-
1
-
-
77949756362
-
Genome-wide association studies in pharmacogenomics
-
Daly AK. 2010. Genome-wide association studies in pharmacogenomics. Nat. Rev. Genet. 11:241-46
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 241-246
-
-
Daly, A.K.1
-
4
-
-
42349112088
-
Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
-
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, et al. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet. 9:356-69
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
-
5
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, et al. 2009. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. USA 106:9362-67
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
Ramos, E.M.4
Mehta, J.5
Al, P.6
-
6
-
-
36448950162
-
Genome-wide association scans for type 2 diabetes: New insights into biology and therapy
-
McCarthy MI, Zeggini E. 2007. Genome-wide association scans for type 2 diabetes: new insights into biology and therapy. Trends Pharmacol. Sci. 28:598-601
-
(2007)
Trends Pharmacol. Sci
, vol.28
, pp. 598-601
-
-
McCarthy, M.I.1
Zeggini, E.2
-
7
-
-
54049144285
-
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
-
Perry JR, FraylingTM. 2008. New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr. Opin. Clin. Nutr. Metab. Care 11:371-77
-
(2008)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.11
, pp. 371-377
-
-
Perry, J.R.1
Frayling, T.M.2
-
8
-
-
78650303722
-
Pharmacogenomics:Will the promise be fulfilled?
-
Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D. 2011. Pharmacogenomics:Will the promise be fulfilled? Nat. Rev. Genet. 12:69-73
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 69-73
-
-
Altman, R.B.1
Kroemer, H.K.2
McCarty, C.A.3
Ratain, M.J.4
Roden, D.5
-
9
-
-
75549084134
-
Personalized genomic information: Preparing for the future of genetic medicine
-
Guttmacher AE, McGuire AL, Ponder B, Stefansson K. 2010. Personalized genomic information: preparing for the future of genetic medicine. Nat. Rev. Genet. 11:161-65
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 161-165
-
-
Guttmacher, A.E.1
McGuire, A.L.2
Ponder, B.3
Stefansson, K.4
-
10
-
-
79951782033
-
Pharmacogenomics at the tipping point: Challenges and opportunities
-
Roden DM, Tyndale RF. 2011. Pharmacogenomics at the tipping point: challenges and opportunities. Clin. Pharmacol. Ther. 89:323-27
-
(2011)
Clin. Pharmacol. Ther
, vol.89
, pp. 323-327
-
-
Roden, D.M.1
Tyndale, R.F.2
-
11
-
-
67649732906
-
Challenges of translating genetic tests into clinical and public health practice
-
Rogowski WH, Grosse SD, Khoury MJ. 2009. Challenges of translating genetic tests into clinical and public health practice. Nat. Rev. Genet. 10:489-95
-
(2009)
Nat. Rev. Genet
, vol.10
, pp. 489-495
-
-
Rogowski, W.H.1
Grosse, S.D.2
Khoury, M.J.3
-
13
-
-
84855906545
-
Using genome-wide association studies to identify genes important in serious adverse drug reactions
-
Daly AK. 2012. Using genome-wide association studies to identify genes important in serious adverse drug reactions. Annu. Rev. Pharmacol. Toxicol. 52:21-35
-
(2012)
Annu. Rev. Pharmacol. Toxicol
, vol.52
, pp. 21-35
-
-
Daly, A.K.1
-
14
-
-
79959524146
-
A haplotype map of the human genome
-
International HapMap Consortium
-
International HapMap Consortium. 2005. A haplotype map of the human genome. Nature 437:1299-320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
15
-
-
77956331627
-
Integrating common and rare genetic variation in diverse human populations
-
Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, et al. 2010. Integrating common and rare genetic variation in diverse human populations. Nature 467:52-58
-
(2010)
Nature
, vol.467
, pp. 52-58
-
-
Altshuler, D.M.1
Gibbs, R.A.2
Peltonen, L.3
Dermitzakis, E.4
Schaffner, S.5
Al, F.6
-
16
-
-
33745279056
-
Evaluating coverage of genome-wide association studies
-
Barrett JC, Cardon LR. 2006. Evaluating coverage of genome-wide association studies. Nat. Genet. 38:659-62
-
(2006)
Nat. Genet
, vol.38
, pp. 659-662
-
-
Barrett, J.C.1
Cardon, L.R.2
-
18
-
-
77956788631
-
Towards a complete resolution of the genetic architecture of disease
-
Singleton AB, Hardy J, Traynor BJ, Houlden H. 2010. Towards a complete resolution of the genetic architecture of disease. Trends Genet. 26:438-42
-
(2010)
Trends Genet
, vol.26
, pp. 438-442
-
-
Singleton, A.B.1
Hardy, J.2
Traynor, B.J.3
Houlden, H.4
-
19
-
-
77957947562
-
Hundreds of variants clustered in genomic loci and biological pathways affect human height
-
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, et al. 2010. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832-38
-
(2010)
Nature
, vol.467
, pp. 832-838
-
-
Lango Allen, H.1
Estrada, K.2
Lettre, G.3
Berndt, S.I.4
Weedon, M.5
Al, N.6
-
20
-
-
77954133026
-
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
-
Park JH, Wacholder S, Gail MH, Peters U, Jacobs KB, et al. 2010. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet. 42:570-75
-
(2010)
Nat. Genet
, vol.42
, pp. 570-575
-
-
Park, J.H.1
Wacholder, S.2
Gail, M.H.3
Peters, U.4
Jacobs, K.5
Al, B.6
-
21
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. 2010. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 42:565-69
-
(2010)
Nat. Genet
, vol.42
, pp. 565-569
-
-
Yang, J.1
Benyamin, B.2
McEvoy, B.P.3
Gordon, S.4
Henders, A.5
Al, K.6
-
22
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. 2009. Finding the missing heritability of complex diseases. Nature 461:747-53
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.5
Al, A.6
-
23
-
-
65949124249
-
Genomewide association studies-illuminating biologic pathways
-
Hirschhorn JN. 2009. Genomewide association studies-illuminating biologic pathways. N. Engl. J.Med. 360:1699-701
-
(2009)
N. Engl. J.Med
, vol.360
, pp. 1699-1701
-
-
Hirschhorn, J.N.1
-
24
-
-
77249134594
-
Rare variants create synthetic genome-wide associations
-
Dickson SP, Wang K, Krantz I, Hakonarson H, Goldstein DB. 2010. Rare variants create synthetic genome-wide associations. PLoS Biol. 8:e1000294
-
(2010)
PLoS Biol
, vol.8
-
-
Dickson, S.P.1
Wang, K.2
Krantz, I.3
Hakonarson, H.4
Goldstein, D.B.5
-
25
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al. 2010. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42:579-89
-
(2010)
Nat. Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
Morris, A.P.4
Dina, C.5
-
26
-
-
84857654651
-
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
-
Bonnefond A, Clement N, Fawcett K, Yengo L, Vaillant E, et al. 2012. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44:297-301
-
(2012)
Nat. Genet
, vol.44
, pp. 297-301
-
-
Bonnefond, A.1
Clement, N.2
Fawcett, K.3
Yengo, L.4
Vaillant, E.5
-
27
-
-
78650711124
-
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease
-
Danoy P, Pryce K, Hadler J, Bradbury LA, Farrar C, et al. 2010. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet. 6:e1001195
-
(2010)
PLoS Genet
, vol.6
-
-
Danoy, P.1
Pryce, K.2
Hadler, J.3
Bradbury, L.A.4
Farrar, C.5
-
28
-
-
75749085686
-
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
-
Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, et al. 2010. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat. Genet. 42:123-27
-
(2010)
Nat. Genet
, vol.42
, pp. 123-127
-
-
Reveille, J.D.1
Sims, A.M.2
Danoy, P.3
Evans, D.M.4
Leo, P.5
-
29
-
-
79958776237
-
New treatment targets in ankylosing spondylitis and other spondyloarthritides
-
Song IH, Poddubnyy D. 2011. New treatment targets in ankylosing spondylitis and other spondyloarthritides. Curr. Opin. Rheumatol. 23:346-51
-
(2011)
Curr. Opin. Rheumatol
, vol.23
, pp. 346-351
-
-
Song, I.H.1
Poddubnyy, D.2
-
30
-
-
65549102575
-
Pharmacogenomic genome-wide association studies: Lessons learned thus far
-
Crowley JJ, Sullivan PF, McLeodHL. 2009. Pharmacogenomic genome-wide association studies: lessons learned thus far. Pharmacogenomics 10:161-63
-
(2009)
Pharmacogenomics
, vol.10
, pp. 161-163
-
-
Crowley, J.J.1
Sullivan, P.F.2
McLeod, H.L.3
-
31
-
-
67649859295
-
HLA-B-5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
-
Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, et al. 2009. HLA-B-5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat. Genet. 41:816-19
-
(2009)
Nat. Genet
, vol.41
, pp. 816-819
-
-
Daly, A.K.1
Donaldson, P.T.2
Bhatnagar, P.3
Shen, Y.4
Pe'Er, I.5
-
32
-
-
49949104757
-
SLCO1B1 variants and statin-induced myopathy-a genomewide study
-
Link E, Parish S, Armitage J, Bowman L, Heath S, et al. 2008. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N. Engl. J. Med. 359:789-99
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 789-799
-
-
Link, E.1
Parish, S.2
Armitage, J.3
Bowman, L.4
Heath, S.5
-
33
-
-
79953197983
-
HLA-A-3101 and carbamazepine-induced hypersensitivity reactions in Europeans
-
McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, et al. 2011. HLA-A?3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N. Engl. J. Med. 364:1134-43
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 1134-1143
-
-
McCormack, M.1
Alfirevic, A.2
Bourgeois, S.3
Farrell, J.J.4
Kasperaviciute, D.5
-
34
-
-
77955082302
-
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
-
Singer JB, Lewitzky S, Leroy E, Yang F, Zhao X, et al. 2010. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat. Genet. 42:711-14
-
(2010)
Nat. Genet
, vol.42
, pp. 711-714
-
-
Singer, J.B.1
Lewitzky, S.2
Leroy, E.3
Yang, F.4
Zhao, X.5
-
35
-
-
80054746492
-
Exome sequencing as a tool for Mendelian disease gene discovery
-
Bamshad MJ, Ng SB, Bigham AW, Tabor HK, Emond MJ, et al. 2011. Exome sequencing as a tool for Mendelian disease gene discovery. Nat. Rev. Genet. 12:745-55
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 745-755
-
-
Bamshad, M.J.1
Ng, S.B.2
Bigham, A.W.3
Tabor, H.K.4
Emond, M.J.5
-
37
-
-
28144454744
-
Several-fold increase in risk of overanticoagulation by CYP2C9 mutations
-
Lindh JD, Lundgren S, Holm L, Alfredsson L, Rane A. 2005. Several-fold increase in risk of overanticoagulation by CYP2C9 mutations. Clin. Pharmacol. Ther. 78:540-50
-
(2005)
Clin. Pharmacol. Ther
, vol.78
, pp. 540-550
-
-
Lindh, J.D.1
Lundgren, S.2
Holm, L.3
Alfredsson, L.4
Rane, A.5
-
38
-
-
23644437525
-
Common VKORC1 and GGCX polymorphisms associated with warfarin dose
-
Wadelius M, Chen LY, Downes K, Ghori J, Hunt S, et al. 2005. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J. 5:262-70
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 262-270
-
-
Wadelius, M.1
Chen, L.Y.2
Downes, K.3
Ghori, J.4
Hunt, S.5
-
39
-
-
51649110496
-
Agenome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
-
Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, et al. 2008.Agenome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 112:1022-27
-
(2008)
Blood
, vol.112
, pp. 1022-1027
-
-
Cooper, G.M.1
Johnson, J.A.2
Langaee, T.Y.3
Feng, H.4
Stanaway, I.B.5
-
40
-
-
63449117825
-
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose
-
Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, et al. 2009. A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet. 5:e1000433
-
(2009)
PLoS Genet
, vol.5
-
-
Takeuchi, F.1
McGinnis, R.2
Bourgeois, S.3
Barnes, C.4
Eriksson, N.5
-
41
-
-
70349292099
-
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
-
Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, et al. 2009. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461:399-401
-
(2009)
Nature
, vol.461
, pp. 399-401
-
-
Ge, D.1
Fellay, J.2
Thompson, A.J.3
Simon, J.S.4
Shianna, K.V.5
-
42
-
-
70349548852
-
IL28B is associated with response to chronic hepatitis C interferon-αand ribavirin therapy
-
Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, et al. 2009. IL28B is associated with response to chronic hepatitis C interferon-αand ribavirin therapy. Nat. Genet. 41:1100-4
-
(2009)
Nat. Genet
, vol.41
, pp. 1100-1104
-
-
Suppiah, V.1
Moldovan, M.2
Ahlenstiel, G.3
Berg, T.4
Weltman, M.5
-
43
-
-
70349533037
-
Genome-wide association of IL28B with response to pegylated interferon-αand ribavirin therapy for chronic hepatitis C
-
Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, et al. 2009. Genome-wide association of IL28B with response to pegylated interferon- αand ribavirin therapy for chronic hepatitis C. Nat. Genet. 41:1105-9
-
(2009)
Nat. Genet
, vol.41
, pp. 1105-1109
-
-
Tanaka, Y.1
Nishida, N.2
Sugiyama, M.3
Kurosaki, M.4
Matsuura, K.5
-
44
-
-
70349966196
-
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
-
Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, et al. 2009. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461:798-801
-
(2009)
Nature
, vol.461
, pp. 798-801
-
-
Thomas, D.L.1
Thio, C.L.2
Martin, M.P.3
Qi, Y.4
Ge, D.5
-
45
-
-
34547585382
-
Variation in TCF7L2 influences therapeutic response to sulfonylureas: A GoDARTs study
-
Pearson ER, Donnelly LA, Kimber C, Whitley A, Doney AS, et al. 2007. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes 56:2178-82
-
(2007)
Diabetes
, vol.56
, pp. 2178-2182
-
-
Pearson, E.R.1
Donnelly, L.A.2
Kimber, C.3
Whitley, A.4
Doney, A.S.5
-
46
-
-
80053370268
-
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
-
Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, et al. 2011. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N. Engl. J. Med. 365:1173-83
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1173-1183
-
-
Tantisira, K.G.1
Lasky-Su, J.2
Harada, M.3
Murphy, A.4
Litonjua, A.A.5
-
47
-
-
79251612707
-
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
-
Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, et al. 2011. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat. Genet. 43:117-20
-
(2011)
Nat. Genet
, vol.43
, pp. 117-120
-
-
Zhou, K.1
Bellenguez, C.2
Spencer, C.C.3
Bennett, A.J.4
Coleman, R.L.5
-
48
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, et al. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Investig. 108:1167-74
-
(2001)
J. Clin. Investig
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
-
49
-
-
77954933558
-
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
-
Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, et al. 2010. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J. Clin. Investig. 120:2355-69
-
(2010)
J. Clin. Investig
, vol.120
, pp. 2355-2369
-
-
Foretz, M.1
Hebrard, S.2
Leclerc, J.3
Zarrinpashneh, E.4
Soty, M.5
-
50
-
-
79956327715
-
Using electronic health records to drive discovery in disease genomics
-
Kohane IS. 2011. Using electronic health records to drive discovery in disease genomics. Nat. Rev. Genet. 12:417-28
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 417-428
-
-
Kohane, I.S.1
-
51
-
-
79951811383
-
The emerging role of electronicmedical records in pharmacogenomics
-
Wilke RA, Xu H, Denny JC, Roden DM, Krauss RM, et al. 2011. The emerging role of electronicmedical records in pharmacogenomics. Clin. Pharmacol. Ther. 89:379-86
-
(2011)
Clin. Pharmacol. Ther
, vol.89
, pp. 379-386
-
-
Wilke, R.A.1
Xu, H.2
Denny, J.C.3
Roden, D.M.4
Krauss, R.M.5
-
52
-
-
49949093313
-
Development of a large-scale de-identified DNA biobank to enable personalized medicine
-
Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, et al. 2008. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin. Pharmacol. Ther. 84:362-69
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 362-369
-
-
Roden, D.M.1
Pulley, J.M.2
Basford, M.A.3
Bernard, G.R.4
Clayton, E.W.5
-
53
-
-
57149115791
-
Community consultation and communication for a population-based DNA biobank: The Marshfield clinic personalized medicine research project
-
McCarty CA, Chapman-Stone D, Derfus T, Giampietro PF, Fost N. 2008. Community consultation and communication for a population-based DNA biobank: the Marshfield clinic personalized medicine research project. Am. J. Med. Genet. A 146A:3026-33
-
(2008)
Am. J. Med. Genet. A
, vol.146 A
, pp. 3026-3033
-
-
McCarty, C.A.1
Chapman-Stone, D.2
Derfus, T.3
Giampietro, P.F.4
Fost, N.5
-
54
-
-
77950338000
-
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
-
Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, et al. 2010. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am. J. Hum. Genet. 86:560-72
-
(2010)
Am. J. Hum. Genet
, vol.86
, pp. 560-572
-
-
Ritchie, M.D.1
Denny, J.C.2
Crawford, D.C.3
Ramirez, A.H.4
Weiner, J.B.5
-
55
-
-
78650860672
-
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records
-
Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, et al. 2011. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am. J. Hum. Genet. 88:57-69
-
(2011)
Am. J. Hum. Genet
, vol.88
, pp. 57-69
-
-
Kurreeman, F.1
Liao, K.2
Chibnik, L.3
Hickey, B.4
Stahl, E.5
-
56
-
-
77958522275
-
A genome-wide association study of red blood cell traits using the electronic medical record
-
Kullo IJ, Ding K, Jouni H, Smith CY, Chute CG. 2010. A genome-wide association study of red blood cell traits using the electronic medical record. PLoS One 5:e13011
-
(2010)
PLoS One
, vol.5
-
-
Kullo, I.J.1
Ding, K.2
Jouni, H.3
Smith, C.Y.4
Chute, C.G.5
-
57
-
-
84855958154
-
Predicting clopidogrel response using DNA samples linked to an electronic health record
-
Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, et al. 2012. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin. Pharmacol. Ther. 91:257-63
-
(2012)
Clin. Pharmacol. Ther
, vol.91
, pp. 257-263
-
-
Delaney, J.T.1
Ramirez, A.H.2
Bowton, E.3
Pulley, J.M.4
Basford, M.A.5
-
58
-
-
12244264435
-
Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits
-
Purcell S, Cherny SS, Sham PC. 2003. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-50
-
(2003)
Bioinformatics
, vol.19
, pp. 149-150
-
-
Purcell, S.1
Cherny, S.S.2
Sham, P.C.3
-
59
-
-
79959557454
-
Power in the phenotypic extremes: A simulation study of power in discovery and replication of rare variants
-
Guey LT, Kravic J, Melander O, Burtt NP, Laramie JM, et al. 2011. Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet. Epidemiol. 35:236-46
-
(2011)
Genet. Epidemiol
, vol.35
, pp. 236-246
-
-
Guey, L.T.1
Kravic, J.2
Melander, O.3
Burtt, N.P.4
Laramie, J.M.5
-
60
-
-
78549251736
-
Analysing biological pathways in genome-wide association studies
-
Wang K, Li M, Hakonarson H. 2010. Analysing biological pathways in genome-wide association studies. Nat. Rev. Genet. 11:843-54
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 843-854
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
61
-
-
34548738566
-
Population genomics of human gene expression
-
Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, et al. 2007. Population genomics of human gene expression. Nat. Genet. 39:1217-24
-
(2007)
Nat. Genet
, vol.39
, pp. 1217-1224
-
-
Stranger, B.E.1
Nica, A.C.2
Forrest, M.S.3
Dimas, A.4
Bird, C.P.5
-
62
-
-
45149108420
-
Mapping the genetic architecture of gene expression in human liver
-
Schadt EE, Molony C, Chudin E, Hao K, Yang X, et al. 2008. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6:e107
-
(2008)
PLoS Biol
, vol.6
-
-
Schadt, E.E.1
Molony, C.2
Chudin, E.3
Hao, K.4
Yang, X.5
-
63
-
-
34548719076
-
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
-
Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, et al. 2007. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat. Genet. 39:1208-16
-
(2007)
Nat. Genet
, vol.39
, pp. 1208-1216
-
-
Goring, H.H.1
Curran, J.E.2
Johnson, M.P.3
Dyer, T.D.4
Charlesworth, J.5
-
64
-
-
69949176863
-
Common regulatory variation impacts gene expression in a cell type-dependent manner
-
Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, et al. 2009. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 325:1246-50
-
(2009)
Science
, vol.325
, pp. 1246-1250
-
-
Dimas, A.S.1
Deutsch, S.2
Stranger, B.E.3
Montgomery, S.B.4
Borel, C.5
-
65
-
-
79957607662
-
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
-
Small KS, Hedman AK, Grundberg E, Nica AC, Thorleifsson G, et al. 2011. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat. Genet. 43:561-64
-
(2011)
Nat. Genet
, vol.43
, pp. 561-564
-
-
Small Kshedman, A.K.1
Grundberg, E.2
Nica, A.C.3
Thorleifsson, G.4
-
66
-
-
82255196220
-
Integrative genomics strategies to elucidate the complexity of drug response
-
Kasarskis A, Yang X, Schadt E. 2011. Integrative genomics strategies to elucidate the complexity of drug response. Pharmacogenomics 12:1695-715
-
(2011)
Pharmacogenomics
, vol.12
, pp. 1695-1715
-
-
Kasarskis, A.1
Yang, X.2
Schadt, E.3
-
67
-
-
80051807776
-
Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study
-
So HC, Li M, Sham PC. 2011. Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet. Epidemiol. 35:447-56
-
(2011)
Genet. Epidemiol
, vol.35
, pp. 447-456
-
-
So, H.C.1
Li, M.2
Sham, P.C.3
-
68
-
-
79957588287
-
Genome partitioning of genetic variation for complex traits using common SNPs
-
Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, et al. 2011. Genome partitioning of genetic variation for complex traits using common SNPs. Nat. Genet. 43:519-25
-
(2011)
Nat. Genet
, vol.43
, pp. 519-525
-
-
Yang, J.1
Manolio, T.A.2
Pasquale, L.R.3
Boerwinkle, E.4
Caporaso, N.5
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