Anticoagulant activity of a unique sulfated pyranosic (1→3)-β-L- arabinan through direct interaction with thrombin

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 223-233

  Fernández, Paula V ^a   Quintana, Irene ^a   Cerezo, Alberto S ^a   Caramelo, Julio J ^b   Pol Fachin, Laercio ^c   Verli, Hugo ^c   Estevez, José M ^d   Ciancia, Marina ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d INSTITUTO DE FISIOLOGÍA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANTICOAGULANT ACTIVITIES; ANTITHROMBIN; ARABINANS; CATALYTIC SITES; CD SPECTRA; CONFORMATIONAL CHANGE; DIRECT INTERACTIONS; GLYCOSAMINOGLYCANS; GREEN SEAWEED; HEPARIN COFACTOR; LIGAND BINDING; MODEL COMPOUND; OCTASACCHARIDE; PYRANOSE; SULFATE GROUPS; SULFATED POLYSACCHARIDES; THROMBIN INHIBITION;

AMINO ACIDS; COAGULATION; COMPUTER SIMULATION; FLUORESCENCE SPECTROSCOPY; OLIGOSACCHARIDES; POLYSACCHARIDES; SEAWEED;

ENZYMES;

ALGAL EXTRACT; AMINO ACID; ARABINOSE; CARBOHYDRATE; HEPARIN COFACTOR II; OLIGOSACCHARIDE; POLYSACCHARIDE; PROTEIN; SULFATED PYRANOSIC BETA ARABINAN; THROMBIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TEST; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DRUG MECHANISM; DRUG STRUCTURE; FLUORESCENCE SPECTROSCOPY; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SEAWEED; SIMULATION;

ANIMALS; ANTICOAGULANTS; BIOPHYSICS; BLOOD COAGULATION; CARBOHYDRATE CONFORMATION; CATTLE; CELL WALL; CIRCULAR DICHROISM; ELECTROPHORESIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MODELS, CHEMICAL; MOLECULAR CONFORMATION; POLYSACCHARIDES; PROTEIN BINDING; PYRANS; SEAWEED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THROMBIN;

CAULERPALES; CODIUM VERMILARA;

EID: 84872092124     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.386441     Document Type: Article

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