273. doi: 10.1016/j.bbamem.2012.01.015
78. +-ATPase. J Biol Chem 275:27832-27837. doi: 10.1074/jbc.M002951200
79. Schoner W, Scheiner-Bobis G (2007) Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293:C509-C536. doi: 10.1152/ajpcell.00098.2007
80. 2+ concentrations. J Biol Chem 275:27838-27844. doi: 10.1074/jbc.M002950200
81. Kominato R, Fujimoto S, Mukai E, Nakamura Y, Nabe K, Shimodahira M, Nishi Y, Funakoshi S, Seino Y, Inagaki N (2008) Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets. Diabetologia 51:1226-1235. doi: 10.1007/s00125-008-1008-x
82. Yuan Z, Cai T, Tian J, Ivanov AV, Giovannucci DR, Xie Z (2005) Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. Mol Biol Cell 16:4034-4045. doi: 10.1091/mbc.E05-04-0295
83. Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS (2010) A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation. Exp Mol Med 42:216-227
84. 2+ entry through plasma membrane IP3 receptors. Science 313:229-233. doi: 10.1126/science.1125203
85. Zhang S, Malmersjo S, Li J, Ando H, Aizman O, Uhlen P, Mikoshiba K, Aperia A (2006) Distinct role of the N-terminal tail of the Na, K-ATPase catalytic subunit as a signal transducer. J Biol Chem 281:21954-21962. doi: 10.1074/jbc.M601578200
86. Aperia A (2007) New roles for an old enzyme: Na, K-ATPase emerges as an interesting drug target. J Intern Med 261:44-52. doi: 10.1111/j.1365-2796.2006. 01745.x
87. Miyakawa-Naito A, Uhlen P, Lal M, Aizman O, Mikoshiba K, Brismar H, Zelenin S, Aperia A (2003) Cell signaling microdomain with Na, K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem 278:50355-50361. doi: 10.1074/jbc.M305378200
88. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657. doi: 10.1126/science.296.5573.1655
89. +-ATPase alpha subunit and regulates its trafficking. Proc Natl Acad Sci USA 97:6556-6561. doi: 10.1073/pnas.100128297
90. Zhou X, Jiang G, Zhao A, Bondeva T, Hirszel P, Balla T (2001) Inhibition of Na, K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells. Biochem Biophys Res Commun 285:46-51. doi: 10.1006/bbrc.2001.5126
91. Liu L, Zhao X, Pierre SV, Askari A (2007) Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am J Physiol Cell Physiol 293:C1489-C1497. doi: 10.1152/ajpcell.00158.2007
92. Eva A, Kirch U, Scheiner-Bobis G (2006) Signaling pathways involving the sodium pump stimulate NO production in endothelial cells. Biochim Biophys Acta 1758:1809-1814. doi: 10.1016/j.bbamem.2006.09.006
93. Liu J, Kesiry R, Periyasamy SM, Malhotra D, Xie Z, Shapiro JI (2004) Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int 66:227-241. doi: 10.1111/j.1523-1755. 2004.00723.x
94. Jung J, Kim M, Kim MJ, Kim J, Moon J, Lim JS, Lee K (2004) Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na, K-ATPase alpha subunit and inhibits the pump activity in HeLa cells. J Biol Chem 279:49868-49875. doi: 10.1074/jbc.M400895200
95. Jung J, Kim HY, Kim M, Sohn K, Lee K (2011) Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene 30:2264-2274. doi: 10.1038/onc.2010.604
96. Matsuoka Y, Li X, Bennett V (2000) Adducin: structure, function and regulation. Cell Mol Life Sci 57:884-895
97. Bennett V (1989) The spectrin-Actin junction of erythrocyte membrane skeletons. Biochim Biophys Acta 988:107-121
98. Kuhlman PA, Hughes CA, Bennett V, Fowler VM (1996) A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. J Biol Chem 271:7986-7991
99. Fukata Y, Oshiro N, Kinoshita N, Kawano Y, Matsuoka Y, Bennett V, Matsuura Y, Kaibuchi K (1999) Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol 145:347-361
100. Hughes CA, Bennett V (1995) Adducin: a physical model with implications for function in assembly of spectrin-Actin complexes. J Biol Chem 270:18990-18996
101. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G (1996) Hypertension-Associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 97:2815-2822. doi: 10.1172/JCI118737
102. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, Leoni P, Torielli L, Cusi D, Ferrandi M et al (1994) Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91:3999-4003
103. Ferrandi M, Salardi S, Tripodi G, Barassi P, Rivera R, Manunta P, Goldshleger R, Ferrari P, Bianchi G, Karlish SJ (1999) Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension. Am J Physiol 277:H1338-H1349
104. Ferrandi M, Molinari I, Torielli L, Padoani G, Salardi S, Rastaldi MP, Ferrari P, Bianchi G (2010) Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies. Sci Transl Med 2:59ra86. doi: 10.1126/scitranslmed.3001815
105. Ferrari P, Torielli L, Ferrandi M, Padoani G, Duzzi L, Florio M, Conti F, Melloni P, Vesci L, Corsico N et al (1998) PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain. J Pharmacol Exp Ther 285:83-94
106. Ferrari P, Ferrandi M, Tripodi G, Torielli L, Padoani G, Minotti E, Melloni P, Bianchi G (1999) PST 2238: a new antihypertensive compound that modulates Na, K-ATPase in genetic hypertension. J Pharmacol Exp Ther 288:1074-1083
107. +-ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290:R529-R535. doi: 10.1152/ajpregu. 00518.2005
108. Ye Q, Li Z, Tian J, Xie JX, Liu L, Xie Z (2011) Identification of a potential receptor that couples ion transport to protein kinase activity. J Biol Chem 286:6225-6232. doi: 10.1074/jbc.M110.202051
109. +-dependent ATPase activity and pump function in corneal endothelial cells. Cornea 30(Suppl 1):S60-S66. doi: 10.1097/ICO.0b013e318227faab
110. Pierre SV, Belliard A, Sottejeau Y (2011) Modulation of Na(+)-K(+)-ATPase cell surface abundance through structural determinants on the alpha1-subunit. Am J Physiol Cell Physiol 300:C42-C48. doi: 10.1152/ajpcell.00386.2010
111. Arystarkhova E, Sweadner KJ (2005) Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidney. J Bioenerg Biomembr 37:381-386. doi: 10.1007/s10863-005-9475-y
112. +-ATPase endocytosis. J Biol Chem 273:8814-8819
113. Efendiev R, Bertorello AM, Pressley TA, Rousselot M, Feraille E, Pedemonte CH (2000) Simultaneous phosphorylation of Ser11 and Ser18 in the alpha-subunit promotes the recruitment of Na(+), K(+)-ATPase molecules to the plasma membrane. Biochemistry 39:9884-9892
114. Taub M, Springate JE, Cutuli F (2010) Targeting of renal proximal tubule Na, K-ATPase by salt-inducible kinase. Biochem Biophys Res Commun 393:339-344. doi: 10.1016/j.bbrc.2010.02.037
115. Sjostrom M, Stenstrom K, Eneling K, Zwiller J, Katz AI, Takemori H, Bertorello AM (2007) SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proc Natl Acad Sci USA 104:16922-16927. doi: 10.1073/pnas.0706838104
116. Kovacs KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (2007) TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc Natl Acad Sci USA 104:4700-4705. doi: 10.1073/pnas.0607524104
117. +-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure. J Hypertens 29:2395-2403. doi: 10.1097/HJH.0b013e32834d3d55
118. Lee K, Jung J, Kim M, Guidotti G (2001) Interaction of the alpha subunit of Na, K-ATPase with cofilin. Biochem J 353:377-385
119. Jung J, Yoon T, Choi EC, Lee K (2002) Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na, K-ATPase via Rho-mediated signaling pathway. J Biol Chem 277:48931-48937. doi: 10.1074/jbc.M208806200
120. Kim M, Jung J, Park CS, Lee K (2002) Identification of the cofilin-binding sites in the large cytoplasmic domain of Na, K-ATPase. Biochimie 84:1021-1029
121. Jung J, Kim M, Choi S, Kim MJ, Suh JK, Choi EC, Lee K (2006) Molecular mechanism of cofilin dephosphorylation by ouabain. Cell Signal 18:2033-2040. doi: 10.1016/j.cellsig.2006.03.014
122. Grabarek Z (2006) Structural basis for diversity of the EF-hand calcium-binding proteins. J Mol Biol 359:509-525. doi: 10.1016/j.jmb.2006.03.066
123. +-ATPase. Neuron 69:974-987. doi: 10.1016/j.neuron.2011.01.022
124. Amara SG, Fontana AC (2002) Excitatory amino acid transporters: keeping up with glutamate. Neurochem Int 41:313-318
125. Shigeri Y, Seal RP, Shimamoto K (2004) Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev 45:250-265. doi: 10.1016/j.brainresrev.2004.04.004
126. Kanner BI (2006) Structure and function of sodium-coupled GABA and glutamate transporters. J Membr Biol 213:89-100. doi: 10.1007/s00232-006-0877-5
127. Li S, Stys PK (2001) Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter. Neuroscience 107:675-683
128. Rose EM, Koo JC, Antflick JE, Ahmed SM, Angers S, Hampson DR (2009) Glutamate transporter coupling to Na, K-ATPase. J Neurosci 29:8143-8155. doi: 10.1523/JNEUROSCI.1081-09.2009
129. Gegelashvili M, Rodriguez-Kern A, Sung L, Shimamoto K, Gegelashvili G (2007) Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes. Neurochem Int 50:916-920. doi: 10.1016/j.neuint.2006.12.015
130. Xie Z (2003) Molecular mechanisms of Na/K-ATPase-mediated signal transduction. Ann N Y Acad Sci 986:497-503
131. +] sensing. Neuron 54:59-72. doi: 10.1016/j.neuron.2007.03.014
132. Bertorello A, Hopfield J, Aperia A, Greengard P (1990) Inhibition by dopamine of (Na(+)+K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism. Nature 347:386-394. doi: 10.1038/347386a0
133. +-ATPase isoforms in rat neostriatum by dopamine and protein kinase C. J Neurochem 73:1492-1993
134. +-ATPase activity via a selective effect on the alpha3 isozyme. Proc Natl Acad Sci U S A 93:8034-8043
135. Callier S, Snapyan M, Le Crom S, Prou D, Vincent J-D, Vernier P (2003) Evolution and cell biology of dopamine receptors in vertebrates. Biol Cell Under Auspices Eur Cell Biol Organ 95:489-991
136. Zhang L, Guo F, Guo H, Wang H, Zhang Z, Liu X, Shi X, Gou X, Su Q, Yin J
137. +-ATPase. FEBS Lett 584:2589-2684. doi: 10.1016/j.febslet.2010.04.035
138. +-ATPases in dendritic spines dissected by STED microscopy. Microsc Res Tech. doi: 10.1002/jemt.21046
139. +-ATPase. J Biol Chem 283:36441-36494. doi: 10.1074/jbc.M805520200
140. +-ATPase in the striatum upon activation of opioid receptors by morphine. Mol Pharmacol 71:519-530. doi: 10.1124/mol.106.029561
141. Bianchi G, Fox U, Di Francesco GF, Bardi U, Radice M (1973) The hypertensive role of the kidney in spontaneously hypertensive rats. Clin Sci Mol Med Suppl 45(Suppl 1):135s-139s
142. Dahl LK, Heine M, Thompson K (1972) Genetic influence of renal homografts on the blood pressure of rats from different strains. Proc Soc Exp Biol Med 140:852-856
143. Alexander RW, Gill JR Jr, Yamabe H, Lovenberg W, Keiser HR (1974) Effects of dietary sodium and of acute saline infusion on the interrelationship between dopamine excretion and adrenergic activity in man. J Clin Invest 54:194-200. doi: 10.1172/JCI107743
144. Bertorello AM, Katz AI (1993) Short-term regulation of renal Na-K-ATPase activity: physiological relevance and cellular mechanisms. Am J Physiol 265:F743-F755
145. +-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am J Physiol 254:F795-F801
146. Bacic D, Kaissling B, McLeroy P, Zou L, Baum M, Moe OW (2003) Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule. Kidney Int 64:2133-2141. doi: 10.1046/j.1523-1755.2003.00308.x
147. + exchange in renal brush border by D1 dopamine agonists. Am J Physiol 264:F1032-F1037
148. Carey RM (2001) Theodore cooper lecture: renal dopamine system: paracrine regulator of sodium homeostasis and blood pressure. Hypertension 38:297-302
149. Pedemonte CH, Efendiev R, Bertorello AM (2005) Inhibition of Na, K-ATPase by dopamine in proximal tubule epithelial cells. Semin Nephrol 25:322-327. doi: 10.1016/j.semnephrol.2005.03.007
150. Yingst DR, Massey KJ, Rossi NF, Mohanty MJ, Mattingly RR (2004) Angiotensin II directly stimulates activity and alters the phosphorylation of Na-K-ATPase in rat proximal tubule with a rapid time course. Am J Physiol Renal Physiol 287:F713-F721. doi: 10.1152/ajprenal.00065.2004
151. Lu M, Lee MD, Smith BL, Jung JS, Agre P, Verdijk MA, Merkx G, Rijss JP, Deen PM (1996) The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc Natl Acad Sci USA 93:10908-10912
152. Illarionova NB, Gunnarson E, Li Y, Brismar H, Bondar A, Zelenin S, Aperia A (2010) Functional and molecular interactions between aquaporins and Na, K-ATPase. Neuroscience 168:915-925. doi: 10.1016/j.neuroscience.2009.11.062
153. Zhang D, Hou Q, Wang M, Lin A, Jarzylo L, Navis A, Raissi A, Liu F, Man HY (2009) Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci 29:4498-4511. doi: 10.1523/JNEUROSCI.6094-08.2009
154. Chapin HC, Caplan MJ (2010) The cell biology of polycystic kidney disease. J Cell Biol 191:701-710. doi: 10.1083/jcb.201006173
155. Zatti A, Chauvet V, Rajendran V, Kimura T, Pagel P, Caplan MJ (2005) The C-terminal tail of the polycystin-1 protein interacts with the Na, K-ATPase alpha-subunit. Mol Biol Cell 16:5087-5093. doi: 10.1091/mbc.E05-03-0200
156. Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL (2000) Structural determinants of phosphoinositide 3-kinase inhibition by Wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6:909-919
157. Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A et al (2006) N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-Amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem 49:6465-6488. doi: 10.1021/jm060434q
158. Feng Y, Liu D, Yao H, Wang J (2007) Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR. Arch Biochem Biophys 467:48-57. doi: 10.1016/j.abb.2007.08.021
159. Pope BJ, Zierler-Gould KM, Kuhne R, Weeds AG, Ball LJ (2004) Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. J Biol Chem 279:4840-4848. doi: 10.1074/jbc.M310148200
160. Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM (2009) Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci USA 106:7437-7442. doi: 10.1073/pnas.0902725106
161. Lifshitz Y, Petrovich E, Haviv H, Goldshleger R, Tal DM, Garty H, Karlish SJD (2007) Purification of the human alpha2 isoform of Na, K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1. Biochemistry 46:14937-14950
162. Cornelius F, Turner N, Christensen HR (2003) Modulation of Na, K-ATPase by phospholipids and cholesterol. II. Steady-state and presteadystate kinetics. Biochemistry 42(28):8541-8549