Efficient [5+1] synthesis of 4-quinolones by domino amination and conjugate addition reactions of 1-(2-fluorophenyl)prop-2-yn-1-ones with amines

Synthesis (Germany)

Volumn 45, Issue 2, 2013, Pages 205-218

  Iaroshenko, Viktoro ^a,b   Mkrtchyan, Satenik ^a   Villinger, Alexander ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

aminations; domino reactions; heterocycles; ketones; Michael additions; quinones

Indexed keywords

AMINATIONS; DOMINO REACTIONS; HETEROCYCLES; MICHAEL ADDITIONS; QUINONES;

ADDITION REACTIONS; AMINATION; KETONES; LITHIUM; REACTION KINETICS;

AMINES;

1 (2 FLUOROPHENYL)PROP 2 YN 1 ONE DERIVATIVE; 1 (3,5 DIMETHOXYPHENYL) 2 PHENYLQUINOLIN 4(1H) ONE; 1 (3,5 DIMETHYLPHENYL) 5 FLUORO 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 1 (3,5 DIMETHYLPHENYL) 5 FLUORO 2 PHENYLQUINOLIN 4(1H) ONE; 1 (3,5 DIMETHYLPHENYL) 7 FLUORO 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 1 (4 ETHYLPHENYL) 5 FLUORO 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 1 (4 METHOXYBENZYL) 2 PHENYLQUINOLIN 4(1H) ONE; 1 (4 TERT BUTYLPHENYL) 7 FLUORO 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 1 HEXYL 2 PHENYLQUINOLIN 4(1H) ONE; 1 PENTYL 2 PHENYLQUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (2 PHENYLETHYL) 5 [(2 PHENYLETHYL)AMINO]QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (3 PHENYLPROPYL) 5 [(3 PHENYLPROPYL)AMINO]QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (3,5 DIMETHOXYPHENYL) 6 FLUOROQUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (4 BROMOPHENYL)QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (4 CHLOROPHENYL)QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 1 (4 METHOXYBENZYL) 5 [(4 METHOXYBENZYL)AMINO]QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 5 FLUORO 1 (3,5 DIMETHOXYPHENYL)QUINOLIN 4(1H) ONE; 2 (4 TERT BUTYLPHENYL) 6 FLUORO 1 (4 METHOXYPHENYL)QUINOLIN 4(1H) ONE; 2 PENTYL 1 (2 PHENYLETHYL) 5 [(2 PHENYLETHYL)AMINO]QUINOLIN 4(1H) ONE; 2 PHENYL 1 (2 PHENYLETHYL)QUINOLIN 4(1H) ONE; 2 PHENYL 1 (3 PHENYLPROPYL)QUINOLIN 4(1H) ONE; 4 QUINOLONE DERIVATIVE; 5 FLUORO 1 (4 METHOXYPHENYL) 2 PENTYLQUINOLIN 4(1H) ONE; 6 FLUORO 1 (2 PHENYLETHYL) 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 6 FLUORO 1 (3 PHENYLPROPYL) 2 (4 TOLYL)QUINOLIN 4(1H) ONE; 6 FLUORO 1 HEXYL 2 (4 TOLYL)QUINOLIN 4(1H) ONE; AMINE; CHEMICAL COMPOUND; LITHIUM CARBONATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINATION; ARTICLE; ATMOSPHERE; CHEMICAL INTERACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH TEMPERATURE; MICHAEL ADDITION;

EID: 84872182253     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316826     Document Type: Article

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