메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages 167-184

A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties

Author keywords

Kinetics in biochemical problems; Molecular reactions; Networks; Ordinary differential equations; Systems biology; Vascular Endothelial Growth Factor (VEGF) signalling

Indexed keywords

VASCULOTROPIN A;

EID: 84872249900     PISSN: 15471063     EISSN: 15510018     Source Type: Journal    
DOI: 10.3934/mbe.2013.10.167     Document Type: Conference Paper
Times cited : (4)

References (69)
  • 2
    • 34047118103 scopus 로고    scopus 로고
    • Mathematical models of the VEGF receptor and its role in cancer therapy
    • T. Alarcón and K. M. Page, Mathematical models of the VEGF receptor and its role in cancer therapy, Journal of The Royal Society Interface, 4 (2007), 283-304.
    • (2007) Journal of the Royal Society Interface , vol.4 , pp. 283-304
    • Alarcón, T.1    Page, K.M.2
  • 4
    • 33745075591 scopus 로고    scopus 로고
    • Tools for kinetic modeling of biochemical networks
    • R. Alves, F. Antunes and A. Salvador, Tools for kinetic modeling of biochemical networks, Nature Biotechnology, 24 (2006), 667-672.
    • (2006) Nature Biotechnology , vol.24 , pp. 667-672
    • Alves, R.1    Antunes, F.2    Salvador, A.3
  • 5
    • 0032170064 scopus 로고    scopus 로고
    • Continuous and discrete mathematical models of tumor-induced angiogenesis
    • A. R. A. Anderson and M. A. J. Chaplain, Continuous and discrete mathematical models of tumor-induced angiogenesis, Bulletin of Mathematical Biology, 60 (1998), 857-899.
    • (1998) Bulletin of Mathematical Biology , vol.60 , pp. 857-899
    • Anderson, A.R.A.1    Chaplain, M.A.J.2
  • 6
    • 3843079723 scopus 로고    scopus 로고
    • A history of the study of solid tumour growth: The contribution of mathematical modelling
    • R. P. Araujo and D. L. S McElwain, A history of the study of solid tumour growth: the contribution of mathematical modelling, Bulletin of Mathematical Biology, 66 (2004) 1039-1091.
    • (2004) Bulletin of Mathematical Biology , vol.66 , pp. 1039-1091
    • Araujo, R.P.1    McElwain, D.L.S.2
  • 7
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • U. S. Bhalla, R. Iyengar and others, Emergent properties of networks of biological signaling pathways, Science, 283 (1999), 381-387.
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 8
    • 33746260079 scopus 로고    scopus 로고
    • Vascular network remodeling via vessel cooption, regression and growth in tumors
    • K. Bartha and H. Rieger, Vascular network remodeling via vessel cooption, regression and growth in tumors, Journal of Theoretical Biology, 241 (2006), 903-918.
    • (2006) Journal of Theoretical Biology , vol.241 , pp. 903-918
    • Bartha, K.1    Rieger, H.2
  • 11
    • 0028790729 scopus 로고
    • Growth of nonnecrotic tumors in the presence and absence of inhibitors
    • H. M. Byrne and M. A. J. Chaplain, Growth of nonnecrotic tumors in the presence and absence of inhibitors, Mathematical Biosciences, 130 (1995), 151-181.
    • (1995) Mathematical Biosciences , vol.130 , pp. 151-181
    • Byrne, H.M.1    Chaplain, M.A.J.2
  • 12
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet and R. K. Jain, Angiogenesis in cancer and other diseases, Nature, 407 (2000), 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 16
    • 79953782986 scopus 로고    scopus 로고
    • Combining epitope-distinct antibodies to HER2: Cooperative inhibitory effects on invasive growth
    • A. Emde, C. R. Pradeep, D. A. Ferraro, N. Ben-Chetrit, M. Sela, B. Ribba, Z. Kam and Y. Yarden, Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth, Oncogene, 30 (2010), 1631-1642.
    • (2010) Oncogene , vol.30 , pp. 1631-1642
    • Emde, A.1    Pradeep, C.R.2    Ferraro, D.A.3    Ben-Chetrit, N.4    Sela, M.5    Ribba, B.6    Kam, Z.7    Yarden, Y.8
  • 17
  • 18
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • N. Ferrara, VEGF and the quest for tumour angiogenesis factors, Nature Reviews Cancer, 2 (2002), 795-803.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 19
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • N. Ferrara, Vascular endothelial growth factor: basic science and clinical progress, Endocrine Reviews, 25 (2004), 581-611.
    • (2004) Endocrine Reviews , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 21
    • 0016256685 scopus 로고
    • Tumor angiogenesis factor
    • J. Folkman, Tumor angiogenesis factor, Cancer Research, 34 (1974), 2109.
    • (1974) Cancer Research , vol.34 , pp. 2109
    • Folkman, J.1
  • 22
    • 0030500450 scopus 로고    scopus 로고
    • New perspectives in clinical oncology from angiogenesis research
    • J. Folkman, New perspectives in clinical oncology from angiogenesis research, European Journal of Cancer (Oxford, England: 1990), 32 (1996), 2534.
    • (1996) European Journal of Cancer (Oxford, England: 1990) , vol.32 , pp. 2534
    • Folkman, J.1
  • 23
    • 57149102486 scopus 로고    scopus 로고
    • Systems biology of vascular endothelial growth factors
    • F. M. Gabhann and A. S. Popel, Systems biology of vascular endothelial growth factors, Microcirculation, 15 (2008), 715-738.
    • (2008) Microcirculation , vol.15 , pp. 715-738
    • Gabhann, F.M.1    Popel, A.S.2
  • 24
    • 14544305077 scopus 로고    scopus 로고
    • Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions
    • G. Gasparini, R. Longo, M. Fanelli and B. A. Teicher, Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions, Journal of Clinical Oncology, 23 (2005), 1295-1311.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 1295-1311
    • Gasparini, G.1    Longo, R.2    Fanelli, M.3    Teicher, B.A.4
  • 25
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
    • H. P. Gerber, A. McMurtrey, J. Kowalski, M. Yan, B. A. Keyt, V. Dixit and N. Ferrara, Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway, Journal of Biological Chemistry, 273 (1998), 30336-30343.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 26
    • 0000135489 scopus 로고
    • Simulation of biological cell sorting using a two-dimensional extended Potts model
    • F. Graner and J. A. Glazier, Simulation of biological cell sorting using a two-dimensional extended Potts model, Physical Review Letters, 69 (1992), 2013-2016.
    • (1992) Physical Review Letters , vol.69 , pp. 2013-2016
    • Graner, F.1    Glazier, J.A.2
  • 28
    • 38949102687 scopus 로고    scopus 로고
    • Analysis of mechanistic pathway models in drug discovery: P38 pathway
    • B. S. Hendriks, F. Hua and J. R. Chabot, Analysis of mechanistic pathway models in drug discovery: p38 pathway, Biotechnology Progress, 24 (2008), 96-109.
    • (2008) Biotechnology Progress , vol.24 , pp. 96-109
    • Hendriks, B.S.1    Hua, F.2    Chabot, J.R.3
  • 31
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • R. K Jain, Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy, Nature Medicine, 7 (2001), 987-989.
    • (2001) Nature Medicine , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 32
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • R. K Jain, Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy, Science, 307 (2005), 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 33
    • 0037079054 scopus 로고    scopus 로고
    • Computational systems biology
    • H. Kitano, Computational systems biology, Nature, 420 (2002), 206-210.
    • (2002) Nature , vol.420 , pp. 206-210
    • Kitano, H.1
  • 34
    • 0344010691 scopus 로고    scopus 로고
    • Cancer robustness: Tumour tactics
    • H. Kitano, Cancer robustness: tumour tactics, Nature, 426 (2003), 125-125.
    • (2003) Nature , vol.426 , pp. 125-125
    • Kitano, H.1
  • 35
    • 23444439817 scopus 로고    scopus 로고
    • Using process diagrams for the graphical representation of biological networks
    • H. Kitano, A. Funahashi, Y. Matsuoka and K. Oda, Using process diagrams for the graphical representation of biological networks, Nature Biotechnology, 23 (2005), 961-966.
    • (2005) Nature Biotechnology , vol.23 , pp. 961-966
    • Kitano, H.1    Funahashi, A.2    Matsuoka, Y.3    Oda, K.4
  • 37
    • 0033570090 scopus 로고    scopus 로고
    • Quantification of short term signaling by the epidermal growth factor receptor
    • B. N. Kholodenko, O. V. Demin, G. Moehren and J. B. Hoek, Quantification of short term signaling by the epidermal growth factor receptor, Journal of Biological Chemistry, 274 (1999), 30169-30181.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 30169-30181
    • Kholodenko, B.N.1    Demin, O.V.2    Moehren, G.3    Hoek, J.B.4
  • 38
    • 0034019315 scopus 로고    scopus 로고
    • Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
    • B. N. Kholodenko, Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades, European Journal of Biochemistry, 267 (2001), 1583-1588.
    • (2001) European Journal of Biochemistry , vol.267 , pp. 1583-1588
    • Kholodenko, B.N.1
  • 39
    • 34147171490 scopus 로고    scopus 로고
    • Endothelial cell migration during angiogenesis
    • L. Lamalice, F. Le Boeuf and J. Huot, Endothelial cell migration during angiogenesis, Circulation Research, 100 (2007), 782-794.
    • (2007) Circulation Research , vol.100 , pp. 782-794
    • Lamalice, L.1    Le Boeuf, F.2    Huot, J.3
  • 40
    • 33144475089 scopus 로고    scopus 로고
    • Flow correlated percolation during vascular remodeling in growing tumors
    • D. S. Lee, H. Rieger and K. Bartha, Flow correlated percolation during vascular remodeling in growing tumors, Physical Review Letters, 96 (2006), 58104.
    • (2006) Physical Review Letters , vol.96 , pp. 58104
    • Lee, D.S.1    Rieger, H.2    Bartha, K.3
  • 41
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • J. Ma and D. J. Waxman, Combination of antiangiogenesis with chemotherapy for more effective cancer treatment, Molecular Cancer Therapeutics, 7 (2008), 3670-3684.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 43
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors
    • D. B. Mendel, A. D. Laird, X. Xin, S. G. Louie, J. G. Christensen, G. Li, R. E. Schreck, T. J. Abrams, T. J. Ngai, L. B. Lee and others, In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors, Clinical Cancer Research, 9 (2003), 327-337.
    • (2003) Clinical Cancer Research , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3    Louie, S.G.4    Christensen, J.G.5    Li, G.6    Schreck, R.E.7    Abrams, T.J.8    Ngai, T.J.9    Lee, L.B.10
  • 49
    • 33748683966 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors: Molecular mechanisms of activation and therapeutic potentials
    • N. Rahimi, Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials, Experimental Eye Research, 83 (2006), 1005-1016.
    • (2006) Experimental Eye Research , vol.83 , pp. 1005-1016
    • Rahimi, N.1
  • 50
    • 33751226638 scopus 로고    scopus 로고
    • A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents
    • B. Ribba, O. Saut, T. Colin, D. Bresch, E. Grenier and J. P. Boissel, A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents, Journal of Theoretical Biology, 243 (2006), 532-541.
    • (2006) Journal of Theoretical Biology , vol.243 , pp. 532-541
    • Ribba, B.1    Saut, O.2    Colin, T.3    Bresch, D.4    Grenier, E.5    Boissel, J.P.6
  • 52
    • 33646249607 scopus 로고    scopus 로고
    • A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies
    • B. Ribba, T. Colin and S. Schnell, A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies, Theoretical Biology and Medical Modelling, 3 (2006).
    • (2006) Theoretical Biology and Medical Modelling , vol.3
    • Ribba, B.1    Colin, T.2    Schnell, S.3
  • 54
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • B. Schoeberl, C. Eichler-Jonsson, E. D. Gilles and G. Muller, Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors, Nature biotechnology, 20 (2002), 370-375.
    • (2002) Nature Biotechnology , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 55
    • 80051671525 scopus 로고    scopus 로고
    • A multiscale hybrid approach for vasculogenesis and related potential blocking therapies
    • M. Scianna, L. Munaron and L. Preziosi, A multiscale hybrid approach for vasculogenesis and related potential blocking therapies, Progress in Biophysics and Molecular Biology, 106 (2011), 450-462.
    • (2011) Progress in Biophysics and Molecular Biology , vol.106 , pp. 450-462
    • Scianna, M.1    Munaron, L.2    Preziosi, L.3
  • 56
    • 34247899028 scopus 로고    scopus 로고
    • Design of clinical trials of radiation combined with antiangiogenic therapy
    • S. Senan and E. F. Smit, Design of clinical trials of radiation combined with antiangiogenic therapy, The Oncologist, 12 (2007), 465-477.
    • (2007) The Oncologist , vol.12 , pp. 465-477
    • Senan, S.1    Smit, E.F.2
  • 57
    • 33750842076 scopus 로고    scopus 로고
    • Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
    • M. Shibuya, Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis., Journal of biochemistry and molecular biology, 39 (2006), 469-478.
    • (2006) Journal of Biochemistry and Molecular Biology , vol.39 , pp. 469-478
    • Shibuya, M.1
  • 58
    • 33344474964 scopus 로고    scopus 로고
    • Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    • M. Shibuya and L. Claesson-Welsh, Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis, Experimental cell research, 312 (2006), 549-560.
    • (2006) Experimental Cell Research , vol.312 , pp. 549-560
    • Shibuya, M.1    Claesson-Welsh, L.2
  • 59
    • 0842282616 scopus 로고    scopus 로고
    • Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents
    • M. Simeoni, P. Magni, C. Cammia, G. De Nicolao, V. Croci, E. Pesenti, M. Germani, I. Poggesi and M. Rocchetti, Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents, Cancer Research, 64 (2004), 1094-1101.
    • (2004) Cancer Research , vol.64 , pp. 1094-1101
    • Simeoni, M.1    Magni, P.2    Cammia, C.3    De Nicolao, G.4    Croci, V.5    Pesenti, E.6    Germani, M.7    Poggesi, I.8    Rocchetti, M.9
  • 60
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • H. Takahashi and M. Shibuya, The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions, Clinical Science, 109 (2005), 227-241.
    • (2005) Clinical Science , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 61
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • R. T. Tong, Y. Boucher, S. V. Kozin, F. Winkler, D. J. Hicklin and R. K. Jain, Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors, Cancer research, 64 (2004), 3731-3736.
    • (2004) Cancer Research , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 62
    • 0016836859 scopus 로고
    • Proliferation-dependent cytotoxicity of anticancer agents: A review
    • F. Valeriote and L. van Putten, Proliferation-dependent cytotoxicity of anticancer agents: a review, Cancer Research, 35 (1975), 2619-2630.
    • (1975) Cancer Research , vol.35 , pp. 2619-2630
    • Valeriote, F.1    Van Putten, L.2
  • 63
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • I. Vivanco and C. L. Sawyers, The phosphatidylinositol 3-Kinase AKT pathway in human cancer., Nature Reviews. Cancer, 2 (2002), 489-501.
    • (2002) Nature Reviews. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 65
    • 84866388429 scopus 로고    scopus 로고
    • Identification of critical molecular components in a multiscale cancer model based on the integration of Monte Carlo, resampling, and ANOVA
    • Z. Wang, V. Bordas and T. Deisboeck, Identification of Critical Molecular Components in a Multiscale Cancer Model Based on the Integration of Monte Carlo, Resampling, and ANOVA, Frontiers in Computational Physiology And Medicine, 2 (2011).
    • (2011) Frontiers in Computational Physiology and Medicine , vol.2
    • Wang, Z.1    Bordas, V.2    Deisboeck, T.3
  • 66
    • 37349011512 scopus 로고    scopus 로고
    • Emergent vascular network inhomogeneities and resulting blood ow patterns in a growing tumor
    • M. Welter, K. Bartha and H. Rieger, Emergent vascular network inhomogeneities and resulting blood ow patterns in a growing tumor, Journal of Theoretical Biology, 250 (2008), 257-280.
    • (2008) Journal of Theoretical Biology , vol.250 , pp. 257-280
    • Welter, M.1    Bartha, K.2    Rieger, H.3
  • 69
    • 13744255578 scopus 로고    scopus 로고
    • Nonlinear simulation of tumor necrosis, neovascularization and tissue invasion via an adaptive finite-element/level-set method
    • X. Zheng, S. M Wise and V. Cristini, Nonlinear simulation of tumor necrosis, neovascularization and tissue invasion via an adaptive finite-element/level-set method, Bulletin of mathematical biology, 67 (2005), 211-259.
    • (2005) Bulletin of Mathematical Biology , vol.67 , pp. 211-259
    • Zheng, X.1    Wise, S.M.2    Cristini, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.