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Volumn 53, Issue , 2013, Pages 147-159

Pluripotent stem cell-derived hepatocytes: Potential and challenges in pharmacology

Author keywords

cytochrome p450 metabolism; drug induced liver injury; genetics; human embryonic stem cell; induced pluripotent stem cell

Indexed keywords

CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL REGENERATION; CELL THERAPY; EXTRACELLULAR MATRIX; HUMAN; LIVER DISEASE; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PLURIPOTENT STEM CELL DERIVED HEPATOCYTE; PRIORITY JOURNAL; REVIEW;

EID: 84872232500     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-011112-140306     Document Type: Review
Times cited : (49)

References (82)
  • 1
    • 0842276792 scopus 로고    scopus 로고
    • Anatomy and physiology of the liver
    • ed. DZ Zakim, TD Boyer Philadelphia, Saunders
    • Saxema R, Zucker S, Crawford J. 2003. Anatomy and physiology of the liver. In Hepatology: A Textbook of Liver Disease, ed. DZ Zakim, TD Boyer, pp. 3-30. Philadelphia: Saunders
    • (2003) Hepatology: A Textbook of Liver Disease , pp. 3-30
    • Saxema, R.1    Zucker, S.2    Crawford, J.3
  • 3
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of non-alcoholic liver disease
    • Adams L, Angulo P. 2006. Treatment of non-alcoholic liver disease. Postgrad. Med. J. 82:315-22
    • (2006) Postgrad. Med. J , vol.82 , pp. 315-322
    • Adams, L.1    Angulo, P.2
  • 4
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • Duffield S,Forbes SJ, Constandinou C, Clay S, Partolina M, et al. 2005. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Investig. 115(1):56-65
    • (2005) J. Clin. Investig , vol.115 , Issue.1 , pp. 56-65
    • Duffield, S.1    Forbes, S.J.2    Constandinou, C.3    Clay, S.4    Partolina, M.5
  • 6
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. 2007. Models of liver fibrosis exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Investig. 117(3):539-48
    • (2007) J. Clin. Investig , vol.117 , Issue.3 , pp. 539-548
    • Iredale, J.P.1
  • 8
    • 79953736762 scopus 로고    scopus 로고
    • Matrix stiffnessmodulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
    • Schrader J, Gordon-Walker T, Aucott R, vanDeemterM,Quaas A, et al. 2011. Matrix stiffnessmodulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology 53(4):1192-205
    • (2011) Hepatology , vol.53 , Issue.4 , pp. 1192-1205
    • Schrader, J.1    Gordon-Walker, T.2    Aucott, R.3    Van Deemter, M.4    Quaas, A.5
  • 9
    • 79958809001 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy
    • Vara D, Salazar M, Olea-Herrero N, Guzm̄an M, Velasco G, Diaz-Laviada I. 2011. Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ. 8(7):1099-111
    • (2011) Cell Death Differ. 8 , vol.7 , pp. 1099-1111
    • Vara, D.1    Salazar, M.2    Olea-Herrero, N.3    Guzman, M.4    Velasco, G.5    Diaz-Laviada, I.6
  • 11
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Wilkinson G. 2005. Drug metabolism and variability among patients in drug response. N. Engl. J. Med. 352:2211-21
    • (2005) N. Engl. J. Med , vol.352 , pp. 2211-2221
    • Wilkinson, G.1
  • 13
    • 77952474499 scopus 로고    scopus 로고
    • Glutathione S-transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma
    • Chen Y, Tseng H, Kuo W, Yang S, Chen DR, Tsai HT. 2010. Glutathione S-transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med. Genet. 11:46
    • (2010) BMC Med. Genet , vol.11 , pp. 46
    • Chen, Y.1    Tseng, H.2    Kuo, W.3    Yang, S.4    Chen, D.R.5    Tsai, H.T.6
  • 14
    • 1542327565 scopus 로고    scopus 로고
    • Drug-induced liver injury
    • Kaplovitz N. 2004. Drug-induced liver injury. Clin. Infect. Dis. 38:44-48
    • (2004) Clin. Infect. Dis , vol.38 , pp. 44-48
    • Kaplovitz, N.1
  • 15
    • 79955464098 scopus 로고    scopus 로고
    • The use of induced pluripotent stem cells in drug development
    • Inoue H, Yamanaka S. 2011. The use of induced pluripotent stem cells in drug development. Clin. Pharmacol. Ther. 89(5):655-61
    • (2011) Clin. Pharmacol. Ther , vol.89 , Issue.5 , pp. 655-661
    • Inoue, H.1    Yamanaka, S.2
  • 16
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M. 2009. RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 10:57-63
    • (2009) Nat. Rev. Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 19
    • 37649001073 scopus 로고    scopus 로고
    • Understanding the roadmap of metabolism by pathway analysis
    • Schuster S, von Kamp A, von Pachko M. 2007. Understanding the roadmap of metabolism by pathway analysis. Methods Mol. Biol. 358:199-226
    • (2007) Methods Mol. Biol , vol.358 , pp. 199-226
    • Schuster, S.1    Von Kamp, A.2    Von Pachko, M.3
  • 20
    • 33748464202 scopus 로고    scopus 로고
    • Flux balance analysis in the era of metabolomics
    • Lee J, Gianchandani E, Papin J. 2006. Flux balance analysis in the era of metabolomics. Brief Bioinforma. 7:140-50
    • (2006) Brief Bioinforma , vol.7 , pp. 140-150
    • Lee, J.1    Gianchandani, E.2    Papin, J.3
  • 21
    • 77956649528 scopus 로고    scopus 로고
    • Metabolic reconstruction, constraint-based analysis and game theory to probe genome-scale metabolic networks
    • Ruppin E, Pappin J, de Figueredo L, Schuster S. 2010. Metabolic reconstruction, constraint-based analysis and game theory to probe genome-scale metabolic networks. Curr. Opin. Biotechnol. 21:1-9
    • (2010) Curr. Opin. Biotechnol , vol.21 , pp. 1-9
    • Ruppin, E.1    Pappin, J.2    De Figueredo, L.3    Schuster, S.4
  • 22
    • 79959770204 scopus 로고    scopus 로고
    • Induced pluripotent stem cells as a nextgeneration biomedical interface
    • Hankowski K, Hamazaki T, Umezewa A, Terada N. 2011. Induced pluripotent stem cells as a nextgeneration biomedical interface. Lab. Investig. 91:927-77
    • (2011) Lab. Investig , vol.91 , pp. 927-977
    • Hankowski, K.1    Hamazaki, T.2    Umezewa, A.3    Terada, N.4
  • 23
    • 0037126649 scopus 로고    scopus 로고
    • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    • Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, et al. 2002. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 137:947-54
    • (2002) Ann. Intern. Med , vol.137 , pp. 947-954
    • Ostapowicz, G.1    Fontana, R.J.2    Schiodt, F.V.3    Larson, A.4    Davern, T.J.5
  • 24
    • 77952718055 scopus 로고    scopus 로고
    • Risk factors for idiosyncratic drug-induced liver injury
    • Chalasani N, Bj ̈ ornsson E. 2010. Risk factors for idiosyncratic drug-induced liver injury. Gastroenterology 138(7):2246-59
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2246-2259
    • Chalasani, N.1    Bj̈ornsson, E.2
  • 25
    • 0036257307 scopus 로고    scopus 로고
    • Biochemical and cellular mechanisms of toxic liver injury
    • Kaplovitz N. 2002. Biochemical and cellular mechanisms of toxic liver injury. Semin. Liver Dis. 22:137-44
    • (2002) Semin. Liver Dis , vol.22 , pp. 137-144
    • Kaplovitz, N.1
  • 26
    • 0034953329 scopus 로고    scopus 로고
    • Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
    • Odin J, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A. 2001. Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J. Clin. Investig. 108(2):223-32
    • (2001) J. Clin. Investig , vol.108 , Issue.2 , pp. 223-232
    • Odin, J.1    Huebert, R.C.2    Casciola-Rosen, L.3    Larusso, N.F.4    Rosen, A.5
  • 28
    • 0033758667 scopus 로고    scopus 로고
    • Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: Reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen
    • Cai J, Ito M, Westerman KA, Kobayashi N, Leboulch P, Fox IJ. 2000. Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen. J. Hepatol. 33:701-8
    • (2000) J. Hepatol , vol.33 , pp. 701-708
    • Cai, J.1    Ito, M.2    Westerman, K.A.3    Kobayashi, N.4    Leboulch, P.5    Fox, I.J.6
  • 29
    • 19944432939 scopus 로고    scopus 로고
    • Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-antigen gene transfer
    • Delgado JP, Parouchev A, Allain JE, PennarunG,Gauthier LR, et al. 2005. Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-antigen gene transfer. Oncogene 24:541-51
    • (2005) Oncogene , vol.24 , pp. 541-551
    • Delgado, J.P.1    Parouchev, A.2    Allain, J.E.3    Pennarunggauthier, L.R.4
  • 30
    • 0347086157 scopus 로고    scopus 로고
    • In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
    • Wege H, Chui MS, Le HT, Strom SC, Zern MA. 2003. In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant. 12:897-906
    • (2003) Cell Transplant , vol.12 , pp. 897-906
    • Wege, H.1    Chui, M.S.2    Le, H.T.3    Strom, S.C.4    Zern, M.A.5
  • 31
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • Guillouzo A, Corlu A, Aninant C, Glaise D,Morel F, Guguen-Guillouzo C. 2007. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem. Biol. Interact. 168(1):66-73
    • (2007) Chem. Biol. Interact , vol.168 , Issue.1 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninant, C.3    Glaise, D.4    Morel, F.5    Guguen-Guillouzo, C.6
  • 32
    • 1642273510 scopus 로고    scopus 로고
    • Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    • Mills JB, Rose KA, Sadagopan N, Sahi J, de Morais SM. 2004. Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J. Pharmacol. Exp. Ther. 309(1):303-9
    • (2004) J. Pharmacol. Exp. Ther , vol.309 , Issue.1 , pp. 303-309
    • Mills, J.B.1    Rose, K.A.2    Sadagopan, N.3    Sahi, J.4    De Morais, S.M.5
  • 34
    • 84858720992 scopus 로고    scopus 로고
    • Stem cell-based toxicity screening: Recent advances in hepatocyte generation
    • Greenhough S, Hay DC. 2012. Stem cell-based toxicity screening: recent advances in hepatocyte generation. Pharm. Med. 26(2):85-89
    • (2012) Pharm. Med. , vol.26 , Issue.2 , pp. 85-89
    • Greenhough, S.1    Hay, D.C.2
  • 36
    • 77955972556 scopus 로고    scopus 로고
    • Role of stem-cell-derived hepatic endoderm in human drug discovery
    • Medine C, Greenhough S, Hay DC. 2010. Role of stem-cell-derived hepatic endoderm in human drug discovery. Biochem. Soc. Trans. 38(4):1033-36
    • (2010) Biochem. Soc. Trans , vol.38 , Issue.4 , pp. 1033-1036
    • Medine, C.1    Greenhough, S.2    Hay, D.C.3
  • 37
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. 2000. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18:399-404
    • (2000) Nat. Biotechnol , vol.18 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 39
    • 10244256290 scopus 로고    scopus 로고
    • Expression of the liverspecific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells
    • Asahina K, Fujimori H, Shimizu-Saito K, Kumashiro Y, Okamura K, et al. 2004. Expression of the liverspecific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells 9:1297-308
    • (2004) Genes Cells , vol.9 , pp. 1297-1308
    • Asahina, K.1    Fujimori, H.2    Shimizu-Saito, K.3    Kumashiro, Y.4    Okamura, K.5
  • 40
    • 9644282186 scopus 로고    scopus 로고
    • Differentiation and isolation of hepatic-like cells from human embryonic stem cells
    • Lavon N, Yanuka O, Benvenisty N. 2004. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation 72(5):230-38
    • (2004) Differentiation , vol.72 , Issue.5 , pp. 230-238
    • Lavon, N.1    Yanuka, O.2    Benvenisty, N.3
  • 41
    • 37349037630 scopus 로고    scopus 로고
    • Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo
    • Duan Y, Catan A, Meng Y. 2007. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells 25:3058-68
    • (2007) Stem Cells , vol.25 , pp. 3058-3068
    • Duan, Y.1    Catan, A.2    Meng, Y.3
  • 42
    • 60449098836 scopus 로고    scopus 로고
    • Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    • Basma H, Soto-Guttierez A, Yannam GR, Liu L, Ito R, et al. 2009. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 136(3):990-99
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 990-999
    • Basma, H.1    Soto-Guttierez, A.2    Yannam, G.R.3    Liu, L.4    Ito, R.5
  • 43
    • 47949092668 scopus 로고    scopus 로고
    • Efficient differentiation of functional hepatocytes from human embryonic stem cells
    • Agarwal S, Holton KL, Lanza R. 2008. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 26:1117-27
    • (2008) Stem Cells , vol.26 , pp. 1117-1127
    • Agarwal, S.1    Holton, K.L.2    Lanza, R.3
  • 44
    • 34248634898 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional hepatic cells
    • Cai J, Zhao Y, Liu Y, Ye F, Song Z, et al. 2007. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 45:1229-39
    • (2007) Hepatology , vol.45 , pp. 1229-1239
    • Cai, J.1    Zhao, Y.2    Liu, Y.3    Ye, F.4    Song, Z.5
  • 45
    • 34247368402 scopus 로고    scopus 로고
    • Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities
    • Hay DC, Zhao D, Ross A, Mandalam R, Lebkowski J, Cui W. 2007. Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities. Cloning Stem Cells 9:51-62
    • (2007) Cloning Stem Cells , vol.9 , pp. 51-62
    • Hay, D.C.1    Zhao, D.2    Ross, A.3    Mandalam, R.4    Lebkowski, J.5    Cui, W.6
  • 46
    • 50449101603 scopus 로고    scopus 로고
    • Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalling
    • Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, et al. 2008. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalling. Proc. Natl. Acad. Sci. USA 105:12301-6
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 12301-12306
    • Hay, D.C.1    Fletcher, J.2    Payne, C.3    Terrace, J.D.4    Gallagher, R.C.5
  • 47
    • 84858729058 scopus 로고    scopus 로고
    • Robust generation of hepatocyte-like cells from human embryonic stem cell populations
    • Medine C, Lucendo-Villarin B, Zhou W, West CC, HayDC. 2011. Robust generation of hepatocyte-like cells from human embryonic stem cell populations. J. Vis. Exp. 56:e2969
    • (2011) J. Vis. Exp , vol.56
    • Medine, C.1    Lucendo-Villarin, B.2    Zhou, W.3    West, C.C.4    Hay, D.C.5
  • 49
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 124(6):663-76
    • (2006) Cell , vol.124 , Issue.6 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 50
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:1-12
    • (2007) Cell , vol.131 , pp. 1-12
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5
  • 51
  • 52
    • 77956354416 scopus 로고    scopus 로고
    • Modelling inheritedmetabolic disorders of the liver using human induced pluripotent stem cells
    • Rashid S, Corbineau S,HannanN,Marciniak S, Miranda E. 2010. Modelling inheritedmetabolic disorders of the liver using human induced pluripotent stem cells. J. Clin. Investig. 120(9):3127-36
    • (2010) J. Clin. Investig , vol.120 , Issue.9 , pp. 3127-3136
    • Rashid, S.1    Corbineau, S.2    Hannan, N.3    Marciniak, S.4    Miranda, E.5
  • 53
    • 0020660763 scopus 로고
    • Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type
    • Guguen-Guillouzo C, Cĺement B, Baffet G, Beaumont C, Morel-Chany E, et al. 1983. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp. Cell Res. 143(1):47-54
    • (1983) Exp. Cell Res , vol.143 , Issue.1 , pp. 47-54
    • Guguen-Guillouzo, C.1    Cĺement, B.2    Baffet, G.3    Beaumont, C.4    Morel-Chany, E.5
  • 54
    • 77958575793 scopus 로고    scopus 로고
    • CathepsinX-deficient gastric epithelial cells in co-culture with macrophages: Characterization of cytokine response and migration capability after Helicobacter pylori infection
    • BernhardtA,Kuester D, Roessner A, Reinheckel T, Krueger S. 2010. CathepsinX-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection. J. Biol. Chem. 285(44):33691-700
    • (2010) J. Biol. Chem , vol.285 , Issue.44 , pp. 33691-33700
    • Bernhardtakuester, D.1    Roessner, A.2    Reinheckel, T.3    Krueger, S.4
  • 55
    • 79955462003 scopus 로고    scopus 로고
    • Hepatic differentiation of human embryonic stem cells is promoted by three-dimensional dynamic perfusion culture conditions
    • Miki T, Ring A, Gerlach J. 2011 Hepatic differentiation of human embryonic stem cells is promoted by three-dimensional dynamic perfusion culture conditions. Tissue Eng. Part C Methods 17:557-68
    • (2011) Tissue Eng. Part C Methods , vol.17 , pp. 557-568
    • Miki, T.1    Ring, A.2    Gerlach, J.3
  • 56
    • 84872258363 scopus 로고    scopus 로고
    • Hepatic differentiation of human embryonic and induced pluripotent stem cells for regenerative medicine
    • ed. MS Kallos Rijeka, Croatia: In Tech
    • Miki T. 2011. Hepatic differentiation of human embryonic and induced pluripotent stem cells for regenerative medicine. In Embryonic Stem Cells: Differentiation and Pluripotent Alternatives, ed. MS Kallos, pp. 303-20. Rijeka, Croatia: InTech
    • (2011) Embryonic Stem Cells: Differentiation and Pluripotent Alternatives , pp. 303-320
    • Miki, T.1
  • 57
    • 79951508587 scopus 로고    scopus 로고
    • Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism
    • Hay DC, Perngallo S, Diaz-Mochon J, Medine C, Greenhough S, et al. 2011. Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem Cell Res. 6:92-102
    • (2011) Stem Cell Res , vol.6 , pp. 92-102
    • Hay, D.C.1    Perngallo, S.2    Diaz-Mochon, J.3    Medine, C.4    Greenhough, S.5
  • 58
    • 84869139920 scopus 로고    scopus 로고
    • SUMOylation of HNF4αregulates protein stability and hepatocyte function
    • Zhou W, Hannoun Z, Jaffray E, Medine CN, Black JR, et al. 2012. SUMOylation of HNF4αregulates protein stability and hepatocyte function. J. Cell Sci. 125:3630-35
    • (2012) J. Cell Sci , vol.125 , pp. 3630-3635
    • Zhou, W.1    Hannoun, Z.2    Jaffray, E.3    Medine, C.N.4    Black, J.R.5
  • 59
    • 77955603299 scopus 로고    scopus 로고
    • The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation
    • Hannoun Z, Fletcher J, Greenhough S, Medine C, Samuel K, et al. 2010. The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation. Cell Reprogram. 12(2):133-40
    • (2010) Cell Reprogram , vol.12 , Issue.2 , pp. 133-140
    • Hannoun, Z.1    Fletcher, J.2    Greenhough, S.3    Medine, C.4    Samuel, K.5
  • 60
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblast by defined factors
    • Huang P, He Z, Ji S, Sun H, Wang X. 2011. Induction of functional hepatocyte-like cells from mouse fibroblast by defined factors. Nature 475:386-89
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3    Sun, H.4    Wang, X.5
  • 61
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S, Suzuki A. 2011. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475:390-93
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 62
    • 77953913401 scopus 로고    scopus 로고
    • Suspension culture of undifferentiated human embryonic and induced pluripotent stem cells
    • Amit M, Chebath J, Margulets V, Laevsky I, Miropolsky Y, et al. 2010. Suspension culture of undifferentiated human embryonic and induced pluripotent stem cells. Stem Cell Rev. 6(2):248-59
    • (2010) Stem Cell Rev , vol.6 , Issue.2 , pp. 248-259
    • Amit, M.1    Chebath, J.2    Margulets, V.3    Laevsky, I.4    Miropolsky, Y.5
  • 63
    • 79960302745 scopus 로고    scopus 로고
    • Long-term maintenance of undifferentiated human embryonic and induced pluripotent stem cells in suspension
    • Larijani M, Seifinejad A, Pournasr B, Hajihoseini V, Hassani SN, et al. 2011. Long-term maintenance of undifferentiated human embryonic and induced pluripotent stem cells in suspension. Stem Cells Dev. 20(11):1911-23
    • (2011) Stem Cells Dev , vol.20 , Issue.11 , pp. 1911-1923
    • Larijani, M.1    Seifinejad, A.2    Pournasr, B.3    Hajihoseini, V.4    Hassani, S.N.5
  • 64
    • 79251512982 scopus 로고    scopus 로고
    • Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation
    • Kim N, Kim H, Jung I, Kim Y, Kim D, Han YM. 2011. Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation. Hepatol. Res. 41(2):170-83
    • (2011) Hepatol. Res , vol.41 , Issue.2 , pp. 170-183
    • Kim, N.1    Kim, H.2    Jung, I.3    Kim, Y.4    Kim, D.5    Han, Y.M.6
  • 65
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman M, Donaghey J, Carey B, Garber M, Grenier J, et al. 2011. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477:295-300
    • (2011) Nature , vol.477 , pp. 295-300
    • Guttman, M.1    Donaghey, J.2    Carey, B.3    Garber, M.4    Grenier, J.5
  • 66
    • 77956157576 scopus 로고    scopus 로고
    • Cadaveric hepatocytes repopulate diseased livers: Life after death
    • Hay DC. 2010. Cadaveric hepatocytes repopulate diseased livers: life after death. Gastroenterology 139(3):729-31
    • (2010) Gastroenterology , vol.139 , Issue.3 , pp. 729-731
    • Hay, D.C.1
  • 67
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
    • Yusa K, Rashid S, Strick-Marhand H, Varela I, Liu PQ, et al. 2011. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478:391-94
    • (2011) Nature , vol.478 , pp. 391-394
    • Yusa, K.1    Rashid, S.2    Strick-Marhand, H.3    Varela, I.4    Liu, P.Q.5
  • 68
    • 78650796308 scopus 로고    scopus 로고
    • Persistence of functional hepatocyte-like cells in immune-compromised mice
    • Payne C, Samuel K, Pryde A, King J, Brownstein D, et al. 2010. Persistence of functional hepatocyte-like cells in immune-compromised mice. Liver Int. 31:254-62
    • (2010) Liver Int , vol.31 , pp. 254-262
    • Payne, C.1    Samuel, K.2    Pryde, A.3    King, J.4    Brownstein, D.5
  • 69
    • 77953284319 scopus 로고    scopus 로고
    • Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells
    • Melkoumian Z, Weber J,Weber D, Fadeev A, Zhou Y, et al. 2010. Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nat. Biotechnol. 28:606-10
    • (2010) Nat. Biotechnol , vol.28 , pp. 606-610
    • Melkoumian, Z.1    Weber, J.2    Weber, D.3    Fadeev, A.4    Zhou, Y.5
  • 71
    • 77953274486 scopus 로고    scopus 로고
    • Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
    • Rodin S, Domogatskaya A, Str ̈om S, Hansson EM, Chien KR, et al. 2010. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat. Biotechnol. 28(6):611-15
    • (2010) Nat. Biotechnol , vol.28 , Issue.6 , pp. 611-615
    • Rodin, S.1    Domogatskaya, A.2    Str̈om, S.3    Hansson, E.M.4    Chien, K.R.5
  • 72
    • 80052294065 scopus 로고    scopus 로고
    • Three-dimensional biomaterials for the study of human pluripotent stem cells
    • Kraehenbuehl T, Langer R, Ferreira L. 2011. Three-dimensional biomaterials for the study of human pluripotent stem cells. Nat. Methods 8(9):731-36
    • (2011) Nat. Methods , vol.8 , Issue.9 , pp. 731-736
    • Kraehenbuehl, T.1    Langer, R.2    Ferreira, L.3
  • 73
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse-induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. 2008. Generation of mouse-induced pluripotent stem cells without viral vectors. Science 322(5903):949-53
    • (2008) Science , vol.322 , Issue.5903 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 74
    • 79953021243 scopus 로고    scopus 로고
    • Development of defective and persistent Sendai virus vector: A unique gene delivery/expression system ideal for cell reprogramming
    • Nishimura K, Sano M, Ohtaka M, Furuta B, et al. 2010. Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J. Biol. Chem. 286(6):4760-71
    • (2010) J. Biol. Chem , vol.286 , Issue.6 , pp. 4760-4771
    • Nishimura, K.1    Sano, M.2    Ohtaka, M.3    Furuta, B.4
  • 75
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L,Manos P, Ahfeldt T, Loh T, Li H, et al. 2010. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7:618-30
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.2    Ahfeldt, T.3    Loh, T.4    Li, H.5
  • 76
    • 78650196632 scopus 로고    scopus 로고
    • Regulation of somatic cell reprogramming through inducible mir-302 expression
    • Lin S-H, Chang DC, Lin C-H, Ying S-Y, Leu D,Wu DT. 2011. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res. 39:1054-65
    • (2011) Nucleic Acids Res , vol.39 , pp. 1054-1065
    • Lin, S.-H.1    Chang, D.C.2    Lin, C.-H.3    Ying, S.-Y.4    Leu Dwu, D.T.5
  • 77
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • Anokye-Danson F, Trivedi CM, Juhr D, Gupta M, Cui Z, et al. 2011. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8:376-88
    • (2011) Cell Stem Cell , vol.8 , pp. 376-388
    • Anokye-Danson, F.1    Trivedi, C.M.2    Juhr, D.3    Gupta, M.4    Cui, Z.5
  • 78
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, Takahashi K, Ichisaka T, Takashi A, Ichisaka T, et al. 2009. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460:1132-35
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Takashi, A.4    Ichisaka, T.5
  • 79
    • 70450265981 scopus 로고    scopus 로고
    • Efficient induction of transgene-free human pluripotent stem cells using vector based on Sendai virus, an RNA virus that does not integrate into the host genome
    • Fusaki N, BanH,Nishiyama A, Saeki K,Hasegawa M. 2009. Efficient induction of transgene-free human pluripotent stem cells using vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 85(8):348-62
    • (2009) Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci , vol.85 , Issue.8 , pp. 348-362
    • Fusaki, N.1    Ban, H.2    Nishiyama, A.3    Saeki, K.4    Hasegawa, M.5
  • 80
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K, Doi A, Wen B, NG K, Zhao R, et al. 2010. Epigenetic memory in induced pluripotent stem cells. Nature 467:285-90
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1    Doi, A.2    Wen, B.3    K, N.G.4    Zhao, R.5
  • 81
    • 77952425747 scopus 로고    scopus 로고
    • Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
    • Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, et al. 2010. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 465:175-81
    • (2010) Nature , vol.465 , pp. 175-181
    • Stadtfeld, M.1    Apostolou, E.2    Akutsu, H.3    Fukuda, A.4    Follett, P.5
  • 82
    • 79952898021 scopus 로고    scopus 로고
    • Investigating monogenic and complex diseases with pluripotent stem cells
    • Zhu H, Lensch M, Cahan P, Daley G. 2011. Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. 12:266-71
    • (2011) Nat. Rev , vol.12 , pp. 266-271
    • Zhu, H.1    Lensch, M.2    Cahan, P.3    Daley, G.4


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