Involvement of GSK3 and PP2A in ginsenoside Rb1's attenuation of aluminum-induced tau hyperphosphorylation

Behavioural Brain Research

Volumn 241, Issue 1, 2013, Pages 228-234

  Zhao, Hai hua ^a   Di, Jing ^a   Liu, Wen su ^b   Liu, Hui li ^a   Lai, Hong ^a   Lü, Yong Li ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Aluminum; Ginsenoside Rb1; Glycogen synthase kinase 3; Protein phosphatase 2A; Tau

Indexed keywords

ALUMINUM CHLORIDE; GINSENOSIDE RB 1; GLYCOGEN SYNTHASE KINASE 3; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TAU PROTEIN;

ALUMINUM OVERLOAD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HIPPOCAMPUS; LEARNING DISORDER; MEMORY DISORDER; MOTOR CORTEX; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSORY CORTEX; SPATIAL LEARNING; SPATIAL MEMORY; UPREGULATION;

ALUMINUM COMPOUNDS; ANIMALS; BRAIN; CHLORIDES; GINSENOSIDES; GLYCOGEN SYNTHASE KINASE 3; MAZE LEARNING; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; TAU PROTEINS;

EID: 84872200183     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.11.037     Document Type: Article

References (41)

1. Yokel R.A., Allen D.D., Ackley D.C. The distribution of aluminum into and out of the brain. Journal of Inorganic Biochemistry 1999, 76(2):127-132.
2. Yokel R.A., Wilson M., Harris W.R., Halestrap A.P. Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport. Brain Research 2002, 930(1-2):101-110.
3. Kaizer R.R., Corrêa M.C., Gris L.R., da Rosa C.S., Bohrer D., Morsch V.M., et al. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochemical Research 2008, 33(11):2294-2301.
4. Abu-Taweel G.M., Ajarem J.S., Ahmad M. Neurobebavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring. Pharmacology Biochemistry and Behavior 2012, 101(1):49-56.
5. Klatzo I., Wisniewski H., Streicher E. Experimental production of neurofibrillary degeneration. Journal of Neuropathology and Experimental Neurology 1965, 24:187-199.
6. Crapper D.R., Krishnan S.S., Dalton A.J. Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration. Science 1973, 180:511-513.
7. Gupta V.B., Anitha S., Hegde M.L., Zeccal L., Garruto R.M., Shankar S.K., et al. Aluminum in Alzheimer's disease: are we still at a crossroad?. Cellular and Molecular Life Sciences 2005, 62(2):143-158.
8. Grundke-Iqbal I., Iqbal K., Quinlan M., Tung Y.C., Zaidi M.S., Wisniewski H.M. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. Journal of Biological Chemistry 1986, 261(13):6084-6089.
9. Eidenmuller J., Fath T., Mass T., Pool M., Sontag E., Brandt R. Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. Biochemical Journal 2001, 357(Pt):759-767.
10. Fath T., Eidenmüller J., Brandt R. Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. Journal of Neuroscience 2002, 22(22):9733-9741.
11. Léger J., Kempf M., Lee G., Brandt R. Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau. Journal of Biological Chemistry 1997, 272(13):8441-8446.
12. Guadaqna S., Esiri M.M., Williams R.J., Francis P.T. Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia. Neurobiology of Aging 2012, [Epub ahead of print].
13. Martin L., Page G., Terro F. Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β. Neurochemistry International 2011, 59(2):235-250.
14. Obeid R., Schlundt J., Umanskaya N., Herrmann W., Herrmann M. Folate is related to phosphorylated neurofilament-H and P-tau(Ser396) in rat brain. Journal of Neurochemistry 2011, 117(6):1047-1054. 10.1111/j. 1471-4159.2011.07280.x.
15. Attele A.S., Wu J.A., Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology 1999, 58(11):1685-1693.
16. Zhao H.H., Lai H., Zeng L., Lü Y.L. Effects of ginsenosides on BDNF in nucleus basalis of Meynert and cerebral cortex of aged rats. Acta Anatomica Sinica 2006, 37(2):223-225.
17. Lai H., Zhao H.H., Zeng L., Yang J.P., Fang X., Lü Y.L. Effects of ginsenosides on BDNF and TrkB protein expression in hippocampal formation of aged rats. Chinese Journal of Histochemistry & Cytochemistry 2006, 15(1):60-65.
18. Lai H., Wang T.M., Zhao H.H., Zeng L., Gao J., Lü Y.L. Effects of ginsenosides on cholinergic fibers in hippocampal formation of aged rats. Chinese Journal of Anatomy 2006, 29(2):249-251.
19. Gao J., Zhao H.H., Lai H., Gao X.H., Li Z.S., Lü Y.L. Effect of ginseng total saponins on the expression of Acetylcholinesterase in cerebral cortex of aged rats. Progress of Anatomical Sciences 2009, 15(1):97-99.
20. Wang Y., Liu J., Zhang Z., Bi P., Qi Z., Zhang C. Anti-neuroinflammation effect of ginsenoside Rb1 in a rat model of Alzheimer disease. Neuroscience Letters 2011, 487(1):70-72.
21. Liu H.L., Zhao G., Cai K., Zhao H.H., Shi L.D. Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation. Behavioural Brain Research 2011, 218(2):308-314.
22. George P., Keith B.J.F. The mouse brain in stereotaxic coordinates 2001, Academic Press, San Diego. 2nd ed.
23. Yu S., Zheng W., Xin N., Chi Z.H., Wang N.Q., Nie Y.X., et al. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation Research 2010, 13(1):55-64.
24. Kesner R.P. Behavioral functions of the CA3 subregion of the hippocampus. Learning and Memory 2007, 14(11):771-781.
25. Ungerleider L.G. Functional brain imaging studies of cortical mechanisms for memory. Science 1995, 270(5237):769-775.
26. Kumar A., Prakash A., Dogra S. Neuroprotective effect of carvedilol against aluminum induced toxicity: possible behavioral and biochemical alterations in rats. Pharmacological Report 2011, 63(4):915-923.
27. Abdel-Aal R.A., Assi A.A., Kostandy B.B. Rivastigmine reverses aluminum-induced behavioral changes in rats. European Journal of Pharmacology 2011, 659(2-3):169-176.
28. Billingsley M.L., Kincaid R.L. Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochemical Journal 1997, 323(Pt 3):577-591.
29. Bramblett G.T., Goedert M., Jakes R., Merrick S.E., Trojanowski J.Q., Lee V.M. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 1993, 10(6):1089-1099.
30. Buée L., Bussière T., Buée-Scherrer V., Delacourte A., Hof P.R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Research. Brain Research Reviews 2000, 33(1):95-130.
31. Wang Q., Sun L.H., Jia W., Liu X.M., Dang H.X., Mai W.L., et al. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy Research 2010, 24(12):1748-1754.
32. Qi D., Zhu Y., Wen L., Liu Q., Qiao H. Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats. Journal of Psychopharmacology 2009, 23(1):74-83.
33. Li W., Ma K.K., Sun W., Paudel H.K. Phosphorylation sensitizes microtubule-associated protein tau to Al(3+)-induced aggregation. Neurochemical Research 1998, 23(12):1467-1476.
34. Murayama H., Shin R.W., Higuchi J., Shibuya S., Muramoto T., Kitamoto T. Interaction of aluminum with PHFtau in Alzheimer's disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method. American Journal of Pathology 1999, 155(3):877-885.
35. Walton J.R. Evidence for participation of aluminum in neurofibrillary tangle formation and growth in Alzheimer's disease. Journal of Alzheimer's Disease 2010, 22(1):65-72.
36. Hanger D.P., Hughes K., Woodgett R., Brion J.P., Anderton B.H. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localization of the kinase. Neuroscience Letters 1992, 147(1):58-62.
37. Forde J.E., Dale T.C. Glycogen synthase kinase 3: a key regulator of cellular fate. Cellular and Molecular Life Sciences 2007, 64(15):1930-1944.
38. Liu F., Grundke-lqbal I., Iqbak K., Gong C.X. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. European Journal of Neuroscience 2005, 22(8):1942-1950.
39. Singla N., Dhawan D.K. Regulatory role of zinc during aluminum-induced altered carbohydrate metabolism in rat brain. Journal of Neuroscience Research 2012, 90(3):698-705.
40. Li Y.K., Chen X.C., Zhu Y.G., Peng X.S., Zeng Y.Q., Sheng J., et al. Ginsenoside Rb1 attenuates okadaic acid-induced Tau protein hyperphosphorylation in rat hippocampal neurons. Sheng Li Xue Bao 2005, 57(2):154-160.
41. Zhao R., Zhang Z., Song Y., Wang D., Qi J., Wen S. Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3β pathway in ginsenoside Rb1's attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation. Journal of Ethnopharmacology 2011, 133(3):1109-1116.