Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 3, 2013, Pages 1131-1142

  Kim, Songmi ^a   Lee, Yuno ^a   Tak, Hyun Min ^b   Park, Hye Jin ^b   Sohn, Young Sik ^a   Hwang, Swan ^a   Han, Jaehee ^b   Kang, Dawon ^b   Lee, Keun Woo ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Blocker binding site; Homology modeling; K2P channel; Molecular docking simulation; Molecular dynamics simulation; TRESK (TWIK related spinal cord K+ channel)

Indexed keywords

ALANINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIDOCAINE; MEMBRANE PROTEIN; MUTANT PROTEIN; PHENYLALANINE; POTASSIUM CHANNEL BLOCKING AGENT; PROPAFENONE; PROTEIN 364A; PROTEIN F156A; QUININE; TANDEM PORE DOMAIN POTASSIUM CHANNEL; TRIETHANOLAMINE; TWIK RELATED SPINAL CORD POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; LIPID BILAYER; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA MUTATIONAL ANALYSIS; ELECTROPHYSIOLOGY; HEK293 CELLS; HUMANS; IONS; LIGANDS; LIPID BILAYERS; MICE; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; POTASSIUM CHANNELS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 84872145001     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2012.11.021     Document Type: Article

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