Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis

Journal of Biomedical Optics

Volumn 16, Issue 8, 2011, Pages

  Maher, Jason R ^a   Takahata, Masahiko ^a,b   Awad, Hani A ^b,c   Bergera, Andrew J ^a,c  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c University of Rochester   (United States)

Author keywords

Biomechanics; Bone; Osteoporosis; Partial least squares; Raman spectroscopy; Rheumatoid arthritis

Indexed keywords

BIOCHEMICAL EFFECTS; BIOMECHANICAL PROPERTIES; BONE DISEASE; BONE MINERAL DENSITY; BONE MINERALS; CORTICAL BONE; EX-VIVO; GLUCOCORTICOIDS; INFLAMMATORY DISORDERS; MICROCOMPUTED TOMOGRAPHY; MOUSE MODELS; OSTEOPOROSIS; PARTIAL LEAST SQUARES; RHEUMATOID ARTHRITIS; SPECTRAL DIFFERENCES; TORSION TESTS; TRANSGENIC MICE; WILD TYPES;

BIOMECHANICS; COMPUTERIZED TOMOGRAPHY; HEALTH; MAMMALS; PATIENT TREATMENT; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SILICATE MINERALS; TORSION TESTING;

BONE;

MUS; MUS MUSCULUS;

GLUCOCORTICOID; PREDNISOLONE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BIOMECHANICS; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; OSTEOPOROSIS; PATHOLOGY; RAMAN SPECTROMETRY; REGRESSION ANALYSIS; REPRODUCIBILITY; RHEUMATOID ARTHRITIS; TIBIA; TORQUE;

ANALYSIS OF VARIANCE; ANIMALS; ARTHRITIS, RHEUMATOID; BIOMECHANICS; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; LEAST-SQUARES ANALYSIS; MICE; OSTEOPOROSIS; PREDNISOLONE; REPRODUCIBILITY OF RESULTS; SPECTRUM ANALYSIS, RAMAN; TIBIA; TORQUE; X-RAY MICROTOMOGRAPHY;

EID: 80455137144     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3613933     Document Type: Article

References (39)

1. C. G. Helmick, D. T. Felson, R. C. Lawrence, S. Gabriel, R. Hirsch, C.K. Kwoh, M. H. Lian, H.M. Kremers,M. D.Mayes, P. A.Merkel, S. R.Pillemer, J. D. Reveille, and J. H. Stone, "Estimates of the prevalenceof arthritis and other rheumatic conditions in the United States. Part I,"Arthritis Rheum. 58, 15-25 (2008).
2. S. C. Manolagas and R. S.Weinstein, "New developments in the pathogenesisand treatment of steroid-induced osteoporosis," J. Bone Miner.Res. 14, 1161-1066 (1999).
3. W. Yao, Z. Cheng, A. Pham, C. Busse, E. A. Zimmermann, R. O.Ritchie, and N. E. Lane, "Glucocorticoid-induced bone loss in micecan be reversed by the actions of parathyroid hormone and risedronateon different pathways for bone formation and mineralization," ArthritisRheum. 58, 34853497 (2008).
4. R. S. Weinstein, R. L. Jilka, A. M. Parfitt, and S. C. Manolagas, "Inhibitionof osteoblastogenesis and promotion of apoptosis of osteoblastsand osteocytes by glucocorticoids. Potential mechanisms of their deleteriouseffects on bone," J. Clin. Invest. 102, 274-282 (1998). (Pubitemid 28335186)
5. D. M. Reid, J.-P. Devogelaer, K. Saag, C. Roux, C.-S. Lau,J.-Y. Reginster, P. Papanastasiou, A. Ferreira, F. Hartl, T. Fashola, P.Mesenbrink, and P. N. Sambrook, "Zoledronic acid and risedronatein the prevention and treatment of glucocorticoid-induced osteoporosis(horizon): A multicentre, double-blind, double-dummy, randomisedcontrolled trial," Lancet 373, 1253-1263 (2009).
6. S. Silverman, "New therapies for osteoporosis: Zoledronic acid, bazedoxifene,and denosumab," Cur. Osteoporosis Rep. 7, 91-95 (2009).
7. J.-P. Devogelaer, R. A. Adler, C. Recknor, K. See, M. R. Warner, M.Wong, and K. Krohn, "Baseline glucocorticoid dose and bone mineraldensity response with teriparatide or alendronate therapy in patientswith glucocorticoid-induced osteoporosis," J. Rheumatol. 37, 141-148(2010).
8. B. Seriolo, S. Paolino, A. Sulli, V. Ferretti, and M. Cutolo, "Bonemetabolism changes during anti-TNF therapy in patients with activerheumatoid arthritis," Ann. N.Y. Acad. Sci. 1069, 420-427 (2006). (Pubitemid 43989885)
9. K. G. Saag, E. Shane, S. Boonen, F. Marin, D. W. Donley, K. A.Taylor, G. P. Dalsky, and R. Marcus, "Teriparatide or alendronate inglucocorticoid- induced osteoporosis," N. Engl. J. of Med. 357, 2028-2039 (2007).
10. K. G. Saag, J. R. Zanchetta, J.-P. Devogelear, R. A. Adler,R. Eastell, K. See, J. H. Krege, K. Krohn, and M. R. Warner, "Effectsof teriparatide versus alendronate for treating glucocorticoid-inducedosteoporosis: Thirty-six-month results of a randomized, double-blind,controlled trial," Arthritis Rheum. 60, 3346-3355 (2009).
11. D. Faibish, S. M. Ott, and A. L. Boskey, "Mineral changes in osteoporosis:A review," Clin. Orthop. and Relat. Res. 443, 28-38 (2006).
12. A. Carden and M. D. Morris, "Application of vibrational spectroscopyto the study of mineralized tissues (review)," J. Biomed.Opt. 5, 259-268(2000).
13. B. R. McCreadie, M. D. Morris, T. Chen, D. S. Rao, W. F. Finney, E.Widjaja, and S. A. Goldstein, "Bone tissue compositional differencesin women with and without osteoporotic fracture," Bone (N.Y.) 39,1190-1195 (2006). (Pubitemid 44827927)
14. M. Raghavan, N. D. Sahar, R. H. Wilson, M.-A. Mycek, N. Pleshko,D. H. Kohn, and M. D. Morris, "Quantitative polarized Ramanspectroscopy in highly turbid bone tissue," J. Biomed. Opt. 15, 037001(2010).
15. K. A. Dehring, N. J. Crane, A. R. Smukler, J. B. McHugh, B. J.Roessler, and M. D. Morris, "Identifying chemical changes in subchondralbone taken from murine knee joints using Raman spectroscopy,"Appl. Spectrosc. 60, 1134-1141 (2006). (Pubitemid 44599990)
16. J. Keffer, L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D.Kioussis, and G. Kollias, "Transgenic mice expressing human tumournecrosis factor: A predictive genetic model of arthritis," EMBO J. 10,4025-4031 (1991). (Pubitemid 21905432)
17. P. Li and E. M. Schwarz, "The TNF-a transgenic mouse model ofinflammatory arthritis," Springer Semin. Immunopathol. 25, 19-33(2003). (Pubitemid 37000036)
18. N. E. Lane, W. Yao, M. Balooch, R. K. Nalla, G. Balooch, S. Habelitz,J. H. Kinney, and L. F. Bonewald, "Glucocorticoid-treated micehave localized changes in trabecular bone material properties andosteocyte lacunar size that are not observed in placebo-treated orestrogen-deficient mice," J. Bone Miner. Res. 21, 466-476 (2006).
19. F. W. Esmonde-White, K. A. Esmonde-White, and M. D. Morris,"Minor distortions with major consequences: Correcting distortions inimaging spectrographs," Appl. Spectrosc. 65, 85-98 (2011).
20. K. A. Dooley, F. W. L. Esmonde-White, and M. D. Morris, "Opticalfiber bundle coupling errors in Raman spectra: Correction via dataprocessing," Proc. SPIE 7560, 75600O (2010).
21. C. A. Lieber and A. Mahadevan-Jansen, "Automated method forsubtraction of fluorescence from biological Raman spectra," Appl.Spectrosc. 57, 1363-1367 (2003).
22. A. Savitzky and M. J.E. Golay, "Smoothing and differentiation of databy simplified least squares procedures," Anal. Chem. 36, 1627-1639(1964).
23. D. G. Reynolds, C. Hock, S. Shaikh, J. Jacobson, X. Zhang, P. T.Rubery, C. A. Beck, R. J. O'Keefe,A. L. Lerner, E. M. Schwarz, andH.A. Awad, "Micro-computed tomography prediction of biomechanicalstrength in murine structural bone grafts," J. Biomech. 40, 3178-3186(2007). (Pubitemid 47532093)
24. J. J. Broz, S. J. Simske, A. R. Greenberg, and M. W. Luttges, "Effectsof rehydration state on the flexural properties of whole mouse longbones," J. Biomech. Eng. 115, 447-449 (1993). (Pubitemid 23356850)
25. M. D. Brodt, C. B. Ellis, and M. J. Silva, "Growing C57Bl/6 miceincrease whole bone mechanical properties by increasing geometricand material properties," J. Bone Miner. Res. 14, 2159-2166 (1999). (Pubitemid 30026966)
26. M. J. Silva, M. D. Brodt, B. Wopenka, S. Thomopoulos, D. Williams,M. H. Wassen, M. Ko, N. Kusano, and R. A. Bank, "Decreasedcollagen organization and content are associated with reduced strengthof demineralized and intact bone in the SAMP6 mouse," J. Bone Miner.Res. 21, 78-88 (2006). (Pubitemid 43023229)
27. D. M. Haaland and E. V. Thomas, "Partial least-squares methodsfor spectral analyses. 1 Relation to other quantitative calibrationmethods and the extraction of qualitative information," Anal. Chem. 60,1193-1202 (1988), http://pubs.acs.org/doi/pdf/10.1021/ac00162a020.
28. D. Qi and A. J. Berger, "Chemical concentration measurement inblood serum and urine samples using liquid-core optical fiber Ramanspectroscopy," Appl. Opt. 46, 1726-1734 (2007). (Pubitemid 46659539)
29. B. D. Beier, R. G. Q.Jr., and A. J. Berger, "Identification of differentbacterial species in biofilms using confocal Raman microscopy," J.Biomed. Opt. 15, 066001 (2010).
30. P. Pennisi,A. Trombetti, andR.Rizzoli, "Glucocorticoid-induced osteoporosisand its treatment," Clin. Orthop. Relat. Res. 443, 39-47 (2006).
31. H. D. Nelson, M. Helfand, S. H. Woolf, and J. D. Allan, "Screeningfor postmenopausal osteoporosis: A review of the evidence for theU.S. preventive services task force," Ann. Intern. Med. 137, 529-541(2002), http://www.annals.org/content/137/6/529.full.pdf+html. (Pubitemid 35024625)
32. M. V. Schulmerich, J. H. Cole, K. A. Dooley, M. D. Morris, J. M.Kreider, and S. A. Goldstein, "Optical clearing in transcutaneousRaman spectroscopy of murine cortical bone tissue," J. Biomed. Opt.13, 021108 (2008).
33. M. V. Schulmerich, J. H. Cole, J. M. Kreider, F. Esmonde-White, K. A.Dooley, S. A. Goldstein, and M. D. Morris, "Transcutaneous Ramanspectroscopy of murine bone in vivo," Appl. Spectrosc. 63, 286-295(2009).
34. M. V. Schulmerich, K. A. Dooley, M. D. Morris, T. M. Vanasse, and S.A. Goldstein, "Transcutaneous fiber optic Raman spectroscopy of boneusing annular illumination and a circular array of collection fibers," J.Biomed. Opt. 11, 060502 (2006).
35. M. V. Schulmerich, J. H. Cole, K. A. Dooley, M. D. Morris, J. M.Kreider, S. A. Goldstein, S. Srinivasan, and B.W. Pogue, "NoninvasiveRaman tomographic imaging of canine bone tissue," J. Biomed. Opt.13, 020506 (2008).
36. P. Matousek, E. R. C. Draper, A. E. Goodship, I. P. Clark, K. L.Ronayne, and A. W. Parker, "Noninvasive Raman spectroscopy ofhuman tissue in vivo," Appl. Spectrosc. 60, 758-763 (2006). (Pubitemid 44140221)
37. O. Akkus, F. Adar, and M. B. Schaffler, "Age-related changes inphysicochemical properties of mineral crystals are related to impairedmechanical function of cortical bone," Bone 34, 443-453 (2004). (Pubitemid 38314909)
38. J. S. Yerramshetty and O. Akkus, "The associations between mineralcrystallinity and the mechanical properties of human cortical bone,"Bone 42, 476-482 (2008).
39. X. Bi, C. A. Patil, C. C. Lynch, G. M. Pharr, A. Mahadevan-Jansen,and J. S. Nyman, "Raman and mechanical properties correlate at wholebone- and tissue-levels in a genetic mouse model," J. Biomech. 44,297-303 (2011).