SUMOylation of HNF4α regulates protein stability and hepatocyte function

Journal of Cell Science

Volumn 125, Issue 15, 2012, Pages 3630-3635

  Zhou, Wenli ^a,b   Hannoun, Zara ^a   Jaffray, Ellis ^b   Medine, Claire N ^a   Black, James R ^a   Greenhough, Sebastian ^a   Zhu, Liang ^c   Ross, James A ^a   Forbes, Stuart ^a   Wilmut, Ian ^a   Iredale, John P ^d   Hay, Ronald T ^b   Hay, David C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cell based modelling; Hepatocyte; Hescs; HNF4 ; Liver; P450; SUMO; Transthyretin; Ubiquitin

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; SUMO PROTEIN; UBIQUITIN;

ARTICLE; ASSAY; CELL DIFFERENTIATION; CELL MATURATION; CELL TYPE; EMBRYO; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; LIVER FUNCTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STABILITY; SOMATIC CELL; SUMOYLATION; UBIQUITINATION;

CATALYTIC DOMAIN; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUMOYLATION; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 84869139920     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.102889     Document Type: Article

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