-
1
-
-
39049183044
-
Regulation and function of IKK and IKKrelated kinases
-
Häcker H, Karin M. 2006. Regulation and function of IKK and IKKrelated kinases. Sci. STKE 2006:re13. http://dx.doi.org/10.1126/stke.3572006re13.
-
(2006)
Sci. STKE
, pp. 13
-
-
Häcker, H.1
Karin, M.2
-
2
-
-
67650724069
-
Regulation and function of NFkappaB transcription factors in the immune system
-
Vallabhapurapu S, Karin M. 2009. Regulation and function of NFkappaB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
3
-
-
77957252647
-
The IKK complex, a central regulator of NF-kappaB activation
-
Israël A. 2010. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harbor Perspect. Biol. 2:a000158. http://dx.doi.org/10.1101/cshperspect.a000158.
-
(2010)
Cold Spring Harbor Perspect. Biol.
, vol.2
-
-
Israël, A.1
-
4
-
-
80051982064
-
Return to homeostasis: Downregulation of NF-kappaB responses
-
Ruland J. 2011. Return to homeostasis: downregulation of NF-kappaB responses. Nat. Immunol. 12:709-714.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 709-714
-
-
Ruland, J.1
-
5
-
-
0035174615
-
Series introduction: The transcription factor NFkappaB and human disease
-
Baldwin AS, Jr. 2001. Series introduction: the transcription factor NFkappaB and human disease. J. Clin. Invest. 107:3-6.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 3-6
-
-
Baldwin, A.S.1
-
6
-
-
33750312876
-
Posttranslational modifications ofNEMOand its partners in NF-kappaB signaling
-
Sebban H, Yamaoka S, Courtois G. 2006. Posttranslational modifications ofNEMOand its partners in NF-kappaB signaling. Trends Cell Biol. 16:569-577.
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 569-577
-
-
Sebban, H.1
Yamaoka, S.2
Courtois, G.3
-
7
-
-
33750457370
-
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
-
Perkins ND. 2006. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25: 6717-6730.
-
(2006)
Oncogene
, vol.25
, pp. 6717-6730
-
-
Perkins, N.D.1
-
8
-
-
78650915536
-
Structural studies of NF-kappaB signaling
-
Zheng C, Yin Q, Wu H. 2011. Structural studies of NF-kappaB signaling. Cell Res. 21:183-195.
-
(2011)
Cell Res.
, vol.21
, pp. 183-195
-
-
Zheng, C.1
Yin, Q.2
Wu, H.3
-
9
-
-
0345826149
-
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
-
Zhou H, et al. 2004. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427:167-171.
-
(2004)
Nature
, vol.427
, pp. 167-171
-
-
Zhou, H.1
-
10
-
-
33747615237
-
Key function for the Ubc13 E2 ubiquitinconjugating enzyme in immune receptor signaling
-
Yamamoto M, et al. 2006. Key function for the Ubc13 E2 ubiquitinconjugating enzyme in immune receptor signaling. Nat. Immunol. 7:962-970.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 962-970
-
-
Yamamoto, M.1
-
11
-
-
0141621240
-
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha
-
Tang ED, Wang CY, Xiong Y, Guan KL. 2003. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J. Biol. Chem. 278:37297-37305.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37297-37305
-
-
Tang, E.D.1
Wang, C.Y.2
Xiong, Y.3
Guan, K.L.4
-
12
-
-
11144289688
-
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
-
Abbott DW, Wilkins A, Asara JM, Cantley LC. 2004. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14:2217-2227.
-
(2004)
Curr. Biol.
, vol.14
, pp. 2217-2227
-
-
Abbott, D.W.1
Wilkins, A.2
Asara, J.M.3
Cantley, L.C.4
-
13
-
-
33644538632
-
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
-
Wu ZH, Shi Y, Tibbetts RS, Miyamoto S. 2006. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311:1141-1146.
-
(2006)
Science
, vol.311
, pp. 1141-1146
-
-
Wu, Z.H.1
Shi, Y.2
Tibbetts, R.S.3
Miyamoto, S.4
-
14
-
-
0344305376
-
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
-
Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S. 2003. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115:565-576.
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.H.3
Miyamoto, S.4
-
15
-
-
63649144413
-
Principles of ubiquitin and Sumo modifications in DNA repair
-
Bergink S, Jentsch S. 2009. Principles of ubiquitin and Sumo modifications in DNA repair. Nature 458:461-467.
-
(2009)
Nature
, vol.458
, pp. 461-467
-
-
Bergink, S.1
Jentsch, S.2
-
16
-
-
0034806402
-
Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity
-
Tarassishin L, Horwitz MS. 2001. Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity. Biochem. Biophys. Res. Commun. 285:555-560.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.285
, pp. 555-560
-
-
Tarassishin, L.1
Horwitz, M.S.2
-
17
-
-
0037024696
-
Regulation of Ikappa B kinase (IKK-)gamma /NEMO function by IKKbeta-mediated phosphorylation
-
Prajapati S, Gaynor RB. 2002. Regulation of Ikappa B kinase (IKK-)gamma /NEMO function by IKKbeta-mediated phosphorylation. J. Biol. Chem. 277:24331-24339.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24331-24339
-
-
Prajapati, S.1
Gaynor, R.B.2
-
18
-
-
0038143356
-
In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase
-
Carter RS, Pennington KN, Ungurait BJ, Ballard DW. 2003. In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. J. Biol. Chem. 278:19642-19648.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19642-19648
-
-
Carter, R.S.1
Pennington, K.N.2
Ungurait, B.J.3
Ballard, D.W.4
-
19
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C, et al. 2001. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
-
20
-
-
17944378526
-
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben U, et al. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293:1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
-
21
-
-
0032583947
-
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of ser-176
-
U. S. A
-
Ling L, Cao Z, Goeddel DV. 1998. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of ser-176. Proc. Natl. Acad. Sci. U. S. A. 95:3792-3797.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Goeddel, D.V.3
-
22
-
-
0033537719
-
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
-
Delhase M, Hayakawa M, Chen Y, Karin M. 1999. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284:309-313.
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
23
-
-
33750433585
-
Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
-
Hiscott J, Nguyen TL, Arguello M, Nakhaei P, Paz S. 2006. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene 25:6844-6867.
-
(2006)
Oncogene
, vol.25
, pp. 6844-6867
-
-
Hiscott, J.1
Nguyen, T.L.2
Arguello, M.3
Nakhaei, P.4
Paz, S.5
-
24
-
-
77951192990
-
KSHV and the pathogenesis of Kaposi sarcoma: Listening to human biology and medicine
-
Ganem D. 2010. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J. Clin. Invest. 120:939-949.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 939-949
-
-
Ganem, D.1
-
25
-
-
0030970013
-
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
Thome M, et al. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386:517-521.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
-
26
-
-
0030950228
-
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis
-
Hu S, Vincenz C, Buller M, Dixit VM. 1997. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J. Biol. Chem. 272: 9621-9624.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9621-9624
-
-
Hu, S.1
Vincenz, C.2
Buller, M.3
Dixit, V.M.4
-
27
-
-
12644286556
-
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
-
U. S. A
-
Bertin J, et al. 1997. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc. Natl. Acad. Sci. U. S. A. 94:1172-1176.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 1172-1176
-
-
Bertin, J.1
-
28
-
-
0346101776
-
The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation
-
Sun Q, Zachariah S, Chaudhary PM. 2003. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J. Biol. Chem. 278:52437-52445.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52437-52445
-
-
Sun, Q.1
Zachariah, S.2
Chaudhary, P.M.3
-
29
-
-
0037134478
-
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex
-
Liu L, et al. 2002. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J. Biol. Chem. 277:13745-13751.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13745-13751
-
-
Liu, L.1
-
30
-
-
0141502126
-
KSHV vFLIP binds to IKK-gamma to activate IKK
-
Field N, et al. 2003. KSHV vFLIP binds to IKK-gamma to activate IKK. J. Cell Sci. 116:3721-3728.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 3721-3728
-
-
Field, N.1
-
31
-
-
0033554648
-
Modulation of the NF-kappa B pathway by virally encoded death effector domainscontaining proteins
-
Chaudhary PM, Jasmin A, Eby MT, Hood L. 1999. Modulation of the NF-kappa B pathway by virally encoded death effector domainscontaining proteins. Oncogene 18:5738-5746.
-
(1999)
Oncogene
, vol.18
, pp. 5738-5746
-
-
Chaudhary, P.M.1
Jasmin, A.2
Eby, M.T.3
Hood, L.4
-
32
-
-
70549086229
-
Large-scale proteomics analysis of the human kinome
-
Oppermann FS, et al. 2009. Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics 8:1751-1764.
-
(2009)
Mol. Cell. Proteomics
, vol.8
, pp. 1751-1764
-
-
Oppermann, F.S.1
-
33
-
-
0030613551
-
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
-
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. 1997. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91:243-252.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
34
-
-
0032541657
-
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
-
Rothwarf DM, Zandi E, Natoli G, Karin M. 1998. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395: 297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
35
-
-
42949159409
-
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
-
Rushe M, et al. 2008. Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site. Structure 16:798-808.
-
(2008)
Structure
, vol.16
, pp. 798-808
-
-
Rushe, M.1
-
36
-
-
0034284715
-
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
-
May MJ, et al. 2000. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 289:1550-1554.
-
(2000)
Science
, vol.289
, pp. 1550-1554
-
-
May, M.J.1
-
37
-
-
0037332580
-
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation
-
Tegethoff S, Behlke J, Scheidereit C. 2003. Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. Mol. Cell. Biol. 23:2029-2041.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2029-2041
-
-
Tegethoff, S.1
Behlke, J.2
Scheidereit, C.3
-
38
-
-
0037124036
-
NEMO trimerizes through its coiled-coil C-terminal domain
-
Agou F, et al. 2002. NEMO trimerizes through its coiled-coil C-terminal domain. J. Biol. Chem. 277:17464-17475.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17464-17475
-
-
Agou, F.1
-
39
-
-
49449085504
-
A quantitative atlas of mitotic phosphorylation
-
U. S. A
-
Dephoure N, et al. 2008. A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 105:10762-10767.
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, pp. 10762-10767
-
-
Dephoure, N.1
-
40
-
-
1642528831
-
Post-translational modifications and their biological functions: Proteomic analysis and systematic approaches
-
Seo J, Lee KJ. 2004. Post-translational modifications and their biological functions: proteomic analysis and systematic approaches. J. Biochem. Mol. Biol. 37:35-44.
-
(2004)
J. Biochem. Mol. Biol.
, vol.37
, pp. 35-44
-
-
Seo, J.1
Lee, K.J.2
-
41
-
-
0034718693
-
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
-
Xiao G, Sun SC. 2000. Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. Oncogene 19:5198-5203.
-
(2000)
Oncogene
, vol.19
, pp. 5198-5203
-
-
Xiao, G.1
Sun, S.C.2
-
42
-
-
0033580931
-
Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I tax interacts directly with IkappaB kinase gamma
-
Jin DY, Giordano V, Kibler KV, Nakano H, Jeang KT. 1999. Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I tax interacts directly with IkappaB kinase gamma. J. Biol. Chem. 274:17402-17405.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17402-17405
-
-
Jin, D.Y.1
Giordano, V.2
Kibler, K.V.3
Nakano, H.4
Jeang, K.T.5
-
43
-
-
0347362814
-
Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory proteininduced NF-kappaB activation
-
Matta H, Sun Q, Moses G, Chaudhary PM. 2003. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory proteininduced NF-kappaB activation. J. Biol. Chem. 278:52406-52411.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52406-52411
-
-
Matta, H.1
Sun, Q.2
Moses, G.3
Chaudhary, P.M.4
-
44
-
-
77951228086
-
Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB
-
Shifera AS. 2010. Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB. J. Cell. Physiol. 223: 558-561.
-
(2010)
J. Cell. Physiol.
, vol.223
, pp. 558-561
-
-
Shifera, A.S.1
-
45
-
-
77953026286
-
Proteins that bind to IKKgamma (NEMO) and downregulate the activation of NF-kappaB
-
Shifera AS. 2010. Proteins that bind to IKKgamma (NEMO) and downregulate the activation of NF-kappaB. Biochem. Biophys. Res. Commun. 396:585-589.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.396
, pp. 585-589
-
-
Shifera, A.S.1
-
46
-
-
3042689762
-
Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domainlike IL-1 beta-converting enzyme inhibitory protein (vFLIP)
-
U. S. A
-
Matta H, Chaudhary PM. 2004. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domainlike IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc. Natl. Acad. Sci. U. S. A. 101:9399-9404.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 9399-9404
-
-
Matta, H.1
Chaudhary, P.M.2
-
47
-
-
79960390341
-
Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways
-
Shimizu A, et al. 2011. Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways. J. Virol. 85: 7444-7448.
-
(2011)
J. Virol.
, vol.85
, pp. 7444-7448
-
-
Shimizu, A.1
-
48
-
-
33947418102
-
Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction
-
Garcia MI, Kaserman J, Chung YH, Jung JU, Lee SH. 2007. Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J. Virol. 81:2663-2674.
-
(2007)
J. Virol.
, vol.81
, pp. 2663-2674
-
-
Garcia, M.I.1
Kaserman, J.2
Chung, Y.H.3
Jung, J.U.4
Lee, S.H.5
|